Incidental Mutation 'R4240:Zfp870'
ID 320193
Institutional Source Beutler Lab
Gene Symbol Zfp870
Ensembl Gene ENSMUSG00000095325
Gene Name zinc finger protein 870
Synonyms
MMRRC Submission 041057-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.070) question?
Stock # R4240 (G1)
Quality Score 225
Status Validated
Chromosome 17
Chromosomal Location 33098193-33110616 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 33104710 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 53 (I53T)
Ref Sequence ENSEMBL: ENSMUSP00000154207 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000178401] [ENSMUST00000228075]
AlphaFold Q6NZJ3
Predicted Effect probably benign
Transcript: ENSMUST00000178401
AA Change: I52T

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000136197
Gene: ENSMUSG00000095325
AA Change: I52T

DomainStartEndE-ValueType
KRAB 3 60 1.01e-19 SMART
ZnF_C2H2 193 215 4.5e1 SMART
ZnF_C2H2 221 241 6.4e0 SMART
ZnF_C2H2 277 299 2.24e-3 SMART
ZnF_C2H2 305 327 9.58e-3 SMART
ZnF_C2H2 333 355 2.86e-1 SMART
ZnF_C2H2 361 383 6.42e-4 SMART
ZnF_C2H2 389 411 1.18e-2 SMART
ZnF_C2H2 417 439 3.89e-3 SMART
ZnF_C2H2 445 467 5.5e-3 SMART
ZnF_C2H2 473 495 4.47e-3 SMART
ZnF_C2H2 501 523 5.9e-3 SMART
ZnF_C2H2 529 551 3.11e-2 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000228075
AA Change: I53T

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000228410
Meta Mutation Damage Score 0.1140 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.8%
  • 10x: 97.5%
  • 20x: 95.7%
Validation Efficiency 93% (50/54)
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4833420G17Rik C T 13: 119,603,478 (GRCm39) P93S probably benign Het
4930488N24Rik A T 17: 14,326,049 (GRCm39) noncoding transcript Het
Areg A T 5: 91,291,375 (GRCm39) N106I probably damaging Het
Ceacam3 G A 7: 16,893,949 (GRCm39) E487K possibly damaging Het
Cfap46 G T 7: 139,246,203 (GRCm39) Q387K possibly damaging Het
Cfap74 C A 4: 155,547,529 (GRCm39) H1238Q probably benign Het
Cnot6l T C 5: 96,225,221 (GRCm39) T491A probably benign Het
Cog7 C T 7: 121,524,707 (GRCm39) V696M possibly damaging Het
Col22a1 C T 15: 71,878,980 (GRCm39) G59D probably damaging Het
Ddi1 A G 9: 6,265,799 (GRCm39) M190T probably benign Het
Eno1b T A 18: 48,180,907 (GRCm39) S362T probably benign Het
Erbb2 A G 11: 98,318,869 (GRCm39) K549R probably benign Het
Fam170a A T 18: 50,414,734 (GRCm39) M127L possibly damaging Het
Gm1979 T C 5: 26,206,119 (GRCm39) T154A probably benign Het
Gm6871 G T 7: 41,195,204 (GRCm39) T511K probably damaging Het
Hsf4 A G 8: 106,001,513 (GRCm39) T378A possibly damaging Het
Irf2bpl C A 12: 86,929,691 (GRCm39) Q327H possibly damaging Het
Klk6 A G 7: 43,478,597 (GRCm39) H168R probably benign Het
Kmt2d G A 15: 98,742,452 (GRCm39) probably benign Het
Kplce T C 3: 92,775,898 (GRCm39) I262V possibly damaging Het
Lad1 T A 1: 135,755,033 (GRCm39) V103D possibly damaging Het
Mcm4 A T 16: 15,445,570 (GRCm39) Y692* probably null Het
Med15 C T 16: 17,473,358 (GRCm39) R497H probably damaging Het
Mfrp T C 9: 44,014,163 (GRCm39) V177A possibly damaging Het
Mr1 T C 1: 155,012,413 (GRCm39) E167G probably damaging Het
Myo18b A G 5: 112,951,053 (GRCm39) probably null Het
Myom2 A G 8: 15,182,895 (GRCm39) D1444G probably benign Het
Nes C A 3: 87,886,666 (GRCm39) P1598T probably damaging Het
Nlrp4d A T 7: 10,115,243 (GRCm39) H479Q noncoding transcript Het
Nphp4 A G 4: 152,640,141 (GRCm39) D1009G probably benign Het
Or13a25 A G 7: 140,247,496 (GRCm39) N99D probably benign Het
Pate10 T A 9: 35,653,449 (GRCm39) Y84* probably null Het
Phactr1 T A 13: 43,248,363 (GRCm39) N437K possibly damaging Het
Polq G T 16: 36,833,543 (GRCm39) V79F probably damaging Het
Prc1 G A 7: 79,960,964 (GRCm39) probably benign Het
Rdh7 T C 10: 127,721,671 (GRCm39) I202V probably benign Het
Rsf1 C CGGCGGCGGT 7: 97,229,142 (GRCm39) probably benign Het
Sgsm3 A G 15: 80,895,983 (GRCm39) probably benign Het
Sipa1l2 T C 8: 126,218,395 (GRCm39) E314G probably benign Het
Slc8a3 T C 12: 81,361,950 (GRCm39) K290E probably damaging Het
Tbc1d17 T C 7: 44,496,250 (GRCm39) Y84C probably damaging Het
Usp46 T G 5: 74,192,928 (GRCm39) probably benign Het
Vmn2r14 T G 5: 109,364,277 (GRCm39) probably null Het
Vmn2r8 A T 5: 108,945,369 (GRCm39) V746D probably damaging Het
Xdh A G 17: 74,202,790 (GRCm39) V1120A possibly damaging Het
Zbtb38 CTCTTCTTCTTCTTCTTCTTCTTC CTCTTCTTCTTCTTCTTCTTC 9: 96,568,155 (GRCm39) probably benign Het
Zfp791 T C 8: 85,836,295 (GRCm39) H523R probably null Het
Other mutations in Zfp870
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01304:Zfp870 APN 17 33,101,980 (GRCm39) missense possibly damaging 0.72
R1591:Zfp870 UTSW 17 33,102,990 (GRCm39) missense probably damaging 1.00
R1892:Zfp870 UTSW 17 33,102,863 (GRCm39) missense possibly damaging 0.66
R1941:Zfp870 UTSW 17 33,101,778 (GRCm39) missense possibly damaging 0.71
R1997:Zfp870 UTSW 17 33,103,027 (GRCm39) missense possibly damaging 0.66
R2289:Zfp870 UTSW 17 33,102,334 (GRCm39) missense probably benign 0.27
R4860:Zfp870 UTSW 17 33,102,314 (GRCm39) nonsense probably null
R4860:Zfp870 UTSW 17 33,102,314 (GRCm39) nonsense probably null
R5306:Zfp870 UTSW 17 33,102,627 (GRCm39) missense probably damaging 1.00
R6425:Zfp870 UTSW 17 33,102,045 (GRCm39) missense possibly damaging 0.66
R6736:Zfp870 UTSW 17 33,102,570 (GRCm39) missense probably benign
R7054:Zfp870 UTSW 17 33,102,456 (GRCm39) missense probably damaging 0.97
R7291:Zfp870 UTSW 17 33,102,828 (GRCm39) missense probably damaging 0.97
R7466:Zfp870 UTSW 17 33,102,736 (GRCm39) missense possibly damaging 0.66
R7681:Zfp870 UTSW 17 33,101,664 (GRCm39) missense probably benign
R8230:Zfp870 UTSW 17 33,102,663 (GRCm39) missense possibly damaging 0.46
R8346:Zfp870 UTSW 17 33,102,843 (GRCm39) missense possibly damaging 0.92
R8673:Zfp870 UTSW 17 33,101,904 (GRCm39) missense probably damaging 0.97
R8695:Zfp870 UTSW 17 33,102,679 (GRCm39) missense possibly damaging 0.46
R8736:Zfp870 UTSW 17 33,104,966 (GRCm39) missense possibly damaging 0.92
R9057:Zfp870 UTSW 17 33,102,793 (GRCm39) missense probably benign 0.27
Predicted Primers PCR Primer
(F):5'- CATCAACACATTCTAGTTTGGTTTG -3'
(R):5'- GCATTGGCTTTTGTAGTCCATC -3'

Sequencing Primer
(F):5'- CACATTCTAGTTTGGTTTGTATGTTG -3'
(R):5'- CCATCAAGGACAAGTGTTTCTAG -3'
Posted On 2015-06-12