Incidental Mutation 'R4181:Or7g30'
ID 319743
Institutional Source Beutler Lab
Gene Symbol Or7g30
Ensembl Gene ENSMUSG00000052182
Gene Name olfactory receptor family 7 subfamily G member 30
Synonyms Olfr849, GA_x6K02T2PVTD-13176842-13177780, MOR151-1
MMRRC Submission 041017-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.146) question?
Stock # R4181 (G1)
Quality Score 225
Status Validated
Chromosome 9
Chromosomal Location 19352211-19353149 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 19353031 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Alanine to Valine at position 274 (A274V)
Ref Sequence ENSEMBL: ENSMUSP00000149769 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000063923] [ENSMUST00000217273]
AlphaFold Q8VFF6
Predicted Effect possibly damaging
Transcript: ENSMUST00000063923
AA Change: A274V

PolyPhen 2 Score 0.862 (Sensitivity: 0.83; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000064123
Gene: ENSMUSG00000052182
AA Change: A274V

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 1.9e-51 PFAM
Pfam:7TM_GPCR_Srsx 35 305 7.6e-6 PFAM
Pfam:7tm_1 41 290 2.6e-23 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000157237
Predicted Effect possibly damaging
Transcript: ENSMUST00000217273
AA Change: A274V

PolyPhen 2 Score 0.862 (Sensitivity: 0.83; Specificity: 0.93)
Meta Mutation Damage Score 0.2055 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.4%
  • 20x: 95.6%
Validation Efficiency 92% (48/52)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Agl T C 3: 116,540,279 (GRCm39) Y1445C probably damaging Het
Arhgap12 T C 18: 6,111,734 (GRCm39) D210G probably damaging Het
Atp11b A G 3: 35,854,714 (GRCm39) K284R probably benign Het
Atp11b A G 3: 35,843,707 (GRCm39) T185A probably damaging Het
Bcas1 A G 2: 170,260,547 (GRCm39) V44A probably benign Het
Carmil3 G A 14: 55,741,412 (GRCm39) D1066N probably benign Het
Cfap251 T C 5: 123,431,873 (GRCm39) I549T probably benign Het
Chil4 G A 3: 106,111,043 (GRCm39) P284S possibly damaging Het
Clic4 A G 4: 134,953,350 (GRCm39) V98A probably benign Het
Cmpk2 T C 12: 26,527,046 (GRCm39) V345A probably damaging Het
Col6a3 A T 1: 90,735,336 (GRCm39) I771N probably damaging Het
Cyp2d34 A T 15: 82,501,486 (GRCm39) probably null Het
Cyp7a1 C T 4: 6,271,205 (GRCm39) G317E probably benign Het
Ddx1 A T 12: 13,281,504 (GRCm39) L353* probably null Het
Dnhd1 T A 7: 105,343,161 (GRCm39) W1502R probably damaging Het
Drc1 T C 5: 30,513,057 (GRCm39) V377A probably benign Het
Fyb1 A G 15: 6,610,404 (GRCm39) N326D probably benign Het
Gapdh C T 6: 125,142,197 (GRCm39) probably benign Het
Gm973 A G 1: 59,590,399 (GRCm39) Y302C possibly damaging Het
Grsf1 G A 5: 88,812,015 (GRCm39) P271S probably benign Het
Gtpbp3 C T 8: 71,944,111 (GRCm39) T285I probably damaging Het
Hnrnpul1 T C 7: 25,426,237 (GRCm39) D538G probably damaging Het
Kif26b G A 1: 178,742,991 (GRCm39) S582N probably damaging Het
Lgals4 T C 7: 28,535,437 (GRCm39) V107A possibly damaging Het
Lmbr1l A T 15: 98,806,601 (GRCm39) L270Q possibly damaging Het
Loxl4 T A 19: 42,596,030 (GRCm39) Y141F probably benign Het
Lpcat3 C T 6: 124,680,187 (GRCm39) probably benign Het
Lrp1b G A 2: 40,501,446 (GRCm39) T219I probably damaging Het
Man2a2 T A 7: 80,001,487 (GRCm39) E1140V possibly damaging Het
Mapk8 T C 14: 33,104,177 (GRCm39) D413G probably damaging Het
Or11h4b C G 14: 50,918,507 (GRCm39) E195Q probably benign Het
Or8k53 A T 2: 86,177,581 (GRCm39) H176Q probably damaging Het
Pdss1 T C 2: 22,805,517 (GRCm39) I265T probably damaging Het
Piezo2 T C 18: 63,257,801 (GRCm39) probably null Het
Rad50 T A 11: 53,592,832 (GRCm39) N106I probably benign Het
Rbbp6 A G 7: 122,593,958 (GRCm39) Y568C probably damaging Het
Rorc G A 3: 94,294,500 (GRCm39) C33Y probably damaging Het
Ssc4d T C 5: 135,990,778 (GRCm39) E470G possibly damaging Het
Tnxb T G 17: 34,928,428 (GRCm39) V2614G possibly damaging Het
Trip11 A T 12: 101,860,027 (GRCm39) D282E probably damaging Het
Ttn G T 2: 76,706,811 (GRCm39) probably benign Het
Vangl1 A T 3: 102,073,097 (GRCm39) probably benign Het
Wiz T C 17: 32,586,959 (GRCm39) E117G probably damaging Het
Zfp982 A G 4: 147,597,150 (GRCm39) K169R probably benign Het
Other mutations in Or7g30
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01285:Or7g30 APN 9 19,352,266 (GRCm39) missense probably benign 0.01
IGL01599:Or7g30 APN 9 19,353,111 (GRCm39) missense probably benign 0.00
IGL01885:Or7g30 APN 9 19,352,760 (GRCm39) missense probably benign 0.01
IGL02258:Or7g30 APN 9 19,352,295 (GRCm39) missense probably benign 0.00
IGL02258:Or7g30 APN 9 19,352,293 (GRCm39) missense possibly damaging 0.66
IGL02282:Or7g30 APN 9 19,352,914 (GRCm39) missense probably benign 0.42
R1293:Or7g30 UTSW 9 19,352,728 (GRCm39) missense probably benign 0.27
R1931:Or7g30 UTSW 9 19,352,647 (GRCm39) missense possibly damaging 0.93
R2444:Or7g30 UTSW 9 19,352,311 (GRCm39) missense possibly damaging 0.78
R4231:Or7g30 UTSW 9 19,352,886 (GRCm39) missense probably damaging 1.00
R4233:Or7g30 UTSW 9 19,352,886 (GRCm39) missense probably damaging 1.00
R4236:Or7g30 UTSW 9 19,352,886 (GRCm39) missense probably damaging 1.00
R4302:Or7g30 UTSW 9 19,352,295 (GRCm39) missense probably benign 0.00
R4651:Or7g30 UTSW 9 19,352,591 (GRCm39) nonsense probably null
R5006:Or7g30 UTSW 9 19,352,545 (GRCm39) missense probably benign 0.30
R5088:Or7g30 UTSW 9 19,353,067 (GRCm39) missense probably damaging 1.00
R5501:Or7g30 UTSW 9 19,352,290 (GRCm39) missense possibly damaging 0.93
R6775:Or7g30 UTSW 9 19,352,718 (GRCm39) missense possibly damaging 0.56
R7038:Or7g30 UTSW 9 19,352,888 (GRCm39) missense possibly damaging 0.88
R8010:Or7g30 UTSW 9 19,352,988 (GRCm39) missense probably benign 0.02
R8850:Or7g30 UTSW 9 19,352,817 (GRCm39) missense probably damaging 0.96
R9154:Or7g30 UTSW 9 19,352,531 (GRCm39) missense probably benign 0.39
R9523:Or7g30 UTSW 9 19,352,580 (GRCm39) missense possibly damaging 0.73
Predicted Primers PCR Primer
(F):5'- TGCTAGTTTACACAGTGTCTGTTC -3'
(R):5'- GCTAAGCATGTTGATTCACAAAGTC -3'

Sequencing Primer
(F):5'- TCCTGTCTTTGGGATTATTTTGTC -3'
(R):5'- GCATGTTGATTCACAAAGTCTTATG -3'
Posted On 2015-06-10