Incidental Mutation 'IGL00502:Pdcd1lg2'
ID 3214
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Pdcd1lg2
Ensembl Gene ENSMUSG00000016498
Gene Name programmed cell death 1 ligand 2
Synonyms B7-DC, PD-L2, F730015O22Rik, Btdc
Accession Numbers
Essential gene? Probably non essential (E-score: 0.048) question?
Stock # IGL00502
Quality Score
Status
Chromosome 19
Chromosomal Location 29388319-29448561 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 29423462 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Serine at position 169 (T169S)
Ref Sequence ENSEMBL: ENSMUSP00000108195 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000112576]
AlphaFold Q9WUL5
PDB Structure Crystal structure of the receptor binding domain of mouse PD-L2 [X-RAY DIFFRACTION]
Crystal structure of the mouse PD-1 and PD-L2 complex [X-RAY DIFFRACTION]
Crystal structure of the mouse PD-1 Mutant and PD-L2 complex [X-RAY DIFFRACTION]
Crystal structure of the complex between mouse PD-1 mutant and PD-L2 IgV domain [X-RAY DIFFRACTION]
Crystal structure of the complex between the extracellular domains of mouse PD-1 mutant and PD-L2 [X-RAY DIFFRACTION]
Predicted Effect possibly damaging
Transcript: ENSMUST00000112576
AA Change: T169S

PolyPhen 2 Score 0.956 (Sensitivity: 0.79; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000108195
Gene: ENSMUSG00000016498
AA Change: T169S

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
IG 27 120 4.43e-5 SMART
Pfam:Ig_3 125 196 5.3e-6 PFAM
Pfam:C2-set_2 126 202 6.6e-7 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for disruptions in this gene have dendritic cells that display a diminished ability to activate CD4+ T cells. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts20 A T 15: 94,301,278 (GRCm39) I82N probably damaging Het
Ampd2 A T 3: 107,984,712 (GRCm39) L422H probably damaging Het
Angptl2 T A 2: 33,118,406 (GRCm39) V60E probably damaging Het
Ano3 G A 2: 110,601,395 (GRCm39) probably benign Het
Arhgap40 A G 2: 158,373,078 (GRCm39) D112G probably benign Het
Bcorl1 T G X: 47,494,919 (GRCm39) V1730G probably damaging Het
Btrc A T 19: 45,515,704 (GRCm39) E553V probably damaging Het
Cacna1b A T 2: 24,541,212 (GRCm39) Y1323* probably null Het
Ccdc146 A G 5: 21,506,420 (GRCm39) C674R possibly damaging Het
Ccdc170 A G 10: 4,496,836 (GRCm39) D458G probably damaging Het
Cfap57 T A 4: 118,438,198 (GRCm39) M898L probably benign Het
Crybg1 C T 10: 43,834,309 (GRCm39) V1961I probably damaging Het
Dsp T C 13: 38,381,822 (GRCm39) S2257P probably damaging Het
Dytn A G 1: 63,717,999 (GRCm39) V12A probably benign Het
Foxk2 A G 11: 121,187,925 (GRCm39) probably benign Het
Galnt2l T C 8: 125,054,837 (GRCm39) M204T probably damaging Het
Gfi1b G A 2: 28,504,797 (GRCm39) Q70* probably null Het
Gsdmc T C 15: 63,676,270 (GRCm39) T58A probably benign Het
Hikeshi G A 7: 89,572,818 (GRCm39) T26I probably benign Het
Mpdz T C 4: 81,287,960 (GRCm39) D433G probably damaging Het
Ndufb5 T A 3: 32,799,048 (GRCm39) V55D probably damaging Het
Nostrin T C 2: 69,014,336 (GRCm39) S431P probably benign Het
Plekha7 A T 7: 115,734,419 (GRCm39) M1006K probably damaging Het
Rgs6 A T 12: 83,098,097 (GRCm39) I94F probably benign Het
Rims2 A T 15: 39,370,380 (GRCm39) D938V probably damaging Het
Slc4a8 A G 15: 100,705,319 (GRCm39) T842A possibly damaging Het
Spata21 C A 4: 140,838,675 (GRCm39) probably null Het
Stk32a C T 18: 43,443,510 (GRCm39) T229I possibly damaging Het
Tent4b C T 8: 88,978,886 (GRCm39) Q63* probably null Het
Trim33 C T 3: 103,237,498 (GRCm39) P185S probably benign Het
Tspoap1 A G 11: 87,668,647 (GRCm39) probably null Het
Vcan A G 13: 89,840,438 (GRCm39) V742A probably benign Het
Vrtn A T 12: 84,695,837 (GRCm39) I196F probably benign Het
Wasf1 A T 10: 40,796,293 (GRCm39) I8F probably damaging Het
Ythdc2 A G 18: 44,980,879 (GRCm39) I491M probably damaging Het
Zfp292 T C 4: 34,809,775 (GRCm39) T1095A possibly damaging Het
Other mutations in Pdcd1lg2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02176:Pdcd1lg2 APN 19 29,414,732 (GRCm39) missense probably benign 0.00
IGL03184:Pdcd1lg2 APN 19 29,431,911 (GRCm39) missense probably benign 0.00
R4992:Pdcd1lg2 UTSW 19 29,423,484 (GRCm39) missense probably damaging 1.00
R5991:Pdcd1lg2 UTSW 19 29,431,867 (GRCm39) missense probably benign
R6006:Pdcd1lg2 UTSW 19 29,431,905 (GRCm39) missense possibly damaging 0.58
R6035:Pdcd1lg2 UTSW 19 29,423,435 (GRCm39) missense probably benign 0.08
R6035:Pdcd1lg2 UTSW 19 29,423,435 (GRCm39) missense probably benign 0.08
R6393:Pdcd1lg2 UTSW 19 29,414,698 (GRCm39) missense probably damaging 1.00
R8884:Pdcd1lg2 UTSW 19 29,423,318 (GRCm39) critical splice acceptor site probably null
R8943:Pdcd1lg2 UTSW 19 29,423,553 (GRCm39) missense probably benign 0.01
Posted On 2012-04-20