Incidental Mutation 'R4106:Cyp2j7'
ID 321383
Institutional Source Beutler Lab
Gene Symbol Cyp2j7
Ensembl Gene ENSMUSG00000081362
Gene Name cytochrome P450, family 2, subfamily j, polypeptide 7
Synonyms OTTMUSG00000007941, Cyp2j7-ps
Accession Numbers
Essential gene? Probably non essential (E-score: 0.063) question?
Stock # R4106 (G1)
Quality Score 225
Status Not validated
Chromosome 4
Chromosomal Location 96083434-96124896 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 96087687 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 408 (T408A)
Ref Sequence ENSEMBL: ENSMUSP00000134331 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000162514]
AlphaFold A0A140T8U1
Predicted Effect possibly damaging
Transcript: ENSMUST00000162514
AA Change: T408A

PolyPhen 2 Score 0.840 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000134331
Gene: ENSMUSG00000081362
AA Change: T408A

DomainStartEndE-ValueType
transmembrane domain 10 32 N/A INTRINSIC
Pfam:p450 44 499 3.7e-130 PFAM
Meta Mutation Damage Score 0.4002 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.4%
  • 20x: 95.7%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 29 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acad10 G T 5: 121,769,527 (GRCm39) S643Y probably damaging Het
Acox3 T C 5: 35,758,896 (GRCm39) F369S probably damaging Het
Cacna1a A G 8: 85,310,324 (GRCm39) I1461V possibly damaging Het
Cdc42bpb A C 12: 111,261,579 (GRCm39) V107G probably benign Het
Cdhr4 A G 9: 107,873,459 (GRCm39) D397G probably damaging Het
Chd1l T C 3: 97,505,019 (GRCm39) T183A probably benign Het
Cnbd2 T C 2: 156,177,318 (GRCm39) V92A probably damaging Het
Col1a2 G A 6: 4,518,822 (GRCm39) probably benign Het
H2-T24 A G 17: 36,328,370 (GRCm39) S38P possibly damaging Het
Mapkapk3 A G 9: 107,134,265 (GRCm39) V333A probably damaging Het
Muc5ac T G 7: 141,356,572 (GRCm39) V1053G possibly damaging Het
Myh1 T C 11: 67,102,403 (GRCm39) V898A probably benign Het
Nnt T C 13: 119,533,327 (GRCm39) I113V probably benign Het
Obscn T C 11: 59,022,472 (GRCm39) R758G possibly damaging Het
Or5d38 A T 2: 87,954,817 (GRCm39) C171S possibly damaging Het
Rpl10a T A 17: 28,549,933 (GRCm39) Y205N probably benign Het
Ryr3 C G 2: 112,506,218 (GRCm39) R3443P probably damaging Het
Scn3a A G 2: 65,325,379 (GRCm39) I1046T probably benign Het
Sertad4 AGAGGAGGAGGAGGAGGAGGAGGA AGAGGAGGAGGAGGAGGAGGA 1: 192,529,050 (GRCm39) probably benign Het
Sipa1l2 T C 8: 126,219,047 (GRCm39) K97E probably damaging Het
Slc19a3 A T 1: 83,000,678 (GRCm39) F113Y probably damaging Het
Slc22a6 A G 19: 8,595,874 (GRCm39) Q72R probably benign Het
St8sia2 A C 7: 73,610,509 (GRCm39) L258R probably damaging Het
Tas1r2 G A 4: 139,387,363 (GRCm39) R245H probably benign Het
Tcerg1l A G 7: 137,861,673 (GRCm39) V352A probably damaging Het
Tpo G A 12: 30,142,585 (GRCm39) P713L probably damaging Het
Tpp2 T C 1: 44,040,617 (GRCm39) Y293H possibly damaging Het
Ttn G C 2: 76,581,215 (GRCm39) A23226G probably damaging Het
Ttn C T 2: 76,608,809 (GRCm39) V15990I probably benign Het
Other mutations in Cyp2j7
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00426:Cyp2j7 APN 4 96,115,750 (GRCm39) splice site probably null
IGL00426:Cyp2j7 APN 4 96,115,749 (GRCm39) splice site probably benign
IGL01505:Cyp2j7 APN 4 96,115,917 (GRCm39) critical splice acceptor site probably null
IGL02100:Cyp2j7 APN 4 96,124,793 (GRCm39) missense probably damaging 0.99
IGL02183:Cyp2j7 APN 4 96,118,384 (GRCm39) splice site probably benign
IGL02596:Cyp2j7 APN 4 96,103,659 (GRCm39) missense possibly damaging 0.56
IGL02661:Cyp2j7 APN 4 96,124,887 (GRCm39) missense probably benign
IGL02723:Cyp2j7 APN 4 96,118,366 (GRCm39) missense probably benign 0.33
IGL03053:Cyp2j7 APN 4 96,118,274 (GRCm39) missense probably benign 0.00
IGL03159:Cyp2j7 APN 4 96,115,749 (GRCm39) splice site probably benign
IGL03168:Cyp2j7 APN 4 96,118,274 (GRCm39) missense probably benign 0.00
IGL03174:Cyp2j7 APN 4 96,083,607 (GRCm39) nonsense probably null
PIT4449001:Cyp2j7 UTSW 4 96,103,575 (GRCm39) missense probably damaging 0.96
R0016:Cyp2j7 UTSW 4 96,090,384 (GRCm39) missense probably damaging 0.99
R0016:Cyp2j7 UTSW 4 96,090,384 (GRCm39) missense probably damaging 0.99
R0392:Cyp2j7 UTSW 4 96,087,671 (GRCm39) missense probably damaging 1.00
R1447:Cyp2j7 UTSW 4 96,083,530 (GRCm39) missense possibly damaging 0.90
R1778:Cyp2j7 UTSW 4 96,087,627 (GRCm39) missense probably damaging 1.00
R1876:Cyp2j7 UTSW 4 96,105,656 (GRCm39) missense probably benign 0.01
R4105:Cyp2j7 UTSW 4 96,087,687 (GRCm39) missense possibly damaging 0.84
R4107:Cyp2j7 UTSW 4 96,087,687 (GRCm39) missense possibly damaging 0.84
R4108:Cyp2j7 UTSW 4 96,087,687 (GRCm39) missense possibly damaging 0.84
R4438:Cyp2j7 UTSW 4 96,105,646 (GRCm39) missense probably benign 0.01
R4660:Cyp2j7 UTSW 4 96,083,579 (GRCm39) missense probably benign 0.29
R6193:Cyp2j7 UTSW 4 96,083,440 (GRCm39) missense probably damaging 1.00
R6380:Cyp2j7 UTSW 4 96,118,211 (GRCm39) critical splice donor site probably null
R6427:Cyp2j7 UTSW 4 96,115,904 (GRCm39) missense probably damaging 0.96
R6624:Cyp2j7 UTSW 4 96,115,855 (GRCm39) missense probably damaging 0.99
R7196:Cyp2j7 UTSW 4 96,103,651 (GRCm39) missense probably benign 0.03
R7417:Cyp2j7 UTSW 4 96,090,225 (GRCm39) critical splice donor site probably null
R7780:Cyp2j7 UTSW 4 96,118,256 (GRCm39) missense probably benign 0.00
R8062:Cyp2j7 UTSW 4 96,103,587 (GRCm39) missense probably null 1.00
R8097:Cyp2j7 UTSW 4 96,103,647 (GRCm39) missense possibly damaging 0.95
R8201:Cyp2j7 UTSW 4 96,083,564 (GRCm39) missense probably damaging 1.00
R8279:Cyp2j7 UTSW 4 96,116,796 (GRCm39) critical splice donor site probably null
R9254:Cyp2j7 UTSW 4 96,105,740 (GRCm39) nonsense probably null
R9328:Cyp2j7 UTSW 4 96,115,869 (GRCm39) missense probably damaging 1.00
R9377:Cyp2j7 UTSW 4 96,124,786 (GRCm39) missense probably benign 0.01
R9489:Cyp2j7 UTSW 4 96,103,591 (GRCm39) missense probably damaging 1.00
R9499:Cyp2j7 UTSW 4 96,115,840 (GRCm39) missense probably damaging 1.00
R9552:Cyp2j7 UTSW 4 96,115,840 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ATGCACAGGGTGGAACTATATG -3'
(R):5'- AATGTCCCTGAAATGCGCTAAG -3'

Sequencing Primer
(F):5'- CCAAATTAGAGTAAAGGTCTCTAGGC -3'
(R):5'- GCAAACACTGTCCATCAATGATCTG -3'
Posted On 2015-06-12