Incidental Mutation 'R4183:Or4a39'
ID |
319805 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Or4a39
|
Ensembl Gene |
ENSMUSG00000111517 |
Gene Name |
olfactory receptor family 4subfamily A member 39 |
Synonyms |
GA_x6K02T2Q125-50849945-50848998, Olfr1238, MOR231-11 |
MMRRC Submission |
041019-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.089)
|
Stock # |
R4183 (G1)
|
Quality Score |
225 |
Status
|
Not validated
|
Chromosome |
2 |
Chromosomal Location |
89236474-89237421 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
T to C
at 89236935 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Threonine to Alanine
at position 163
(T163A)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000150367
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000099781]
[ENSMUST00000217226]
[ENSMUST00000217237]
|
AlphaFold |
Q8VG59 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000099781
AA Change: T163A
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
SMART Domains |
Protein: ENSMUSP00000097369 Gene: ENSMUSG00000111517 AA Change: T163A
Domain | Start | End | E-Value | Type |
Pfam:7tm_4
|
29 |
303 |
7.7e-46 |
PFAM |
Pfam:7TM_GPCR_Srsx
|
33 |
300 |
1.1e-5 |
PFAM |
Pfam:7tm_1
|
39 |
285 |
6.7e-20 |
PFAM |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000215283
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000217226
AA Change: T163A
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000217237
AA Change: T163A
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.2%
- 20x: 95.2%
|
Validation Efficiency |
|
MGI Phenotype |
FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 43 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Ankrd11 |
T |
C |
8: 123,626,415 (GRCm39) |
I198V |
possibly damaging |
Het |
Arhgap12 |
T |
C |
18: 6,111,734 (GRCm39) |
D210G |
probably damaging |
Het |
Arpc2 |
T |
A |
1: 74,287,322 (GRCm39) |
N31K |
probably damaging |
Het |
Atp11a |
T |
A |
8: 12,866,990 (GRCm39) |
V139D |
possibly damaging |
Het |
Bicral |
T |
C |
17: 47,124,955 (GRCm39) |
K615E |
probably damaging |
Het |
Ccdc27 |
TTCCTCCTCCTCCTCCTCCTC |
TTCCTCCTCCTCCTCCTC |
4: 154,120,763 (GRCm39) |
|
probably benign |
Het |
Chrnb1 |
T |
C |
11: 69,677,922 (GRCm39) |
M277V |
possibly damaging |
Het |
Csmd1 |
C |
T |
8: 15,960,464 (GRCm39) |
C3317Y |
probably damaging |
Het |
Ddx1 |
A |
T |
12: 13,281,504 (GRCm39) |
L353* |
probably null |
Het |
Degs2 |
T |
C |
12: 108,658,358 (GRCm39) |
K207R |
probably damaging |
Het |
Fam167a |
T |
C |
14: 63,689,769 (GRCm39) |
V22A |
probably benign |
Het |
Fam186a |
G |
A |
15: 99,831,566 (GRCm39) |
|
probably benign |
Het |
Gprc5b |
T |
C |
7: 118,583,749 (GRCm39) |
D40G |
probably benign |
Het |
Grsf1 |
G |
A |
5: 88,812,015 (GRCm39) |
P271S |
probably benign |
Het |
Inpp5j |
A |
G |
11: 3,451,134 (GRCm39) |
I505T |
probably damaging |
Het |
Lurap1l |
G |
A |
4: 80,872,095 (GRCm39) |
S196N |
probably benign |
Het |
Mapk8 |
T |
C |
14: 33,104,177 (GRCm39) |
D413G |
probably damaging |
Het |
Mapkbp1 |
A |
G |
2: 119,848,346 (GRCm39) |
D632G |
probably damaging |
Het |
Mcidas |
A |
G |
13: 113,130,906 (GRCm39) |
D77G |
probably damaging |
Het |
Mdga1 |
A |
G |
17: 30,188,964 (GRCm39) |
V33A |
unknown |
Het |
Me3 |
A |
G |
7: 89,501,038 (GRCm39) |
D583G |
probably benign |
Het |
Mndal |
T |
A |
1: 173,703,337 (GRCm39) |
T23S |
possibly damaging |
Het |
Myh13 |
T |
C |
11: 67,240,436 (GRCm39) |
M780T |
possibly damaging |
Het |
Nat10 |
A |
G |
2: 103,570,158 (GRCm39) |
L395P |
probably damaging |
Het |
Naxd |
T |
C |
8: 11,552,757 (GRCm39) |
V59A |
probably damaging |
Het |
Nbeal2 |
A |
T |
9: 110,465,743 (GRCm39) |
V876E |
probably benign |
Het |
Or11h4b |
C |
G |
14: 50,918,507 (GRCm39) |
E195Q |
probably benign |
Het |
Or1o2 |
T |
G |
17: 37,542,739 (GRCm39) |
H174P |
possibly damaging |
Het |
Or51v8 |
T |
C |
7: 103,320,178 (GRCm39) |
Y20C |
possibly damaging |
Het |
Or8g50 |
A |
G |
9: 39,648,344 (GRCm39) |
T78A |
probably benign |
Het |
Pcdhgb8 |
G |
C |
18: 37,896,594 (GRCm39) |
D555H |
probably damaging |
Het |
Pcsk4 |
C |
T |
10: 80,160,845 (GRCm39) |
R327Q |
probably benign |
Het |
Pkhd1 |
C |
T |
1: 20,188,031 (GRCm39) |
V3426I |
probably benign |
Het |
Ranbp2 |
T |
C |
10: 58,301,488 (GRCm39) |
F687L |
possibly damaging |
Het |
Rb1 |
A |
G |
14: 73,435,966 (GRCm39) |
|
probably null |
Het |
Tfpi2 |
C |
A |
6: 3,963,926 (GRCm39) |
V51L |
probably damaging |
Het |
Tnn |
T |
C |
1: 159,924,925 (GRCm39) |
D1143G |
probably damaging |
Het |
Ttn |
A |
G |
2: 76,541,586 (GRCm39) |
M25473T |
probably benign |
Het |
Vmn1r201 |
A |
G |
13: 22,659,022 (GRCm39) |
I79V |
probably benign |
Het |
Vmn2r79 |
A |
G |
7: 86,651,099 (GRCm39) |
H166R |
possibly damaging |
Het |
Wdr25 |
T |
A |
12: 108,993,257 (GRCm39) |
F491Y |
probably benign |
Het |
Zfp972 |
G |
A |
2: 177,563,250 (GRCm39) |
Q56* |
probably null |
Het |
Zfp982 |
A |
G |
4: 147,597,150 (GRCm39) |
K169R |
probably benign |
Het |
|
Other mutations in Or4a39 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL01326:Or4a39
|
APN |
2 |
89,236,675 (GRCm39) |
missense |
possibly damaging |
0.95 |
IGL01648:Or4a39
|
APN |
2 |
89,236,535 (GRCm39) |
missense |
probably damaging |
0.99 |
IGL03005:Or4a39
|
APN |
2 |
89,237,315 (GRCm39) |
missense |
possibly damaging |
0.95 |
R0450:Or4a39
|
UTSW |
2 |
89,237,135 (GRCm39) |
missense |
probably damaging |
0.99 |
R0469:Or4a39
|
UTSW |
2 |
89,237,135 (GRCm39) |
missense |
probably damaging |
0.99 |
R0510:Or4a39
|
UTSW |
2 |
89,237,135 (GRCm39) |
missense |
probably damaging |
0.99 |
R1983:Or4a39
|
UTSW |
2 |
89,236,770 (GRCm39) |
missense |
probably benign |
0.00 |
R4737:Or4a39
|
UTSW |
2 |
89,236,830 (GRCm39) |
missense |
probably benign |
0.05 |
R4748:Or4a39
|
UTSW |
2 |
89,236,599 (GRCm39) |
missense |
probably benign |
0.02 |
R4749:Or4a39
|
UTSW |
2 |
89,236,599 (GRCm39) |
missense |
probably benign |
0.02 |
R4969:Or4a39
|
UTSW |
2 |
89,236,770 (GRCm39) |
missense |
probably benign |
0.00 |
R5047:Or4a39
|
UTSW |
2 |
89,237,057 (GRCm39) |
missense |
probably damaging |
1.00 |
R5992:Or4a39
|
UTSW |
2 |
89,237,223 (GRCm39) |
missense |
probably benign |
0.02 |
R6031:Or4a39
|
UTSW |
2 |
89,237,316 (GRCm39) |
missense |
probably damaging |
1.00 |
R6031:Or4a39
|
UTSW |
2 |
89,237,316 (GRCm39) |
missense |
probably damaging |
1.00 |
R6263:Or4a39
|
UTSW |
2 |
89,237,074 (GRCm39) |
missense |
possibly damaging |
0.80 |
R6416:Or4a39
|
UTSW |
2 |
89,236,866 (GRCm39) |
missense |
possibly damaging |
0.78 |
R7352:Or4a39
|
UTSW |
2 |
89,236,806 (GRCm39) |
missense |
probably benign |
0.00 |
R7515:Or4a39
|
UTSW |
2 |
89,237,250 (GRCm39) |
missense |
possibly damaging |
0.91 |
R7796:Or4a39
|
UTSW |
2 |
89,237,157 (GRCm39) |
missense |
possibly damaging |
0.73 |
R7893:Or4a39
|
UTSW |
2 |
89,237,414 (GRCm39) |
missense |
probably benign |
0.00 |
R8034:Or4a39
|
UTSW |
2 |
89,237,081 (GRCm39) |
missense |
probably benign |
0.44 |
R8399:Or4a39
|
UTSW |
2 |
89,237,028 (GRCm39) |
missense |
probably benign |
0.10 |
R8694:Or4a39
|
UTSW |
2 |
89,237,378 (GRCm39) |
missense |
probably damaging |
1.00 |
R9085:Or4a39
|
UTSW |
2 |
89,236,641 (GRCm39) |
missense |
probably damaging |
0.99 |
R9486:Or4a39
|
UTSW |
2 |
89,236,959 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
Predicted Primers |
PCR Primer
(F):5'- GATAAGGCTTTGCGTCTCCC -3'
(R):5'- ATGGGCCAACTCTTTATTGAGC -3'
Sequencing Primer
(F):5'- CCTTCCTGACTGTAGTTTTTAAGAG -3'
(R):5'- ACTCTTTATTGAGCACTTATTTGGTG -3'
|
Posted On |
2015-06-10 |