Incidental Mutation 'R4190:Or5p64'
ID 319914
Institutional Source Beutler Lab
Gene Symbol Or5p64
Ensembl Gene ENSMUSG00000096465
Gene Name olfactory receptor family 5 subfamily P member 64
Synonyms Olfr488, MOR204-15, GA_x6K02T2PBJ9-10586187-10585243
MMRRC Submission 041021-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.258) question?
Stock # R4190 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 107854399-107855343 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 107855330 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 5 (D5G)
Ref Sequence ENSEMBL: ENSMUSP00000149427 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000072968] [ENSMUST00000211345] [ENSMUST00000211508] [ENSMUST00000215173]
AlphaFold Q8VG02
Predicted Effect probably benign
Transcript: ENSMUST00000072968
AA Change: D5G

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000072735
Gene: ENSMUSG00000096465
AA Change: D5G

DomainStartEndE-ValueType
Pfam:7tm_4 34 311 5.7e-53 PFAM
Pfam:7tm_1 44 293 2.6e-22 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000211345
AA Change: D5G
Predicted Effect probably benign
Transcript: ENSMUST00000211508
AA Change: D5G

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Predicted Effect probably benign
Transcript: ENSMUST00000215173
AA Change: D5G

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 95.1%
Validation Efficiency 96% (50/52)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acot4 T C 12: 84,089,948 (GRCm39) probably benign Het
Adgre1 A G 17: 57,709,811 (GRCm39) Y156C unknown Het
Ankrd13b G A 11: 77,367,201 (GRCm39) A21V probably damaging Het
Atf7ip T C 6: 136,564,499 (GRCm39) V914A probably damaging Het
C230029F24Rik AGAAAG A 1: 49,350,088 (GRCm39) noncoding transcript Het
Calcr T A 6: 3,717,106 (GRCm39) D118V possibly damaging Het
Cdc42bpg T C 19: 6,371,711 (GRCm39) V1330A probably damaging Het
Cfap54 T C 10: 92,720,885 (GRCm39) E2567G unknown Het
Ctse T A 1: 131,590,479 (GRCm39) V67D probably benign Het
Ddx19b A T 8: 111,737,980 (GRCm39) L256Q probably damaging Het
Dipk1b T C 2: 26,526,193 (GRCm39) Y376H probably damaging Het
Fahd2a C T 2: 127,280,486 (GRCm39) V156I probably benign Het
Fam185a T A 5: 21,630,122 (GRCm39) probably benign Het
Fam234a A T 17: 26,432,834 (GRCm39) L467Q probably damaging Het
Gabra2 G A 5: 71,165,341 (GRCm39) P210S probably benign Het
Heatr3 T C 8: 88,864,888 (GRCm39) probably benign Het
Herc2 T C 7: 55,772,196 (GRCm39) V1125A probably benign Het
Itga11 T A 9: 62,639,391 (GRCm39) C129S probably damaging Het
Lama2 A G 10: 27,142,660 (GRCm39) L606P probably damaging Het
Macf1 A G 4: 123,366,835 (GRCm39) F1077S possibly damaging Het
Mtmr10 G T 7: 63,963,934 (GRCm39) W223L probably benign Het
Nlgn1 T A 3: 25,488,062 (GRCm39) T758S probably benign Het
Nr4a1 T C 15: 101,171,993 (GRCm39) S556P probably damaging Het
Or4c126 C A 2: 89,823,918 (GRCm39) Y60* probably null Het
Or6c201 T C 10: 128,968,836 (GRCm39) N267S possibly damaging Het
Or6c33 A T 10: 129,853,847 (GRCm39) I206F probably damaging Het
Pcdhgb8 G C 18: 37,896,594 (GRCm39) D555H probably damaging Het
Plscr5 T C 9: 92,080,651 (GRCm39) S46P probably benign Het
Ppp2r3d T C 9: 124,424,123 (GRCm38) probably benign Het
Prodh C T 16: 17,891,504 (GRCm39) V480I probably benign Het
Senp2 G T 16: 21,865,417 (GRCm39) W580L probably damaging Het
Sorcs3 T C 19: 48,737,812 (GRCm39) V743A possibly damaging Het
Sp110 C G 1: 85,516,839 (GRCm39) E219D probably damaging Het
Stab2 G T 10: 86,714,808 (GRCm39) N119K probably damaging Het
Telo2 T C 17: 25,320,987 (GRCm39) T743A probably benign Het
Trav6-1 A G 14: 52,875,976 (GRCm39) N2S probably benign Het
Trmt44 C A 5: 35,732,314 (GRCm39) V26L possibly damaging Het
Ttbk1 A T 17: 46,790,173 (GRCm39) C91S probably damaging Het
Vit A G 17: 78,894,255 (GRCm39) H219R probably benign Het
Vmn2r84 A T 10: 130,227,163 (GRCm39) L225* probably null Het
Vmn2r87 A G 10: 130,308,556 (GRCm39) Y561H probably damaging Het
Yars1 T A 4: 129,093,820 (GRCm39) C60* probably null Het
Zfp202 T C 9: 40,122,633 (GRCm39) V465A probably benign Het
Other mutations in Or5p64
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01575:Or5p64 APN 7 107,854,742 (GRCm39) missense possibly damaging 0.89
IGL02510:Or5p64 APN 7 107,855,348 (GRCm39) utr 5 prime probably benign
IGL02943:Or5p64 APN 7 107,854,623 (GRCm39) missense possibly damaging 0.80
IGL02962:Or5p64 APN 7 107,854,910 (GRCm39) missense possibly damaging 0.78
PIT4472001:Or5p64 UTSW 7 107,855,310 (GRCm39) missense possibly damaging 0.46
R0980:Or5p64 UTSW 7 107,855,229 (GRCm39) small deletion probably benign
R0981:Or5p64 UTSW 7 107,855,229 (GRCm39) small deletion probably benign
R0981:Or5p64 UTSW 7 107,855,228 (GRCm39) small deletion probably benign
R1957:Or5p64 UTSW 7 107,854,403 (GRCm39) nonsense probably null
R3147:Or5p64 UTSW 7 107,854,883 (GRCm39) missense possibly damaging 0.89
R4163:Or5p64 UTSW 7 107,855,039 (GRCm39) missense probably benign 0.06
R4911:Or5p64 UTSW 7 107,855,244 (GRCm39) missense possibly damaging 0.81
R5274:Or5p64 UTSW 7 107,854,842 (GRCm39) missense probably benign 0.02
R5684:Or5p64 UTSW 7 107,855,246 (GRCm39) missense possibly damaging 0.75
R6394:Or5p64 UTSW 7 107,854,970 (GRCm39) missense possibly damaging 0.95
R6467:Or5p64 UTSW 7 107,855,109 (GRCm39) missense probably damaging 0.99
R7173:Or5p64 UTSW 7 107,854,955 (GRCm39) missense possibly damaging 0.78
R7317:Or5p64 UTSW 7 107,854,425 (GRCm39) missense probably benign 0.00
R7348:Or5p64 UTSW 7 107,855,330 (GRCm39) missense probably benign
R7485:Or5p64 UTSW 7 107,855,045 (GRCm39) missense probably damaging 1.00
R9358:Or5p64 UTSW 7 107,854,799 (GRCm39) missense probably damaging 0.99
R9715:Or5p64 UTSW 7 107,855,198 (GRCm39) missense probably benign 0.45
Predicted Primers PCR Primer
(F):5'- TCAACAGTAGCTAAGTGGCTG -3'
(R):5'- TGTGTCTGAAGAGAGCGACAC -3'

Sequencing Primer
(F):5'- AGTCACCAGGTAGATGCA -3'
(R):5'- GACAACATCCAGGAATTAGCTTTC -3'
Posted On 2015-06-10