Mutagenetix > Incidental Mutations

Incidental Mutation 'R4225:Vmn2r101'

320013

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r101

Ensembl Gene

ENSMUSG00000094892

Gene Name

vomeronasal 2, receptor 101

Synonyms

EG627576

MMRRC Submission

041045-MU

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.105) question?

Stock #

R4225 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

19577231-19612317 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 19611689 bp

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Asparagine at position 649 (I649N)

Ref Sequence

ENSEMBL: ENSMUSP00000131583 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000171914]

Predicted Effect

probably damaging
Transcript: ENSMUST00000171914
AA Change: I649N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000131583
Gene: ENSMUSG00000094892
AA Change: I649N

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
Pfam:ANF_receptor	82	466	1.6e-36	PFAM
Pfam:NCD3G	509	562	6.4e-22	PFAM
Pfam:7tm_3	595	830	1.4e-51	PFAM

Meta Mutation Damage Score

0.6467

Coding Region Coverage

1x: 99.3%
3x: 98.7%
10x: 97.6%
20x: 96.1%

Validation Efficiency

100% (38/38)

Allele List at MGI

Other mutations in this stock

Total: 34 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca1	T	C	4: 53,085,106	I569V	possibly damaging	Het
AI314180	A	T	4: 58,847,027	Y512N	probably damaging	Het
Aif1l	A	T	2: 31,962,239	S40C	probably damaging	Het
Arhgef26	A	G	3: 62,380,922	D471G	probably benign	Het
Armc4	A	G	18: 7,181,732		probably null	Het
Atp2a2	A	G	5: 122,469,726	V240A	probably benign	Het
Bsn	A	G	9: 108,106,733	M3374T	unknown	Het
Ccdc66	A	G	14: 27,490,779	L529P	probably damaging	Het
Ctif	A	G	18: 75,435,237	I610T	probably benign	Het
Eif3c	C	G	7: 126,566,299		probably benign	Het
Esyt1	T	C	10: 128,520,648	Y376C	probably damaging	Het
Gba2	A	T	4: 43,569,464		probably benign	Het
Grin1	T	C	2: 25,297,320		probably benign	Het
Herc2	A	G	7: 56,164,987	E2696G	probably damaging	Het
Itgal	A	T	7: 127,305,312	K319M	probably damaging	Het
Lama3	T	C	18: 12,450,403	C683R	probably damaging	Het
Lrig1	T	A	6: 94,622,658	I348F	probably damaging	Het
Mc3r	G	A	2: 172,249,034	V59M	probably damaging	Het
Msh3	T	C	13: 92,285,923	K575R	probably benign	Het
Musk	A	T	4: 58,373,240	M714L	probably damaging	Het
Pcdhgb7	T	A	18: 37,753,803	D675E	probably benign	Het
Pkd1	T	C	17: 24,593,523	I3810T	possibly damaging	Het
Pou2f1	T	C	1: 165,911,320	I177V	possibly damaging	Het
Rb1	T	C	14: 73,269,191	M373V	possibly damaging	Het
Ric1	A	G	19: 29,602,731	N1311D	possibly damaging	Het
Scn3a	A	G	2: 65,536,427	Y84H	probably damaging	Het
Slc25a45	A	T	19: 5,880,118	I39F	probably damaging	Het
Slc8a1	A	G	17: 81,649,352	F86L	probably damaging	Het
Spdya	G	A	17: 71,562,524	V105I	probably benign	Het
Sspo	G	T	6: 48,451,157	V313L	possibly damaging	Het
Stard9	A	G	2: 120,664,991	T116A	possibly damaging	Het
Stpg2	G	A	3: 139,215,292	R86Q	probably damaging	Het
Tdrd6	C	T	17: 43,625,973	D1395N	probably damaging	Het
Zcchc18	A	T	X: 136,994,666	N10I	probably damaging	Het

Other mutations in Vmn2r101

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01121:Vmn2r101	APN	17	19589674	missense	probably damaging	0.99
IGL02125:Vmn2r101	APN	17	19589701	missense	possibly damaging	0.95
IGL02300:Vmn2r101	APN	17	19611937	missense	probably damaging	1.00
IGL02682:Vmn2r101	APN	17	19612245	missense	possibly damaging	0.82
IGL02825:Vmn2r101	APN	17	19589870	missense	probably benign	0.00
IGL02862:Vmn2r101	APN	17	19611605	missense	probably damaging	1.00
IGL02943:Vmn2r101	APN	17	19611404	missense	probably damaging	0.99
R0371:Vmn2r101	UTSW	17	19590132	missense	probably benign	0.07
R0462:Vmn2r101	UTSW	17	19590169	missense	probably benign	0.04
R0492:Vmn2r101	UTSW	17	19588983	missense	probably damaging	1.00
R0654:Vmn2r101	UTSW	17	19590111	missense	probably benign	0.01
R1120:Vmn2r101	UTSW	17	19577461	splice site	probably benign
R1323:Vmn2r101	UTSW	17	19612051	missense	probably damaging	1.00
R1323:Vmn2r101	UTSW	17	19612051	missense	probably damaging	1.00
R1676:Vmn2r101	UTSW	17	19611922	missense	probably benign	0.00
R2023:Vmn2r101	UTSW	17	19590106	nonsense	probably null
R2149:Vmn2r101	UTSW	17	19588963	missense	probably benign	0.00
R2350:Vmn2r101	UTSW	17	19589783	missense	probably benign	0.01
R2760:Vmn2r101	UTSW	17	19589639	missense	probably benign	0.14
R3085:Vmn2r101	UTSW	17	19588815	splice site	probably null
R3086:Vmn2r101	UTSW	17	19588815	splice site	probably null
R3719:Vmn2r101	UTSW	17	19589549	missense	possibly damaging	0.50
R3771:Vmn2r101	UTSW	17	19589657	missense	probably benign
R3773:Vmn2r101	UTSW	17	19589657	missense	probably benign
R4248:Vmn2r101	UTSW	17	19589114	missense	probably damaging	1.00
R4290:Vmn2r101	UTSW	17	19612041	missense	probably damaging	1.00
R4291:Vmn2r101	UTSW	17	19612041	missense	probably damaging	1.00
R4293:Vmn2r101	UTSW	17	19612041	missense	probably damaging	1.00
R4307:Vmn2r101	UTSW	17	19590161	missense	probably damaging	1.00
R4721:Vmn2r101	UTSW	17	19612025	missense	probably damaging	0.99
R4829:Vmn2r101	UTSW	17	19611967	missense	probably benign	0.03
R5022:Vmn2r101	UTSW	17	19611387	critical splice acceptor site	probably null
R5110:Vmn2r101	UTSW	17	19611635	missense	possibly damaging	0.92
R5244:Vmn2r101	UTSW	17	19611526	missense	probably damaging	1.00
R5397:Vmn2r101	UTSW	17	19588842	missense	probably damaging	1.00
R5875:Vmn2r101	UTSW	17	19588830	missense	probably damaging	0.99
R5944:Vmn2r101	UTSW	17	19589507	missense	probably benign	0.00
R6216:Vmn2r101	UTSW	17	19591005	missense	probably benign	0.00
R6334:Vmn2r101	UTSW	17	19589850	missense	possibly damaging	0.83
R6512:Vmn2r101	UTSW	17	19588884	missense	probably damaging	1.00
R6607:Vmn2r101	UTSW	17	19612034	missense	probably damaging	1.00
R6965:Vmn2r101	UTSW	17	19591022	missense	probably benign	0.00
R7101:Vmn2r101	UTSW	17	19589088	missense	probably null	0.14
R7183:Vmn2r101	UTSW	17	19612178	missense	probably damaging	1.00
R7344:Vmn2r101	UTSW	17	19611797	missense	probably benign	0.38
R7375:Vmn2r101	UTSW	17	19611390	missense	probably damaging	1.00
R7574:Vmn2r101	UTSW	17	19611637	missense	possibly damaging	0.91
R7575:Vmn2r101	UTSW	17	19611392	missense	probably benign	0.01
R7592:Vmn2r101	UTSW	17	19591181	splice site	probably null
R7626:Vmn2r101	UTSW	17	19611930	nonsense	probably null
R7715:Vmn2r101	UTSW	17	19611915	missense	probably damaging	1.00
R7730:Vmn2r101	UTSW	17	19611688	missense	possibly damaging	0.81
Z1088:Vmn2r101	UTSW	17	19588975	missense	possibly damaging	0.78

Predicted Primers

PCR Primer
(F):5'- TCTAGCCAGCATAGCTTTGTGC -3'
(R):5'- CGGTGGAGAAGTTGTCATCC -3'

Sequencing Primer
(F):5'- GCTTATCTGCACTCACATTCTTTG -3'
(R):5'- GTGGAGAAGTTGTCATCCATATTCC -3'

Posted On

2015-06-12