Incidental Mutation 'R4182:Vmn1r72'
| ID |
319774 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn1r72
|
| Ensembl Gene |
ENSMUSG00000095430 |
| Gene Name |
vomeronasal 1 receptor 72 |
| Synonyms |
V1rg1 |
| MMRRC Submission |
041018-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.055)
|
| Stock # |
R4182 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
7 |
| Chromosomal Location |
11403526-11404446 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to T
at 11403995 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Arginine to Lysine
at position 151
(R151K)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000154511
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000053134]
[ENSMUST00000209638]
[ENSMUST00000227010]
|
| AlphaFold |
Q8K3N7 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000053134
AA Change: R151K
PolyPhen 2
Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
|
| SMART Domains |
Protein: ENSMUSP00000052997
Gene: ENSMUSG00000095430
AA Change: R151K
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:TAS2R
|
1 |
305 |
1.8e-9 |
PFAM |
|
Pfam:V1R
|
25 |
300 |
6.7e-26 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000209638
AA Change: R151K
PolyPhen 2
Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000227010
AA Change: R151K
PolyPhen 2
Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
|
| Meta Mutation Damage Score |
0.0898 |
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.7%
- 10x: 97.4%
- 20x: 95.6%
|
| Validation Efficiency |
98% (43/44) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 37 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Arhgap12 |
T |
C |
18: 6,111,734 (GRCm39) |
D210G |
probably damaging |
Het |
| Baz2b |
A |
T |
2: 59,928,801 (GRCm39) |
|
probably benign |
Het |
| Bcl9 |
A |
G |
3: 97,120,999 (GRCm39) |
|
probably null |
Het |
| Cfap20 |
A |
T |
8: 96,151,284 (GRCm39) |
I19N |
probably damaging |
Het |
| Clnk |
T |
A |
5: 38,905,193 (GRCm39) |
|
probably benign |
Het |
| Col18a1 |
C |
T |
10: 76,894,675 (GRCm39) |
|
probably null |
Het |
| Cux2 |
C |
T |
5: 122,006,555 (GRCm39) |
G905D |
probably damaging |
Het |
| Ddx1 |
A |
T |
12: 13,281,504 (GRCm39) |
L353* |
probably null |
Het |
| Ddx59 |
T |
A |
1: 136,367,599 (GRCm39) |
S569T |
probably benign |
Het |
| Des |
C |
G |
1: 75,339,228 (GRCm39) |
A251G |
probably benign |
Het |
| Dnajc21 |
T |
C |
15: 10,460,019 (GRCm39) |
|
probably null |
Het |
| Fam217a |
T |
C |
13: 35,094,239 (GRCm39) |
T416A |
possibly damaging |
Het |
| Gbp9 |
T |
A |
5: 105,231,461 (GRCm39) |
Q375L |
probably benign |
Het |
| Grsf1 |
G |
A |
5: 88,812,015 (GRCm39) |
P271S |
probably benign |
Het |
| H2-T24 |
A |
T |
17: 36,326,376 (GRCm39) |
N174K |
possibly damaging |
Het |
| Heatr3 |
T |
C |
8: 88,897,630 (GRCm39) |
|
probably benign |
Het |
| Lurap1l |
G |
A |
4: 80,872,095 (GRCm39) |
S196N |
probably benign |
Het |
| Naaa |
C |
T |
5: 92,420,413 (GRCm39) |
|
probably null |
Het |
| Nbea |
A |
G |
3: 55,915,848 (GRCm39) |
C875R |
probably damaging |
Het |
| Nme1 |
G |
A |
11: 93,851,630 (GRCm39) |
T87I |
probably benign |
Het |
| Nphp3 |
T |
C |
9: 103,915,663 (GRCm39) |
S124P |
probably benign |
Het |
| Nrap |
C |
T |
19: 56,338,759 (GRCm39) |
V907M |
probably damaging |
Het |
| Or1o2 |
T |
G |
17: 37,542,739 (GRCm39) |
H174P |
possibly damaging |
Het |
| Or4f59 |
G |
T |
2: 111,872,873 (GRCm39) |
P168Q |
probably damaging |
Het |
| Pcdhga8 |
A |
G |
18: 37,860,336 (GRCm39) |
N464S |
probably damaging |
Het |
| Pdcd6ip |
T |
C |
9: 113,529,078 (GRCm39) |
I75V |
probably benign |
Het |
| Ralgapa2 |
G |
A |
2: 146,277,914 (GRCm39) |
P416S |
probably damaging |
Het |
| Saal1 |
A |
G |
7: 46,360,076 (GRCm39) |
|
probably benign |
Het |
| Susd5 |
A |
G |
9: 113,925,053 (GRCm39) |
E312G |
probably benign |
Het |
| Tgfb2 |
T |
A |
1: 186,361,222 (GRCm39) |
D315V |
possibly damaging |
Het |
| Tll1 |
C |
T |
8: 64,494,545 (GRCm39) |
D737N |
probably damaging |
Het |
| Tmem115 |
A |
G |
9: 107,412,482 (GRCm39) |
T269A |
probably damaging |
Het |
| Ttc39b |
T |
C |
4: 83,155,538 (GRCm39) |
D490G |
probably damaging |
Het |
| Vmn2r74 |
A |
T |
7: 85,606,395 (GRCm39) |
F317Y |
possibly damaging |
Het |
| Vmn2r79 |
A |
G |
7: 86,651,099 (GRCm39) |
H166R |
possibly damaging |
Het |
| Zfp560 |
A |
G |
9: 20,258,744 (GRCm39) |
I706T |
probably benign |
Het |
| Zfp982 |
A |
G |
4: 147,597,150 (GRCm39) |
K169R |
probably benign |
Het |
|
| Other mutations in Vmn1r72 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00885:Vmn1r72
|
APN |
7 |
11,404,424 (GRCm39) |
missense |
probably benign |
0.41 |
|
IGL02375:Vmn1r72
|
APN |
7 |
11,403,672 (GRCm39) |
missense |
probably benign |
0.10 |
|
IGL02809:Vmn1r72
|
APN |
7 |
11,403,930 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL03104:Vmn1r72
|
APN |
7 |
11,403,812 (GRCm39) |
missense |
probably damaging |
1.00 |
|
3-1:Vmn1r72
|
UTSW |
7 |
11,403,825 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL03014:Vmn1r72
|
UTSW |
7 |
11,403,711 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R0346:Vmn1r72
|
UTSW |
7 |
11,403,621 (GRCm39) |
missense |
probably benign |
|
|
R0524:Vmn1r72
|
UTSW |
7 |
11,403,719 (GRCm39) |
missense |
probably benign |
0.32 |
|
R1951:Vmn1r72
|
UTSW |
7 |
11,403,731 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1953:Vmn1r72
|
UTSW |
7 |
11,403,731 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2181:Vmn1r72
|
UTSW |
7 |
11,403,595 (GRCm39) |
nonsense |
probably null |
|
|
R4345:Vmn1r72
|
UTSW |
7 |
11,403,963 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R4496:Vmn1r72
|
UTSW |
7 |
11,403,791 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4999:Vmn1r72
|
UTSW |
7 |
11,404,300 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R5401:Vmn1r72
|
UTSW |
7 |
11,403,843 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5700:Vmn1r72
|
UTSW |
7 |
11,404,350 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5754:Vmn1r72
|
UTSW |
7 |
11,403,776 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6292:Vmn1r72
|
UTSW |
7 |
11,403,579 (GRCm39) |
missense |
probably benign |
0.02 |
|
R6439:Vmn1r72
|
UTSW |
7 |
11,413,064 (GRCm39) |
splice site |
probably null |
|
|
R7616:Vmn1r72
|
UTSW |
7 |
11,404,272 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7629:Vmn1r72
|
UTSW |
7 |
11,403,711 (GRCm39) |
missense |
probably benign |
|
|
R7737:Vmn1r72
|
UTSW |
7 |
11,403,634 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7819:Vmn1r72
|
UTSW |
7 |
11,403,552 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8358:Vmn1r72
|
UTSW |
7 |
11,404,310 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8797:Vmn1r72
|
UTSW |
7 |
11,403,965 (GRCm39) |
missense |
probably benign |
|
|
R8848:Vmn1r72
|
UTSW |
7 |
11,404,269 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8947:Vmn1r72
|
UTSW |
7 |
11,403,807 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R9010:Vmn1r72
|
UTSW |
7 |
11,404,145 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R9165:Vmn1r72
|
UTSW |
7 |
11,412,951 (GRCm39) |
intron |
probably benign |
|
|
R9578:Vmn1r72
|
UTSW |
7 |
11,404,347 (GRCm39) |
missense |
probably benign |
0.10 |
|
X0063:Vmn1r72
|
UTSW |
7 |
11,403,639 (GRCm39) |
missense |
probably benign |
0.00 |
|
Z1088:Vmn1r72
|
UTSW |
7 |
11,404,100 (GRCm39) |
missense |
probably benign |
0.03 |
|
| Predicted Primers |
PCR Primer
(F):5'- TAATGATCATGGACACACTTGAGC -3'
(R):5'- AAAGATTTCCTGGATGTCACTGG -3'
Sequencing Primer
(F):5'- ACACTTGAGCAGGCCATG -3'
(R):5'- CCTGGATGTCACTGGATGTAAATTG -3'
|
| Posted On |
2015-06-10 |
Incidental Mutation