Incidental Mutation 'R4246:Zcchc14'
ID 320427
Institutional Source Beutler Lab
Gene Symbol Zcchc14
Ensembl Gene ENSMUSG00000061410
Gene Name zinc finger, CCHC domain containing 14
Synonyms Bdg29
MMRRC Submission 041062-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R4246 (G1)
Quality Score 217
Status Not validated
Chromosome 8
Chromosomal Location 122325442-122379640 bp(-) (GRCm39)
Type of Mutation small deletion (4 aa in frame mutation)
DNA Base Change (assembly) CTGATGGTGGTGGTGATGGTGGTGG to CTGATGGTGGTGG at 122331031 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Gene Model predicted gene model for transcript(s): [ENSMUST00000046386] [ENSMUST00000127664]
AlphaFold Q8VIG0
Predicted Effect probably benign
Transcript: ENSMUST00000046386
SMART Domains Protein: ENSMUSP00000040360
Gene: ENSMUSG00000061410

DomainStartEndE-ValueType
low complexity region 30 41 N/A INTRINSIC
low complexity region 129 145 N/A INTRINSIC
low complexity region 206 225 N/A INTRINSIC
low complexity region 246 265 N/A INTRINSIC
Blast:SAM 299 349 2e-25 BLAST
SCOP:d1kw4a_ 307 358 1e-6 SMART
low complexity region 422 432 N/A INTRINSIC
low complexity region 438 454 N/A INTRINSIC
low complexity region 532 543 N/A INTRINSIC
low complexity region 709 790 N/A INTRINSIC
low complexity region 791 808 N/A INTRINSIC
ZnF_C2HC 914 930 3.44e-4 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000127664
SMART Domains Protein: ENSMUSP00000118564
Gene: ENSMUSG00000092329

DomainStartEndE-ValueType
Pfam:Glycos_transf_2 104 287 7.4e-31 PFAM
Pfam:Glyco_transf_7C 261 331 4.9e-8 PFAM
RICIN 406 531 9.28e-27 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000134212
Predicted Effect noncoding transcript
Transcript: ENSMUST00000139379
Predicted Effect probably benign
Transcript: ENSMUST00000154725
SMART Domains Protein: ENSMUSP00000120570
Gene: ENSMUSG00000061410

DomainStartEndE-ValueType
low complexity region 7 88 N/A INTRINSIC
low complexity region 89 106 N/A INTRINSIC
ZnF_C2HC 212 228 3.44e-4 SMART
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.9%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2700062C07Rik A G 18: 24,606,013 (GRCm39) N36S possibly damaging Het
Ak1 A G 2: 32,523,384 (GRCm39) T151A possibly damaging Het
Asxl3 A G 18: 22,658,557 (GRCm39) D2189G probably damaging Het
Ccdc91 C T 6: 147,493,646 (GRCm39) A346V unknown Het
Dnah6 C T 6: 73,106,431 (GRCm39) E1769K probably benign Het
Dock6 A T 9: 21,750,786 (GRCm39) probably null Het
Fhod3 A G 18: 25,123,123 (GRCm39) K271R probably null Het
Glyatl3 T A 17: 41,220,989 (GRCm39) D126V probably benign Het
Gnal C G 18: 67,221,654 (GRCm39) P19R unknown Het
Igkv8-21 T A 6: 70,292,436 (GRCm39) M1L possibly damaging Het
Itih4 C A 14: 30,613,359 (GRCm39) H261N probably damaging Het
Jpt1 T C 11: 115,405,119 (GRCm39) probably benign Het
Kif14 G T 1: 136,401,126 (GRCm39) M492I possibly damaging Het
Klhl32 A C 4: 24,800,822 (GRCm39) S3A possibly damaging Het
Kmt2d C T 15: 98,737,970 (GRCm39) probably benign Het
Lamtor5 T C 3: 107,186,354 (GRCm39) V41A probably benign Het
Lmtk3 G A 7: 45,443,486 (GRCm39) C723Y possibly damaging Het
Lrfn1 G T 7: 28,159,367 (GRCm39) V429L probably benign Het
Mapkbp1 T A 2: 119,843,508 (GRCm39) I252N probably damaging Het
Nelfa A G 5: 34,056,373 (GRCm39) F464S probably damaging Het
Nipbl G A 15: 8,361,916 (GRCm39) L1454F probably damaging Het
Nr4a3 C T 4: 48,083,125 (GRCm39) P553S possibly damaging Het
Nrg3 G A 14: 39,194,198 (GRCm39) T187I possibly damaging Het
Or5m5 T A 2: 85,814,624 (GRCm39) C147S possibly damaging Het
Or8g36 A G 9: 39,422,899 (GRCm39) V39A probably benign Het
Pcdha8 A G 18: 37,125,950 (GRCm39) E144G probably damaging Het
Pik3cb T C 9: 98,983,229 (GRCm39) probably null Het
Pira1 C T 7: 3,740,348 (GRCm39) G291E probably damaging Het
Pkd1l1 C T 11: 8,815,543 (GRCm39) R1456K possibly damaging Het
Ppp1r3a T A 6: 14,719,780 (GRCm39) E378V probably damaging Het
Psd2 T C 18: 36,139,172 (GRCm39) L540P probably damaging Het
Rnf14 T A 18: 38,434,701 (GRCm39) probably null Het
Satl1 A G X: 111,316,033 (GRCm39) S141P probably benign Het
Setx GTGGCT GT 2: 29,044,073 (GRCm39) 1814 probably null Het
Sh3d19 G A 3: 86,033,995 (GRCm39) V783I probably benign Het
Snca T C 6: 60,710,149 (GRCm39) E110G possibly damaging Het
Sumf1 A C 6: 108,131,974 (GRCm39) V156G probably damaging Het
Trhr A T 15: 44,096,856 (GRCm39) probably null Het
Tsen2 A G 6: 115,524,785 (GRCm39) probably benign Het
Tuft1 C A 3: 94,522,108 (GRCm39) M319I probably benign Het
Vill C A 9: 118,889,461 (GRCm39) N132K probably damaging Het
Wars2 T A 3: 99,123,904 (GRCm39) V255E probably damaging Het
Other mutations in Zcchc14
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02035:Zcchc14 APN 8 122,331,354 (GRCm39) unclassified probably benign
IGL02060:Zcchc14 APN 8 122,330,634 (GRCm39) missense probably damaging 0.98
IGL02455:Zcchc14 APN 8 122,333,009 (GRCm39) unclassified probably benign
IGL03196:Zcchc14 APN 8 122,335,877 (GRCm39) unclassified probably benign
P0033:Zcchc14 UTSW 8 122,336,898 (GRCm39) intron probably benign
R0483:Zcchc14 UTSW 8 122,355,388 (GRCm39) intron probably benign
R0639:Zcchc14 UTSW 8 122,332,188 (GRCm39) nonsense probably null
R1013:Zcchc14 UTSW 8 122,333,664 (GRCm39) unclassified probably benign
R1129:Zcchc14 UTSW 8 122,335,154 (GRCm39) unclassified probably benign
R1546:Zcchc14 UTSW 8 122,331,002 (GRCm39) intron probably benign
R1563:Zcchc14 UTSW 8 122,330,718 (GRCm39) missense probably benign 0.10
R1861:Zcchc14 UTSW 8 122,335,990 (GRCm39) unclassified probably benign
R2200:Zcchc14 UTSW 8 122,332,167 (GRCm39) unclassified probably benign
R2419:Zcchc14 UTSW 8 122,330,675 (GRCm39) missense probably damaging 0.99
R4249:Zcchc14 UTSW 8 122,331,031 (GRCm39) small deletion probably benign
R4424:Zcchc14 UTSW 8 122,378,680 (GRCm39) intron probably benign
R4470:Zcchc14 UTSW 8 122,378,498 (GRCm39) intron probably benign
R4520:Zcchc14 UTSW 8 122,335,834 (GRCm39) unclassified probably benign
R4681:Zcchc14 UTSW 8 122,335,339 (GRCm39) unclassified probably benign
R5253:Zcchc14 UTSW 8 122,345,433 (GRCm39) intron probably benign
R5314:Zcchc14 UTSW 8 122,335,337 (GRCm39) unclassified probably benign
R5591:Zcchc14 UTSW 8 122,332,187 (GRCm39) unclassified probably benign
R5746:Zcchc14 UTSW 8 122,331,378 (GRCm39) unclassified probably benign
R5781:Zcchc14 UTSW 8 122,331,332 (GRCm39) unclassified probably benign
R5897:Zcchc14 UTSW 8 122,331,899 (GRCm39) unclassified probably benign
R5930:Zcchc14 UTSW 8 122,338,097 (GRCm39) intron probably benign
R5963:Zcchc14 UTSW 8 122,355,362 (GRCm39) intron probably benign
R6364:Zcchc14 UTSW 8 122,331,598 (GRCm39) unclassified probably benign
R6562:Zcchc14 UTSW 8 122,330,842 (GRCm39) missense probably damaging 0.99
R6579:Zcchc14 UTSW 8 122,331,206 (GRCm39) intron probably benign
R6592:Zcchc14 UTSW 8 122,331,378 (GRCm39) unclassified probably benign
R6699:Zcchc14 UTSW 8 122,335,355 (GRCm39) unclassified probably benign
R7195:Zcchc14 UTSW 8 122,335,200 (GRCm39) missense unknown
R7420:Zcchc14 UTSW 8 122,378,530 (GRCm39) intron probably benign
R7490:Zcchc14 UTSW 8 122,331,756 (GRCm39) missense unknown
R7597:Zcchc14 UTSW 8 122,335,239 (GRCm39) missense unknown
R7758:Zcchc14 UTSW 8 122,331,428 (GRCm39) missense unknown
R7773:Zcchc14 UTSW 8 122,378,514 (GRCm39) missense unknown
R7831:Zcchc14 UTSW 8 122,331,984 (GRCm39) missense not run
R7889:Zcchc14 UTSW 8 122,331,634 (GRCm39) missense unknown
R7919:Zcchc14 UTSW 8 122,330,912 (GRCm39) missense probably damaging 1.00
R9000:Zcchc14 UTSW 8 122,336,880 (GRCm39) missense unknown
R9124:Zcchc14 UTSW 8 122,331,969 (GRCm39) missense unknown
R9667:Zcchc14 UTSW 8 122,331,863 (GRCm39) missense unknown
Predicted Primers PCR Primer
(F):5'- GACATAGCCATTGCCACACATG -3'
(R):5'- TCTGCGCCAATAGCAACACTG -3'

Sequencing Primer
(F):5'- CCACACATGGGACTGAAGG -3'
(R):5'- ACTGCCTCCCCCAGCAG -3'
Posted On 2015-06-12