Incidental Mutation 'R4233:Coro2b'
ID 320969
Institutional Source Beutler Lab
Gene Symbol Coro2b
Ensembl Gene ENSMUSG00000041729
Gene Name coronin, actin binding protein, 2B
Synonyms E130012P22Rik
MMRRC Submission 041642-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.091) question?
Stock # R4233 (G1)
Quality Score 218
Status Validated
Chromosome 9
Chromosomal Location 62326774-62444326 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 62333467 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Glycine at position 376 (E376G)
Ref Sequence ENSEMBL: ENSMUSP00000041826 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000048043] [ENSMUST00000164246] [ENSMUST00000174439]
AlphaFold Q8BH44
Predicted Effect possibly damaging
Transcript: ENSMUST00000048043
AA Change: E376G

PolyPhen 2 Score 0.690 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000041826
Gene: ENSMUSG00000041729
AA Change: E376G

DomainStartEndE-ValueType
DUF1899 10 74 2.89e-31 SMART
WD40 73 116 8.75e-5 SMART
WD40 126 166 4.95e-4 SMART
WD40 169 208 1.33e-4 SMART
WD40 211 254 2.56e1 SMART
DUF1900 261 397 1.62e-84 SMART
coiled coil region 436 476 N/A INTRINSIC
Predicted Effect unknown
Transcript: ENSMUST00000131981
AA Change: E75G
SMART Domains Protein: ENSMUSP00000133481
Gene: ENSMUSG00000041729
AA Change: E75G

DomainStartEndE-ValueType
DUF1900 3 97 6.37e-42 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000151604
Predicted Effect probably benign
Transcript: ENSMUST00000164246
SMART Domains Protein: ENSMUSP00000128441
Gene: ENSMUSG00000041729

DomainStartEndE-ValueType
DUF1899 5 69 2.89e-31 SMART
WD40 68 111 8.75e-5 SMART
WD40 121 161 4.95e-4 SMART
WD40 164 203 1.33e-4 SMART
WD40 206 249 2.56e1 SMART
DUF1900 256 317 5.33e-12 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000174439
SMART Domains Protein: ENSMUSP00000134079
Gene: ENSMUSG00000041729

DomainStartEndE-ValueType
WD40 1 41 4.95e-4 SMART
WD40 44 83 1.33e-4 SMART
Meta Mutation Damage Score 0.1557 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.8%
  • 10x: 97.6%
  • 20x: 96.2%
Validation Efficiency 100% (53/53)
MGI Phenotype PHENOTYPE: Homozygous knockout reduces susceptibility to Doxorubicin-induced focal segmental glomerulosclerosis with lower levels of proteinuria and less renal glomerulus damage. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700123K08Rik A T 5: 138,562,454 (GRCm39) Y96N probably damaging Het
Abca15 C T 7: 120,002,202 (GRCm39) Q1572* probably null Het
Ajuba T C 14: 54,806,983 (GRCm39) R490G probably damaging Het
Akap6 T A 12: 53,186,454 (GRCm39) N1289K probably damaging Het
Ankfy1 G A 11: 72,605,310 (GRCm39) probably null Het
Aph1c A G 9: 66,740,603 (GRCm39) F41S probably damaging Het
Arhgap21 A G 2: 20,891,948 (GRCm39) V161A probably damaging Het
Arhgef18 T C 8: 3,500,317 (GRCm39) I541T possibly damaging Het
Arhgef40 T C 14: 52,227,628 (GRCm39) V458A possibly damaging Het
Atg14 T C 14: 47,788,802 (GRCm39) K184E probably benign Het
Casp8 T C 1: 58,883,929 (GRCm39) V432A probably damaging Het
Ccar2 T C 14: 70,388,540 (GRCm39) T169A possibly damaging Het
Cfap58 G A 19: 47,963,994 (GRCm39) V541M possibly damaging Het
Dnah11 T C 12: 117,880,526 (GRCm39) T3865A probably damaging Het
Dync2h1 T C 9: 7,134,360 (GRCm39) E1549G probably benign Het
Ercc6l2 T C 13: 64,019,982 (GRCm39) probably benign Het
Fbxo32 G T 15: 58,055,729 (GRCm39) T135K possibly damaging Het
Fhip2b A C 14: 70,824,318 (GRCm39) V473G probably damaging Het
Fras1 A T 5: 96,862,235 (GRCm39) I2205F possibly damaging Het
Gm12034 A G 11: 20,396,785 (GRCm39) noncoding transcript Het
Gm26678 T C 3: 54,540,504 (GRCm39) noncoding transcript Het
Gm5108 C A 5: 68,132,496 (GRCm39) T55K unknown Het
Gpa33 A T 1: 165,974,340 (GRCm39) D59V probably damaging Het
Gpn2 T A 4: 133,312,016 (GRCm39) Y83N probably damaging Het
Gzf1 C T 2: 148,528,453 (GRCm39) P460S possibly damaging Het
Ifi203 A T 1: 173,764,099 (GRCm39) S124R possibly damaging Het
Impg1 A G 9: 80,252,611 (GRCm39) L523P probably damaging Het
Ldlrap1 T A 4: 134,484,649 (GRCm39) probably null Het
Madd T C 2: 91,008,581 (GRCm39) E107G probably benign Het
Med12l T G 3: 59,164,644 (GRCm39) probably null Het
Nxpe4 A T 9: 48,310,137 (GRCm39) T467S probably damaging Het
Or52n4 A G 7: 104,294,195 (GRCm39) V126A probably benign Het
Or7g30 T A 9: 19,352,886 (GRCm39) L226I probably damaging Het
Pam A T 1: 97,792,119 (GRCm39) V434D possibly damaging Het
Plxnd1 T C 6: 115,942,914 (GRCm39) N1257D probably benign Het
Prkdc C T 16: 15,653,783 (GRCm39) A3870V probably benign Het
Ralgapa1 C T 12: 55,687,429 (GRCm39) R2019Q probably damaging Het
Rufy4 T C 1: 74,186,822 (GRCm39) C537R probably damaging Het
Ryr2 T C 13: 11,765,611 (GRCm39) D1375G probably benign Het
Skint11 C A 4: 114,101,856 (GRCm39) Q99K probably benign Het
Slc13a2 A G 11: 78,294,361 (GRCm39) probably benign Het
Slc7a13 T C 4: 19,819,070 (GRCm39) F90S probably damaging Het
Spc24 T C 9: 21,667,498 (GRCm39) probably null Het
Stard13 A G 5: 150,986,164 (GRCm39) S331P probably benign Het
Sult2a8 T A 7: 14,147,608 (GRCm39) I228L probably benign Het
Tas2r140 A T 6: 133,031,915 (GRCm39) V281D probably damaging Het
Tmem38b T C 4: 53,840,710 (GRCm39) C66R probably damaging Het
Tshz1 C A 18: 84,034,320 (GRCm39) E29D probably benign Het
Zfp599 T A 9: 22,161,041 (GRCm39) K375* probably null Het
Other mutations in Coro2b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01772:Coro2b APN 9 62,333,090 (GRCm39) missense probably damaging 0.99
IGL01834:Coro2b APN 9 62,338,639 (GRCm39) missense possibly damaging 0.93
IGL03242:Coro2b APN 9 62,336,243 (GRCm39) nonsense probably null
PIT4151001:Coro2b UTSW 9 62,336,286 (GRCm39) missense probably damaging 1.00
R0422:Coro2b UTSW 9 62,335,259 (GRCm39) missense probably benign 0.00
R0835:Coro2b UTSW 9 62,333,119 (GRCm39) missense possibly damaging 0.68
R0944:Coro2b UTSW 9 62,335,263 (GRCm39) missense probably benign 0.08
R1115:Coro2b UTSW 9 62,338,609 (GRCm39) missense probably damaging 0.96
R1254:Coro2b UTSW 9 62,336,247 (GRCm39) missense probably damaging 0.98
R1422:Coro2b UTSW 9 62,336,229 (GRCm39) critical splice donor site probably null
R1532:Coro2b UTSW 9 62,396,705 (GRCm39) missense probably damaging 1.00
R1543:Coro2b UTSW 9 62,333,123 (GRCm39) missense probably benign 0.32
R3424:Coro2b UTSW 9 62,336,590 (GRCm39) splice site probably null
R3971:Coro2b UTSW 9 62,336,522 (GRCm39) missense possibly damaging 0.55
R3972:Coro2b UTSW 9 62,336,522 (GRCm39) missense possibly damaging 0.55
R4035:Coro2b UTSW 9 62,333,071 (GRCm39) unclassified probably benign
R4734:Coro2b UTSW 9 62,333,860 (GRCm39) missense probably benign 0.02
R4825:Coro2b UTSW 9 62,361,905 (GRCm39) missense probably benign 0.30
R5332:Coro2b UTSW 9 62,336,512 (GRCm39) missense probably damaging 0.97
R5702:Coro2b UTSW 9 62,333,859 (GRCm39) missense probably damaging 0.97
R6474:Coro2b UTSW 9 62,333,910 (GRCm39) missense probably benign 0.16
R6500:Coro2b UTSW 9 62,396,606 (GRCm39) missense probably benign 0.24
R6674:Coro2b UTSW 9 62,339,709 (GRCm39) missense probably damaging 1.00
R7102:Coro2b UTSW 9 62,328,667 (GRCm39) missense possibly damaging 0.81
R7347:Coro2b UTSW 9 62,396,654 (GRCm39) missense probably benign
R8199:Coro2b UTSW 9 62,336,302 (GRCm39) missense probably benign 0.00
R8447:Coro2b UTSW 9 62,333,842 (GRCm39) missense probably damaging 1.00
R8970:Coro2b UTSW 9 62,333,809 (GRCm39) unclassified probably benign
R9023:Coro2b UTSW 9 62,332,978 (GRCm39) missense
R9211:Coro2b UTSW 9 62,427,662 (GRCm39) missense probably benign 0.06
R9325:Coro2b UTSW 9 62,396,609 (GRCm39) missense probably benign
R9443:Coro2b UTSW 9 62,333,080 (GRCm39) missense probably benign 0.21
R9516:Coro2b UTSW 9 62,335,291 (GRCm39) nonsense probably null
R9653:Coro2b UTSW 9 62,335,259 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AGGCTGGGCTATAGAGTGAC -3'
(R):5'- AAAGGGGTCAGTTCTCGAAG -3'

Sequencing Primer
(F):5'- GACATATCACTGTCCCAAGCTTG -3'
(R):5'- TCAGTTCTCGAAGGGAGGC -3'
Posted On 2015-06-12