Mutagenetix > Incidental Mutation

Incidental Mutation 'R4167:Oog2'

320619

Institutional Source

Beutler Lab

Gene Symbol

Oog2

Ensembl Gene

ENSMUSG00000066030

Gene Name

oogenesin 2

Synonyms

MMRRC Submission

041008-MU

Accession Numbers

Is this an essential gene?

Non essential (E-score: 0.000) question?

Stock #

R4167 (G1)

Quality Score

172

Status

Not validated

Chromosome

Chromosomal Location

144190719-144196934 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 144196212 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Glutamine to Leucine at position 349 (Q349L)

Ref Sequence

ENSEMBL: ENSMUSP00000079267 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000080405] [ENSMUST00000143978]

AlphaFold

Q7TPX8

Predicted Effect

probably benign
Transcript: ENSMUST00000080405
AA Change: Q349L

PolyPhen 2 Score 0.176 (Sensitivity: 0.92; Specificity: 0.87)

SMART Domains

Protein: ENSMUSP00000079267
Gene: ENSMUSG00000066030
AA Change: Q349L

Domain	Start	End	E-Value	Type
SCOP:d1a4ya_	204	391	2e-7	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000129781

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000141847

Predicted Effect

probably benign
Transcript: ENSMUST00000143978

Coding Region Coverage

1x: 99.3%
3x: 98.6%
10x: 97.5%
20x: 96.0%

Validation Efficiency

94% (31/33)

Allele List at MGI

Other mutations in this stock

Total: 29 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Casp6	A	G	3: 129,913,344	H201R	probably damaging	Het
Cd200r3	T	A	16: 44,954,189	D188E	probably benign	Het
Cdh16	A	G	8: 104,617,730	L59P	probably benign	Het
Dcp2	T	A	18: 44,395,967	Y50N	probably damaging	Het
Elk3	A	G	10: 93,265,335		probably null	Het
Fam78b	T	C	1: 167,001,732	V51A	possibly damaging	Het
Gabrb2	A	T	11: 42,421,328		probably benign	Het
Glyctk	G	T	9: 106,157,762	A35E	probably benign	Het
Kat14	A	G	2: 144,394,110	E254G	probably damaging	Het
Kcng1	T	A	2: 168,262,697	S410C	probably damaging	Het
Krt74	A	G	15: 101,758,869		noncoding transcript	Het
Lrp12	T	C	15: 39,885,013	T70A	probably damaging	Het
Man2c1	A	G	9: 57,138,026	D473G	probably benign	Het
Mindy4	G	A	6: 55,224,346	G339S	possibly damaging	Het
Naip1	C	T	13: 100,444,286	G151D	probably benign	Het
Ndufaf7	G	A	17: 78,944,986	V275I	probably benign	Het
Nppb	T	A	4: 147,986,974	L121*	probably null	Het
Olfr111	T	C	17: 37,530,006	S10P	possibly damaging	Het
Olfr1167	T	C	2: 88,149,845	H58R	probably damaging	Het
Pcdhgb8	T	G	18: 37,762,543	V222G	possibly damaging	Het
Plcd3	A	T	11: 103,078,464	C226S	probably damaging	Het
Plxdc2	A	G	2: 16,565,385	E125G	probably damaging	Het
Rnf213	A	G	11: 119,441,243	E2426G	probably damaging	Het
Rraga	T	C	4: 86,576,067	V50A	possibly damaging	Het
Scmh1	T	C	4: 120,529,276		probably benign	Het
Slc9a9	A	G	9: 95,228,899	Y590C	probably damaging	Het
Snx20	C	T	8: 88,627,385	R239Q	probably benign	Het
Vmn2r59	A	G	7: 42,021,308		probably benign	Het
Zfp128	A	G	7: 12,890,362	D219G	probably benign	Het

Other mutations in Oog2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00843:Oog2	APN	4	144195172	missense	probably damaging	1.00
IGL01317:Oog2	APN	4	144195267	missense	probably benign	0.16
IGL01697:Oog2	APN	4	144195184	missense	possibly damaging	0.90
IGL02237:Oog2	APN	4	144196446	missense	possibly damaging	0.95
IGL02411:Oog2	APN	4	144195048	missense	probably damaging	0.99
IGL02476:Oog2	APN	4	144195229	missense	probably benign	0.02
IGL03284:Oog2	APN	4	144196607	unclassified	probably benign
IGL03394:Oog2	APN	4	144194006	missense	probably benign	0.17
R0538:Oog2	UTSW	4	144196084	nonsense	probably null
R0892:Oog2	UTSW	4	144196499	missense	probably benign	0.00
R1024:Oog2	UTSW	4	144196286	missense	probably damaging	1.00
R4156:Oog2	UTSW	4	144193953	intron	probably benign
R4157:Oog2	UTSW	4	144193953	intron	probably benign
R4166:Oog2	UTSW	4	144194841	missense	probably damaging	1.00
R4732:Oog2	UTSW	4	144193941	intron	probably benign
R4734:Oog2	UTSW	4	144196451	missense	probably benign	0.00
R4741:Oog2	UTSW	4	144195145	missense	possibly damaging	0.94
R4909:Oog2	UTSW	4	144195099	missense	possibly damaging	0.78
R4954:Oog2	UTSW	4	144190732	start gained	probably benign
R6437:Oog2	UTSW	4	144195108	splice site	probably null
R6487:Oog2	UTSW	4	144196485	missense	possibly damaging	0.48
R6946:Oog2	UTSW	4	144196464	missense	possibly damaging	0.95
R7000:Oog2	UTSW	4	144195327	missense	probably damaging	1.00
R7167:Oog2	UTSW	4	144195175	missense	probably benign	0.04
R7303:Oog2	UTSW	4	144195342	missense	probably benign	0.04
R7399:Oog2	UTSW	4	144195281	missense	probably benign	0.01
R8004:Oog2	UTSW	4	144194251	missense	probably benign	0.00
R8141:Oog2	UTSW	4	144194207	missense	probably damaging	0.97
R8411:Oog2	UTSW	4	144194173	missense	probably damaging	1.00
R8932:Oog2	UTSW	4	144194115	missense	probably benign	0.00
R9290:Oog2	UTSW	4	144196445	missense	probably benign	0.02
R9348:Oog2	UTSW	4	144195219	missense	probably damaging	1.00
R9614:Oog2	UTSW	4	144196137	missense	probably damaging	1.00
RF009:Oog2	UTSW	4	144195285	missense	probably benign	0.36
Z1177:Oog2	UTSW	4	144194015	missense	probably damaging	0.99

Predicted Primers

PCR Primer
(F):5'- TCCAGAAAGCAACCATTTCTTC -3'
(R):5'- GGCAGGGTATAGCTCATCAG -3'

Sequencing Primer
(F):5'- AGAAGCCCTTGGAAGTACTTTCG -3'
(R):5'- CTCATCAGCTAGCTGGCTAAG -3'

Posted On

2015-06-12