Incidental Mutation 'R4232:Zfp831'
ID 320897
Institutional Source Beutler Lab
Gene Symbol Zfp831
Ensembl Gene ENSMUSG00000050600
Gene Name zinc finger protein 831
Synonyms ENSMUSG00000050600, OTTMUSG00000017459
MMRRC Submission 041051-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R4232 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 174485327-174552625 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to C at 174547447 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tryptophan to Cysteine at position 1543 (W1543C)
Ref Sequence ENSEMBL: ENSMUSP00000060255 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000059452]
AlphaFold A2ADM8
Predicted Effect possibly damaging
Transcript: ENSMUST00000059452
AA Change: W1543C

PolyPhen 2 Score 0.956 (Sensitivity: 0.79; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000060255
Gene: ENSMUSG00000050600
AA Change: W1543C

DomainStartEndE-ValueType
low complexity region 120 135 N/A INTRINSIC
ZnF_C2H2 143 165 5.06e-2 SMART
ZnF_C2H2 171 195 7.78e-3 SMART
low complexity region 201 216 N/A INTRINSIC
low complexity region 237 248 N/A INTRINSIC
low complexity region 345 371 N/A INTRINSIC
low complexity region 383 392 N/A INTRINSIC
low complexity region 447 459 N/A INTRINSIC
low complexity region 645 657 N/A INTRINSIC
low complexity region 717 736 N/A INTRINSIC
low complexity region 856 870 N/A INTRINSIC
low complexity region 1520 1529 N/A INTRINSIC
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.1%
  • 20x: 94.9%
Validation Efficiency 92% (58/63)
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930567H17Rik C T X: 69,438,135 (GRCm39) A53T probably benign Het
Ajuba T C 14: 54,806,983 (GRCm39) R490G probably damaging Het
Akap6 T A 12: 53,186,454 (GRCm39) N1289K probably damaging Het
Arhgap21 A G 2: 20,891,948 (GRCm39) V161A probably damaging Het
Atg14 T C 14: 47,788,802 (GRCm39) K184E probably benign Het
Aven A G 2: 112,458,113 (GRCm39) D167G probably damaging Het
Celsr2 A G 3: 108,321,088 (GRCm39) F575L probably benign Het
Cflar A T 1: 58,780,152 (GRCm39) Q249L possibly damaging Het
Col7a1 G A 9: 108,801,881 (GRCm39) probably null Het
Dmxl2 T C 9: 54,327,193 (GRCm39) D944G possibly damaging Het
Dnah1 T C 14: 31,026,873 (GRCm39) N717S probably benign Het
Dnaja3 T A 16: 4,517,735 (GRCm39) N322K possibly damaging Het
Dnajb3 A G 1: 88,132,974 (GRCm39) S143P possibly damaging Het
Dtx3 A G 10: 127,029,058 (GRCm39) I60T possibly damaging Het
Dvl3 A G 16: 20,342,983 (GRCm39) probably benign Het
Fkbp7 A T 2: 76,493,661 (GRCm39) D177E possibly damaging Het
Galnt7 T C 8: 58,106,000 (GRCm39) I5V probably benign Het
Garin3 C A 11: 46,298,232 (GRCm39) T512K possibly damaging Het
Helz2 A T 2: 180,871,695 (GRCm39) L2639Q probably damaging Het
Hnrnpr T C 4: 136,066,500 (GRCm39) M394T probably benign Het
Ip6k2 G A 9: 108,682,847 (GRCm39) R319Q probably benign Het
Kif14 T A 1: 136,444,101 (GRCm39) C1364* probably null Het
Macf1 T C 4: 123,326,185 (GRCm39) E5104G probably damaging Het
Mrps30 T C 13: 118,523,376 (GRCm39) D132G probably damaging Het
Mrtfa T A 15: 80,907,796 (GRCm39) K29M probably damaging Het
Mtbp CATGA CATGAATGA 15: 55,484,073 (GRCm39) probably null Het
Nfkb1 A G 3: 135,309,531 (GRCm39) V521A probably damaging Het
Or2b7 T C 13: 21,739,631 (GRCm39) D187G probably damaging Het
Or7g32 G T 9: 19,389,022 (GRCm39) L175M probably damaging Het
P2rx6 T C 16: 17,388,631 (GRCm39) L335P probably damaging Het
Pcdhga5 A G 18: 37,829,001 (GRCm39) D483G possibly damaging Het
Pgpep1l T C 7: 67,886,827 (GRCm39) T161A probably benign Het
Prss40 A G 1: 34,599,873 (GRCm39) V38A probably benign Het
Ptk2 C A 15: 73,181,698 (GRCm39) R104L possibly damaging Het
Ralgapa1 C T 12: 55,687,429 (GRCm39) R2019Q probably damaging Het
Rin2 C T 2: 145,702,366 (GRCm39) T354I probably benign Het
Rtp4 A G 16: 23,431,833 (GRCm39) N122D possibly damaging Het
Samd8 A G 14: 21,830,213 (GRCm39) Y213C probably benign Het
Shcbp1 T A 8: 4,786,372 (GRCm39) T577S probably benign Het
Tiprl A G 1: 165,050,156 (GRCm39) V153A probably damaging Het
Tmprss7 A T 16: 45,476,936 (GRCm39) D775E probably damaging Het
Tnr T C 1: 159,713,785 (GRCm39) S738P possibly damaging Het
Tsc22d4 T C 5: 137,749,632 (GRCm39) probably null Het
Ttc21a A T 9: 119,771,684 (GRCm39) H161L probably benign Het
Ubqln3 T A 7: 103,791,010 (GRCm39) E360V probably benign Het
Ugt1a10 C A 1: 87,983,932 (GRCm39) D243E probably benign Het
Vmn2r19 G A 6: 123,306,871 (GRCm39) V460I probably benign Het
Vmn2r58 T A 7: 41,487,011 (GRCm39) Y628F possibly damaging Het
Wnk1 A T 6: 119,926,222 (GRCm39) S1588T possibly damaging Het
Wscd2 A G 5: 113,699,045 (GRCm39) D200G probably benign Het
Other mutations in Zfp831
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00089:Zfp831 APN 2 174,488,078 (GRCm39) missense possibly damaging 0.86
IGL00091:Zfp831 APN 2 174,487,451 (GRCm39) missense possibly damaging 0.73
IGL00764:Zfp831 APN 2 174,487,701 (GRCm39) missense possibly damaging 0.72
IGL01538:Zfp831 APN 2 174,486,399 (GRCm39) missense possibly damaging 0.72
IGL01700:Zfp831 APN 2 174,486,711 (GRCm39) missense possibly damaging 0.86
IGL01718:Zfp831 APN 2 174,485,631 (GRCm39) missense possibly damaging 0.86
IGL02221:Zfp831 APN 2 174,485,519 (GRCm39) missense probably benign 0.33
IGL02250:Zfp831 APN 2 174,489,994 (GRCm39) missense possibly damaging 0.53
IGL03209:Zfp831 APN 2 174,487,059 (GRCm39) missense probably benign 0.40
D4043:Zfp831 UTSW 2 174,487,059 (GRCm39) missense probably benign 0.40
FR4304:Zfp831 UTSW 2 174,487,274 (GRCm39) small insertion probably benign
FR4340:Zfp831 UTSW 2 174,487,273 (GRCm39) small insertion probably benign
FR4449:Zfp831 UTSW 2 174,487,275 (GRCm39) small insertion probably benign
FR4449:Zfp831 UTSW 2 174,487,264 (GRCm39) small insertion probably benign
FR4589:Zfp831 UTSW 2 174,487,261 (GRCm39) small insertion probably benign
FR4737:Zfp831 UTSW 2 174,487,276 (GRCm39) small insertion probably benign
FR4737:Zfp831 UTSW 2 174,487,269 (GRCm39) small insertion probably benign
FR4737:Zfp831 UTSW 2 174,487,264 (GRCm39) small insertion probably benign
IGL02802:Zfp831 UTSW 2 174,486,945 (GRCm39) missense possibly damaging 0.73
P0028:Zfp831 UTSW 2 174,487,139 (GRCm39) missense possibly damaging 0.53
PIT4531001:Zfp831 UTSW 2 174,488,516 (GRCm39) missense possibly damaging 0.90
R0631:Zfp831 UTSW 2 174,487,083 (GRCm39) missense possibly damaging 0.53
R0644:Zfp831 UTSW 2 174,487,656 (GRCm39) missense probably benign 0.33
R0782:Zfp831 UTSW 2 174,488,423 (GRCm39) missense probably benign 0.06
R1156:Zfp831 UTSW 2 174,488,710 (GRCm39) missense possibly damaging 0.53
R1280:Zfp831 UTSW 2 174,545,852 (GRCm39) missense probably benign 0.00
R1709:Zfp831 UTSW 2 174,487,683 (GRCm39) missense probably benign 0.33
R1883:Zfp831 UTSW 2 174,545,870 (GRCm39) missense possibly damaging 0.53
R1884:Zfp831 UTSW 2 174,545,870 (GRCm39) missense possibly damaging 0.53
R2127:Zfp831 UTSW 2 174,489,917 (GRCm39) missense probably benign 0.33
R2137:Zfp831 UTSW 2 174,547,539 (GRCm39) missense possibly damaging 0.53
R2268:Zfp831 UTSW 2 174,486,034 (GRCm39) missense probably benign 0.01
R2330:Zfp831 UTSW 2 174,489,882 (GRCm39) nonsense probably null
R3547:Zfp831 UTSW 2 174,499,476 (GRCm39) missense probably benign
R3821:Zfp831 UTSW 2 174,485,816 (GRCm39) missense possibly damaging 0.73
R4163:Zfp831 UTSW 2 174,485,822 (GRCm39) missense possibly damaging 0.53
R4778:Zfp831 UTSW 2 174,488,600 (GRCm39) missense possibly damaging 0.53
R4820:Zfp831 UTSW 2 174,547,097 (GRCm39) missense possibly damaging 0.73
R4912:Zfp831 UTSW 2 174,486,417 (GRCm39) missense probably damaging 1.00
R5119:Zfp831 UTSW 2 174,547,103 (GRCm39) missense probably benign 0.18
R5152:Zfp831 UTSW 2 174,486,357 (GRCm39) missense probably benign 0.33
R5723:Zfp831 UTSW 2 174,487,200 (GRCm39) missense probably benign 0.23
R5741:Zfp831 UTSW 2 174,486,945 (GRCm39) missense possibly damaging 0.73
R5888:Zfp831 UTSW 2 174,485,420 (GRCm39) missense probably benign 0.18
R5975:Zfp831 UTSW 2 174,485,885 (GRCm39) missense possibly damaging 0.93
R6092:Zfp831 UTSW 2 174,547,299 (GRCm39) missense probably damaging 0.98
R6158:Zfp831 UTSW 2 174,485,651 (GRCm39) missense possibly damaging 0.53
R6212:Zfp831 UTSW 2 174,487,661 (GRCm39) missense possibly damaging 0.53
R6233:Zfp831 UTSW 2 174,488,490 (GRCm39) missense possibly damaging 0.85
R6248:Zfp831 UTSW 2 174,486,308 (GRCm39) missense possibly damaging 0.53
R6255:Zfp831 UTSW 2 174,488,214 (GRCm39) missense possibly damaging 0.96
R6460:Zfp831 UTSW 2 174,488,360 (GRCm39) missense possibly damaging 0.46
R6477:Zfp831 UTSW 2 174,545,960 (GRCm39) missense probably benign
R6864:Zfp831 UTSW 2 174,488,533 (GRCm39) missense possibly damaging 0.72
R7396:Zfp831 UTSW 2 174,487,002 (GRCm39) missense possibly damaging 0.73
R7447:Zfp831 UTSW 2 174,487,896 (GRCm39) missense possibly damaging 0.88
R7499:Zfp831 UTSW 2 174,485,816 (GRCm39) missense possibly damaging 0.73
R7662:Zfp831 UTSW 2 174,487,934 (GRCm39) missense possibly damaging 0.85
R7857:Zfp831 UTSW 2 174,547,035 (GRCm39) missense probably benign 0.33
R7889:Zfp831 UTSW 2 174,487,097 (GRCm39) missense possibly damaging 0.53
R7896:Zfp831 UTSW 2 174,488,921 (GRCm39) missense possibly damaging 0.53
R8074:Zfp831 UTSW 2 174,486,528 (GRCm39) missense possibly damaging 0.72
R8089:Zfp831 UTSW 2 174,486,717 (GRCm39) missense possibly damaging 0.96
R8438:Zfp831 UTSW 2 174,486,796 (GRCm39) missense possibly damaging 0.53
R8716:Zfp831 UTSW 2 174,547,049 (GRCm39) missense possibly damaging 0.53
R8757:Zfp831 UTSW 2 174,487,874 (GRCm39) missense probably benign
R8759:Zfp831 UTSW 2 174,487,874 (GRCm39) missense probably benign
R8899:Zfp831 UTSW 2 174,485,978 (GRCm39) missense probably damaging 0.97
R8976:Zfp831 UTSW 2 174,487,079 (GRCm39) missense possibly damaging 0.76
R9146:Zfp831 UTSW 2 174,487,461 (GRCm39) missense possibly damaging 0.72
R9257:Zfp831 UTSW 2 174,488,156 (GRCm39) missense possibly damaging 0.53
R9324:Zfp831 UTSW 2 174,547,113 (GRCm39) missense probably benign 0.33
R9467:Zfp831 UTSW 2 174,486,789 (GRCm39) missense probably benign 0.33
R9729:Zfp831 UTSW 2 174,487,938 (GRCm39) missense possibly damaging 0.96
X0021:Zfp831 UTSW 2 174,547,662 (GRCm39) missense possibly damaging 0.85
Z1177:Zfp831 UTSW 2 174,485,981 (GRCm39) missense possibly damaging 0.93
Predicted Primers PCR Primer
(F):5'- ACTCCCCAGATAGAAGAGGC -3'
(R):5'- TCACTGCTGGTATCGCTGAG -3'

Sequencing Primer
(F):5'- GGCACACCGGACAGCATTC -3'
(R):5'- TGGTATCGCTGAGCTCCAC -3'
Posted On 2015-06-12