Incidental Mutation 'R4232:Or2b7'
ID 320923
Institutional Source Beutler Lab
Gene Symbol Or2b7
Ensembl Gene ENSMUSG00000054890
Gene Name olfactory receptor family 2 subfamily B member 7
Synonyms MOR256-63, Olfr1535, Olfr1365, MOR256-36, MOR256-36, GA_x6K02T2QHY8-11688984-11689964
MMRRC Submission 041051-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.066) question?
Stock # R4232 (G1)
Quality Score 225
Status Validated
Chromosome 13
Chromosomal Location 21739210-21740190 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 21739631 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 187 (D187G)
Ref Sequence ENSEMBL: ENSMUSP00000149589 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000068163] [ENSMUST00000217519]
AlphaFold Q7TQU0
Predicted Effect probably damaging
Transcript: ENSMUST00000068163
AA Change: D187G

PolyPhen 2 Score 0.976 (Sensitivity: 0.76; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000064142
Gene: ENSMUSG00000054890
AA Change: D187G

DomainStartEndE-ValueType
Pfam:7tm_4 31 320 5.4e-46 PFAM
Pfam:7tm_1 41 302 1.3e-19 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000217519
AA Change: D187G

PolyPhen 2 Score 0.976 (Sensitivity: 0.76; Specificity: 0.96)
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.1%
  • 20x: 94.9%
Validation Efficiency 92% (58/63)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930567H17Rik C T X: 69,438,135 (GRCm39) A53T probably benign Het
Ajuba T C 14: 54,806,983 (GRCm39) R490G probably damaging Het
Akap6 T A 12: 53,186,454 (GRCm39) N1289K probably damaging Het
Arhgap21 A G 2: 20,891,948 (GRCm39) V161A probably damaging Het
Atg14 T C 14: 47,788,802 (GRCm39) K184E probably benign Het
Aven A G 2: 112,458,113 (GRCm39) D167G probably damaging Het
Celsr2 A G 3: 108,321,088 (GRCm39) F575L probably benign Het
Cflar A T 1: 58,780,152 (GRCm39) Q249L possibly damaging Het
Col7a1 G A 9: 108,801,881 (GRCm39) probably null Het
Dmxl2 T C 9: 54,327,193 (GRCm39) D944G possibly damaging Het
Dnah1 T C 14: 31,026,873 (GRCm39) N717S probably benign Het
Dnaja3 T A 16: 4,517,735 (GRCm39) N322K possibly damaging Het
Dnajb3 A G 1: 88,132,974 (GRCm39) S143P possibly damaging Het
Dtx3 A G 10: 127,029,058 (GRCm39) I60T possibly damaging Het
Dvl3 A G 16: 20,342,983 (GRCm39) probably benign Het
Fkbp7 A T 2: 76,493,661 (GRCm39) D177E possibly damaging Het
Galnt7 T C 8: 58,106,000 (GRCm39) I5V probably benign Het
Garin3 C A 11: 46,298,232 (GRCm39) T512K possibly damaging Het
Helz2 A T 2: 180,871,695 (GRCm39) L2639Q probably damaging Het
Hnrnpr T C 4: 136,066,500 (GRCm39) M394T probably benign Het
Ip6k2 G A 9: 108,682,847 (GRCm39) R319Q probably benign Het
Kif14 T A 1: 136,444,101 (GRCm39) C1364* probably null Het
Macf1 T C 4: 123,326,185 (GRCm39) E5104G probably damaging Het
Mrps30 T C 13: 118,523,376 (GRCm39) D132G probably damaging Het
Mrtfa T A 15: 80,907,796 (GRCm39) K29M probably damaging Het
Mtbp CATGA CATGAATGA 15: 55,484,073 (GRCm39) probably null Het
Nfkb1 A G 3: 135,309,531 (GRCm39) V521A probably damaging Het
Or7g32 G T 9: 19,389,022 (GRCm39) L175M probably damaging Het
P2rx6 T C 16: 17,388,631 (GRCm39) L335P probably damaging Het
Pcdhga5 A G 18: 37,829,001 (GRCm39) D483G possibly damaging Het
Pgpep1l T C 7: 67,886,827 (GRCm39) T161A probably benign Het
Prss40 A G 1: 34,599,873 (GRCm39) V38A probably benign Het
Ptk2 C A 15: 73,181,698 (GRCm39) R104L possibly damaging Het
Ralgapa1 C T 12: 55,687,429 (GRCm39) R2019Q probably damaging Het
Rin2 C T 2: 145,702,366 (GRCm39) T354I probably benign Het
Rtp4 A G 16: 23,431,833 (GRCm39) N122D possibly damaging Het
Samd8 A G 14: 21,830,213 (GRCm39) Y213C probably benign Het
Shcbp1 T A 8: 4,786,372 (GRCm39) T577S probably benign Het
Tiprl A G 1: 165,050,156 (GRCm39) V153A probably damaging Het
Tmprss7 A T 16: 45,476,936 (GRCm39) D775E probably damaging Het
Tnr T C 1: 159,713,785 (GRCm39) S738P possibly damaging Het
Tsc22d4 T C 5: 137,749,632 (GRCm39) probably null Het
Ttc21a A T 9: 119,771,684 (GRCm39) H161L probably benign Het
Ubqln3 T A 7: 103,791,010 (GRCm39) E360V probably benign Het
Ugt1a10 C A 1: 87,983,932 (GRCm39) D243E probably benign Het
Vmn2r19 G A 6: 123,306,871 (GRCm39) V460I probably benign Het
Vmn2r58 T A 7: 41,487,011 (GRCm39) Y628F possibly damaging Het
Wnk1 A T 6: 119,926,222 (GRCm39) S1588T possibly damaging Het
Wscd2 A G 5: 113,699,045 (GRCm39) D200G probably benign Het
Zfp831 G C 2: 174,547,447 (GRCm39) W1543C possibly damaging Het
Other mutations in Or2b7
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01593:Or2b7 APN 13 21,739,389 (GRCm39) missense probably damaging 0.98
IGL01866:Or2b7 APN 13 21,739,343 (GRCm39) missense probably benign 0.07
IGL02289:Or2b7 APN 13 21,739,758 (GRCm39) missense probably benign 0.02
IGL02350:Or2b7 APN 13 21,739,772 (GRCm39) missense probably damaging 1.00
IGL02357:Or2b7 APN 13 21,739,772 (GRCm39) missense probably damaging 1.00
IGL02793:Or2b7 APN 13 21,740,172 (GRCm39) missense probably damaging 1.00
IGL02875:Or2b7 APN 13 21,740,172 (GRCm39) missense probably damaging 1.00
R0785:Or2b7 UTSW 13 21,739,958 (GRCm39) missense probably benign 0.02
R1773:Or2b7 UTSW 13 21,739,982 (GRCm39) missense probably damaging 1.00
R3429:Or2b7 UTSW 13 21,739,975 (GRCm39) nonsense probably null
R3430:Or2b7 UTSW 13 21,739,975 (GRCm39) nonsense probably null
R4883:Or2b7 UTSW 13 21,739,658 (GRCm39) missense probably benign 0.22
R5586:Or2b7 UTSW 13 21,739,266 (GRCm39) missense probably damaging 1.00
R6032:Or2b7 UTSW 13 21,740,077 (GRCm39) missense probably benign 0.01
R6032:Or2b7 UTSW 13 21,740,077 (GRCm39) missense probably benign 0.01
R6542:Or2b7 UTSW 13 21,739,677 (GRCm39) missense probably damaging 0.99
R7014:Or2b7 UTSW 13 21,740,108 (GRCm39) missense probably benign 0.02
R7579:Or2b7 UTSW 13 21,740,176 (GRCm39) missense probably benign 0.08
R7598:Or2b7 UTSW 13 21,739,358 (GRCm39) missense probably damaging 1.00
R7982:Or2b7 UTSW 13 21,740,136 (GRCm39) missense probably benign
R8239:Or2b7 UTSW 13 21,739,788 (GRCm39) missense probably benign 0.01
R8339:Or2b7 UTSW 13 21,739,996 (GRCm39) missense probably damaging 0.99
R8698:Or2b7 UTSW 13 21,739,890 (GRCm39) missense probably damaging 1.00
R8956:Or2b7 UTSW 13 21,740,169 (GRCm39) missense probably benign 0.00
R8977:Or2b7 UTSW 13 21,740,016 (GRCm39) missense possibly damaging 0.57
RF051:Or2b7 UTSW 13 21,739,693 (GRCm39) frame shift probably null
Predicted Primers PCR Primer
(F):5'- ACAGGTTCCAAAGGCCTTCC -3'
(R):5'- ATGATCGCTATGCTGCTGTCTG -3'

Sequencing Primer
(F):5'- CGCCTTCCCTGTGCTGAC -3'
(R):5'- ATGCTGCTGTCTGCCGAC -3'
Posted On 2015-06-12