Incidental Mutation 'R4182:Or1o2'
ID 319793
Institutional Source Beutler Lab
Gene Symbol Or1o2
Ensembl Gene ENSMUSG00000058802
Gene Name olfactory receptor family 1 subfamily O member 2
Synonyms MOR156-2, GA_x6K02T2PSCP-1672287-1671355, Olfr97
MMRRC Submission 041018-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.063) question?
Stock # R4182 (G1)
Quality Score 225
Status Validated
Chromosome 17
Chromosomal Location 37542327-37543259 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to G at 37542739 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Histidine to Proline at position 174 (H174P)
Ref Sequence ENSEMBL: ENSMUSP00000151044 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000073667] [ENSMUST00000207414] [ENSMUST00000213328] [ENSMUST00000214622] [ENSMUST00000214848] [ENSMUST00000216225]
AlphaFold Q8VFE1
Predicted Effect possibly damaging
Transcript: ENSMUST00000073667
AA Change: H174P

PolyPhen 2 Score 0.925 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000094937
Gene: ENSMUSG00000058802
AA Change: H174P

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srv 24 305 4.5e-9 PFAM
Pfam:7tm_4 29 306 1.4e-54 PFAM
Pfam:7TM_GPCR_Srsx 33 303 1.1e-5 PFAM
Pfam:7tm_1 39 288 8.6e-21 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000207414
AA Change: H174P

PolyPhen 2 Score 0.925 (Sensitivity: 0.81; Specificity: 0.94)
Predicted Effect possibly damaging
Transcript: ENSMUST00000213328
AA Change: H174P

PolyPhen 2 Score 0.925 (Sensitivity: 0.81; Specificity: 0.94)
Predicted Effect possibly damaging
Transcript: ENSMUST00000214622
AA Change: H174P

PolyPhen 2 Score 0.925 (Sensitivity: 0.81; Specificity: 0.94)
Predicted Effect possibly damaging
Transcript: ENSMUST00000214848
AA Change: H174P

PolyPhen 2 Score 0.925 (Sensitivity: 0.81; Specificity: 0.94)
Predicted Effect possibly damaging
Transcript: ENSMUST00000216225
AA Change: H174P

PolyPhen 2 Score 0.925 (Sensitivity: 0.81; Specificity: 0.94)
Meta Mutation Damage Score 0.3178 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.4%
  • 20x: 95.6%
Validation Efficiency 98% (43/44)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arhgap12 T C 18: 6,111,734 (GRCm39) D210G probably damaging Het
Baz2b A T 2: 59,928,801 (GRCm39) probably benign Het
Bcl9 A G 3: 97,120,999 (GRCm39) probably null Het
Cfap20 A T 8: 96,151,284 (GRCm39) I19N probably damaging Het
Clnk T A 5: 38,905,193 (GRCm39) probably benign Het
Col18a1 C T 10: 76,894,675 (GRCm39) probably null Het
Cux2 C T 5: 122,006,555 (GRCm39) G905D probably damaging Het
Ddx1 A T 12: 13,281,504 (GRCm39) L353* probably null Het
Ddx59 T A 1: 136,367,599 (GRCm39) S569T probably benign Het
Des C G 1: 75,339,228 (GRCm39) A251G probably benign Het
Dnajc21 T C 15: 10,460,019 (GRCm39) probably null Het
Fam217a T C 13: 35,094,239 (GRCm39) T416A possibly damaging Het
Gbp9 T A 5: 105,231,461 (GRCm39) Q375L probably benign Het
Grsf1 G A 5: 88,812,015 (GRCm39) P271S probably benign Het
H2-T24 A T 17: 36,326,376 (GRCm39) N174K possibly damaging Het
Heatr3 T C 8: 88,897,630 (GRCm39) probably benign Het
Lurap1l G A 4: 80,872,095 (GRCm39) S196N probably benign Het
Naaa C T 5: 92,420,413 (GRCm39) probably null Het
Nbea A G 3: 55,915,848 (GRCm39) C875R probably damaging Het
Nme1 G A 11: 93,851,630 (GRCm39) T87I probably benign Het
Nphp3 T C 9: 103,915,663 (GRCm39) S124P probably benign Het
Nrap C T 19: 56,338,759 (GRCm39) V907M probably damaging Het
Or4f59 G T 2: 111,872,873 (GRCm39) P168Q probably damaging Het
Pcdhga8 A G 18: 37,860,336 (GRCm39) N464S probably damaging Het
Pdcd6ip T C 9: 113,529,078 (GRCm39) I75V probably benign Het
Ralgapa2 G A 2: 146,277,914 (GRCm39) P416S probably damaging Het
Saal1 A G 7: 46,360,076 (GRCm39) probably benign Het
Susd5 A G 9: 113,925,053 (GRCm39) E312G probably benign Het
Tgfb2 T A 1: 186,361,222 (GRCm39) D315V possibly damaging Het
Tll1 C T 8: 64,494,545 (GRCm39) D737N probably damaging Het
Tmem115 A G 9: 107,412,482 (GRCm39) T269A probably damaging Het
Ttc39b T C 4: 83,155,538 (GRCm39) D490G probably damaging Het
Vmn1r72 C T 7: 11,403,995 (GRCm39) R151K probably benign Het
Vmn2r74 A T 7: 85,606,395 (GRCm39) F317Y possibly damaging Het
Vmn2r79 A G 7: 86,651,099 (GRCm39) H166R possibly damaging Het
Zfp560 A G 9: 20,258,744 (GRCm39) I706T probably benign Het
Zfp982 A G 4: 147,597,150 (GRCm39) K169R probably benign Het
Other mutations in Or1o2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01934:Or1o2 APN 17 37,542,439 (GRCm39) missense probably damaging 1.00
IGL02424:Or1o2 APN 17 37,543,263 (GRCm39) start gained probably benign
IGL03129:Or1o2 APN 17 37,543,087 (GRCm39) missense probably damaging 1.00
R0619:Or1o2 UTSW 17 37,543,046 (GRCm39) missense possibly damaging 0.92
R0811:Or1o2 UTSW 17 37,543,223 (GRCm39) missense probably benign 0.00
R0812:Or1o2 UTSW 17 37,543,223 (GRCm39) missense probably benign 0.00
R1122:Or1o2 UTSW 17 37,542,934 (GRCm39) missense probably damaging 1.00
R1927:Or1o2 UTSW 17 37,542,434 (GRCm39) missense probably damaging 1.00
R1997:Or1o2 UTSW 17 37,542,523 (GRCm39) missense probably damaging 1.00
R3771:Or1o2 UTSW 17 37,542,356 (GRCm39) missense possibly damaging 0.53
R3775:Or1o2 UTSW 17 37,543,121 (GRCm39) missense probably damaging 0.98
R4183:Or1o2 UTSW 17 37,542,739 (GRCm39) missense possibly damaging 0.93
R4184:Or1o2 UTSW 17 37,542,739 (GRCm39) missense possibly damaging 0.93
R4198:Or1o2 UTSW 17 37,543,025 (GRCm39) missense probably benign 0.01
R7453:Or1o2 UTSW 17 37,542,871 (GRCm39) missense probably damaging 1.00
R7615:Or1o2 UTSW 17 37,542,341 (GRCm39) missense probably benign 0.25
R7829:Or1o2 UTSW 17 37,543,201 (GRCm39) missense probably benign 0.01
R8223:Or1o2 UTSW 17 37,542,727 (GRCm39) missense possibly damaging 0.89
R8526:Or1o2 UTSW 17 37,542,470 (GRCm39) missense probably damaging 0.97
R9098:Or1o2 UTSW 17 37,542,961 (GRCm39) missense probably benign 0.12
Z1177:Or1o2 UTSW 17 37,543,187 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- GGGAACTGCATGTAGCCAAG -3'
(R):5'- ACATGGATAACCTGCTTCTAGC -3'

Sequencing Primer
(F):5'- TTTCCTTTTTCCCTGTGCTGATGG -3'
(R):5'- AGCAGTCATGGCTATTGACC -3'
Posted On 2015-06-10