Incidental Mutation 'R0396:Synj1'
| ID |
32084 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Synj1
|
| Ensembl Gene |
ENSMUSG00000022973 |
| Gene Name |
synaptojanin 1 |
| Synonyms |
A930006D20Rik |
| MMRRC Submission |
038602-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R0396 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
16 |
| Chromosomal Location |
90732980-90808196 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 90735528 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Alanine
at position 1475
(V1475A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000113308
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000023694]
[ENSMUST00000121759]
[ENSMUST00000125519]
[ENSMUST00000129743]
[ENSMUST00000170853]
[ENSMUST00000149833]
[ENSMUST00000142340]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000023694
|
| SMART Domains |
Protein: ENSMUSP00000023694
Gene: ENSMUSG00000022972
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:DUF2870
|
189 |
285 |
4.7e-47 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000118390
|
| SMART Domains |
Protein: ENSMUSP00000113518
Gene: ENSMUSG00000022973
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
1 |
15 |
N/A |
INTRINSIC |
|
Pfam:Syja_N
|
75 |
356 |
3.1e-71 |
PFAM |
|
IPPc
|
546 |
889 |
6.37e-177 |
SMART |
|
DUF1866
|
882 |
1024 |
1.24e-80 |
SMART |
|
low complexity region
|
1040 |
1069 |
N/A |
INTRINSIC |
|
low complexity region
|
1117 |
1151 |
N/A |
INTRINSIC |
|
low complexity region
|
1155 |
1166 |
N/A |
INTRINSIC |
|
low complexity region
|
1189 |
1208 |
N/A |
INTRINSIC |
|
low complexity region
|
1289 |
1322 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000121759
AA Change: V1475A
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000113308
Gene: ENSMUSG00000022973
AA Change: V1475A
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
9 |
40 |
N/A |
INTRINSIC |
|
Pfam:Syja_N
|
100 |
381 |
4.2e-71 |
PFAM |
|
IPPc
|
571 |
914 |
6.37e-177 |
SMART |
|
DUF1866
|
907 |
1049 |
1.24e-80 |
SMART |
|
low complexity region
|
1065 |
1094 |
N/A |
INTRINSIC |
|
low complexity region
|
1142 |
1176 |
N/A |
INTRINSIC |
|
low complexity region
|
1180 |
1191 |
N/A |
INTRINSIC |
|
low complexity region
|
1214 |
1233 |
N/A |
INTRINSIC |
|
low complexity region
|
1314 |
1343 |
N/A |
INTRINSIC |
|
Blast:IPPc
|
1344 |
1428 |
1e-17 |
BLAST |
|
low complexity region
|
1564 |
1596 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000125519
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000129041
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000129743
|
| SMART Domains |
Protein: ENSMUSP00000123231
Gene: ENSMUSG00000022973
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
69 |
101 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000131583
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000154276
|
| SMART Domains |
Protein: ENSMUSP00000122675
Gene: ENSMUSG00000022973
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
2 |
32 |
N/A |
INTRINSIC |
|
low complexity region
|
54 |
73 |
N/A |
INTRINSIC |
|
low complexity region
|
154 |
187 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000170853
|
| SMART Domains |
Protein: ENSMUSP00000128997
Gene: ENSMUSG00000022973
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Syja_N
|
59 |
346 |
1.7e-85 |
PFAM |
|
IPPc
|
531 |
874 |
6.37e-177 |
SMART |
|
DUF1866
|
867 |
1009 |
1.24e-80 |
SMART |
|
low complexity region
|
1025 |
1054 |
N/A |
INTRINSIC |
|
low complexity region
|
1102 |
1136 |
N/A |
INTRINSIC |
|
low complexity region
|
1140 |
1151 |
N/A |
INTRINSIC |
|
low complexity region
|
1174 |
1193 |
N/A |
INTRINSIC |
|
low complexity region
|
1274 |
1307 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000232326
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000149833
|
| SMART Domains |
Protein: ENSMUSP00000123417
Gene: ENSMUSG00000022972
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:DUF2870
|
171 |
198 |
5.8e-14 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000142340
|
| Meta Mutation Damage Score |
0.0682 |
| Coding Region Coverage |
- 1x: 99.0%
- 3x: 98.0%
- 10x: 95.5%
- 20x: 89.8%
|
| Validation Efficiency |
92% (96/104) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a phosphoinositide phosphatase that regulates levels of membrane phosphatidylinositol-4,5-bisphosphate. As such, expression of this enzyme may affect synaptic transmission and membrane trafficking. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
PHENOTYPE: Homozygotes for a targeted null mutation exhibit neurological defects associated with impaired phosphoinositide metabolism and accumulation of clathrin-coated vesicles at nerve endings. Mutants show impaired suckling and most die within 24 hours of birth. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 101 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4933405L10Rik |
G |
A |
8: 106,436,412 (GRCm39) |
V194I |
probably benign |
Het |
| Acsm1 |
A |
T |
7: 119,235,678 (GRCm39) |
I133F |
probably damaging |
Het |
| Adamts9 |
T |
A |
6: 92,774,986 (GRCm39) |
T1676S |
probably benign |
Het |
| Adcy4 |
T |
C |
14: 56,009,745 (GRCm39) |
D769G |
probably benign |
Het |
| Aif1 |
T |
C |
17: 35,390,085 (GRCm39) |
*148W |
probably null |
Het |
| Akna |
C |
T |
4: 63,310,363 (GRCm39) |
|
probably benign |
Het |
| Arhgap32 |
G |
A |
9: 32,156,551 (GRCm39) |
|
probably null |
Het |
| Atpaf1 |
G |
A |
4: 115,642,449 (GRCm39) |
E92K |
possibly damaging |
Het |
| Bltp2 |
T |
C |
11: 78,159,203 (GRCm39) |
V467A |
possibly damaging |
Het |
| C1s1 |
T |
C |
6: 124,510,313 (GRCm39) |
E378G |
probably benign |
Het |
| Caprin1 |
T |
A |
2: 103,599,914 (GRCm39) |
Q108L |
probably damaging |
Het |
| Car13 |
A |
T |
3: 14,721,299 (GRCm39) |
H154L |
probably benign |
Het |
| Cdon |
C |
A |
9: 35,381,426 (GRCm39) |
N605K |
probably damaging |
Het |
| Ceacam10 |
G |
A |
7: 24,480,439 (GRCm39) |
G70E |
probably damaging |
Het |
| Cfap221 |
G |
A |
1: 119,881,930 (GRCm39) |
T286M |
probably benign |
Het |
| Cfap61 |
T |
C |
2: 145,791,864 (GRCm39) |
F107S |
possibly damaging |
Het |
| Coil |
C |
A |
11: 88,872,449 (GRCm39) |
T270N |
probably benign |
Het |
| Crocc2 |
T |
G |
1: 93,151,936 (GRCm39) |
|
probably benign |
Het |
| Crot |
T |
C |
5: 9,019,959 (GRCm39) |
E461G |
probably damaging |
Het |
| D130052B06Rik |
G |
T |
11: 33,573,391 (GRCm39) |
R41L |
unknown |
Het |
| D630045J12Rik |
T |
C |
6: 38,173,671 (GRCm39) |
S166G |
possibly damaging |
Het |
| Dennd4a |
T |
G |
9: 64,769,673 (GRCm39) |
V460G |
probably damaging |
Het |
| Depdc7 |
A |
T |
2: 104,557,668 (GRCm39) |
|
probably benign |
Het |
| Dgkb |
G |
A |
12: 38,240,134 (GRCm39) |
|
probably null |
Het |
| Dhx57 |
T |
G |
17: 80,582,226 (GRCm39) |
S407R |
probably benign |
Het |
| Dnase2a |
G |
T |
8: 85,636,392 (GRCm39) |
|
probably benign |
Het |
| Dqx1 |
T |
G |
6: 83,035,986 (GRCm39) |
M106R |
probably benign |
Het |
| Eno1b |
T |
C |
18: 48,180,806 (GRCm39) |
I328T |
probably benign |
Het |
| Ephx2 |
T |
G |
14: 66,345,512 (GRCm39) |
I151L |
probably benign |
Het |
| Gdf3 |
C |
T |
6: 122,584,094 (GRCm39) |
G91D |
probably damaging |
Het |
| Gpc5 |
T |
A |
14: 115,665,620 (GRCm39) |
N481K |
possibly damaging |
Het |
| Gsdme |
T |
A |
6: 50,198,087 (GRCm39) |
H291L |
probably benign |
Het |
| H2-T13 |
A |
G |
17: 36,394,614 (GRCm39) |
I103T |
possibly damaging |
Het |
| Hif3a |
G |
A |
7: 16,785,946 (GRCm39) |
|
probably benign |
Het |
| Hmox2 |
A |
T |
16: 4,583,627 (GRCm39) |
I232L |
probably benign |
Het |
| Itgb2 |
A |
G |
10: 77,397,023 (GRCm39) |
Y686C |
probably damaging |
Het |
| Jmjd1c |
A |
G |
10: 67,055,302 (GRCm39) |
T528A |
possibly damaging |
Het |
| Kdr |
T |
C |
5: 76,121,388 (GRCm39) |
I541V |
possibly damaging |
Het |
| Khdrbs2 |
C |
A |
1: 32,559,054 (GRCm39) |
V343L |
probably damaging |
Het |
| Kif16b |
C |
T |
2: 142,695,579 (GRCm39) |
R175H |
probably damaging |
Het |
| Klri2 |
T |
G |
6: 129,717,251 (GRCm39) |
E44A |
possibly damaging |
Het |
| Kmt2b |
G |
T |
7: 30,276,180 (GRCm39) |
T1773K |
probably damaging |
Het |
| Lair1 |
A |
G |
7: 4,013,785 (GRCm39) |
L154P |
probably damaging |
Het |
| Larp1b |
G |
A |
3: 40,924,996 (GRCm39) |
V158M |
probably damaging |
Het |
| Lgi3 |
T |
A |
14: 70,772,280 (GRCm39) |
I275N |
probably damaging |
Het |
| Lrba |
A |
G |
3: 86,202,486 (GRCm39) |
N246D |
probably damaging |
Het |
| Lrrc45 |
T |
A |
11: 120,605,733 (GRCm39) |
|
probably benign |
Het |
| Mdh2 |
G |
T |
5: 135,818,533 (GRCm39) |
V263L |
probably benign |
Het |
| Myom1 |
T |
A |
17: 71,341,688 (GRCm39) |
V149E |
probably damaging |
Het |
| Nanos1 |
A |
T |
19: 60,745,479 (GRCm39) |
D259V |
probably damaging |
Het |
| Nedd4l |
T |
A |
18: 65,294,725 (GRCm39) |
|
probably benign |
Het |
| Npas3 |
A |
G |
12: 53,878,528 (GRCm39) |
Y150C |
probably damaging |
Het |
| Or10ab4 |
A |
T |
7: 107,655,170 (GRCm39) |
H327L |
probably benign |
Het |
| Or10ag59 |
T |
A |
2: 87,405,911 (GRCm39) |
V161D |
possibly damaging |
Het |
| Or2h1b |
C |
T |
17: 37,462,446 (GRCm39) |
C139Y |
probably damaging |
Het |
| Or2y1f |
A |
T |
11: 49,184,165 (GRCm39) |
I6F |
probably benign |
Het |
| Or52e15 |
G |
A |
7: 104,645,913 (GRCm39) |
A66V |
probably damaging |
Het |
| Or8k28 |
T |
C |
2: 86,286,363 (GRCm39) |
N84S |
possibly damaging |
Het |
| Pde4c |
A |
G |
8: 71,202,725 (GRCm39) |
N637S |
probably benign |
Het |
| Pds5b |
T |
A |
5: 150,702,740 (GRCm39) |
V824D |
possibly damaging |
Het |
| Pole2 |
A |
T |
12: 69,269,160 (GRCm39) |
|
probably benign |
Het |
| Ppig |
C |
T |
2: 69,566,320 (GRCm39) |
|
probably benign |
Het |
| Prep |
A |
G |
10: 44,968,772 (GRCm39) |
Y90C |
probably damaging |
Het |
| Proca1 |
A |
T |
11: 78,085,731 (GRCm39) |
R11S |
probably damaging |
Het |
| Prph |
T |
A |
15: 98,954,872 (GRCm39) |
W313R |
probably benign |
Het |
| Prune2 |
C |
T |
19: 17,100,444 (GRCm39) |
P1983S |
probably benign |
Het |
| Ptbp2 |
G |
A |
3: 119,517,847 (GRCm39) |
|
probably benign |
Het |
| Rsph6a |
C |
T |
7: 18,808,031 (GRCm39) |
P398L |
probably damaging |
Het |
| Sdk2 |
T |
C |
11: 113,720,793 (GRCm39) |
I1379V |
probably benign |
Het |
| Sf3b1 |
C |
T |
1: 55,058,430 (GRCm39) |
G53E |
probably damaging |
Het |
| Slc9a3 |
T |
C |
13: 74,305,903 (GRCm39) |
|
probably null |
Het |
| Smarcal1 |
A |
T |
1: 72,665,632 (GRCm39) |
H710L |
probably benign |
Het |
| Soat2 |
GAGAAG |
GAG |
15: 102,059,142 (GRCm39) |
|
probably benign |
Het |
| Sptan1 |
T |
C |
2: 29,881,045 (GRCm39) |
V438A |
probably damaging |
Het |
| Sstr4 |
T |
A |
2: 148,238,181 (GRCm39) |
V264D |
probably damaging |
Het |
| Susd2 |
A |
G |
10: 75,475,745 (GRCm39) |
L418P |
probably damaging |
Het |
| Szt2 |
G |
A |
4: 118,233,544 (GRCm39) |
|
probably benign |
Het |
| Tbc1d4 |
T |
C |
14: 101,695,499 (GRCm39) |
|
probably null |
Het |
| Tesk1 |
A |
G |
4: 43,446,000 (GRCm39) |
E311G |
probably damaging |
Het |
| Tmed5 |
A |
T |
5: 108,273,882 (GRCm39) |
V119E |
probably damaging |
Het |
| Tmem260 |
T |
C |
14: 48,724,324 (GRCm39) |
S201P |
possibly damaging |
Het |
| Tnxb |
A |
G |
17: 34,890,707 (GRCm39) |
Y350C |
probably damaging |
Het |
| Tpte |
T |
C |
8: 22,825,624 (GRCm39) |
|
probably benign |
Het |
| Trim37 |
A |
T |
11: 87,037,794 (GRCm39) |
D161V |
probably damaging |
Het |
| Trrap |
C |
A |
5: 144,751,366 (GRCm39) |
Q1640K |
probably damaging |
Het |
| Tspoap1 |
T |
C |
11: 87,667,172 (GRCm39) |
|
probably benign |
Het |
| Ttk |
T |
A |
9: 83,729,313 (GRCm39) |
|
probably benign |
Het |
| Vmn1r172 |
A |
G |
7: 23,359,957 (GRCm39) |
S281G |
probably benign |
Het |
| Vmn1r177 |
A |
G |
7: 23,565,022 (GRCm39) |
S285P |
probably damaging |
Het |
| Vmn1r231 |
C |
T |
17: 21,110,661 (GRCm39) |
V85I |
probably damaging |
Het |
| Vmn2r100 |
C |
A |
17: 19,742,382 (GRCm39) |
P252Q |
possibly damaging |
Het |
| Vmn2r118 |
T |
C |
17: 55,915,643 (GRCm39) |
I436V |
probably benign |
Het |
| Vmn2r12 |
T |
C |
5: 109,240,765 (GRCm39) |
K116R |
probably benign |
Het |
| Vmn2r28 |
T |
A |
7: 5,491,513 (GRCm39) |
I245L |
probably benign |
Het |
| Wdr26 |
A |
T |
1: 181,008,216 (GRCm39) |
|
probably benign |
Het |
| Xrcc3 |
A |
T |
12: 111,776,391 (GRCm39) |
H67Q |
probably benign |
Het |
| Zbbx |
A |
T |
3: 74,985,802 (GRCm39) |
S417T |
possibly damaging |
Het |
| Zc3h13 |
A |
G |
14: 75,560,922 (GRCm39) |
D504G |
unknown |
Het |
| Zfp1005 |
G |
A |
2: 150,109,973 (GRCm39) |
G221D |
probably damaging |
Het |
| Zfp217 |
C |
T |
2: 169,957,382 (GRCm39) |
A539T |
probably benign |
Het |
| Zyg11b |
A |
T |
4: 108,112,505 (GRCm39) |
F388I |
probably damaging |
Het |
|
| Other mutations in Synj1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01143:Synj1
|
APN |
16 |
90,748,864 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01468:Synj1
|
APN |
16 |
90,807,060 (GRCm39) |
splice site |
probably benign |
|
|
IGL02209:Synj1
|
APN |
16 |
90,784,307 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL02452:Synj1
|
APN |
16 |
90,758,253 (GRCm39) |
splice site |
probably benign |
|
|
IGL02619:Synj1
|
APN |
16 |
90,770,933 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02650:Synj1
|
APN |
16 |
90,773,584 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL02708:Synj1
|
APN |
16 |
90,788,350 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02863:Synj1
|
APN |
16 |
90,758,322 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL03131:Synj1
|
APN |
16 |
90,785,056 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03295:Synj1
|
APN |
16 |
90,735,318 (GRCm39) |
missense |
probably benign |
0.14 |
|
IGL03356:Synj1
|
APN |
16 |
90,784,280 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT1430001:Synj1
|
UTSW |
16 |
90,761,396 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0179:Synj1
|
UTSW |
16 |
90,761,519 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R0426:Synj1
|
UTSW |
16 |
90,764,242 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0486:Synj1
|
UTSW |
16 |
90,735,151 (GRCm39) |
utr 3 prime |
probably benign |
|
|
R0515:Synj1
|
UTSW |
16 |
90,790,910 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R0535:Synj1
|
UTSW |
16 |
90,744,975 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R0697:Synj1
|
UTSW |
16 |
90,757,503 (GRCm39) |
missense |
probably benign |
0.44 |
|
R0698:Synj1
|
UTSW |
16 |
90,757,503 (GRCm39) |
missense |
probably benign |
0.44 |
|
R0945:Synj1
|
UTSW |
16 |
90,757,333 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R1327:Synj1
|
UTSW |
16 |
90,743,743 (GRCm39) |
missense |
probably benign |
0.05 |
|
R1562:Synj1
|
UTSW |
16 |
90,784,290 (GRCm39) |
missense |
probably benign |
0.09 |
|
R1732:Synj1
|
UTSW |
16 |
90,761,118 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1752:Synj1
|
UTSW |
16 |
90,735,361 (GRCm39) |
missense |
probably benign |
|
|
R1785:Synj1
|
UTSW |
16 |
90,761,405 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1786:Synj1
|
UTSW |
16 |
90,761,405 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2011:Synj1
|
UTSW |
16 |
90,735,584 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2012:Synj1
|
UTSW |
16 |
90,735,584 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2065:Synj1
|
UTSW |
16 |
90,788,537 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R2862:Synj1
|
UTSW |
16 |
90,766,217 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3026:Synj1
|
UTSW |
16 |
90,775,622 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3151:Synj1
|
UTSW |
16 |
90,757,514 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R3946:Synj1
|
UTSW |
16 |
90,806,984 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R3971:Synj1
|
UTSW |
16 |
90,788,491 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4472:Synj1
|
UTSW |
16 |
90,766,069 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4547:Synj1
|
UTSW |
16 |
90,785,170 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R4647:Synj1
|
UTSW |
16 |
90,770,877 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4739:Synj1
|
UTSW |
16 |
90,752,307 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5027:Synj1
|
UTSW |
16 |
90,737,407 (GRCm39) |
splice site |
probably null |
|
|
R5428:Synj1
|
UTSW |
16 |
90,788,406 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5586:Synj1
|
UTSW |
16 |
90,806,865 (GRCm39) |
intron |
probably benign |
|
|
R5769:Synj1
|
UTSW |
16 |
90,735,141 (GRCm39) |
utr 3 prime |
probably benign |
|
|
R6005:Synj1
|
UTSW |
16 |
90,766,174 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6119:Synj1
|
UTSW |
16 |
90,735,877 (GRCm39) |
missense |
probably benign |
0.30 |
|
R6313:Synj1
|
UTSW |
16 |
90,743,703 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6324:Synj1
|
UTSW |
16 |
90,735,518 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6549:Synj1
|
UTSW |
16 |
90,735,565 (GRCm39) |
missense |
probably benign |
|
|
R6696:Synj1
|
UTSW |
16 |
90,757,340 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6698:Synj1
|
UTSW |
16 |
90,757,340 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6861:Synj1
|
UTSW |
16 |
90,760,768 (GRCm39) |
nonsense |
probably null |
|
|
R7008:Synj1
|
UTSW |
16 |
90,790,833 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7153:Synj1
|
UTSW |
16 |
90,744,978 (GRCm39) |
missense |
probably benign |
0.04 |
|
R7393:Synj1
|
UTSW |
16 |
90,748,887 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7510:Synj1
|
UTSW |
16 |
90,735,565 (GRCm39) |
missense |
probably benign |
|
|
R7560:Synj1
|
UTSW |
16 |
90,737,371 (GRCm39) |
missense |
probably benign |
|
|
R7724:Synj1
|
UTSW |
16 |
90,758,387 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7913:Synj1
|
UTSW |
16 |
90,788,315 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R8326:Synj1
|
UTSW |
16 |
90,785,084 (GRCm39) |
missense |
probably benign |
0.12 |
|
R8707:Synj1
|
UTSW |
16 |
90,752,319 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8711:Synj1
|
UTSW |
16 |
90,806,971 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8767:Synj1
|
UTSW |
16 |
90,758,406 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8911:Synj1
|
UTSW |
16 |
90,775,622 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9052:Synj1
|
UTSW |
16 |
90,735,728 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9124:Synj1
|
UTSW |
16 |
90,735,513 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9307:Synj1
|
UTSW |
16 |
90,785,095 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9408:Synj1
|
UTSW |
16 |
90,741,740 (GRCm39) |
missense |
probably benign |
0.27 |
|
R9458:Synj1
|
UTSW |
16 |
90,766,200 (GRCm39) |
missense |
probably benign |
0.05 |
|
R9567:Synj1
|
UTSW |
16 |
90,790,912 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R9651:Synj1
|
UTSW |
16 |
90,757,343 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R9651:Synj1
|
UTSW |
16 |
90,735,412 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9707:Synj1
|
UTSW |
16 |
90,758,300 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R9730:Synj1
|
UTSW |
16 |
90,757,552 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9732:Synj1
|
UTSW |
16 |
90,761,414 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Synj1
|
UTSW |
16 |
90,784,228 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- AACGCTCGCACCTTTACTCCAG -3'
(R):5'- TCCAGGTCCAGAGGAAAGCAAGTC -3'
Sequencing Primer
(F):5'- TCATCATCAAATGAAGCTGGCG -3'
(R):5'- CACAGGAGAGTATGGGCAGTTC -3'
|
| Posted On |
2013-04-24 |
Incidental Mutation