Incidental Mutation 'R4243:Vmn1r79'
ID320295
Institutional Source Beutler Lab
Gene Symbol Vmn1r79
Ensembl Gene ENSMUSG00000096735
Gene Namevomeronasal 1 receptor 79
SynonymsGm9807
MMRRC Submission 041643-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.059) question?
Stock #R4243 (G1)
Quality Score225
Status Validated
Chromosome7
Chromosomal Location12171279-12181533 bp(+) (GRCm38)
Type of Mutationnonsense
DNA Base Change (assembly) T to A at 12177044 bp
ZygosityHeterozygous
Amino Acid Change Cysteine to Stop codon at position 284 (C284*)
Ref Sequence ENSEMBL: ENSMUSP00000154092 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000062811] [ENSMUST00000210112] [ENSMUST00000226953] [ENSMUST00000227530]
Predicted Effect probably null
Transcript: ENSMUST00000062811
AA Change: C284*
SMART Domains Protein: ENSMUSP00000056232
Gene: ENSMUSG00000096735
AA Change: C284*

DomainStartEndE-ValueType
Pfam:TAS2R 7 302 4.9e-9 PFAM
Pfam:7tm_1 27 292 2.8e-7 PFAM
Pfam:V1R 34 298 1.7e-35 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000210112
Predicted Effect probably null
Transcript: ENSMUST00000226953
AA Change: C284*
Predicted Effect probably null
Transcript: ENSMUST00000227530
AA Change: C284*
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.8%
  • 10x: 97.6%
  • 20x: 96.0%
Validation Efficiency 100% (50/50)
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1500011B03Rik C A 5: 114,813,794 R40L possibly damaging Het
4930449A18Rik T A 3: 59,825,782 noncoding transcript Het
4930578I06Rik C T 14: 63,973,209 R190H probably benign Het
4933409G03Rik C T 2: 68,593,543 probably benign Het
Actr1b T C 1: 36,701,830 Y171C possibly damaging Het
Birc2 T C 9: 7,834,385 T32A probably benign Het
Cdh13 T A 8: 119,242,257 V451E probably damaging Het
Cdh20 C T 1: 104,942,143 T196I probably damaging Het
Cdt1 A G 8: 122,571,418 M383V probably benign Het
Chrna9 T C 5: 65,935,036 probably null Het
Cpne9 C T 6: 113,283,023 probably benign Het
Cspg4 T C 9: 56,887,857 S959P probably benign Het
Ctbp2 A G 7: 132,998,854 I647T probably benign Het
Cyld A T 8: 88,730,755 R536* probably null Het
Ddx1 A T 12: 13,240,909 C68* probably null Het
Dock10 T A 1: 80,566,755 E905V probably benign Het
Dynlt1b T C 17: 6,430,240 probably null Het
Faxc G A 4: 21,982,491 R310Q probably benign Het
Fhdc1 C A 3: 84,444,826 V1031F probably benign Het
Frmd5 C A 2: 121,562,882 probably null Het
Gm5174 C A 10: 86,656,280 noncoding transcript Het
Hspa12b C T 2: 131,141,858 H293Y possibly damaging Het
Jakmip2 A G 18: 43,577,436 V234A probably benign Het
Jkamp G A 12: 72,094,025 V108I probably benign Het
Mettl23 T C 11: 116,848,300 V72A possibly damaging Het
Morc2b T A 17: 33,136,401 Y799F probably benign Het
Mtmr11 T A 3: 96,168,077 C358S probably damaging Het
Myo18b G A 5: 112,692,395 H2511Y possibly damaging Het
Mysm1 A G 4: 94,969,011 V120A probably benign Het
Nhlrc1 C T 13: 47,014,026 V252I probably benign Het
Olfr319 T G 11: 58,702,451 L250R probably damaging Het
Olfr530 G A 7: 140,372,944 A222V probably benign Het
Olfr855 C A 9: 19,584,558 T7K probably damaging Het
Pard3 G A 8: 127,371,647 A390T probably benign Het
Pcdhga1 T A 18: 37,663,552 D536E probably damaging Het
Phactr3 G A 2: 178,283,189 probably null Het
Pkn2 T C 3: 142,820,578 N413D possibly damaging Het
Ppp1r12b T G 1: 134,782,108 probably benign Het
Ptprf A G 4: 118,226,452 probably null Het
Rab3gap1 T C 1: 127,937,567 probably null Het
Rasa1 A G 13: 85,244,195 Y407H probably damaging Het
Rfx7 A G 9: 72,591,769 T72A possibly damaging Het
Slc27a1 A G 8: 71,584,973 T535A probably benign Het
Stra6 G A 9: 58,143,026 A237T probably benign Het
Tor1aip2 A G 1: 156,065,436 E496G probably damaging Het
Usp47 A G 7: 112,108,629 D1294G probably damaging Het
Utp20 A G 10: 88,807,325 probably null Het
Zar1 T C 5: 72,580,393 E121G possibly damaging Het
Zbtb40 C T 4: 137,018,549 A58T probably benign Het
Zfhx3 A G 8: 108,792,320 T25A probably damaging Het
Other mutations in Vmn1r79
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00592:Vmn1r79 APN 7 12177007 missense probably benign 0.05
IGL01431:Vmn1r79 APN 7 12176400 missense possibly damaging 0.88
IGL01953:Vmn1r79 APN 7 12176455 missense probably damaging 1.00
PIT4418001:Vmn1r79 UTSW 7 12176839 missense probably damaging 1.00
R0831:Vmn1r79 UTSW 7 12177063 missense probably damaging 0.98
R1791:Vmn1r79 UTSW 7 12176431 missense probably damaging 1.00
R1869:Vmn1r79 UTSW 7 12176647 missense probably benign 0.00
R3713:Vmn1r79 UTSW 7 12176212 missense possibly damaging 0.66
R4210:Vmn1r79 UTSW 7 12176488 missense possibly damaging 0.46
R4244:Vmn1r79 UTSW 7 12177044 nonsense probably null
R4839:Vmn1r79 UTSW 7 12176434 missense probably benign 0.30
R5677:Vmn1r79 UTSW 7 12177001 missense possibly damaging 0.77
R6048:Vmn1r79 UTSW 7 12176521 missense probably damaging 0.99
R7388:Vmn1r79 UTSW 7 12176741 nonsense probably null
R7751:Vmn1r79 UTSW 7 12176835 nonsense probably null
R8207:Vmn1r79 UTSW 7 12176488 missense possibly damaging 0.46
Predicted Primers PCR Primer
(F):5'- TTTCTGAAAGTCTCACCTGAAGAC -3'
(R):5'- GTCACAAAATTACTACTGATCATTCCA -3'

Sequencing Primer
(F):5'- GTCTCACCTGAAGACAGAGC -3'
(R):5'- GCCCCAGCCTCATATCAT -3'
Posted On2015-06-12