Mutagenetix > Incidental Mutation

Incidental Mutation 'R0396:Tnxb'

32086

Institutional Source

Beutler Lab

Gene Symbol

Tnxb

Ensembl Gene

ENSMUSG00000033327

Gene Name

tenascin XB

Synonyms

Tnx, TN-MHC

MMRRC Submission

038602-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R0396 (G1)

Quality Score

215

Status

Validated

Chromosome

Chromosomal Location

34670535-34719815 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 34671733 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Cysteine at position 350 (Y350C)

Ref Sequence

ENSEMBL: ENSMUSP00000084661 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000087399] [ENSMUST00000168533]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000087399
AA Change: Y350C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000084661
Gene: ENSMUSG00000033327
AA Change: Y350C

Domain	Start	End	E-Value	Type
signal peptide	1	21	N/A	INTRINSIC
low complexity region	33	44	N/A	INTRINSIC
low complexity region	69	89	N/A	INTRINSIC
low complexity region	92	103	N/A	INTRINSIC
EGF	173	201	1.59e1	SMART
EGF	204	232	7.41e0	SMART
EGF	235	263	2.64e1	SMART
EGF	266	294	2.64e1	SMART
EGF	297	325	9.13e0	SMART
EGF	328	356	2.07e1	SMART
EGF_like	359	387	3.16e1	SMART
EGF_like	390	418	4.64e1	SMART
EGF_like	421	449	3.29e1	SMART
EGF_like	452	480	7.09e1	SMART
EGF	483	511	1.15e1	SMART
EGF	514	542	1.91e1	SMART
EGF_like	545	573	4.11e1	SMART
EGF	576	604	7.95e0	SMART
EGF	607	635	1.23e1	SMART
EGF_like	638	666	4.93e1	SMART
EGF_like	674	702	5.24e1	SMART
EGF	705	733	2.29e1	SMART
FN3	736	816	4.12e-3	SMART
FN3	827	904	1.21e-9	SMART
FN3	1047	1126	3.97e-5	SMART
FN3	1142	1223	3.62e-8	SMART
low complexity region	1230	1241	N/A	INTRINSIC
FN3	1242	1320	2.31e-6	SMART
FN3	1351	1431	8.77e-7	SMART
FN3	1460	1539	3.01e-5	SMART
FN3	1556	1636	2.76e-4	SMART
FN3	1657	1736	5.78e-7	SMART
FN3	1752	1832	4.7e-7	SMART
FN3	1851	1929	1.95e-4	SMART
FN3	1955	2034	4.56e-5	SMART
FN3	2066	2145	2.23e-8	SMART
FN3	2164	2244	7.75e-8	SMART
FN3	2279	2358	8.5e-5	SMART
FN3	2387	2467	2.94e-8	SMART
FN3	2501	2580	1.7e-4	SMART
low complexity region	2588	2598	N/A	INTRINSIC
FN3	2607	2687	6.75e-8	SMART
FN3	2716	2795	7.4e-5	SMART
FN3	2822	2902	1.35e-7	SMART
FN3	2931	3010	5.61e-5	SMART
FN3	3026	3106	6.01e-5	SMART
FN3	3120	3199	6.45e-5	SMART
FN3	3214	3293	9.54e-8	SMART
FN3	3316	3396	2.81e-5	SMART
FN3	3416	3502	1.98e-5	SMART
FN3	3518	3596	5.65e-10	SMART
FN3	3607	3682	7.63e-7	SMART
FN3	3695	3770	6.54e-6	SMART
FBG	3787	3997	8.88e-125	SMART

Predicted Effect

unknown
Transcript: ENSMUST00000168533
AA Change: Y350C

SMART Domains

Protein: ENSMUSP00000127487
Gene: ENSMUSG00000033327
AA Change: Y350C

Domain	Start	End	E-Value	Type
signal peptide	1	21	N/A	INTRINSIC
low complexity region	33	44	N/A	INTRINSIC
low complexity region	69	89	N/A	INTRINSIC
low complexity region	92	103	N/A	INTRINSIC
EGF	173	201	1.59e1	SMART
EGF	204	232	7.41e0	SMART
EGF	235	263	2.64e1	SMART
EGF	266	294	2.64e1	SMART
EGF	297	325	9.13e0	SMART
EGF	328	356	2.07e1	SMART
EGF_like	359	387	3.16e1	SMART
EGF_like	390	418	4.64e1	SMART
EGF_like	421	449	3.29e1	SMART
EGF_like	452	480	7.09e1	SMART
EGF	483	511	1.15e1	SMART
EGF	514	542	1.91e1	SMART
EGF_like	545	573	4.11e1	SMART
EGF	576	604	7.95e0	SMART
EGF	607	635	1.23e1	SMART
EGF_like	638	666	4.93e1	SMART
EGF_like	674	702	5.24e1	SMART
EGF	705	733	2.29e1	SMART
FN3	736	816	4.12e-3	SMART
FN3	827	904	1.21e-9	SMART
FN3	924	1003	3.97e-5	SMART
FN3	1019	1100	3.62e-8	SMART
low complexity region	1107	1118	N/A	INTRINSIC
FN3	1119	1197	2.31e-6	SMART
FN3	1228	1308	8.77e-7	SMART
FN3	1337	1416	3.01e-5	SMART
FN3	1433	1513	2.76e-4	SMART
FN3	1534	1613	5.78e-7	SMART
FN3	1629	1709	4.7e-7	SMART
FN3	1728	1806	1.95e-4	SMART
FN3	1832	1911	4.56e-5	SMART
FN3	1943	2022	2.23e-8	SMART
FN3	2051	2130	5.61e-5	SMART
FN3	2146	2226	6.01e-5	SMART
FN3	2240	2319	6.45e-5	SMART
FN3	2334	2413	9.54e-8	SMART
FN3	2436	2516	2.81e-5	SMART
FN3	2536	2622	1.98e-5	SMART
FN3	2638	2716	5.65e-10	SMART
FN3	2727	2802	7.63e-7	SMART
FN3	2815	2890	6.54e-6	SMART
FBG	2907	3117	8.88e-125	SMART

Meta Mutation Damage Score

0.8427

Coding Region Coverage

1x: 99.0%
3x: 98.0%
10x: 95.5%
20x: 89.8%

Validation Efficiency

92% (96/104)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the tenascin family of extracellular matrix glycoproteins. The tenascins have anti-adhesive effects, as opposed to fibronectin which is adhesive. This protein is thought to function in matrix maturation during wound healing, and its deficiency has been associated with the connective tissue disorder Ehlers-Danlos syndrome. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. It is one of four genes in this cluster which have been duplicated. The duplicated copy of this gene is incomplete and is a pseudogene which is transcribed but does not encode a protein. The structure of this gene is unusual in that it overlaps the CREBL1 and CYP21A2 genes at its 5' and 3' ends, respectively. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous null mice have stretchy skin, similar to patients with human Ehlers-Danlos syndrome. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 101 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2610507B11Rik	T	C	11: 78,268,377 (GRCm38)	V467A	possibly damaging	Het
4933405L10Rik	G	A	8: 105,709,780 (GRCm38)	V194I	probably benign	Het
Acsm1	A	T	7: 119,636,455 (GRCm38)	I133F	probably damaging	Het
Adamts9	T	A	6: 92,798,005 (GRCm38)	T1676S	probably benign	Het
Adcy4	T	C	14: 55,772,288 (GRCm38)	D769G	probably benign	Het
Aif1	T	C	17: 35,171,109 (GRCm38)	*148W	probably null	Het
Akna	C	T	4: 63,392,126 (GRCm38)		probably benign	Het
Arhgap32	G	A	9: 32,245,255 (GRCm38)		probably null	Het
Atpaf1	G	A	4: 115,785,252 (GRCm38)	E92K	possibly damaging	Het
C1s1	T	C	6: 124,533,354 (GRCm38)	E378G	probably benign	Het
Caprin1	T	A	2: 103,769,569 (GRCm38)	Q108L	probably damaging	Het
Car13	A	T	3: 14,656,239 (GRCm38)	H154L	probably benign	Het
Cdon	C	A	9: 35,470,130 (GRCm38)	N605K	probably damaging	Het
Ceacam10	G	A	7: 24,781,014 (GRCm38)	G70E	probably damaging	Het
Cfap221	G	A	1: 119,954,200 (GRCm38)	T286M	probably benign	Het
Cfap61	T	C	2: 145,949,944 (GRCm38)	F107S	possibly damaging	Het
Coil	C	A	11: 88,981,623 (GRCm38)	T270N	probably benign	Het
Crocc2	T	G	1: 93,224,214 (GRCm38)		probably benign	Het
Crot	T	C	5: 8,969,959 (GRCm38)	E461G	probably damaging	Het
D130052B06Rik	G	T	11: 33,623,391 (GRCm38)	R41L	unknown	Het
D630045J12Rik	T	C	6: 38,196,736 (GRCm38)	S166G	possibly damaging	Het
Dennd4a	T	G	9: 64,862,391 (GRCm38)	V460G	probably damaging	Het
Depdc7	A	T	2: 104,727,323 (GRCm38)		probably benign	Het
Dgkb	G	A	12: 38,190,135 (GRCm38)		probably null	Het
Dhx57	T	G	17: 80,274,797 (GRCm38)	S407R	probably benign	Het
Dnase2a	G	T	8: 84,909,763 (GRCm38)		probably benign	Het
Dqx1	T	G	6: 83,059,005 (GRCm38)	M106R	probably benign	Het
Eno1b	T	C	18: 48,047,739 (GRCm38)	I328T	probably benign	Het
Ephx2	T	G	14: 66,108,063 (GRCm38)	I151L	probably benign	Het
Gdf3	C	T	6: 122,607,135 (GRCm38)	G91D	probably damaging	Het
Gm14124	G	A	2: 150,268,053 (GRCm38)	G221D	probably damaging	Het
Gpc5	T	A	14: 115,428,208 (GRCm38)	N481K	possibly damaging	Het
Gsdme	T	A	6: 50,221,107 (GRCm38)	H291L	probably benign	Het
H2-Bl	A	G	17: 36,083,722 (GRCm38)	I103T	possibly damaging	Het
Hif3a	G	A	7: 17,052,021 (GRCm38)		probably benign	Het
Hmox2	A	T	16: 4,765,763 (GRCm38)	I232L	probably benign	Het
Itgb2	A	G	10: 77,561,189 (GRCm38)	Y686C	probably damaging	Het
Jmjd1c	A	G	10: 67,219,523 (GRCm38)	T528A	possibly damaging	Het
Kdr	T	C	5: 75,960,728 (GRCm38)	I541V	possibly damaging	Het
Khdrbs2	C	A	1: 32,519,973 (GRCm38)	V343L	probably damaging	Het
Kif16b	C	T	2: 142,853,659 (GRCm38)	R175H	probably damaging	Het
Klri2	T	G	6: 129,740,288 (GRCm38)	E44A	possibly damaging	Het
Kmt2b	G	T	7: 30,576,755 (GRCm38)	T1773K	probably damaging	Het
Lair1	A	G	7: 4,010,786 (GRCm38)	L154P	probably damaging	Het
Larp1b	G	A	3: 40,970,561 (GRCm38)	V158M	probably damaging	Het
Lgi3	T	A	14: 70,534,840 (GRCm38)	I275N	probably damaging	Het
Lrba	A	G	3: 86,295,179 (GRCm38)	N246D	probably damaging	Het
Lrrc45	T	A	11: 120,714,907 (GRCm38)		probably benign	Het
Mdh2	G	T	5: 135,789,679 (GRCm38)	V263L	probably benign	Het
Myom1	T	A	17: 71,034,693 (GRCm38)	V149E	probably damaging	Het
Nanos1	A	T	19: 60,757,041 (GRCm38)	D259V	probably damaging	Het
Nedd4l	T	A	18: 65,161,654 (GRCm38)		probably benign	Het
Npas3	A	G	12: 53,831,745 (GRCm38)	Y150C	probably damaging	Het
Olfr1066	T	C	2: 86,456,019 (GRCm38)	N84S	possibly damaging	Het
Olfr1129	T	A	2: 87,575,567 (GRCm38)	V161D	possibly damaging	Het
Olfr1392	A	T	11: 49,293,338 (GRCm38)	I6F	probably benign	Het
Olfr479	A	T	7: 108,055,963 (GRCm38)	H327L	probably benign	Het
Olfr672	G	A	7: 104,996,706 (GRCm38)	A66V	probably damaging	Het
Olfr93	C	T	17: 37,151,555 (GRCm38)	C139Y	probably damaging	Het
Pde4c	A	G	8: 70,750,076 (GRCm38)	N637S	probably benign	Het
Pds5b	T	A	5: 150,779,275 (GRCm38)	V824D	possibly damaging	Het
Pole2	A	T	12: 69,222,386 (GRCm38)		probably benign	Het
Ppig	C	T	2: 69,735,976 (GRCm38)		probably benign	Het
Prep	A	G	10: 45,092,676 (GRCm38)	Y90C	probably damaging	Het
Proca1	A	T	11: 78,194,905 (GRCm38)	R11S	probably damaging	Het
Prph	T	A	15: 99,056,991 (GRCm38)	W313R	probably benign	Het
Prune2	C	T	19: 17,123,080 (GRCm38)	P1983S	probably benign	Het
Ptbp2	G	A	3: 119,724,198 (GRCm38)		probably benign	Het
Rsph6a	C	T	7: 19,074,106 (GRCm38)	P398L	probably damaging	Het
Sdk2	T	C	11: 113,829,967 (GRCm38)	I1379V	probably benign	Het
Sf3b1	C	T	1: 55,019,271 (GRCm38)	G53E	probably damaging	Het
Slc9a3	T	C	13: 74,157,784 (GRCm38)		probably null	Het
Smarcal1	A	T	1: 72,626,473 (GRCm38)	H710L	probably benign	Het
Soat2	GAGAAG	GAG	15: 102,150,707 (GRCm38)		probably benign	Het
Sptan1	T	C	2: 29,991,033 (GRCm38)	V438A	probably damaging	Het
Sstr4	T	A	2: 148,396,261 (GRCm38)	V264D	probably damaging	Het
Susd2	A	G	10: 75,639,911 (GRCm38)	L418P	probably damaging	Het
Synj1	A	G	16: 90,938,640 (GRCm38)	V1475A	probably benign	Het
Szt2	G	A	4: 118,376,347 (GRCm38)		probably benign	Het
Tbc1d4	T	C	14: 101,458,063 (GRCm38)		probably null	Het
Tesk1	A	G	4: 43,446,000 (GRCm38)	E311G	probably damaging	Het
Tmed5	A	T	5: 108,126,016 (GRCm38)	V119E	probably damaging	Het
Tmem260	T	C	14: 48,486,867 (GRCm38)	S201P	possibly damaging	Het
Tpte	T	C	8: 22,335,608 (GRCm38)		probably benign	Het
Trim37	A	T	11: 87,146,968 (GRCm38)	D161V	probably damaging	Het
Trrap	C	A	5: 144,814,556 (GRCm38)	Q1640K	probably damaging	Het
Tspoap1	T	C	11: 87,776,346 (GRCm38)		probably benign	Het
Ttk	T	A	9: 83,847,260 (GRCm38)		probably benign	Het
Vmn1r172	A	G	7: 23,660,532 (GRCm38)	S281G	probably benign	Het
Vmn1r177	A	G	7: 23,865,597 (GRCm38)	S285P	probably damaging	Het
Vmn1r231	C	T	17: 20,890,399 (GRCm38)	V85I	probably damaging	Het
Vmn2r100	C	A	17: 19,522,120 (GRCm38)	P252Q	possibly damaging	Het
Vmn2r118	T	C	17: 55,608,643 (GRCm38)	I436V	probably benign	Het
Vmn2r12	T	C	5: 109,092,899 (GRCm38)	K116R	probably benign	Het
Vmn2r28	T	A	7: 5,488,514 (GRCm38)	I245L	probably benign	Het
Wdr26	A	T	1: 181,180,651 (GRCm38)		probably benign	Het
Xrcc3	A	T	12: 111,809,957 (GRCm38)	H67Q	probably benign	Het
Zbbx	A	T	3: 75,078,495 (GRCm38)	S417T	possibly damaging	Het
Zc3h13	A	G	14: 75,323,482 (GRCm38)	D504G	unknown	Het
Zfp217	C	T	2: 170,115,462 (GRCm38)	A539T	probably benign	Het
Zyg11b	A	T	4: 108,255,308 (GRCm38)	F388I	probably damaging	Het

Other mutations in Tnxb

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00094:Tnxb	APN	17	34,685,629 (GRCm38)	missense	probably damaging	1.00
IGL00424:Tnxb	APN	17	34,714,692 (GRCm38)	missense	probably damaging	1.00
IGL00486:Tnxb	APN	17	34,692,382 (GRCm38)	missense	probably damaging	1.00
IGL00952:Tnxb	APN	17	34,713,128 (GRCm38)	missense	probably damaging	1.00
IGL00974:Tnxb	APN	17	34,718,733 (GRCm38)	critical splice donor site	probably null
IGL01017:Tnxb	APN	17	34,693,808 (GRCm38)	missense	probably damaging	0.98
IGL01082:Tnxb	APN	17	34,714,610 (GRCm38)	missense	probably damaging	0.97
IGL01397:Tnxb	APN	17	34,714,673 (GRCm38)	missense	probably damaging	0.99
IGL01473:Tnxb	APN	17	34,685,701 (GRCm38)	missense	probably damaging	0.99
IGL01642:Tnxb	APN	17	34,718,514 (GRCm38)	missense	probably damaging	1.00
IGL01774:Tnxb	APN	17	34,688,839 (GRCm38)	missense	probably damaging	1.00
IGL01971:Tnxb	APN	17	34,672,297 (GRCm38)	missense	probably damaging	1.00
IGL02016:Tnxb	APN	17	34,672,275 (GRCm38)	missense	probably damaging	0.98
IGL02160:Tnxb	APN	17	34,714,745 (GRCm38)	missense	probably benign	0.01
IGL02473:Tnxb	APN	17	34,717,762 (GRCm38)	missense	probably damaging	1.00
IGL02666:Tnxb	APN	17	34,684,939 (GRCm38)	missense	probably benign	0.20
IGL02831:Tnxb	APN	17	34,703,571 (GRCm38)	missense	possibly damaging	0.93
IGL02838:Tnxb	APN	17	34,689,632 (GRCm38)	missense	possibly damaging	0.74
IGL02965:Tnxb	APN	17	34,709,654 (GRCm38)	missense	possibly damaging	0.93
IGL03155:Tnxb	APN	17	34,713,595 (GRCm38)	missense	probably damaging	1.00
IGL03194:Tnxb	APN	17	34,695,947 (GRCm38)	nonsense	probably null
IGL03215:Tnxb	APN	17	34,692,525 (GRCm38)	missense	possibly damaging	0.66
IGL03256:Tnxb	APN	17	34,688,720 (GRCm38)	missense	probably damaging	1.00
BB008:Tnxb	UTSW	17	34,688,698 (GRCm38)	missense	probably damaging	1.00
BB018:Tnxb	UTSW	17	34,688,698 (GRCm38)	missense	probably damaging	1.00
E0370:Tnxb	UTSW	17	34,678,943 (GRCm38)	missense	probably damaging	1.00
R0006:Tnxb	UTSW	17	34,682,292 (GRCm38)	missense	probably benign	0.07
R0049:Tnxb	UTSW	17	34,709,568 (GRCm38)	missense	possibly damaging	0.93
R0050:Tnxb	UTSW	17	34,673,325 (GRCm38)	missense	probably damaging	1.00
R0233:Tnxb	UTSW	17	34,699,033 (GRCm38)	missense	probably benign	0.32
R0233:Tnxb	UTSW	17	34,699,033 (GRCm38)	missense	probably benign	0.32
R0311:Tnxb	UTSW	17	34,716,984 (GRCm38)	missense	probably damaging	0.97
R0326:Tnxb	UTSW	17	34,698,179 (GRCm38)	missense	probably benign	0.32
R0387:Tnxb	UTSW	17	34,683,574 (GRCm38)	missense	probably benign	0.30
R0511:Tnxb	UTSW	17	34,718,245 (GRCm38)	missense	probably damaging	0.96
R0540:Tnxb	UTSW	17	34,671,918 (GRCm38)	missense	probably damaging	1.00
R0563:Tnxb	UTSW	17	34,716,947 (GRCm38)	missense	probably benign	0.05
R0575:Tnxb	UTSW	17	34,717,206 (GRCm38)	missense	possibly damaging	0.91
R0586:Tnxb	UTSW	17	34,672,144 (GRCm38)	missense	probably damaging	1.00
R0607:Tnxb	UTSW	17	34,671,918 (GRCm38)	missense	probably damaging	1.00
R0622:Tnxb	UTSW	17	34,718,729 (GRCm38)	missense	probably damaging	1.00
R0624:Tnxb	UTSW	17	34,683,548 (GRCm38)	missense	probably damaging	1.00
R0709:Tnxb	UTSW	17	34,689,354 (GRCm38)	missense	probably damaging	1.00
R0898:Tnxb	UTSW	17	34,670,745 (GRCm38)	missense	probably damaging	1.00
R0970:Tnxb	UTSW	17	34,698,943 (GRCm38)	missense	possibly damaging	0.85
R0972:Tnxb	UTSW	17	34,685,143 (GRCm38)	missense	probably damaging	1.00
R1118:Tnxb	UTSW	17	34,685,043 (GRCm38)	missense	probably damaging	1.00
R1119:Tnxb	UTSW	17	34,685,043 (GRCm38)	missense	probably damaging	1.00
R1226:Tnxb	UTSW	17	34,688,929 (GRCm38)	missense	probably damaging	1.00
R1296:Tnxb	UTSW	17	34,671,577 (GRCm38)	missense	probably damaging	1.00
R1297:Tnxb	UTSW	17	34,710,166 (GRCm38)	missense	probably damaging	0.96
R1349:Tnxb	UTSW	17	34,710,293 (GRCm38)	missense	possibly damaging	0.67
R1356:Tnxb	UTSW	17	34,695,472 (GRCm38)	missense	possibly damaging	0.53
R1372:Tnxb	UTSW	17	34,710,293 (GRCm38)	missense	possibly damaging	0.67
R1521:Tnxb	UTSW	17	34,711,503 (GRCm38)	missense	probably damaging	1.00
R1522:Tnxb	UTSW	17	34,718,638 (GRCm38)	missense	probably damaging	1.00
R1532:Tnxb	UTSW	17	34,710,830 (GRCm38)	missense	probably damaging	1.00
R1735:Tnxb	UTSW	17	34,717,970 (GRCm38)	missense	probably damaging	1.00
R1778:Tnxb	UTSW	17	34,683,574 (GRCm38)	missense	probably benign	0.30
R1802:Tnxb	UTSW	17	34,703,889 (GRCm38)	missense	probably damaging	0.98
R1824:Tnxb	UTSW	17	34,692,333 (GRCm38)	nonsense	probably null
R1838:Tnxb	UTSW	17	34,678,910 (GRCm38)	missense	probably damaging	0.96
R1863:Tnxb	UTSW	17	34,670,874 (GRCm38)	missense	probably damaging	1.00
R1865:Tnxb	UTSW	17	34,703,457 (GRCm38)	nonsense	probably null
R1867:Tnxb	UTSW	17	34,671,847 (GRCm38)	missense	probably damaging	1.00
R1883:Tnxb	UTSW	17	34,689,565 (GRCm38)	missense	probably benign	0.01
R1884:Tnxb	UTSW	17	34,689,565 (GRCm38)	missense	probably benign	0.01
R1889:Tnxb	UTSW	17	34,695,825 (GRCm38)	missense	probably damaging	0.97
R1969:Tnxb	UTSW	17	34,679,081 (GRCm38)	missense	probably benign	0.20
R1989:Tnxb	UTSW	17	34,693,885 (GRCm38)	missense	probably damaging	1.00
R1989:Tnxb	UTSW	17	34,683,377 (GRCm38)	missense	probably benign	0.08
R1991:Tnxb	UTSW	17	34,682,251 (GRCm38)	missense	probably damaging	1.00
R1991:Tnxb	UTSW	17	34,671,904 (GRCm38)	missense	probably damaging	1.00
R1992:Tnxb	UTSW	17	34,671,904 (GRCm38)	missense	probably damaging	1.00
R2001:Tnxb	UTSW	17	34,692,579 (GRCm38)	missense	possibly damaging	0.82
R2018:Tnxb	UTSW	17	34,671,750 (GRCm38)	missense	probably benign	0.04
R2030:Tnxb	UTSW	17	34,718,469 (GRCm38)	missense	probably damaging	1.00
R2037:Tnxb	UTSW	17	34,699,205 (GRCm38)	missense	probably damaging	1.00
R2103:Tnxb	UTSW	17	34,682,251 (GRCm38)	missense	probably damaging	1.00
R2116:Tnxb	UTSW	17	34,672,227 (GRCm38)	missense	probably damaging	1.00
R2206:Tnxb	UTSW	17	34,709,417 (GRCm38)	missense	possibly damaging	0.86
R2207:Tnxb	UTSW	17	34,709,417 (GRCm38)	missense	possibly damaging	0.86
R2215:Tnxb	UTSW	17	34,704,140 (GRCm38)	missense	possibly damaging	0.93
R2413:Tnxb	UTSW	17	34,718,278 (GRCm38)	missense	probably damaging	0.99
R2680:Tnxb	UTSW	17	34,703,620 (GRCm38)	missense	possibly damaging	0.51
R2910:Tnxb	UTSW	17	34,672,450 (GRCm38)	missense	probably damaging	1.00
R2984:Tnxb	UTSW	17	34,678,662 (GRCm38)	nonsense	probably null
R3120:Tnxb	UTSW	17	34,692,355 (GRCm38)	missense	possibly damaging	0.86
R3429:Tnxb	UTSW	17	34,703,587 (GRCm38)	missense	probably damaging	0.98
R3429:Tnxb	UTSW	17	34,672,631 (GRCm38)	nonsense	probably null
R3552:Tnxb	UTSW	17	34,718,721 (GRCm38)	missense	probably damaging	1.00
R3698:Tnxb	UTSW	17	34,690,433 (GRCm38)	critical splice donor site	probably null
R3720:Tnxb	UTSW	17	34,712,964 (GRCm38)	missense	possibly damaging	0.95
R3841:Tnxb	UTSW	17	34,698,923 (GRCm38)	missense	possibly damaging	0.72
R3848:Tnxb	UTSW	17	34,690,395 (GRCm38)	missense	possibly damaging	0.82
R3886:Tnxb	UTSW	17	34,718,911 (GRCm38)	missense	probably damaging	1.00
R4074:Tnxb	UTSW	17	34,671,871 (GRCm38)	missense	probably benign	0.22
R4159:Tnxb	UTSW	17	34,711,517 (GRCm38)	missense	probably damaging	0.99
R4160:Tnxb	UTSW	17	34,711,517 (GRCm38)	missense	probably damaging	0.99
R4161:Tnxb	UTSW	17	34,711,517 (GRCm38)	missense	probably damaging	0.99
R4181:Tnxb	UTSW	17	34,709,454 (GRCm38)	missense	possibly damaging	0.93
R4210:Tnxb	UTSW	17	34,710,977 (GRCm38)	missense	possibly damaging	0.84
R4275:Tnxb	UTSW	17	34,698,231 (GRCm38)	missense	probably damaging	0.98
R4329:Tnxb	UTSW	17	34,693,864 (GRCm38)	missense	probably damaging	1.00
R4394:Tnxb	UTSW	17	34,678,662 (GRCm38)	nonsense	probably null
R4395:Tnxb	UTSW	17	34,678,662 (GRCm38)	nonsense	probably null
R4397:Tnxb	UTSW	17	34,678,662 (GRCm38)	nonsense	probably null
R4540:Tnxb	UTSW	17	34,703,335 (GRCm38)	missense	possibly damaging	0.86
R4673:Tnxb	UTSW	17	34,672,540 (GRCm38)	missense	probably damaging	0.99
R4719:Tnxb	UTSW	17	34,689,420 (GRCm38)	missense	probably damaging	1.00
R4725:Tnxb	UTSW	17	34,699,067 (GRCm38)	missense	probably damaging	0.99
R4753:Tnxb	UTSW	17	34,695,935 (GRCm38)	missense	possibly damaging	0.71
R4777:Tnxb	UTSW	17	34,671,943 (GRCm38)	missense	probably damaging	1.00
R4837:Tnxb	UTSW	17	34,718,007 (GRCm38)	missense	probably damaging	0.98
R4898:Tnxb	UTSW	17	34,695,592 (GRCm38)	missense	possibly damaging	0.95
R4938:Tnxb	UTSW	17	34,713,632 (GRCm38)	missense	probably damaging	1.00
R5044:Tnxb	UTSW	17	34,717,483 (GRCm38)	missense	probably damaging	1.00
R5100:Tnxb	UTSW	17	34,710,928 (GRCm38)	missense	probably damaging	0.99
R5223:Tnxb	UTSW	17	34,704,078 (GRCm38)	missense	possibly damaging	0.51
R5269:Tnxb	UTSW	17	34,703,608 (GRCm38)	missense	possibly damaging	0.95
R5333:Tnxb	UTSW	17	34,690,231 (GRCm38)	missense	probably damaging	1.00
R5454:Tnxb	UTSW	17	34,709,625 (GRCm38)	missense	possibly damaging	0.71
R5470:Tnxb	UTSW	17	34,716,973 (GRCm38)	missense	probably null	1.00
R5475:Tnxb	UTSW	17	34,689,593 (GRCm38)	missense	probably damaging	1.00
R5574:Tnxb	UTSW	17	34,711,024 (GRCm38)	missense	probably benign
R5596:Tnxb	UTSW	17	34,688,804 (GRCm38)	missense	probably damaging	1.00
R5599:Tnxb	UTSW	17	34,690,205 (GRCm38)	missense	probably benign	0.22
R5599:Tnxb	UTSW	17	34,690,202 (GRCm38)	missense	probably damaging	1.00
R5615:Tnxb	UTSW	17	34,683,418 (GRCm38)	missense	probably damaging	1.00
R5620:Tnxb	UTSW	17	34,717,530 (GRCm38)	nonsense	probably null
R5625:Tnxb	UTSW	17	34,685,211 (GRCm38)	missense	probably benign	0.30
R5734:Tnxb	UTSW	17	34,698,910 (GRCm38)	missense	possibly damaging	0.53
R5896:Tnxb	UTSW	17	34,672,152 (GRCm38)	missense	probably damaging	1.00
R5961:Tnxb	UTSW	17	34,718,635 (GRCm38)	missense	probably damaging	1.00
R5974:Tnxb	UTSW	17	34,685,707 (GRCm38)	missense	probably damaging	1.00
R6091:Tnxb	UTSW	17	34,710,364 (GRCm38)	missense	probably damaging	0.98
R6134:Tnxb	UTSW	17	34,672,012 (GRCm38)	missense	probably damaging	0.96
R6325:Tnxb	UTSW	17	34,692,424 (GRCm38)	missense	probably damaging	1.00
R6358:Tnxb	UTSW	17	34,678,994 (GRCm38)	missense	probably damaging	0.98
R6362:Tnxb	UTSW	17	34,694,388 (GRCm38)	missense	probably damaging	1.00
R6432:Tnxb	UTSW	17	34,717,917 (GRCm38)	missense	probably damaging	1.00
R6461:Tnxb	UTSW	17	34,671,898 (GRCm38)	missense	probably damaging	1.00
R6467:Tnxb	UTSW	17	34,693,924 (GRCm38)	missense	probably damaging	1.00
R6476:Tnxb	UTSW	17	34,690,192 (GRCm38)	missense	probably damaging	0.98
R6477:Tnxb	UTSW	17	34,719,539 (GRCm38)	missense	probably damaging	1.00
R6631:Tnxb	UTSW	17	34,718,248 (GRCm38)	missense	probably damaging	1.00
R6774:Tnxb	UTSW	17	34,709,632 (GRCm38)	nonsense	probably null
R6787:Tnxb	UTSW	17	34,710,736 (GRCm38)	missense	probably benign	0.02
R6805:Tnxb	UTSW	17	34,698,153 (GRCm38)	missense	possibly damaging	0.93
R6860:Tnxb	UTSW	17	34,713,157 (GRCm38)	missense	probably damaging	0.99
R6883:Tnxb	UTSW	17	34,718,519 (GRCm38)	missense	probably damaging	1.00
R7049:Tnxb	UTSW	17	34,717,268 (GRCm38)	critical splice donor site	probably null
R7107:Tnxb	UTSW	17	34,671,340 (GRCm38)	missense	unknown
R7172:Tnxb	UTSW	17	34,696,020 (GRCm38)	missense	probably damaging	1.00
R7206:Tnxb	UTSW	17	34,704,101 (GRCm38)	missense	possibly damaging	0.71
R7219:Tnxb	UTSW	17	34,679,065 (GRCm38)	missense	probably benign	0.08
R7237:Tnxb	UTSW	17	34,682,196 (GRCm38)	missense	possibly damaging	0.82
R7257:Tnxb	UTSW	17	34,716,501 (GRCm38)	missense	probably benign	0.44
R7269:Tnxb	UTSW	17	34,695,454 (GRCm38)	missense	probably damaging	1.00
R7302:Tnxb	UTSW	17	34,678,901 (GRCm38)	missense	probably benign	0.41
R7372:Tnxb	UTSW	17	34,717,254 (GRCm38)	missense	possibly damaging	0.72
R7384:Tnxb	UTSW	17	34,718,518 (GRCm38)	missense	probably damaging	1.00
R7447:Tnxb	UTSW	17	34,718,470 (GRCm38)	missense	probably damaging	1.00
R7449:Tnxb	UTSW	17	34,703,361 (GRCm38)	missense	possibly damaging	0.93
R7480:Tnxb	UTSW	17	34,715,773 (GRCm38)	missense	probably damaging	0.96
R7506:Tnxb	UTSW	17	34,715,691 (GRCm38)	missense	possibly damaging	0.89
R7586:Tnxb	UTSW	17	34,716,408 (GRCm38)	missense	probably damaging	0.98
R7688:Tnxb	UTSW	17	34,671,906 (GRCm38)	missense	probably benign	0.23
R7690:Tnxb	UTSW	17	34,689,527 (GRCm38)	missense	probably damaging	1.00
R7690:Tnxb	UTSW	17	34,689,520 (GRCm38)	missense	probably benign	0.03
R7732:Tnxb	UTSW	17	34,694,280 (GRCm38)	missense	probably damaging	1.00
R7735:Tnxb	UTSW	17	34,671,424 (GRCm38)	missense	unknown
R7760:Tnxb	UTSW	17	34,712,937 (GRCm38)	missense	probably damaging	0.96
R7874:Tnxb	UTSW	17	34,711,443 (GRCm38)	missense	probably damaging	1.00
R7909:Tnxb	UTSW	17	34,692,454 (GRCm38)	missense	probably benign	0.02
R7922:Tnxb	UTSW	17	34,714,603 (GRCm38)	missense	probably damaging	1.00
R7931:Tnxb	UTSW	17	34,688,698 (GRCm38)	missense	probably damaging	1.00
R7949:Tnxb	UTSW	17	34,717,129 (GRCm38)	missense	probably damaging	1.00
R7953:Tnxb	UTSW	17	34,710,103 (GRCm38)	missense	probably benign	0.03
R7953:Tnxb	UTSW	17	34,709,535 (GRCm38)	missense	possibly damaging	0.86
R7977:Tnxb	UTSW	17	34,710,220 (GRCm38)	missense	possibly damaging	0.92
R7985:Tnxb	UTSW	17	34,717,010 (GRCm38)	critical splice donor site	probably null
R7987:Tnxb	UTSW	17	34,710,220 (GRCm38)	missense	possibly damaging	0.92
R8040:Tnxb	UTSW	17	34,716,558 (GRCm38)	missense	probably damaging	1.00
R8053:Tnxb	UTSW	17	34,704,179 (GRCm38)	missense	probably damaging	0.98
R8074:Tnxb	UTSW	17	34,703,981 (GRCm38)	missense	probably benign	0.32
R8089:Tnxb	UTSW	17	34,672,789 (GRCm38)	missense	unknown
R8169:Tnxb	UTSW	17	34,699,207 (GRCm38)	missense	possibly damaging	0.96
R8348:Tnxb	UTSW	17	34,710,128 (GRCm38)	missense	possibly damaging	0.92
R8352:Tnxb	UTSW	17	34,689,407 (GRCm38)	missense	probably damaging	1.00
R8362:Tnxb	UTSW	17	34,712,972 (GRCm38)	missense	probably damaging	0.99
R8452:Tnxb	UTSW	17	34,689,407 (GRCm38)	missense	probably damaging	1.00
R8527:Tnxb	UTSW	17	34,688,660 (GRCm38)	missense	probably damaging	1.00
R8754:Tnxb	UTSW	17	34,715,908 (GRCm38)	missense	probably damaging	1.00
R8813:Tnxb	UTSW	17	34,719,162 (GRCm38)	missense	probably damaging	1.00
R8936:Tnxb	UTSW	17	34,685,672 (GRCm38)	missense	probably damaging	1.00
R8986:Tnxb	UTSW	17	34,678,672 (GRCm38)	missense	possibly damaging	0.66
R9001:Tnxb	UTSW	17	34,703,436 (GRCm38)	missense	probably benign	0.32
R9215:Tnxb	UTSW	17	34,672,590 (GRCm38)	missense	unknown
R9226:Tnxb	UTSW	17	34,685,792 (GRCm38)	missense	probably damaging	1.00
R9276:Tnxb	UTSW	17	34,710,160 (GRCm38)	missense	possibly damaging	0.60
R9279:Tnxb	UTSW	17	34,679,114 (GRCm38)	missense	possibly damaging	0.46
R9363:Tnxb	UTSW	17	34,698,320 (GRCm38)	missense	possibly damaging	0.93
R9367:Tnxb	UTSW	17	34,713,019 (GRCm38)	missense	probably damaging	1.00
R9494:Tnxb	UTSW	17	34,685,822 (GRCm38)	missense	probably damaging	1.00
R9606:Tnxb	UTSW	17	34,695,604 (GRCm38)	missense	possibly damaging	0.82
R9650:Tnxb	UTSW	17	34,711,655 (GRCm38)	missense	probably damaging	0.99
R9677:Tnxb	UTSW	17	34,698,904 (GRCm38)	missense	possibly damaging	0.93
R9690:Tnxb	UTSW	17	34,717,197 (GRCm38)	missense	probably damaging	1.00
R9761:Tnxb	UTSW	17	34,685,013 (GRCm38)	missense	probably benign	0.32
X0004:Tnxb	UTSW	17	34,703,415 (GRCm38)	missense	possibly damaging	0.71
X0010:Tnxb	UTSW	17	34,671,934 (GRCm38)	missense	probably damaging	1.00
X0019:Tnxb	UTSW	17	34,694,189 (GRCm38)	missense	possibly damaging	0.51
X0063:Tnxb	UTSW	17	34,703,508 (GRCm38)	missense	probably damaging	0.98
X0064:Tnxb	UTSW	17	34,694,032 (GRCm38)	missense	probably damaging	1.00
Z1177:Tnxb	UTSW	17	34,718,726 (GRCm38)	missense	probably damaging	0.99
Z1177:Tnxb	UTSW	17	34,683,331 (GRCm38)	missense	probably damaging	1.00
Z1177:Tnxb	UTSW	17	34,671,766 (GRCm38)	missense	unknown

Predicted Primers

PCR Primer
(F):5'- AAGTCCTGTCCCGAAGACTGCAAC -3'
(R):5'- TGCTACAGTCCGCTCCAGTATACC -3'

Sequencing Primer
(F):5'- CTACTCTGGCGAGGACTGTG -3'
(R):5'- TGGCCCCTTTGGTTACAGT -3'

Posted On

2013-04-24