Incidental Mutation 'R4233:Gzf1'
ID 320945
Institutional Source Beutler Lab
Gene Symbol Gzf1
Ensembl Gene ENSMUSG00000027439
Gene Name GDNF-inducible zinc finger protein 1
Synonyms Zfp336, 8430437G08Rik
MMRRC Submission 041642-MU
Accession Numbers
Essential gene? Possibly essential (E-score: 0.500) question?
Stock # R4233 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 148522943-148534869 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 148528453 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Proline to Serine at position 460 (P460S)
Ref Sequence ENSEMBL: ENSMUSP00000028928 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000028928] [ENSMUST00000131292]
AlphaFold Q4VBD9
Predicted Effect possibly damaging
Transcript: ENSMUST00000028928
AA Change: P460S

PolyPhen 2 Score 0.862 (Sensitivity: 0.83; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000028928
Gene: ENSMUSG00000027439
AA Change: P460S

DomainStartEndE-ValueType
BTB 31 133 2.01e-20 SMART
low complexity region 199 213 N/A INTRINSIC
coiled coil region 287 308 N/A INTRINSIC
ZnF_C2H2 315 337 6.32e-3 SMART
ZnF_C2H2 346 369 1.2e-3 SMART
ZnF_C2H2 375 398 8.34e-3 SMART
ZnF_C2H2 405 427 7.78e-3 SMART
ZnF_C2H2 433 455 1.69e-3 SMART
ZnF_C2H2 461 483 1.43e-1 SMART
ZnF_C2H2 489 511 2.4e-3 SMART
ZnF_C2H2 517 539 1.47e-3 SMART
ZnF_C2H2 545 567 1.38e-3 SMART
ZnF_C2H2 573 595 1.04e-3 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000131292
SMART Domains Protein: ENSMUSP00000121799
Gene: ENSMUSG00000027439

DomainStartEndE-ValueType
BTB 31 133 2.01e-20 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000151362
Meta Mutation Damage Score 0.7218 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.8%
  • 10x: 97.6%
  • 20x: 96.2%
Validation Efficiency 100% (53/53)
Allele List at MGI

All alleles(5) : Gene trapped(5)

Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700123K08Rik A T 5: 138,562,454 (GRCm39) Y96N probably damaging Het
Abca15 C T 7: 120,002,202 (GRCm39) Q1572* probably null Het
Ajuba T C 14: 54,806,983 (GRCm39) R490G probably damaging Het
Akap6 T A 12: 53,186,454 (GRCm39) N1289K probably damaging Het
Ankfy1 G A 11: 72,605,310 (GRCm39) probably null Het
Aph1c A G 9: 66,740,603 (GRCm39) F41S probably damaging Het
Arhgap21 A G 2: 20,891,948 (GRCm39) V161A probably damaging Het
Arhgef18 T C 8: 3,500,317 (GRCm39) I541T possibly damaging Het
Arhgef40 T C 14: 52,227,628 (GRCm39) V458A possibly damaging Het
Atg14 T C 14: 47,788,802 (GRCm39) K184E probably benign Het
Casp8 T C 1: 58,883,929 (GRCm39) V432A probably damaging Het
Ccar2 T C 14: 70,388,540 (GRCm39) T169A possibly damaging Het
Cfap58 G A 19: 47,963,994 (GRCm39) V541M possibly damaging Het
Coro2b T C 9: 62,333,467 (GRCm39) E376G possibly damaging Het
Dnah11 T C 12: 117,880,526 (GRCm39) T3865A probably damaging Het
Dync2h1 T C 9: 7,134,360 (GRCm39) E1549G probably benign Het
Ercc6l2 T C 13: 64,019,982 (GRCm39) probably benign Het
Fbxo32 G T 15: 58,055,729 (GRCm39) T135K possibly damaging Het
Fhip2b A C 14: 70,824,318 (GRCm39) V473G probably damaging Het
Fras1 A T 5: 96,862,235 (GRCm39) I2205F possibly damaging Het
Gm12034 A G 11: 20,396,785 (GRCm39) noncoding transcript Het
Gm26678 T C 3: 54,540,504 (GRCm39) noncoding transcript Het
Gm5108 C A 5: 68,132,496 (GRCm39) T55K unknown Het
Gpa33 A T 1: 165,974,340 (GRCm39) D59V probably damaging Het
Gpn2 T A 4: 133,312,016 (GRCm39) Y83N probably damaging Het
Ifi203 A T 1: 173,764,099 (GRCm39) S124R possibly damaging Het
Impg1 A G 9: 80,252,611 (GRCm39) L523P probably damaging Het
Ldlrap1 T A 4: 134,484,649 (GRCm39) probably null Het
Madd T C 2: 91,008,581 (GRCm39) E107G probably benign Het
Med12l T G 3: 59,164,644 (GRCm39) probably null Het
Nxpe4 A T 9: 48,310,137 (GRCm39) T467S probably damaging Het
Or52n4 A G 7: 104,294,195 (GRCm39) V126A probably benign Het
Or7g30 T A 9: 19,352,886 (GRCm39) L226I probably damaging Het
Pam A T 1: 97,792,119 (GRCm39) V434D possibly damaging Het
Plxnd1 T C 6: 115,942,914 (GRCm39) N1257D probably benign Het
Prkdc C T 16: 15,653,783 (GRCm39) A3870V probably benign Het
Ralgapa1 C T 12: 55,687,429 (GRCm39) R2019Q probably damaging Het
Rufy4 T C 1: 74,186,822 (GRCm39) C537R probably damaging Het
Ryr2 T C 13: 11,765,611 (GRCm39) D1375G probably benign Het
Skint11 C A 4: 114,101,856 (GRCm39) Q99K probably benign Het
Slc13a2 A G 11: 78,294,361 (GRCm39) probably benign Het
Slc7a13 T C 4: 19,819,070 (GRCm39) F90S probably damaging Het
Spc24 T C 9: 21,667,498 (GRCm39) probably null Het
Stard13 A G 5: 150,986,164 (GRCm39) S331P probably benign Het
Sult2a8 T A 7: 14,147,608 (GRCm39) I228L probably benign Het
Tas2r140 A T 6: 133,031,915 (GRCm39) V281D probably damaging Het
Tmem38b T C 4: 53,840,710 (GRCm39) C66R probably damaging Het
Tshz1 C A 18: 84,034,320 (GRCm39) E29D probably benign Het
Zfp599 T A 9: 22,161,041 (GRCm39) K375* probably null Het
Other mutations in Gzf1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01129:Gzf1 APN 2 148,532,916 (GRCm39) missense probably damaging 0.99
IGL01647:Gzf1 APN 2 148,525,570 (GRCm39) missense probably damaging 1.00
IGL01789:Gzf1 APN 2 148,525,981 (GRCm39) missense probably benign 0.41
IGL01791:Gzf1 APN 2 148,525,981 (GRCm39) missense probably benign 0.41
IGL01952:Gzf1 APN 2 148,525,981 (GRCm39) missense probably benign 0.41
IGL01954:Gzf1 APN 2 148,525,981 (GRCm39) missense probably benign 0.41
IGL01956:Gzf1 APN 2 148,525,981 (GRCm39) missense probably benign 0.41
IGL03391:Gzf1 APN 2 148,525,603 (GRCm39) missense probably damaging 1.00
I0000:Gzf1 UTSW 2 148,528,540 (GRCm39) unclassified probably benign
P0019:Gzf1 UTSW 2 148,525,900 (GRCm39) missense probably damaging 1.00
R0420:Gzf1 UTSW 2 148,525,753 (GRCm39) missense probably benign 0.30
R0725:Gzf1 UTSW 2 148,526,569 (GRCm39) nonsense probably null
R1131:Gzf1 UTSW 2 148,532,787 (GRCm39) missense probably benign 0.02
R2000:Gzf1 UTSW 2 148,526,531 (GRCm39) missense probably benign 0.16
R2211:Gzf1 UTSW 2 148,526,870 (GRCm39) missense probably damaging 1.00
R2251:Gzf1 UTSW 2 148,525,856 (GRCm39) missense probably damaging 1.00
R2252:Gzf1 UTSW 2 148,525,856 (GRCm39) missense probably damaging 1.00
R2253:Gzf1 UTSW 2 148,525,856 (GRCm39) missense probably damaging 1.00
R5551:Gzf1 UTSW 2 148,526,248 (GRCm39) missense probably damaging 1.00
R6050:Gzf1 UTSW 2 148,526,158 (GRCm39) missense possibly damaging 0.89
R6891:Gzf1 UTSW 2 148,526,689 (GRCm39) nonsense probably null
R7457:Gzf1 UTSW 2 148,532,002 (GRCm39) missense probably damaging 0.99
R7735:Gzf1 UTSW 2 148,530,083 (GRCm39) missense possibly damaging 0.91
R7839:Gzf1 UTSW 2 148,525,815 (GRCm39) nonsense probably null
R8168:Gzf1 UTSW 2 148,526,686 (GRCm39) missense probably damaging 1.00
R8225:Gzf1 UTSW 2 148,532,764 (GRCm39) missense probably benign 0.02
R8432:Gzf1 UTSW 2 148,532,115 (GRCm39) missense probably benign 0.22
R9081:Gzf1 UTSW 2 148,525,317 (GRCm39) intron probably benign
R9761:Gzf1 UTSW 2 148,530,011 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- TATGGTGAACTTCTGATCAGTTCC -3'
(R):5'- AGGCAGCAGGTATATCTGTAAG -3'

Sequencing Primer
(F):5'- GGTGAACTTCTGATCAGTTCCATTAG -3'
(R):5'- CAGGTATATCTGTAAGCCTGACTCG -3'
Posted On 2015-06-12