Incidental Mutation 'R0396:Dennd4a'
| ID |
32057 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Dennd4a
|
| Ensembl Gene |
ENSMUSG00000053641 |
| Gene Name |
DENN/MADD domain containing 4A |
| Synonyms |
F730015K02Rik |
| MMRRC Submission |
038602-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.432)
|
| Stock # |
R0396 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
9 |
| Chromosomal Location |
64811340-64919667 bp(+) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to G
at 64862391 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Glycine
at position 460
(V460G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000037915
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000038890]
|
| AlphaFold |
E9Q8V6 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000038890
AA Change: V460G
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000037915
Gene: ENSMUSG00000053641
AA Change: V460G
| Domain | Start | End | E-Value | Type |
|---|
|
internal_repeat_1
|
45 |
93 |
3.26e-5 |
PROSPERO |
|
uDENN
|
169 |
276 |
1.71e-28 |
SMART |
|
DENN
|
309 |
493 |
2.4e-73 |
SMART |
|
dDENN
|
559 |
633 |
4.15e-27 |
SMART |
|
low complexity region
|
724 |
735 |
N/A |
INTRINSIC |
|
low complexity region
|
936 |
950 |
N/A |
INTRINSIC |
|
low complexity region
|
1176 |
1191 |
N/A |
INTRINSIC |
|
low complexity region
|
1249 |
1262 |
N/A |
INTRINSIC |
|
low complexity region
|
1402 |
1417 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000215025
|
| Meta Mutation Damage Score |
0.7282 |
| Coding Region Coverage |
- 1x: 99.0%
- 3x: 98.0%
- 10x: 95.5%
- 20x: 89.8%
|
| Validation Efficiency |
92% (96/104) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a DENN domain-containing protein that may function as a guanine nucleotide exchange factor that specifically activates ras-related protein Rab-10. This protein also contains a interferon stimulated response element-binding domain and may be involved in regulating the v-myc avian myelocytomatosis viral (MYC) oncogene. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 8. [provided by RefSeq, Mar 2016]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 101 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4933405L10Rik |
G |
A |
8: 105,709,780 (GRCm38) |
V194I |
probably benign |
Het |
| Acsm1 |
A |
T |
7: 119,636,455 (GRCm38) |
I133F |
probably damaging |
Het |
| Adamts9 |
T |
A |
6: 92,798,005 (GRCm38) |
T1676S |
probably benign |
Het |
| Adcy4 |
T |
C |
14: 55,772,288 (GRCm38) |
D769G |
probably benign |
Het |
| Aif1 |
T |
C |
17: 35,171,109 (GRCm38) |
*148W |
probably null |
Het |
| Akna |
C |
T |
4: 63,392,126 (GRCm38) |
|
probably benign |
Het |
| Arhgap32 |
G |
A |
9: 32,245,255 (GRCm38) |
|
probably null |
Het |
| Atpaf1 |
G |
A |
4: 115,785,252 (GRCm38) |
E92K |
possibly damaging |
Het |
| Bltp2 |
T |
C |
11: 78,268,377 (GRCm38) |
V467A |
possibly damaging |
Het |
| C1s1 |
T |
C |
6: 124,533,354 (GRCm38) |
E378G |
probably benign |
Het |
| Caprin1 |
T |
A |
2: 103,769,569 (GRCm38) |
Q108L |
probably damaging |
Het |
| Car13 |
A |
T |
3: 14,656,239 (GRCm38) |
H154L |
probably benign |
Het |
| Cdon |
C |
A |
9: 35,470,130 (GRCm38) |
N605K |
probably damaging |
Het |
| Ceacam10 |
G |
A |
7: 24,781,014 (GRCm38) |
G70E |
probably damaging |
Het |
| Cfap221 |
G |
A |
1: 119,954,200 (GRCm38) |
T286M |
probably benign |
Het |
| Cfap61 |
T |
C |
2: 145,949,944 (GRCm38) |
F107S |
possibly damaging |
Het |
| Coil |
C |
A |
11: 88,981,623 (GRCm38) |
T270N |
probably benign |
Het |
| Crocc2 |
T |
G |
1: 93,224,214 (GRCm38) |
|
probably benign |
Het |
| Crot |
T |
C |
5: 8,969,959 (GRCm38) |
E461G |
probably damaging |
Het |
| D130052B06Rik |
G |
T |
11: 33,623,391 (GRCm38) |
R41L |
unknown |
Het |
| D630045J12Rik |
T |
C |
6: 38,196,736 (GRCm38) |
S166G |
possibly damaging |
Het |
| Depdc7 |
A |
T |
2: 104,727,323 (GRCm38) |
|
probably benign |
Het |
| Dgkb |
G |
A |
12: 38,190,135 (GRCm38) |
|
probably null |
Het |
| Dhx57 |
T |
G |
17: 80,274,797 (GRCm38) |
S407R |
probably benign |
Het |
| Dnase2a |
G |
T |
8: 84,909,763 (GRCm38) |
|
probably benign |
Het |
| Dqx1 |
T |
G |
6: 83,059,005 (GRCm38) |
M106R |
probably benign |
Het |
| Eno1b |
T |
C |
18: 48,047,739 (GRCm38) |
I328T |
probably benign |
Het |
| Ephx2 |
T |
G |
14: 66,108,063 (GRCm38) |
I151L |
probably benign |
Het |
| Gdf3 |
C |
T |
6: 122,607,135 (GRCm38) |
G91D |
probably damaging |
Het |
| Gpc5 |
T |
A |
14: 115,428,208 (GRCm38) |
N481K |
possibly damaging |
Het |
| Gsdme |
T |
A |
6: 50,221,107 (GRCm38) |
H291L |
probably benign |
Het |
| H2-Bl |
A |
G |
17: 36,083,722 (GRCm38) |
I103T |
possibly damaging |
Het |
| Hif3a |
G |
A |
7: 17,052,021 (GRCm38) |
|
probably benign |
Het |
| Hmox2 |
A |
T |
16: 4,765,763 (GRCm38) |
I232L |
probably benign |
Het |
| Itgb2 |
A |
G |
10: 77,561,189 (GRCm38) |
Y686C |
probably damaging |
Het |
| Jmjd1c |
A |
G |
10: 67,219,523 (GRCm38) |
T528A |
possibly damaging |
Het |
| Kdr |
T |
C |
5: 75,960,728 (GRCm38) |
I541V |
possibly damaging |
Het |
| Khdrbs2 |
C |
A |
1: 32,519,973 (GRCm38) |
V343L |
probably damaging |
Het |
| Kif16b |
C |
T |
2: 142,853,659 (GRCm38) |
R175H |
probably damaging |
Het |
| Klri2 |
T |
G |
6: 129,740,288 (GRCm38) |
E44A |
possibly damaging |
Het |
| Kmt2b |
G |
T |
7: 30,576,755 (GRCm38) |
T1773K |
probably damaging |
Het |
| Lair1 |
A |
G |
7: 4,010,786 (GRCm38) |
L154P |
probably damaging |
Het |
| Larp1b |
G |
A |
3: 40,970,561 (GRCm38) |
V158M |
probably damaging |
Het |
| Lgi3 |
T |
A |
14: 70,534,840 (GRCm38) |
I275N |
probably damaging |
Het |
| Lrba |
A |
G |
3: 86,295,179 (GRCm38) |
N246D |
probably damaging |
Het |
| Lrrc45 |
T |
A |
11: 120,714,907 (GRCm38) |
|
probably benign |
Het |
| Mdh2 |
G |
T |
5: 135,789,679 (GRCm38) |
V263L |
probably benign |
Het |
| Myom1 |
T |
A |
17: 71,034,693 (GRCm38) |
V149E |
probably damaging |
Het |
| Nanos1 |
A |
T |
19: 60,757,041 (GRCm38) |
D259V |
probably damaging |
Het |
| Nedd4l |
T |
A |
18: 65,161,654 (GRCm38) |
|
probably benign |
Het |
| Npas3 |
A |
G |
12: 53,831,745 (GRCm38) |
Y150C |
probably damaging |
Het |
| Or10ab4 |
A |
T |
7: 108,055,963 (GRCm38) |
H327L |
probably benign |
Het |
| Or10ag59 |
T |
A |
2: 87,575,567 (GRCm38) |
V161D |
possibly damaging |
Het |
| Or2h1b |
C |
T |
17: 37,151,555 (GRCm38) |
C139Y |
probably damaging |
Het |
| Or2y1f |
A |
T |
11: 49,293,338 (GRCm38) |
I6F |
probably benign |
Het |
| Or52e15 |
G |
A |
7: 104,996,706 (GRCm38) |
A66V |
probably damaging |
Het |
| Or8k28 |
T |
C |
2: 86,456,019 (GRCm38) |
N84S |
possibly damaging |
Het |
| Pde4c |
A |
G |
8: 70,750,076 (GRCm38) |
N637S |
probably benign |
Het |
| Pds5b |
T |
A |
5: 150,779,275 (GRCm38) |
V824D |
possibly damaging |
Het |
| Pole2 |
A |
T |
12: 69,222,386 (GRCm38) |
|
probably benign |
Het |
| Ppig |
C |
T |
2: 69,735,976 (GRCm38) |
|
probably benign |
Het |
| Prep |
A |
G |
10: 45,092,676 (GRCm38) |
Y90C |
probably damaging |
Het |
| Proca1 |
A |
T |
11: 78,194,905 (GRCm38) |
R11S |
probably damaging |
Het |
| Prph |
T |
A |
15: 99,056,991 (GRCm38) |
W313R |
probably benign |
Het |
| Prune2 |
C |
T |
19: 17,123,080 (GRCm38) |
P1983S |
probably benign |
Het |
| Ptbp2 |
G |
A |
3: 119,724,198 (GRCm38) |
|
probably benign |
Het |
| Rsph6a |
C |
T |
7: 19,074,106 (GRCm38) |
P398L |
probably damaging |
Het |
| Sdk2 |
T |
C |
11: 113,829,967 (GRCm38) |
I1379V |
probably benign |
Het |
| Sf3b1 |
C |
T |
1: 55,019,271 (GRCm38) |
G53E |
probably damaging |
Het |
| Slc9a3 |
T |
C |
13: 74,157,784 (GRCm38) |
|
probably null |
Het |
| Smarcal1 |
A |
T |
1: 72,626,473 (GRCm38) |
H710L |
probably benign |
Het |
| Soat2 |
GAGAAG |
GAG |
15: 102,150,707 (GRCm38) |
|
probably benign |
Het |
| Sptan1 |
T |
C |
2: 29,991,033 (GRCm38) |
V438A |
probably damaging |
Het |
| Sstr4 |
T |
A |
2: 148,396,261 (GRCm38) |
V264D |
probably damaging |
Het |
| Susd2 |
A |
G |
10: 75,639,911 (GRCm38) |
L418P |
probably damaging |
Het |
| Synj1 |
A |
G |
16: 90,938,640 (GRCm38) |
V1475A |
probably benign |
Het |
| Szt2 |
G |
A |
4: 118,376,347 (GRCm38) |
|
probably benign |
Het |
| Tbc1d4 |
T |
C |
14: 101,458,063 (GRCm38) |
|
probably null |
Het |
| Tesk1 |
A |
G |
4: 43,446,000 (GRCm38) |
E311G |
probably damaging |
Het |
| Tmed5 |
A |
T |
5: 108,126,016 (GRCm38) |
V119E |
probably damaging |
Het |
| Tmem260 |
T |
C |
14: 48,486,867 (GRCm38) |
S201P |
possibly damaging |
Het |
| Tnxb |
A |
G |
17: 34,671,733 (GRCm38) |
Y350C |
probably damaging |
Het |
| Tpte |
T |
C |
8: 22,335,608 (GRCm38) |
|
probably benign |
Het |
| Trim37 |
A |
T |
11: 87,146,968 (GRCm38) |
D161V |
probably damaging |
Het |
| Trrap |
C |
A |
5: 144,814,556 (GRCm38) |
Q1640K |
probably damaging |
Het |
| Tspoap1 |
T |
C |
11: 87,776,346 (GRCm38) |
|
probably benign |
Het |
| Ttk |
T |
A |
9: 83,847,260 (GRCm38) |
|
probably benign |
Het |
| Vmn1r172 |
A |
G |
7: 23,660,532 (GRCm38) |
S281G |
probably benign |
Het |
| Vmn1r177 |
A |
G |
7: 23,865,597 (GRCm38) |
S285P |
probably damaging |
Het |
| Vmn1r231 |
C |
T |
17: 20,890,399 (GRCm38) |
V85I |
probably damaging |
Het |
| Vmn2r100 |
C |
A |
17: 19,522,120 (GRCm38) |
P252Q |
possibly damaging |
Het |
| Vmn2r118 |
T |
C |
17: 55,608,643 (GRCm38) |
I436V |
probably benign |
Het |
| Vmn2r12 |
T |
C |
5: 109,092,899 (GRCm38) |
K116R |
probably benign |
Het |
| Vmn2r28 |
T |
A |
7: 5,488,514 (GRCm38) |
I245L |
probably benign |
Het |
| Wdr26 |
A |
T |
1: 181,180,651 (GRCm38) |
|
probably benign |
Het |
| Xrcc3 |
A |
T |
12: 111,809,957 (GRCm38) |
H67Q |
probably benign |
Het |
| Zbbx |
A |
T |
3: 75,078,495 (GRCm38) |
S417T |
possibly damaging |
Het |
| Zc3h13 |
A |
G |
14: 75,323,482 (GRCm38) |
D504G |
unknown |
Het |
| Zfp1005 |
G |
A |
2: 150,268,053 (GRCm38) |
G221D |
probably damaging |
Het |
| Zfp217 |
C |
T |
2: 170,115,462 (GRCm38) |
A539T |
probably benign |
Het |
| Zyg11b |
A |
T |
4: 108,255,308 (GRCm38) |
F388I |
probably damaging |
Het |
|
| Other mutations in Dennd4a |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00476:Dennd4a
|
APN |
9 |
64,911,762 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01610:Dennd4a
|
APN |
9 |
64,906,884 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL01788:Dennd4a
|
APN |
9 |
64,842,621 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL01827:Dennd4a
|
APN |
9 |
64,842,561 (GRCm38) |
nonsense |
probably null |
|
|
IGL01828:Dennd4a
|
APN |
9 |
64,842,561 (GRCm38) |
nonsense |
probably null |
|
|
IGL01829:Dennd4a
|
APN |
9 |
64,842,561 (GRCm38) |
nonsense |
probably null |
|
|
IGL01979:Dennd4a
|
APN |
9 |
64,894,409 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL02100:Dennd4a
|
APN |
9 |
64,909,706 (GRCm38) |
splice site |
probably benign |
|
|
IGL02339:Dennd4a
|
APN |
9 |
64,842,561 (GRCm38) |
nonsense |
probably null |
|
|
IGL02341:Dennd4a
|
APN |
9 |
64,842,561 (GRCm38) |
nonsense |
probably null |
|
|
IGL02584:Dennd4a
|
APN |
9 |
64,851,298 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02607:Dennd4a
|
APN |
9 |
64,862,327 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL02654:Dennd4a
|
APN |
9 |
64,910,191 (GRCm38) |
splice site |
probably benign |
|
|
IGL02701:Dennd4a
|
APN |
9 |
64,897,353 (GRCm38) |
missense |
possibly damaging |
0.50 |
|
IGL03051:Dennd4a
|
APN |
9 |
64,862,414 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03257:Dennd4a
|
APN |
9 |
64,871,874 (GRCm38) |
missense |
possibly damaging |
0.93 |
|
IGL03346:Dennd4a
|
APN |
9 |
64,888,526 (GRCm38) |
missense |
possibly damaging |
0.47 |
|
IGL03349:Dennd4a
|
APN |
9 |
64,888,974 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03398:Dennd4a
|
APN |
9 |
64,871,882 (GRCm38) |
missense |
probably benign |
0.32 |
|
R0010:Dennd4a
|
UTSW |
9 |
64,896,715 (GRCm38) |
missense |
probably benign |
0.00 |
|
R0010:Dennd4a
|
UTSW |
9 |
64,896,715 (GRCm38) |
missense |
probably benign |
0.00 |
|
R0129:Dennd4a
|
UTSW |
9 |
64,893,294 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0220:Dennd4a
|
UTSW |
9 |
64,852,445 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0881:Dennd4a
|
UTSW |
9 |
64,851,383 (GRCm38) |
critical splice donor site |
probably null |
|
|
R1225:Dennd4a
|
UTSW |
9 |
64,911,675 (GRCm38) |
missense |
probably benign |
0.03 |
|
R1311:Dennd4a
|
UTSW |
9 |
64,910,004 (GRCm38) |
missense |
probably benign |
0.34 |
|
R1448:Dennd4a
|
UTSW |
9 |
64,906,045 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
R1450:Dennd4a
|
UTSW |
9 |
64,911,665 (GRCm38) |
missense |
probably benign |
0.03 |
|
R1630:Dennd4a
|
UTSW |
9 |
64,871,882 (GRCm38) |
missense |
probably benign |
0.32 |
|
R1709:Dennd4a
|
UTSW |
9 |
64,889,605 (GRCm38) |
missense |
possibly damaging |
0.92 |
|
R1824:Dennd4a
|
UTSW |
9 |
64,859,358 (GRCm38) |
critical splice donor site |
probably null |
|
|
R1851:Dennd4a
|
UTSW |
9 |
64,862,030 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1870:Dennd4a
|
UTSW |
9 |
64,897,234 (GRCm38) |
missense |
probably benign |
0.00 |
|
R1900:Dennd4a
|
UTSW |
9 |
64,897,336 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R1911:Dennd4a
|
UTSW |
9 |
64,889,086 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1938:Dennd4a
|
UTSW |
9 |
64,842,490 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1954:Dennd4a
|
UTSW |
9 |
64,852,467 (GRCm38) |
missense |
probably benign |
0.02 |
|
R1955:Dennd4a
|
UTSW |
9 |
64,852,467 (GRCm38) |
missense |
probably benign |
0.02 |
|
R2049:Dennd4a
|
UTSW |
9 |
64,889,605 (GRCm38) |
missense |
possibly damaging |
0.92 |
|
R2129:Dennd4a
|
UTSW |
9 |
64,905,974 (GRCm38) |
splice site |
probably null |
|
|
R2138:Dennd4a
|
UTSW |
9 |
64,889,337 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2929:Dennd4a
|
UTSW |
9 |
64,852,417 (GRCm38) |
missense |
possibly damaging |
0.85 |
|
R3083:Dennd4a
|
UTSW |
9 |
64,906,081 (GRCm38) |
missense |
probably benign |
0.03 |
|
R3108:Dennd4a
|
UTSW |
9 |
64,912,387 (GRCm38) |
missense |
probably benign |
0.23 |
|
R3176:Dennd4a
|
UTSW |
9 |
64,888,993 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3177:Dennd4a
|
UTSW |
9 |
64,888,993 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3276:Dennd4a
|
UTSW |
9 |
64,888,993 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3277:Dennd4a
|
UTSW |
9 |
64,888,993 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3890:Dennd4a
|
UTSW |
9 |
64,872,028 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3953:Dennd4a
|
UTSW |
9 |
64,852,575 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3963:Dennd4a
|
UTSW |
9 |
64,862,331 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4059:Dennd4a
|
UTSW |
9 |
64,911,892 (GRCm38) |
missense |
possibly damaging |
0.92 |
|
R4499:Dennd4a
|
UTSW |
9 |
64,910,123 (GRCm38) |
missense |
possibly damaging |
0.78 |
|
R4500:Dennd4a
|
UTSW |
9 |
64,910,123 (GRCm38) |
missense |
possibly damaging |
0.78 |
|
R4501:Dennd4a
|
UTSW |
9 |
64,910,123 (GRCm38) |
missense |
possibly damaging |
0.78 |
|
R4671:Dennd4a
|
UTSW |
9 |
64,894,407 (GRCm38) |
missense |
probably benign |
|
|
R4701:Dennd4a
|
UTSW |
9 |
64,897,357 (GRCm38) |
missense |
possibly damaging |
0.91 |
|
R4821:Dennd4a
|
UTSW |
9 |
64,897,249 (GRCm38) |
missense |
possibly damaging |
0.92 |
|
R4829:Dennd4a
|
UTSW |
9 |
64,889,056 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4876:Dennd4a
|
UTSW |
9 |
64,896,590 (GRCm38) |
missense |
probably benign |
|
|
R4881:Dennd4a
|
UTSW |
9 |
64,838,844 (GRCm38) |
missense |
possibly damaging |
0.77 |
|
R4962:Dennd4a
|
UTSW |
9 |
64,906,003 (GRCm38) |
missense |
probably benign |
0.00 |
|
R5225:Dennd4a
|
UTSW |
9 |
64,888,928 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R5557:Dennd4a
|
UTSW |
9 |
64,904,227 (GRCm38) |
missense |
probably benign |
0.07 |
|
R5649:Dennd4a
|
UTSW |
9 |
64,851,209 (GRCm38) |
splice site |
probably null |
|
|
R5868:Dennd4a
|
UTSW |
9 |
64,896,729 (GRCm38) |
missense |
probably benign |
0.02 |
|
R5876:Dennd4a
|
UTSW |
9 |
64,911,755 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6052:Dennd4a
|
UTSW |
9 |
64,886,945 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6411:Dennd4a
|
UTSW |
9 |
64,871,899 (GRCm38) |
missense |
probably benign |
0.04 |
|
R6596:Dennd4a
|
UTSW |
9 |
64,852,420 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6668:Dennd4a
|
UTSW |
9 |
64,886,965 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6915:Dennd4a
|
UTSW |
9 |
64,852,489 (GRCm38) |
nonsense |
probably null |
|
|
R7056:Dennd4a
|
UTSW |
9 |
64,906,923 (GRCm38) |
missense |
possibly damaging |
0.89 |
|
R7107:Dennd4a
|
UTSW |
9 |
64,894,399 (GRCm38) |
missense |
possibly damaging |
0.79 |
|
R7203:Dennd4a
|
UTSW |
9 |
64,896,474 (GRCm38) |
missense |
probably benign |
0.05 |
|
R7238:Dennd4a
|
UTSW |
9 |
64,861,956 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7373:Dennd4a
|
UTSW |
9 |
64,897,269 (GRCm38) |
missense |
probably benign |
0.01 |
|
R7454:Dennd4a
|
UTSW |
9 |
64,852,570 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7546:Dennd4a
|
UTSW |
9 |
64,873,044 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7590:Dennd4a
|
UTSW |
9 |
64,888,587 (GRCm38) |
missense |
probably benign |
0.01 |
|
R7662:Dennd4a
|
UTSW |
9 |
64,852,431 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7782:Dennd4a
|
UTSW |
9 |
64,906,920 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R7909:Dennd4a
|
UTSW |
9 |
64,872,993 (GRCm38) |
critical splice acceptor site |
probably null |
|
|
R7976:Dennd4a
|
UTSW |
9 |
64,852,512 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
R8026:Dennd4a
|
UTSW |
9 |
64,873,030 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8034:Dennd4a
|
UTSW |
9 |
64,888,568 (GRCm38) |
missense |
probably benign |
0.01 |
|
R8089:Dennd4a
|
UTSW |
9 |
64,849,175 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8298:Dennd4a
|
UTSW |
9 |
64,906,875 (GRCm38) |
missense |
probably benign |
0.00 |
|
R8397:Dennd4a
|
UTSW |
9 |
64,889,109 (GRCm38) |
missense |
probably benign |
|
|
R8425:Dennd4a
|
UTSW |
9 |
64,838,974 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8495:Dennd4a
|
UTSW |
9 |
64,886,879 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8855:Dennd4a
|
UTSW |
9 |
64,912,390 (GRCm38) |
missense |
probably benign |
|
|
R9219:Dennd4a
|
UTSW |
9 |
64,889,094 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R9275:Dennd4a
|
UTSW |
9 |
64,842,624 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9376:Dennd4a
|
UTSW |
9 |
64,912,692 (GRCm38) |
missense |
probably benign |
0.00 |
|
R9485:Dennd4a
|
UTSW |
9 |
64,907,106 (GRCm38) |
nonsense |
probably null |
|
|
R9672:Dennd4a
|
UTSW |
9 |
64,893,358 (GRCm38) |
missense |
probably benign |
|
|
R9746:Dennd4a
|
UTSW |
9 |
64,894,511 (GRCm38) |
missense |
probably benign |
|
|
X0026:Dennd4a
|
UTSW |
9 |
64,897,320 (GRCm38) |
missense |
possibly damaging |
0.67 |
|
Z1088:Dennd4a
|
UTSW |
9 |
64,872,022 (GRCm38) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- CTGTGCTCACCAGTGTGACAGAAG -3'
(R):5'- ACAGTGAAGTCATGGAGTCTCGGC -3'
Sequencing Primer
(F):5'- ACCATTTCTCATAGGCAGTCAGG -3'
(R):5'- CATGGAGTCTCGGCTATGAC -3'
|
| Posted On |
2013-04-24 |
Incidental Mutation