Incidental Mutation 'R4183:Mndal'
ID 319801
Institutional Source Beutler Lab
Gene Symbol Mndal
Ensembl Gene ENSMUSG00000090272
Gene Name myeloid nuclear differentiation antigen like
Synonyms Ifi212
MMRRC Submission 041019-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.103) question?
Stock # R4183 (G1)
Quality Score 225
Status Not validated
Chromosome 1
Chromosomal Location 173684786-173708038 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 173703337 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Serine at position 23 (T23S)
Ref Sequence ENSEMBL: ENSMUSP00000140191 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000111210] [ENSMUST00000186442] [ENSMUST00000188804] [ENSMUST00000190071] [ENSMUST00000190651]
AlphaFold D0QMC3
Predicted Effect unknown
Transcript: ENSMUST00000111210
AA Change: T23S
SMART Domains Protein: ENSMUSP00000106841
Gene: ENSMUSG00000090272
AA Change: T23S

DomainStartEndE-ValueType
PYRIN 5 83 3.71e-20 SMART
internal_repeat_1 152 166 2.38e-7 PROSPERO
low complexity region 170 200 N/A INTRINSIC
internal_repeat_1 208 222 2.38e-7 PROSPERO
low complexity region 225 249 N/A INTRINSIC
low complexity region 276 292 N/A INTRINSIC
low complexity region 294 305 N/A INTRINSIC
Pfam:HIN 311 479 3.4e-76 PFAM
low complexity region 497 507 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000186442
AA Change: T23S

PolyPhen 2 Score 0.631 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000140539
Gene: ENSMUSG00000090272
AA Change: T23S

DomainStartEndE-ValueType
PYRIN 5 83 1.8e-24 SMART
internal_repeat_1 152 166 4.72e-7 PROSPERO
low complexity region 170 200 N/A INTRINSIC
internal_repeat_1 208 222 4.72e-7 PROSPERO
low complexity region 225 237 N/A INTRINSIC
low complexity region 239 250 N/A INTRINSIC
Pfam:HIN 258 427 2.9e-83 PFAM
low complexity region 444 454 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000187636
Predicted Effect unknown
Transcript: ENSMUST00000188804
AA Change: T23S
SMART Domains Protein: ENSMUSP00000140610
Gene: ENSMUSG00000090272
AA Change: T23S

DomainStartEndE-ValueType
PYRIN 5 83 3.71e-20 SMART
internal_repeat_1 152 166 2.38e-7 PROSPERO
low complexity region 170 200 N/A INTRINSIC
internal_repeat_1 208 222 2.38e-7 PROSPERO
low complexity region 225 249 N/A INTRINSIC
low complexity region 276 292 N/A INTRINSIC
low complexity region 294 305 N/A INTRINSIC
Pfam:HIN 311 480 4.3e-86 PFAM
low complexity region 497 507 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000189501
Predicted Effect probably benign
Transcript: ENSMUST00000190071
SMART Domains Protein: ENSMUSP00000141055
Gene: ENSMUSG00000090272

DomainStartEndE-ValueType
internal_repeat_1 21 35 3.67e-8 PROSPERO
low complexity region 39 69 N/A INTRINSIC
internal_repeat_1 77 91 3.67e-8 PROSPERO
low complexity region 94 106 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000190651
AA Change: T23S

PolyPhen 2 Score 0.955 (Sensitivity: 0.79; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000140191
Gene: ENSMUSG00000090272
AA Change: T23S

DomainStartEndE-ValueType
PYRIN 5 83 1.8e-24 SMART
low complexity region 170 182 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000191500
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 95.2%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ankrd11 T C 8: 123,626,415 (GRCm39) I198V possibly damaging Het
Arhgap12 T C 18: 6,111,734 (GRCm39) D210G probably damaging Het
Arpc2 T A 1: 74,287,322 (GRCm39) N31K probably damaging Het
Atp11a T A 8: 12,866,990 (GRCm39) V139D possibly damaging Het
Bicral T C 17: 47,124,955 (GRCm39) K615E probably damaging Het
Ccdc27 TTCCTCCTCCTCCTCCTCCTC TTCCTCCTCCTCCTCCTC 4: 154,120,763 (GRCm39) probably benign Het
Chrnb1 T C 11: 69,677,922 (GRCm39) M277V possibly damaging Het
Csmd1 C T 8: 15,960,464 (GRCm39) C3317Y probably damaging Het
Ddx1 A T 12: 13,281,504 (GRCm39) L353* probably null Het
Degs2 T C 12: 108,658,358 (GRCm39) K207R probably damaging Het
Fam167a T C 14: 63,689,769 (GRCm39) V22A probably benign Het
Fam186a G A 15: 99,831,566 (GRCm39) probably benign Het
Gprc5b T C 7: 118,583,749 (GRCm39) D40G probably benign Het
Grsf1 G A 5: 88,812,015 (GRCm39) P271S probably benign Het
Inpp5j A G 11: 3,451,134 (GRCm39) I505T probably damaging Het
Lurap1l G A 4: 80,872,095 (GRCm39) S196N probably benign Het
Mapk8 T C 14: 33,104,177 (GRCm39) D413G probably damaging Het
Mapkbp1 A G 2: 119,848,346 (GRCm39) D632G probably damaging Het
Mcidas A G 13: 113,130,906 (GRCm39) D77G probably damaging Het
Mdga1 A G 17: 30,188,964 (GRCm39) V33A unknown Het
Me3 A G 7: 89,501,038 (GRCm39) D583G probably benign Het
Myh13 T C 11: 67,240,436 (GRCm39) M780T possibly damaging Het
Nat10 A G 2: 103,570,158 (GRCm39) L395P probably damaging Het
Naxd T C 8: 11,552,757 (GRCm39) V59A probably damaging Het
Nbeal2 A T 9: 110,465,743 (GRCm39) V876E probably benign Het
Or11h4b C G 14: 50,918,507 (GRCm39) E195Q probably benign Het
Or1o2 T G 17: 37,542,739 (GRCm39) H174P possibly damaging Het
Or4a39 T C 2: 89,236,935 (GRCm39) T163A probably benign Het
Or51v8 T C 7: 103,320,178 (GRCm39) Y20C possibly damaging Het
Or8g50 A G 9: 39,648,344 (GRCm39) T78A probably benign Het
Pcdhgb8 G C 18: 37,896,594 (GRCm39) D555H probably damaging Het
Pcsk4 C T 10: 80,160,845 (GRCm39) R327Q probably benign Het
Pkhd1 C T 1: 20,188,031 (GRCm39) V3426I probably benign Het
Ranbp2 T C 10: 58,301,488 (GRCm39) F687L possibly damaging Het
Rb1 A G 14: 73,435,966 (GRCm39) probably null Het
Tfpi2 C A 6: 3,963,926 (GRCm39) V51L probably damaging Het
Tnn T C 1: 159,924,925 (GRCm39) D1143G probably damaging Het
Ttn A G 2: 76,541,586 (GRCm39) M25473T probably benign Het
Vmn1r201 A G 13: 22,659,022 (GRCm39) I79V probably benign Het
Vmn2r79 A G 7: 86,651,099 (GRCm39) H166R possibly damaging Het
Wdr25 T A 12: 108,993,257 (GRCm39) F491Y probably benign Het
Zfp972 G A 2: 177,563,250 (GRCm39) Q56* probably null Het
Zfp982 A G 4: 147,597,150 (GRCm39) K169R probably benign Het
Other mutations in Mndal
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01363:Mndal APN 1 173,685,022 (GRCm39) missense possibly damaging 0.68
IGL02309:Mndal APN 1 173,702,021 (GRCm39) missense probably damaging 0.98
IGL02559:Mndal APN 1 173,700,486 (GRCm39) missense probably benign 0.06
IGL02637:Mndal APN 1 173,685,003 (GRCm39) missense possibly damaging 0.63
LCD18:Mndal UTSW 1 173,707,784 (GRCm39) unclassified probably benign
R0076:Mndal UTSW 1 173,702,013 (GRCm39) nonsense probably null
R0123:Mndal UTSW 1 173,685,079 (GRCm39) splice site probably benign
R0134:Mndal UTSW 1 173,685,079 (GRCm39) splice site probably benign
R0225:Mndal UTSW 1 173,685,079 (GRCm39) splice site probably benign
R0976:Mndal UTSW 1 173,690,411 (GRCm39) missense possibly damaging 0.70
R1081:Mndal UTSW 1 173,687,788 (GRCm39) missense probably benign 0.01
R1497:Mndal UTSW 1 173,700,441 (GRCm39) missense probably benign 0.04
R1522:Mndal UTSW 1 173,699,032 (GRCm39) missense possibly damaging 0.68
R1630:Mndal UTSW 1 173,701,958 (GRCm39) missense possibly damaging 0.52
R1874:Mndal UTSW 1 173,687,933 (GRCm39) unclassified probably benign
R4544:Mndal UTSW 1 173,703,230 (GRCm39) nonsense probably null
R4545:Mndal UTSW 1 173,703,230 (GRCm39) nonsense probably null
R4907:Mndal UTSW 1 173,690,256 (GRCm39) missense probably damaging 0.99
R5066:Mndal UTSW 1 173,703,229 (GRCm39) missense probably damaging 1.00
R5853:Mndal UTSW 1 173,690,070 (GRCm39) missense probably damaging 0.98
R6208:Mndal UTSW 1 173,684,988 (GRCm39) missense possibly damaging 0.84
R6395:Mndal UTSW 1 173,698,999 (GRCm39) missense possibly damaging 0.73
R6923:Mndal UTSW 1 173,712,264 (GRCm39) splice site probably null
R6933:Mndal UTSW 1 173,703,249 (GRCm39) missense probably damaging 1.00
R7030:Mndal UTSW 1 173,703,160 (GRCm39) missense probably damaging 1.00
R7327:Mndal UTSW 1 173,703,185 (GRCm39) missense unknown
R7648:Mndal UTSW 1 173,684,961 (GRCm39) missense probably benign 0.01
R8130:Mndal UTSW 1 173,699,111 (GRCm39) nonsense probably null
R8514:Mndal UTSW 1 173,687,758 (GRCm39) missense possibly damaging 0.84
R8697:Mndal UTSW 1 173,700,558 (GRCm39) nonsense probably null
R9134:Mndal UTSW 1 173,699,096 (GRCm39) missense unknown
R9257:Mndal UTSW 1 173,690,274 (GRCm39) missense probably damaging 1.00
R9458:Mndal UTSW 1 173,687,749 (GRCm39) missense probably damaging 1.00
Z1177:Mndal UTSW 1 173,701,970 (GRCm39) missense unknown
Predicted Primers PCR Primer
(F):5'- CTCAGGGTGTTGCCTATTACC -3'
(R):5'- TTCACTCACATGAGAATATCCTGTC -3'

Sequencing Primer
(F):5'- CAGGGTGTTGCCTATTACCTTTTGC -3'
(R):5'- TCCTGTCTTGAATATGTGTGAAAATG -3'
Posted On 2015-06-10