Incidental Mutation 'R4105:Sult6b1'
ID 321371
Institutional Source Beutler Lab
Gene Symbol Sult6b1
Ensembl Gene ENSMUSG00000038045
Gene Name sulfotransferase family, cytosolic, 6B, member 1
Synonyms 2410078J06Rik
MMRRC Submission 040985-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.069) question?
Stock # R4105 (G1)
Quality Score 225
Status Validated
Chromosome 17
Chromosomal Location 79192314-79214421 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 79214291 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Asparagine at position 6 (T6N)
Ref Sequence ENSEMBL: ENSMUSP00000124309 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000042683] [ENSMUST00000159710] [ENSMUST00000169544]
AlphaFold P0CC03
Predicted Effect probably benign
Transcript: ENSMUST00000042683
AA Change: T6N

PolyPhen 2 Score 0.061 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000038282
Gene: ENSMUSG00000038045
AA Change: T6N

DomainStartEndE-ValueType
Pfam:Sulfotransfer_1 17 252 2.6e-57 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000159710
AA Change: T6N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect possibly damaging
Transcript: ENSMUST00000169544
AA Change: T44N

PolyPhen 2 Score 0.602 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000132823
Gene: ENSMUSG00000038045
AA Change: T44N

DomainStartEndE-ValueType
Pfam:Sulfotransfer_1 55 290 2.1e-57 PFAM
Meta Mutation Damage Score 0.1028 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.4%
  • 20x: 95.7%
Validation Efficiency 96% (46/48)
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adar T C 3: 89,647,401 (GRCm39) S127P probably benign Het
Arhgap31 A G 16: 38,422,788 (GRCm39) S1093P probably damaging Het
Asb18 T C 1: 89,896,243 (GRCm39) S266G possibly damaging Het
Atg9a A G 1: 75,162,603 (GRCm39) Y471H probably damaging Het
Atosa A G 9: 74,916,058 (GRCm39) Q226R probably damaging Het
Bmper G A 9: 23,136,059 (GRCm39) V47I probably benign Het
Cel T C 2: 28,448,039 (GRCm39) D329G probably benign Het
Ces2f T C 8: 105,677,824 (GRCm39) probably null Het
Cyp2j7 T C 4: 96,087,687 (GRCm39) T408A possibly damaging Het
Dchs1 A C 7: 105,414,347 (GRCm39) S823A probably damaging Het
Dnajb2 G T 1: 75,213,543 (GRCm39) E6* probably null Het
Eif2b3 G A 4: 116,938,831 (GRCm39) G427R probably damaging Het
Eml5 T C 12: 98,807,807 (GRCm39) probably null Het
Fat1 A G 8: 45,489,888 (GRCm39) Y3600C probably damaging Het
Fbxo10 A G 4: 45,059,054 (GRCm39) F228L probably benign Het
Fgf7 T A 2: 125,877,599 (GRCm39) probably benign Het
Gm2832 A T 14: 41,002,856 (GRCm39) M122L unknown Het
Lrrcc1 T C 3: 14,615,388 (GRCm39) V73A probably benign Het
Mrc2 G A 11: 105,239,257 (GRCm39) probably null Het
Naip5 T C 13: 100,356,247 (GRCm39) R1123G probably benign Het
Nfya G T 17: 48,699,912 (GRCm39) Y37* probably null Het
Or2o1 A G 11: 49,051,375 (GRCm39) H178R possibly damaging Het
Pikfyve A G 1: 65,229,679 (GRCm39) probably benign Het
Pnma8a T C 7: 16,695,104 (GRCm39) S320P possibly damaging Het
Polr1a A G 6: 71,953,175 (GRCm39) N1581S probably damaging Het
Polrmt G T 10: 79,577,567 (GRCm39) T344K probably benign Het
Postn T C 3: 54,283,462 (GRCm39) F514L probably damaging Het
Ptprq G T 10: 107,408,828 (GRCm39) T1895N probably damaging Het
Slc15a2 G T 16: 36,602,755 (GRCm39) probably benign Het
Slco2a1 T A 9: 102,945,075 (GRCm39) L150Q probably benign Het
Slco2a1 T C 9: 102,950,449 (GRCm39) F347S probably damaging Het
Smim13 T A 13: 41,426,127 (GRCm39) D54E probably benign Het
Snrnp200 T A 2: 127,069,936 (GRCm39) I1027N probably damaging Het
Tas1r2 G A 4: 139,387,363 (GRCm39) R245H probably benign Het
Tpo G A 12: 30,142,585 (GRCm39) P713L probably damaging Het
Trank1 T C 9: 111,181,265 (GRCm39) I429T probably damaging Het
Trip11 G A 12: 101,860,581 (GRCm39) R254* probably null Het
Vmn2r65 A G 7: 84,595,691 (GRCm39) V331A probably benign Het
Ypel3 T C 7: 126,377,265 (GRCm39) S82P probably damaging Het
Zfp128 T C 7: 12,618,667 (GRCm39) L55P probably damaging Het
Zscan4e T C 7: 11,041,437 (GRCm39) D173G probably benign Het
Other mutations in Sult6b1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01479:Sult6b1 APN 17 79,213,005 (GRCm39) missense probably benign 0.00
IGL02065:Sult6b1 APN 17 79,196,504 (GRCm39) missense probably damaging 0.99
R0522:Sult6b1 UTSW 17 79,212,958 (GRCm39) missense probably damaging 0.97
R1911:Sult6b1 UTSW 17 79,196,393 (GRCm39) missense possibly damaging 0.81
R3546:Sult6b1 UTSW 17 79,214,336 (GRCm39) missense probably benign 0.00
R4107:Sult6b1 UTSW 17 79,214,291 (GRCm39) missense probably damaging 1.00
R4108:Sult6b1 UTSW 17 79,214,291 (GRCm39) missense probably damaging 1.00
R5063:Sult6b1 UTSW 17 79,213,005 (GRCm39) missense probably benign 0.00
R5478:Sult6b1 UTSW 17 79,202,101 (GRCm39) splice site probably null
R5845:Sult6b1 UTSW 17 79,202,059 (GRCm39) missense probably damaging 1.00
R6256:Sult6b1 UTSW 17 79,214,343 (GRCm39) missense probably benign 0.05
R6374:Sult6b1 UTSW 17 79,214,360 (GRCm39) missense probably benign 0.04
R7128:Sult6b1 UTSW 17 79,202,070 (GRCm39) missense probably damaging 1.00
R7357:Sult6b1 UTSW 17 79,202,059 (GRCm39) missense probably damaging 1.00
R7903:Sult6b1 UTSW 17 79,198,279 (GRCm39) missense probably benign 0.31
Predicted Primers PCR Primer
(F):5'- TTGACTTTGTAACGCATGCACTC -3'
(R):5'- AATAGTCACTCCACCTGGGTG -3'

Sequencing Primer
(F):5'- GTAACGCATGCACTCTCCTG -3'
(R):5'- TGACACAGAGTGGACACATTATC -3'
Posted On 2015-06-12