Mutagenetix > Incidental Mutation

Incidental Mutation 'R4105:Gm2832'

321367

Institutional Source

Beutler Lab

Gene Symbol

Gm2832

Ensembl Gene

ENSMUSG00000091110

Gene Name

predicted gene 2832

Synonyms

MMRRC Submission

040985-MU

Accession Numbers

Essential gene?

Not available question?

Stock #

R4105 (G1)

Quality Score

Status

Not validated

Chromosome

Chromosomal Location

41000762-41010772 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 41002856 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Leucine at position 122 (M122L)

Gene Model

predicted gene model for transcript(s):

AlphaFold

no structure available at present

Predicted Effect

unknown
Transcript: ENSMUST00000172412
AA Change: M122L

SMART Domains

Protein: ENSMUSP00000131087
Gene: ENSMUSG00000091110
AA Change: M122L

Domain	Start	End	E-Value	Type
Pfam:Takusan	57	137	7.3e-26	PFAM
coiled coil region	156	185	N/A	INTRINSIC

Coding Region Coverage

1x: 99.2%
3x: 98.7%
10x: 97.4%
20x: 95.7%

Validation Efficiency

96% (46/48)

Allele List at MGI

Other mutations in this stock

Total: 41 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adar	T	C	3: 89,647,401 (GRCm39)	S127P	probably benign	Het
Arhgap31	A	G	16: 38,422,788 (GRCm39)	S1093P	probably damaging	Het
Asb18	T	C	1: 89,896,243 (GRCm39)	S266G	possibly damaging	Het
Atg9a	A	G	1: 75,162,603 (GRCm39)	Y471H	probably damaging	Het
Atosa	A	G	9: 74,916,058 (GRCm39)	Q226R	probably damaging	Het
Bmper	G	A	9: 23,136,059 (GRCm39)	V47I	probably benign	Het
Cel	T	C	2: 28,448,039 (GRCm39)	D329G	probably benign	Het
Ces2f	T	C	8: 105,677,824 (GRCm39)		probably null	Het
Cyp2j7	T	C	4: 96,087,687 (GRCm39)	T408A	possibly damaging	Het
Dchs1	A	C	7: 105,414,347 (GRCm39)	S823A	probably damaging	Het
Dnajb2	G	T	1: 75,213,543 (GRCm39)	E6*	probably null	Het
Eif2b3	G	A	4: 116,938,831 (GRCm39)	G427R	probably damaging	Het
Eml5	T	C	12: 98,807,807 (GRCm39)		probably null	Het
Fat1	A	G	8: 45,489,888 (GRCm39)	Y3600C	probably damaging	Het
Fbxo10	A	G	4: 45,059,054 (GRCm39)	F228L	probably benign	Het
Fgf7	T	A	2: 125,877,599 (GRCm39)		probably benign	Het
Lrrcc1	T	C	3: 14,615,388 (GRCm39)	V73A	probably benign	Het
Mrc2	G	A	11: 105,239,257 (GRCm39)		probably null	Het
Naip5	T	C	13: 100,356,247 (GRCm39)	R1123G	probably benign	Het
Nfya	G	T	17: 48,699,912 (GRCm39)	Y37*	probably null	Het
Or2o1	A	G	11: 49,051,375 (GRCm39)	H178R	possibly damaging	Het
Pikfyve	A	G	1: 65,229,679 (GRCm39)		probably benign	Het
Pnma8a	T	C	7: 16,695,104 (GRCm39)	S320P	possibly damaging	Het
Polr1a	A	G	6: 71,953,175 (GRCm39)	N1581S	probably damaging	Het
Polrmt	G	T	10: 79,577,567 (GRCm39)	T344K	probably benign	Het
Postn	T	C	3: 54,283,462 (GRCm39)	F514L	probably damaging	Het
Ptprq	G	T	10: 107,408,828 (GRCm39)	T1895N	probably damaging	Het
Slc15a2	G	T	16: 36,602,755 (GRCm39)		probably benign	Het
Slco2a1	T	A	9: 102,945,075 (GRCm39)	L150Q	probably benign	Het
Slco2a1	T	C	9: 102,950,449 (GRCm39)	F347S	probably damaging	Het
Smim13	T	A	13: 41,426,127 (GRCm39)	D54E	probably benign	Het
Snrnp200	T	A	2: 127,069,936 (GRCm39)	I1027N	probably damaging	Het
Sult6b1	G	T	17: 79,214,291 (GRCm39)	T6N	probably damaging	Het
Tas1r2	G	A	4: 139,387,363 (GRCm39)	R245H	probably benign	Het
Tpo	G	A	12: 30,142,585 (GRCm39)	P713L	probably damaging	Het
Trank1	T	C	9: 111,181,265 (GRCm39)	I429T	probably damaging	Het
Trip11	G	A	12: 101,860,581 (GRCm39)	R254*	probably null	Het
Vmn2r65	A	G	7: 84,595,691 (GRCm39)	V331A	probably benign	Het
Ypel3	T	C	7: 126,377,265 (GRCm39)	S82P	probably damaging	Het
Zfp128	T	C	7: 12,618,667 (GRCm39)	L55P	probably damaging	Het
Zscan4e	T	C	7: 11,041,437 (GRCm39)	D173G	probably benign	Het

Other mutations in Gm2832

Allele	Source	Chr	Coord	Type	Predicted Effect
IGL01528:Gm2832	APN	14	41,003,670 (GRCm39)	missense	unknown
R1997:Gm2832	UTSW	14	41,002,943 (GRCm39)	critical splice donor site	probably null
R7024:Gm2832	UTSW	14	41,001,696 (GRCm39)	missense
R7526:Gm2832	UTSW	14	41,002,919 (GRCm39)	missense
R8124:Gm2832	UTSW	14	41,000,894 (GRCm39)	missense
R8187:Gm2832	UTSW	14	41,000,915 (GRCm39)	missense
R8793:Gm2832	UTSW	14	41,003,726 (GRCm39)	missense
R9460:Gm2832	UTSW	14	41,000,843 (GRCm39)	missense

Predicted Primers

PCR Primer
(F):5'- CATTTGGTCCCCTGGATCTG -3'
(R):5'- AGAACTAGAGCTCTCACTTTTGTTC -3'

Sequencing Primer
(F):5'- TCTGCCCAAGATATTTAATCAGCAC -3'
(R):5'- GTTCAAAGTCTTAGAAGGTCACAAGC -3'

Posted On

2015-06-12