Incidental Mutation 'R4233:Tas2r140'
ID 320959
Institutional Source Beutler Lab
Gene Symbol Tas2r140
Ensembl Gene ENSMUSG00000071147
Gene Name taste receptor, type 2, member 140
Synonyms TRB5, mt2r64, Tas2r40, Tas2r13, mTRB3, TRB3, T2R40
MMRRC Submission 041642-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.058) question?
Stock # R4233 (G1)
Quality Score 225
Status Validated
Chromosome 6
Chromosomal Location 133031818-133032756 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 133031915 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Aspartic acid at position 281 (V281D)
Ref Sequence ENSEMBL: ENSMUSP00000093040 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000095391]
AlphaFold Q7TQA4
Predicted Effect probably damaging
Transcript: ENSMUST00000095391
AA Change: V281D

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000093040
Gene: ENSMUSG00000071147
AA Change: V281D

DomainStartEndE-ValueType
Pfam:TAS2R 1 301 6.7e-86 PFAM
Meta Mutation Damage Score 0.6104 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.8%
  • 10x: 97.6%
  • 20x: 96.2%
Validation Efficiency 100% (53/53)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene product belongs to the family of candidate taste receptors that are members of the G-protein-coupled receptor superfamily. These proteins are specifically expressed in the taste receptor cells of the tongue and palate epithelia. They are organized in the genome in clusters and are genetically linked to loci that influence bitter perception in mice and humans. In functional expression studies, they respond to bitter tastants. This gene maps to the taste receptor gene cluster on chromosome 12p13. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700123K08Rik A T 5: 138,562,454 (GRCm39) Y96N probably damaging Het
Abca15 C T 7: 120,002,202 (GRCm39) Q1572* probably null Het
Ajuba T C 14: 54,806,983 (GRCm39) R490G probably damaging Het
Akap6 T A 12: 53,186,454 (GRCm39) N1289K probably damaging Het
Ankfy1 G A 11: 72,605,310 (GRCm39) probably null Het
Aph1c A G 9: 66,740,603 (GRCm39) F41S probably damaging Het
Arhgap21 A G 2: 20,891,948 (GRCm39) V161A probably damaging Het
Arhgef18 T C 8: 3,500,317 (GRCm39) I541T possibly damaging Het
Arhgef40 T C 14: 52,227,628 (GRCm39) V458A possibly damaging Het
Atg14 T C 14: 47,788,802 (GRCm39) K184E probably benign Het
Casp8 T C 1: 58,883,929 (GRCm39) V432A probably damaging Het
Ccar2 T C 14: 70,388,540 (GRCm39) T169A possibly damaging Het
Cfap58 G A 19: 47,963,994 (GRCm39) V541M possibly damaging Het
Coro2b T C 9: 62,333,467 (GRCm39) E376G possibly damaging Het
Dnah11 T C 12: 117,880,526 (GRCm39) T3865A probably damaging Het
Dync2h1 T C 9: 7,134,360 (GRCm39) E1549G probably benign Het
Ercc6l2 T C 13: 64,019,982 (GRCm39) probably benign Het
Fbxo32 G T 15: 58,055,729 (GRCm39) T135K possibly damaging Het
Fhip2b A C 14: 70,824,318 (GRCm39) V473G probably damaging Het
Fras1 A T 5: 96,862,235 (GRCm39) I2205F possibly damaging Het
Gm12034 A G 11: 20,396,785 (GRCm39) noncoding transcript Het
Gm26678 T C 3: 54,540,504 (GRCm39) noncoding transcript Het
Gm5108 C A 5: 68,132,496 (GRCm39) T55K unknown Het
Gpa33 A T 1: 165,974,340 (GRCm39) D59V probably damaging Het
Gpn2 T A 4: 133,312,016 (GRCm39) Y83N probably damaging Het
Gzf1 C T 2: 148,528,453 (GRCm39) P460S possibly damaging Het
Ifi203 A T 1: 173,764,099 (GRCm39) S124R possibly damaging Het
Impg1 A G 9: 80,252,611 (GRCm39) L523P probably damaging Het
Ldlrap1 T A 4: 134,484,649 (GRCm39) probably null Het
Madd T C 2: 91,008,581 (GRCm39) E107G probably benign Het
Med12l T G 3: 59,164,644 (GRCm39) probably null Het
Nxpe4 A T 9: 48,310,137 (GRCm39) T467S probably damaging Het
Or52n4 A G 7: 104,294,195 (GRCm39) V126A probably benign Het
Or7g30 T A 9: 19,352,886 (GRCm39) L226I probably damaging Het
Pam A T 1: 97,792,119 (GRCm39) V434D possibly damaging Het
Plxnd1 T C 6: 115,942,914 (GRCm39) N1257D probably benign Het
Prkdc C T 16: 15,653,783 (GRCm39) A3870V probably benign Het
Ralgapa1 C T 12: 55,687,429 (GRCm39) R2019Q probably damaging Het
Rufy4 T C 1: 74,186,822 (GRCm39) C537R probably damaging Het
Ryr2 T C 13: 11,765,611 (GRCm39) D1375G probably benign Het
Skint11 C A 4: 114,101,856 (GRCm39) Q99K probably benign Het
Slc13a2 A G 11: 78,294,361 (GRCm39) probably benign Het
Slc7a13 T C 4: 19,819,070 (GRCm39) F90S probably damaging Het
Spc24 T C 9: 21,667,498 (GRCm39) probably null Het
Stard13 A G 5: 150,986,164 (GRCm39) S331P probably benign Het
Sult2a8 T A 7: 14,147,608 (GRCm39) I228L probably benign Het
Tmem38b T C 4: 53,840,710 (GRCm39) C66R probably damaging Het
Tshz1 C A 18: 84,034,320 (GRCm39) E29D probably benign Het
Zfp599 T A 9: 22,161,041 (GRCm39) K375* probably null Het
Other mutations in Tas2r140
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00088:Tas2r140 APN 6 40,468,274 (GRCm39) missense probably benign 0.20
IGL00951:Tas2r140 APN 6 40,468,913 (GRCm39) nonsense probably null
IGL00980:Tas2r140 APN 6 40,468,352 (GRCm39) missense possibly damaging 0.60
IGL02055:Tas2r140 APN 6 40,468,493 (GRCm39) missense probably damaging 1.00
IGL03101:Tas2r140 APN 6 40,468,764 (GRCm39) missense probably benign 0.03
R0149:Tas2r140 UTSW 6 40,468,232 (GRCm39) missense probably benign 0.08
R0244:Tas2r140 UTSW 6 133,032,290 (GRCm39) missense possibly damaging 0.46
R0361:Tas2r140 UTSW 6 40,468,232 (GRCm39) missense probably benign 0.08
R0666:Tas2r140 UTSW 6 133,032,405 (GRCm39) missense probably benign 0.22
R0755:Tas2r140 UTSW 6 40,468,344 (GRCm39) missense probably damaging 0.99
R1174:Tas2r140 UTSW 6 133,031,834 (GRCm39) missense probably benign 0.27
R1237:Tas2r140 UTSW 6 133,032,171 (GRCm39) missense probably benign 0.04
R1553:Tas2r140 UTSW 6 133,032,471 (GRCm39) missense probably damaging 0.99
R2030:Tas2r140 UTSW 6 133,032,213 (GRCm39) missense probably benign 0.23
R2030:Tas2r140 UTSW 6 40,469,154 (GRCm39) missense possibly damaging 0.58
R3123:Tas2r140 UTSW 6 133,032,204 (GRCm39) missense probably benign 0.05
R3124:Tas2r140 UTSW 6 133,032,204 (GRCm39) missense probably benign 0.05
R4234:Tas2r140 UTSW 6 133,031,915 (GRCm39) missense probably damaging 1.00
R4236:Tas2r140 UTSW 6 133,031,915 (GRCm39) missense probably damaging 1.00
R4525:Tas2r140 UTSW 6 133,032,207 (GRCm39) missense possibly damaging 0.66
R4803:Tas2r140 UTSW 6 133,032,743 (GRCm39) missense possibly damaging 0.77
R4840:Tas2r140 UTSW 6 133,032,528 (GRCm39) missense probably benign 0.01
R4885:Tas2r140 UTSW 6 40,468,334 (GRCm39) missense probably damaging 0.98
R5092:Tas2r140 UTSW 6 40,468,200 (GRCm39) missense probably benign
R5182:Tas2r140 UTSW 6 40,468,866 (GRCm39) missense probably benign 0.01
R5317:Tas2r140 UTSW 6 133,032,543 (GRCm39) missense probably benign 0.06
R5937:Tas2r140 UTSW 6 133,032,236 (GRCm39) missense probably benign 0.01
R5952:Tas2r140 UTSW 6 40,468,476 (GRCm39) missense probably benign 0.43
R6142:Tas2r140 UTSW 6 133,032,698 (GRCm39) missense probably damaging 1.00
R7127:Tas2r140 UTSW 6 133,031,922 (GRCm39) missense possibly damaging 0.62
R7143:Tas2r140 UTSW 6 133,032,482 (GRCm39) missense probably benign 0.00
R7178:Tas2r140 UTSW 6 133,032,623 (GRCm39) missense probably damaging 1.00
R7494:Tas2r140 UTSW 6 40,468,254 (GRCm39) missense probably damaging 0.99
R7513:Tas2r140 UTSW 6 40,469,084 (GRCm39) missense probably damaging 1.00
R7875:Tas2r140 UTSW 6 40,469,097 (GRCm39) missense probably damaging 1.00
R7979:Tas2r140 UTSW 6 40,468,601 (GRCm39) missense probably damaging 1.00
R8804:Tas2r140 UTSW 6 133,032,326 (GRCm39) missense probably damaging 0.98
R9029:Tas2r140 UTSW 6 133,032,181 (GRCm39) missense possibly damaging 0.69
R9055:Tas2r140 UTSW 6 133,032,380 (GRCm39) missense possibly damaging 0.77
R9257:Tas2r140 UTSW 6 40,468,592 (GRCm39) missense probably damaging 0.98
R9385:Tas2r140 UTSW 6 133,032,241 (GRCm39) missense probably benign 0.03
R9530:Tas2r140 UTSW 6 133,032,494 (GRCm39) missense probably benign 0.00
R9760:Tas2r140 UTSW 6 40,469,036 (GRCm39) missense probably benign 0.41
X0022:Tas2r140 UTSW 6 40,468,275 (GRCm39) missense possibly damaging 0.63
Predicted Primers PCR Primer
(F):5'- GGTTCATGCTGACATCATTATATGTAC -3'
(R):5'- GCCCATATTAAGGCCCTGC -3'

Sequencing Primer
(F):5'- TTTGTACAGTACTTGATTCCCAAAG -3'
(R):5'- TTAAGGCCCTGCAAATGATGGTC -3'
Posted On 2015-06-12