Incidental Mutation 'R4183:Or4a39'
ID 319805
Institutional Source Beutler Lab
Gene Symbol Or4a39
Ensembl Gene ENSMUSG00000111517
Gene Name olfactory receptor family 4subfamily A member 39
Synonyms GA_x6K02T2Q125-50849945-50848998, Olfr1238, MOR231-11
MMRRC Submission 041019-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.089) question?
Stock # R4183 (G1)
Quality Score 225
Status Not validated
Chromosome 2
Chromosomal Location 89236474-89237421 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 89236935 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 163 (T163A)
Ref Sequence ENSEMBL: ENSMUSP00000150367 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099781] [ENSMUST00000217226] [ENSMUST00000217237]
AlphaFold Q8VG59
Predicted Effect probably benign
Transcript: ENSMUST00000099781
AA Change: T163A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000097369
Gene: ENSMUSG00000111517
AA Change: T163A

DomainStartEndE-ValueType
Pfam:7tm_4 29 303 7.7e-46 PFAM
Pfam:7TM_GPCR_Srsx 33 300 1.1e-5 PFAM
Pfam:7tm_1 39 285 6.7e-20 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000215283
Predicted Effect probably benign
Transcript: ENSMUST00000217226
AA Change: T163A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Predicted Effect probably benign
Transcript: ENSMUST00000217237
AA Change: T163A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 95.2%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ankrd11 T C 8: 123,626,415 (GRCm39) I198V possibly damaging Het
Arhgap12 T C 18: 6,111,734 (GRCm39) D210G probably damaging Het
Arpc2 T A 1: 74,287,322 (GRCm39) N31K probably damaging Het
Atp11a T A 8: 12,866,990 (GRCm39) V139D possibly damaging Het
Bicral T C 17: 47,124,955 (GRCm39) K615E probably damaging Het
Ccdc27 TTCCTCCTCCTCCTCCTCCTC TTCCTCCTCCTCCTCCTC 4: 154,120,763 (GRCm39) probably benign Het
Chrnb1 T C 11: 69,677,922 (GRCm39) M277V possibly damaging Het
Csmd1 C T 8: 15,960,464 (GRCm39) C3317Y probably damaging Het
Ddx1 A T 12: 13,281,504 (GRCm39) L353* probably null Het
Degs2 T C 12: 108,658,358 (GRCm39) K207R probably damaging Het
Fam167a T C 14: 63,689,769 (GRCm39) V22A probably benign Het
Fam186a G A 15: 99,831,566 (GRCm39) probably benign Het
Gprc5b T C 7: 118,583,749 (GRCm39) D40G probably benign Het
Grsf1 G A 5: 88,812,015 (GRCm39) P271S probably benign Het
Inpp5j A G 11: 3,451,134 (GRCm39) I505T probably damaging Het
Lurap1l G A 4: 80,872,095 (GRCm39) S196N probably benign Het
Mapk8 T C 14: 33,104,177 (GRCm39) D413G probably damaging Het
Mapkbp1 A G 2: 119,848,346 (GRCm39) D632G probably damaging Het
Mcidas A G 13: 113,130,906 (GRCm39) D77G probably damaging Het
Mdga1 A G 17: 30,188,964 (GRCm39) V33A unknown Het
Me3 A G 7: 89,501,038 (GRCm39) D583G probably benign Het
Mndal T A 1: 173,703,337 (GRCm39) T23S possibly damaging Het
Myh13 T C 11: 67,240,436 (GRCm39) M780T possibly damaging Het
Nat10 A G 2: 103,570,158 (GRCm39) L395P probably damaging Het
Naxd T C 8: 11,552,757 (GRCm39) V59A probably damaging Het
Nbeal2 A T 9: 110,465,743 (GRCm39) V876E probably benign Het
Or11h4b C G 14: 50,918,507 (GRCm39) E195Q probably benign Het
Or1o2 T G 17: 37,542,739 (GRCm39) H174P possibly damaging Het
Or51v8 T C 7: 103,320,178 (GRCm39) Y20C possibly damaging Het
Or8g50 A G 9: 39,648,344 (GRCm39) T78A probably benign Het
Pcdhgb8 G C 18: 37,896,594 (GRCm39) D555H probably damaging Het
Pcsk4 C T 10: 80,160,845 (GRCm39) R327Q probably benign Het
Pkhd1 C T 1: 20,188,031 (GRCm39) V3426I probably benign Het
Ranbp2 T C 10: 58,301,488 (GRCm39) F687L possibly damaging Het
Rb1 A G 14: 73,435,966 (GRCm39) probably null Het
Tfpi2 C A 6: 3,963,926 (GRCm39) V51L probably damaging Het
Tnn T C 1: 159,924,925 (GRCm39) D1143G probably damaging Het
Ttn A G 2: 76,541,586 (GRCm39) M25473T probably benign Het
Vmn1r201 A G 13: 22,659,022 (GRCm39) I79V probably benign Het
Vmn2r79 A G 7: 86,651,099 (GRCm39) H166R possibly damaging Het
Wdr25 T A 12: 108,993,257 (GRCm39) F491Y probably benign Het
Zfp972 G A 2: 177,563,250 (GRCm39) Q56* probably null Het
Zfp982 A G 4: 147,597,150 (GRCm39) K169R probably benign Het
Other mutations in Or4a39
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01326:Or4a39 APN 2 89,236,675 (GRCm39) missense possibly damaging 0.95
IGL01648:Or4a39 APN 2 89,236,535 (GRCm39) missense probably damaging 0.99
IGL03005:Or4a39 APN 2 89,237,315 (GRCm39) missense possibly damaging 0.95
R0450:Or4a39 UTSW 2 89,237,135 (GRCm39) missense probably damaging 0.99
R0469:Or4a39 UTSW 2 89,237,135 (GRCm39) missense probably damaging 0.99
R0510:Or4a39 UTSW 2 89,237,135 (GRCm39) missense probably damaging 0.99
R1983:Or4a39 UTSW 2 89,236,770 (GRCm39) missense probably benign 0.00
R4737:Or4a39 UTSW 2 89,236,830 (GRCm39) missense probably benign 0.05
R4748:Or4a39 UTSW 2 89,236,599 (GRCm39) missense probably benign 0.02
R4749:Or4a39 UTSW 2 89,236,599 (GRCm39) missense probably benign 0.02
R4969:Or4a39 UTSW 2 89,236,770 (GRCm39) missense probably benign 0.00
R5047:Or4a39 UTSW 2 89,237,057 (GRCm39) missense probably damaging 1.00
R5992:Or4a39 UTSW 2 89,237,223 (GRCm39) missense probably benign 0.02
R6031:Or4a39 UTSW 2 89,237,316 (GRCm39) missense probably damaging 1.00
R6031:Or4a39 UTSW 2 89,237,316 (GRCm39) missense probably damaging 1.00
R6263:Or4a39 UTSW 2 89,237,074 (GRCm39) missense possibly damaging 0.80
R6416:Or4a39 UTSW 2 89,236,866 (GRCm39) missense possibly damaging 0.78
R7352:Or4a39 UTSW 2 89,236,806 (GRCm39) missense probably benign 0.00
R7515:Or4a39 UTSW 2 89,237,250 (GRCm39) missense possibly damaging 0.91
R7796:Or4a39 UTSW 2 89,237,157 (GRCm39) missense possibly damaging 0.73
R7893:Or4a39 UTSW 2 89,237,414 (GRCm39) missense probably benign 0.00
R8034:Or4a39 UTSW 2 89,237,081 (GRCm39) missense probably benign 0.44
R8399:Or4a39 UTSW 2 89,237,028 (GRCm39) missense probably benign 0.10
R8694:Or4a39 UTSW 2 89,237,378 (GRCm39) missense probably damaging 1.00
R9085:Or4a39 UTSW 2 89,236,641 (GRCm39) missense probably damaging 0.99
R9486:Or4a39 UTSW 2 89,236,959 (GRCm39) missense possibly damaging 0.53
Predicted Primers PCR Primer
(F):5'- GATAAGGCTTTGCGTCTCCC -3'
(R):5'- ATGGGCCAACTCTTTATTGAGC -3'

Sequencing Primer
(F):5'- CCTTCCTGACTGTAGTTTTTAAGAG -3'
(R):5'- ACTCTTTATTGAGCACTTATTTGGTG -3'
Posted On 2015-06-10