Incidental Mutation 'R4246:Wars2'
ID 320413
Institutional Source Beutler Lab
Gene Symbol Wars2
Ensembl Gene ENSMUSG00000004233
Gene Name tryptophanyl tRNA synthetase 2 (mitochondrial)
Synonyms TrpRS, 9430020O07Rik
MMRRC Submission 041062-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R4246 (G1)
Quality Score 225
Status Not validated
Chromosome 3
Chromosomal Location 99047423-99128546 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 99123904 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Glutamic Acid at position 255 (V255E)
Ref Sequence ENSEMBL: ENSMUSP00000004343 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000004343] [ENSMUST00000135960] [ENSMUST00000145650] [ENSMUST00000198044]
AlphaFold Q9CYK1
Predicted Effect probably damaging
Transcript: ENSMUST00000004343
AA Change: V255E

PolyPhen 2 Score 0.990 (Sensitivity: 0.72; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000004343
Gene: ENSMUSG00000004233
AA Change: V255E

DomainStartEndE-ValueType
Pfam:tRNA-synt_1b 30 315 2.7e-70 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000135960
SMART Domains Protein: ENSMUSP00000142470
Gene: ENSMUSG00000004233

DomainStartEndE-ValueType
Pfam:tRNA-synt_1b 30 175 1e-39 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000145650
SMART Domains Protein: ENSMUSP00000142723
Gene: ENSMUSG00000004233

DomainStartEndE-ValueType
Pfam:tRNA-synt_1b 30 178 1.7e-42 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000198044
SMART Domains Protein: ENSMUSP00000142361
Gene: ENSMUSG00000004233

DomainStartEndE-ValueType
Pfam:tRNA-synt_1b 25 92 4.1e-11 PFAM
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.9%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Two forms of tryptophanyl-tRNA synthetase exist, a cytoplasmic form, named WARS, and a mitochondrial form, named WARS2. This gene encodes the mitochondrial tryptophanyl-tRNA synthetase. Two alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for an ENU-induced mutation exhibit decreased body fat mass, cardiomyopathy, and progressive hearing loss. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2700062C07Rik A G 18: 24,606,013 (GRCm39) N36S possibly damaging Het
Ak1 A G 2: 32,523,384 (GRCm39) T151A possibly damaging Het
Asxl3 A G 18: 22,658,557 (GRCm39) D2189G probably damaging Het
Ccdc91 C T 6: 147,493,646 (GRCm39) A346V unknown Het
Dnah6 C T 6: 73,106,431 (GRCm39) E1769K probably benign Het
Dock6 A T 9: 21,750,786 (GRCm39) probably null Het
Fhod3 A G 18: 25,123,123 (GRCm39) K271R probably null Het
Glyatl3 T A 17: 41,220,989 (GRCm39) D126V probably benign Het
Gnal C G 18: 67,221,654 (GRCm39) P19R unknown Het
Igkv8-21 T A 6: 70,292,436 (GRCm39) M1L possibly damaging Het
Itih4 C A 14: 30,613,359 (GRCm39) H261N probably damaging Het
Jpt1 T C 11: 115,405,119 (GRCm39) probably benign Het
Kif14 G T 1: 136,401,126 (GRCm39) M492I possibly damaging Het
Klhl32 A C 4: 24,800,822 (GRCm39) S3A possibly damaging Het
Kmt2d C T 15: 98,737,970 (GRCm39) probably benign Het
Lamtor5 T C 3: 107,186,354 (GRCm39) V41A probably benign Het
Lmtk3 G A 7: 45,443,486 (GRCm39) C723Y possibly damaging Het
Lrfn1 G T 7: 28,159,367 (GRCm39) V429L probably benign Het
Mapkbp1 T A 2: 119,843,508 (GRCm39) I252N probably damaging Het
Nelfa A G 5: 34,056,373 (GRCm39) F464S probably damaging Het
Nipbl G A 15: 8,361,916 (GRCm39) L1454F probably damaging Het
Nr4a3 C T 4: 48,083,125 (GRCm39) P553S possibly damaging Het
Nrg3 G A 14: 39,194,198 (GRCm39) T187I possibly damaging Het
Or5m5 T A 2: 85,814,624 (GRCm39) C147S possibly damaging Het
Or8g36 A G 9: 39,422,899 (GRCm39) V39A probably benign Het
Pcdha8 A G 18: 37,125,950 (GRCm39) E144G probably damaging Het
Pik3cb T C 9: 98,983,229 (GRCm39) probably null Het
Pira1 C T 7: 3,740,348 (GRCm39) G291E probably damaging Het
Pkd1l1 C T 11: 8,815,543 (GRCm39) R1456K possibly damaging Het
Ppp1r3a T A 6: 14,719,780 (GRCm39) E378V probably damaging Het
Psd2 T C 18: 36,139,172 (GRCm39) L540P probably damaging Het
Rnf14 T A 18: 38,434,701 (GRCm39) probably null Het
Satl1 A G X: 111,316,033 (GRCm39) S141P probably benign Het
Setx GTGGCT GT 2: 29,044,073 (GRCm39) 1814 probably null Het
Sh3d19 G A 3: 86,033,995 (GRCm39) V783I probably benign Het
Snca T C 6: 60,710,149 (GRCm39) E110G possibly damaging Het
Sumf1 A C 6: 108,131,974 (GRCm39) V156G probably damaging Het
Trhr A T 15: 44,096,856 (GRCm39) probably null Het
Tsen2 A G 6: 115,524,785 (GRCm39) probably benign Het
Tuft1 C A 3: 94,522,108 (GRCm39) M319I probably benign Het
Vill C A 9: 118,889,461 (GRCm39) N132K probably damaging Het
Zcchc14 CTGATGGTGGTGGTGATGGTGGTGG CTGATGGTGGTGG 8: 122,331,031 (GRCm39) probably benign Het
Other mutations in Wars2
AlleleSourceChrCoordTypePredicted EffectPPH Score
LCD18:Wars2 UTSW 3 99,214,774 (GRCm38) frame shift probably null
PIT4449001:Wars2 UTSW 3 99,112,595 (GRCm39) missense possibly damaging 0.90
R0511:Wars2 UTSW 3 99,123,865 (GRCm39) missense probably damaging 1.00
R0748:Wars2 UTSW 3 99,123,888 (GRCm39) missense probably damaging 1.00
R1446:Wars2 UTSW 3 99,094,843 (GRCm39) missense probably benign 0.12
R1534:Wars2 UTSW 3 99,124,177 (GRCm39) missense probably damaging 1.00
R2118:Wars2 UTSW 3 99,123,883 (GRCm39) missense probably benign 0.06
R5069:Wars2 UTSW 3 99,094,849 (GRCm39) missense probably damaging 1.00
R5973:Wars2 UTSW 3 99,094,962 (GRCm39) missense probably benign
R6518:Wars2 UTSW 3 99,124,116 (GRCm39) missense probably benign
R7098:Wars2 UTSW 3 99,123,957 (GRCm39) missense probably damaging 1.00
R8010:Wars2 UTSW 3 99,124,146 (GRCm39) missense probably benign 0.01
R8247:Wars2 UTSW 3 99,094,965 (GRCm39) missense probably benign 0.00
R8794:Wars2 UTSW 3 99,123,888 (GRCm39) missense probably damaging 1.00
R9087:Wars2 UTSW 3 99,124,063 (GRCm39) missense possibly damaging 0.84
R9341:Wars2 UTSW 3 99,094,846 (GRCm39) missense probably benign
R9343:Wars2 UTSW 3 99,094,846 (GRCm39) missense probably benign
R9528:Wars2 UTSW 3 99,111,922 (GRCm39) missense possibly damaging 0.81
Predicted Primers PCR Primer
(F):5'- GAAGACATGCTATTGTGCAATCAG -3'
(R):5'- AATTTCTCAATCACAGCATCGGC -3'

Sequencing Primer
(F):5'- GTCTTCCAGGACTAGACTGTAACG -3'
(R):5'- ATCGGCCACTAGCAGCTTGTAG -3'
Posted On 2015-06-12