Incidental Mutation 'R4233:Abca15'
ID 320962
Institutional Source Beutler Lab
Gene Symbol Abca15
Ensembl Gene ENSMUSG00000054746
Gene Name ATP-binding cassette, sub-family A member 15
Synonyms 4930500I12Rik
MMRRC Submission 041642-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.059) question?
Stock # R4233 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 119927893-120006910 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) C to T at 120002202 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamine to Stop codon at position 1572 (Q1572*)
Ref Sequence ENSEMBL: ENSMUSP00000112821 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000076272] [ENSMUST00000121265]
AlphaFold E9PWH4
Predicted Effect probably null
Transcript: ENSMUST00000076272
AA Change: Q1572*
SMART Domains Protein: ENSMUSP00000075621
Gene: ENSMUSG00000054746
AA Change: Q1572*

DomainStartEndE-ValueType
Pfam:ABC2_membrane_3 24 464 5.7e-21 PFAM
AAA 550 732 9.14e-11 SMART
Pfam:ABC2_membrane_3 892 1293 7.9e-24 PFAM
AAA 1381 1565 1.16e-3 SMART
Predicted Effect probably null
Transcript: ENSMUST00000121265
AA Change: Q1572*
SMART Domains Protein: ENSMUSP00000112821
Gene: ENSMUSG00000054746
AA Change: Q1572*

DomainStartEndE-ValueType
Pfam:ABC2_membrane_3 24 464 2.1e-21 PFAM
AAA 550 732 9.14e-11 SMART
Pfam:ABC2_membrane_3 907 1293 1e-25 PFAM
AAA 1381 1565 1.16e-3 SMART
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.8%
  • 10x: 97.6%
  • 20x: 96.2%
Validation Efficiency 100% (53/53)
Allele List at MGI

All alleles(2) : Targeted(2

Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700123K08Rik A T 5: 138,562,454 (GRCm39) Y96N probably damaging Het
Ajuba T C 14: 54,806,983 (GRCm39) R490G probably damaging Het
Akap6 T A 12: 53,186,454 (GRCm39) N1289K probably damaging Het
Ankfy1 G A 11: 72,605,310 (GRCm39) probably null Het
Aph1c A G 9: 66,740,603 (GRCm39) F41S probably damaging Het
Arhgap21 A G 2: 20,891,948 (GRCm39) V161A probably damaging Het
Arhgef18 T C 8: 3,500,317 (GRCm39) I541T possibly damaging Het
Arhgef40 T C 14: 52,227,628 (GRCm39) V458A possibly damaging Het
Atg14 T C 14: 47,788,802 (GRCm39) K184E probably benign Het
Casp8 T C 1: 58,883,929 (GRCm39) V432A probably damaging Het
Ccar2 T C 14: 70,388,540 (GRCm39) T169A possibly damaging Het
Cfap58 G A 19: 47,963,994 (GRCm39) V541M possibly damaging Het
Coro2b T C 9: 62,333,467 (GRCm39) E376G possibly damaging Het
Dnah11 T C 12: 117,880,526 (GRCm39) T3865A probably damaging Het
Dync2h1 T C 9: 7,134,360 (GRCm39) E1549G probably benign Het
Ercc6l2 T C 13: 64,019,982 (GRCm39) probably benign Het
Fbxo32 G T 15: 58,055,729 (GRCm39) T135K possibly damaging Het
Fhip2b A C 14: 70,824,318 (GRCm39) V473G probably damaging Het
Fras1 A T 5: 96,862,235 (GRCm39) I2205F possibly damaging Het
Gm12034 A G 11: 20,396,785 (GRCm39) noncoding transcript Het
Gm26678 T C 3: 54,540,504 (GRCm39) noncoding transcript Het
Gm5108 C A 5: 68,132,496 (GRCm39) T55K unknown Het
Gpa33 A T 1: 165,974,340 (GRCm39) D59V probably damaging Het
Gpn2 T A 4: 133,312,016 (GRCm39) Y83N probably damaging Het
Gzf1 C T 2: 148,528,453 (GRCm39) P460S possibly damaging Het
Ifi203 A T 1: 173,764,099 (GRCm39) S124R possibly damaging Het
Impg1 A G 9: 80,252,611 (GRCm39) L523P probably damaging Het
Ldlrap1 T A 4: 134,484,649 (GRCm39) probably null Het
Madd T C 2: 91,008,581 (GRCm39) E107G probably benign Het
Med12l T G 3: 59,164,644 (GRCm39) probably null Het
Nxpe4 A T 9: 48,310,137 (GRCm39) T467S probably damaging Het
Or52n4 A G 7: 104,294,195 (GRCm39) V126A probably benign Het
Or7g30 T A 9: 19,352,886 (GRCm39) L226I probably damaging Het
Pam A T 1: 97,792,119 (GRCm39) V434D possibly damaging Het
Plxnd1 T C 6: 115,942,914 (GRCm39) N1257D probably benign Het
Prkdc C T 16: 15,653,783 (GRCm39) A3870V probably benign Het
Ralgapa1 C T 12: 55,687,429 (GRCm39) R2019Q probably damaging Het
Rufy4 T C 1: 74,186,822 (GRCm39) C537R probably damaging Het
Ryr2 T C 13: 11,765,611 (GRCm39) D1375G probably benign Het
Skint11 C A 4: 114,101,856 (GRCm39) Q99K probably benign Het
Slc13a2 A G 11: 78,294,361 (GRCm39) probably benign Het
Slc7a13 T C 4: 19,819,070 (GRCm39) F90S probably damaging Het
Spc24 T C 9: 21,667,498 (GRCm39) probably null Het
Stard13 A G 5: 150,986,164 (GRCm39) S331P probably benign Het
Sult2a8 T A 7: 14,147,608 (GRCm39) I228L probably benign Het
Tas2r140 A T 6: 133,031,915 (GRCm39) V281D probably damaging Het
Tmem38b T C 4: 53,840,710 (GRCm39) C66R probably damaging Het
Tshz1 C A 18: 84,034,320 (GRCm39) E29D probably benign Het
Zfp599 T A 9: 22,161,041 (GRCm39) K375* probably null Het
Other mutations in Abca15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00429:Abca15 APN 7 119,996,277 (GRCm39) missense probably damaging 1.00
IGL00505:Abca15 APN 7 119,968,459 (GRCm39) critical splice donor site probably null
IGL00851:Abca15 APN 7 119,939,230 (GRCm39) missense probably damaging 1.00
IGL00985:Abca15 APN 7 119,996,241 (GRCm39) missense probably damaging 1.00
IGL01114:Abca15 APN 7 119,960,643 (GRCm39) missense probably damaging 0.99
IGL01287:Abca15 APN 7 119,932,081 (GRCm39) utr 3 prime probably benign
IGL01333:Abca15 APN 7 119,981,531 (GRCm39) missense probably damaging 1.00
IGL01482:Abca15 APN 7 119,981,969 (GRCm39) missense probably benign 0.00
IGL01610:Abca15 APN 7 119,939,867 (GRCm39) missense probably damaging 0.98
IGL02238:Abca15 APN 7 119,995,829 (GRCm39) missense probably benign 0.02
IGL02377:Abca15 APN 7 119,965,133 (GRCm39) splice site probably benign
IGL02666:Abca15 APN 7 119,934,431 (GRCm39) missense probably damaging 1.00
IGL02836:Abca15 APN 7 119,987,439 (GRCm39) missense probably benign
IGL03337:Abca15 APN 7 119,995,930 (GRCm39) missense probably benign 0.24
IGL03354:Abca15 APN 7 119,993,711 (GRCm39) nonsense probably null
H8562:Abca15 UTSW 7 119,974,077 (GRCm39) splice site probably benign
IGL03098:Abca15 UTSW 7 119,987,499 (GRCm39) splice site probably null
R0029:Abca15 UTSW 7 119,945,225 (GRCm39) missense probably benign 0.01
R0029:Abca15 UTSW 7 119,945,225 (GRCm39) missense probably benign 0.01
R0076:Abca15 UTSW 7 119,972,908 (GRCm39) splice site probably benign
R0165:Abca15 UTSW 7 119,950,126 (GRCm39) splice site probably benign
R0311:Abca15 UTSW 7 120,002,127 (GRCm39) missense probably damaging 0.98
R0387:Abca15 UTSW 7 119,932,075 (GRCm39) critical splice donor site probably null
R0610:Abca15 UTSW 7 119,965,009 (GRCm39) missense possibly damaging 0.75
R0612:Abca15 UTSW 7 119,936,478 (GRCm39) missense probably damaging 1.00
R0704:Abca15 UTSW 7 119,953,746 (GRCm39) missense probably damaging 0.98
R0890:Abca15 UTSW 7 119,972,936 (GRCm39) missense probably benign 0.01
R0961:Abca15 UTSW 7 119,960,208 (GRCm39) nonsense probably null
R1144:Abca15 UTSW 7 119,960,083 (GRCm39) splice site probably benign
R1412:Abca15 UTSW 7 119,944,546 (GRCm39) missense possibly damaging 0.93
R1419:Abca15 UTSW 7 119,974,125 (GRCm39) missense probably benign 0.10
R1467:Abca15 UTSW 7 119,939,761 (GRCm39) splice site probably null
R1467:Abca15 UTSW 7 119,939,761 (GRCm39) splice site probably null
R1469:Abca15 UTSW 7 119,981,720 (GRCm39) missense probably benign 0.00
R1469:Abca15 UTSW 7 119,981,720 (GRCm39) missense probably benign 0.00
R1493:Abca15 UTSW 7 119,981,513 (GRCm39) missense probably benign 0.00
R1513:Abca15 UTSW 7 119,939,322 (GRCm39) missense probably damaging 0.96
R1702:Abca15 UTSW 7 119,981,925 (GRCm39) missense probably benign 0.10
R1857:Abca15 UTSW 7 119,960,592 (GRCm39) missense probably damaging 1.00
R1893:Abca15 UTSW 7 119,939,776 (GRCm39) missense possibly damaging 0.85
R1901:Abca15 UTSW 7 119,945,322 (GRCm39) missense probably damaging 1.00
R1951:Abca15 UTSW 7 119,960,655 (GRCm39) missense probably damaging 1.00
R1953:Abca15 UTSW 7 119,960,655 (GRCm39) missense probably damaging 1.00
R1962:Abca15 UTSW 7 119,940,468 (GRCm39) missense probably damaging 1.00
R2063:Abca15 UTSW 7 119,960,127 (GRCm39) missense possibly damaging 0.61
R2141:Abca15 UTSW 7 120,006,697 (GRCm39) missense probably damaging 1.00
R2145:Abca15 UTSW 7 119,953,701 (GRCm39) missense probably benign 0.08
R2182:Abca15 UTSW 7 119,939,450 (GRCm39) nonsense probably null
R2425:Abca15 UTSW 7 119,959,033 (GRCm39) missense probably damaging 1.00
R2444:Abca15 UTSW 7 119,965,120 (GRCm39) missense probably damaging 1.00
R3023:Abca15 UTSW 7 119,982,002 (GRCm39) missense probably benign 0.40
R3079:Abca15 UTSW 7 119,984,392 (GRCm39) missense probably damaging 1.00
R3106:Abca15 UTSW 7 119,995,856 (GRCm39) missense possibly damaging 0.63
R3622:Abca15 UTSW 7 119,950,036 (GRCm39) nonsense probably null
R4085:Abca15 UTSW 7 119,981,949 (GRCm39) missense probably damaging 1.00
R4591:Abca15 UTSW 7 119,981,636 (GRCm39) missense probably damaging 1.00
R4612:Abca15 UTSW 7 119,934,384 (GRCm39) missense probably benign 0.03
R4721:Abca15 UTSW 7 119,949,998 (GRCm39) missense probably benign 0.01
R4838:Abca15 UTSW 7 119,944,523 (GRCm39) missense probably benign 0.00
R4940:Abca15 UTSW 7 119,931,917 (GRCm39) missense probably benign
R4963:Abca15 UTSW 7 119,960,142 (GRCm39) missense probably damaging 1.00
R4993:Abca15 UTSW 7 120,000,941 (GRCm39) missense probably damaging 0.99
R5022:Abca15 UTSW 7 119,945,319 (GRCm39) missense probably damaging 0.98
R5030:Abca15 UTSW 7 119,939,224 (GRCm39) missense probably damaging 1.00
R5072:Abca15 UTSW 7 120,006,198 (GRCm39) missense probably damaging 1.00
R5090:Abca15 UTSW 7 119,984,422 (GRCm39) missense probably damaging 1.00
R5309:Abca15 UTSW 7 119,944,592 (GRCm39) missense probably damaging 0.96
R5310:Abca15 UTSW 7 119,931,839 (GRCm39) missense possibly damaging 0.46
R5312:Abca15 UTSW 7 119,944,592 (GRCm39) missense probably damaging 0.96
R5482:Abca15 UTSW 7 119,968,370 (GRCm39) missense probably damaging 1.00
R5596:Abca15 UTSW 7 120,000,972 (GRCm39) missense possibly damaging 0.94
R5853:Abca15 UTSW 7 119,939,806 (GRCm39) missense probably benign 0.00
R5950:Abca15 UTSW 7 119,981,879 (GRCm39) missense probably damaging 1.00
R5953:Abca15 UTSW 7 119,960,241 (GRCm39) missense probably damaging 1.00
R6072:Abca15 UTSW 7 119,987,481 (GRCm39) missense probably damaging 0.98
R6131:Abca15 UTSW 7 119,939,428 (GRCm39) missense probably benign 0.03
R6132:Abca15 UTSW 7 119,960,643 (GRCm39) missense probably benign 0.14
R6136:Abca15 UTSW 7 119,939,272 (GRCm39) missense possibly damaging 0.81
R6207:Abca15 UTSW 7 119,973,017 (GRCm39) missense probably benign 0.01
R6315:Abca15 UTSW 7 119,945,315 (GRCm39) missense probably damaging 1.00
R6417:Abca15 UTSW 7 119,996,351 (GRCm39) missense possibly damaging 0.95
R6420:Abca15 UTSW 7 119,996,351 (GRCm39) missense possibly damaging 0.95
R6595:Abca15 UTSW 7 119,993,710 (GRCm39) missense probably benign 0.00
R6653:Abca15 UTSW 7 119,945,229 (GRCm39) missense probably benign 0.03
R6859:Abca15 UTSW 7 120,002,217 (GRCm39) nonsense probably null
R6983:Abca15 UTSW 7 119,953,686 (GRCm39) missense probably benign 0.26
R7127:Abca15 UTSW 7 119,931,825 (GRCm39) missense probably benign 0.06
R7205:Abca15 UTSW 7 119,993,587 (GRCm39) missense possibly damaging 0.89
R7336:Abca15 UTSW 7 119,987,456 (GRCm39) missense possibly damaging 0.66
R7426:Abca15 UTSW 7 119,945,221 (GRCm39) missense possibly damaging 0.88
R7745:Abca15 UTSW 7 119,931,440 (GRCm39) missense probably damaging 1.00
R7751:Abca15 UTSW 7 119,965,044 (GRCm39) missense possibly damaging 0.72
R7806:Abca15 UTSW 7 119,932,059 (GRCm39) missense probably damaging 0.96
R8042:Abca15 UTSW 7 120,002,233 (GRCm39) missense possibly damaging 0.95
R8098:Abca15 UTSW 7 119,960,619 (GRCm39) missense probably benign 0.09
R8153:Abca15 UTSW 7 119,999,812 (GRCm39) missense probably damaging 1.00
R8247:Abca15 UTSW 7 119,936,445 (GRCm39) missense possibly damaging 0.83
R8259:Abca15 UTSW 7 119,939,422 (GRCm39) missense probably benign 0.00
R8272:Abca15 UTSW 7 120,006,665 (GRCm39) missense probably damaging 1.00
R8295:Abca15 UTSW 7 119,974,188 (GRCm39) missense probably benign 0.00
R8757:Abca15 UTSW 7 120,006,631 (GRCm39) missense probably damaging 0.96
R8759:Abca15 UTSW 7 120,006,631 (GRCm39) missense probably damaging 0.96
R8905:Abca15 UTSW 7 119,960,771 (GRCm39) missense probably benign 0.28
R9145:Abca15 UTSW 7 119,987,388 (GRCm39) missense probably benign 0.13
R9217:Abca15 UTSW 7 119,987,439 (GRCm39) missense probably benign
R9264:Abca15 UTSW 7 120,001,056 (GRCm39) missense probably benign 0.14
R9517:Abca15 UTSW 7 119,987,424 (GRCm39) missense probably benign 0.07
RF018:Abca15 UTSW 7 119,993,683 (GRCm39) missense possibly damaging 0.50
Z1176:Abca15 UTSW 7 119,981,728 (GRCm39) missense probably damaging 0.99
Z1176:Abca15 UTSW 7 119,945,249 (GRCm39) missense probably benign 0.22
Predicted Primers PCR Primer
(F):5'- ATTGGAAGATGCAACTTGTGG -3'
(R):5'- CTGGGTATCAGTAACACAGGGATAC -3'

Sequencing Primer
(F):5'- TGGTTGATAACAAGATCCTGGC -3'
(R):5'- CCTTGTGGGTAGTGAGAAC -3'
Posted On 2015-06-12