Incidental Mutation 'R4108:Leprotl1'
ID 321475
Institutional Source Beutler Lab
Gene Symbol Leprotl1
Ensembl Gene ENSMUSG00000031513
Gene Name leptin receptor overlapping transcript-like 1
Synonyms 1110067H13Rik, 1520402O14Rik
MMRRC Submission 040987-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R4108 (G1)
Quality Score 225
Status Validated
Chromosome 8
Chromosomal Location 34602726-34613893 bp(-) (GRCm39)
Type of Mutation critical splice donor site (2 bp from exon)
DNA Base Change (assembly) A to G at 34607913 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000033910 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000033910]
AlphaFold Q9CQ74
Predicted Effect probably null
Transcript: ENSMUST00000033910
SMART Domains Protein: ENSMUSP00000033910
Gene: ENSMUSG00000031513

DomainStartEndE-ValueType
Pfam:Vps55 7 124 1.7e-42 PFAM
Meta Mutation Damage Score 0.9497 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.4%
  • 20x: 95.7%
Validation Efficiency 97% (65/67)
Allele List at MGI
Other mutations in this stock
Total: 60 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700113H08Rik A G 10: 87,061,796 (GRCm39) Y82C probably damaging Het
4930579F01Rik T C 3: 137,889,431 (GRCm39) N62S probably benign Het
Acad10 G T 5: 121,769,527 (GRCm39) S643Y probably damaging Het
Acox3 T C 5: 35,758,896 (GRCm39) F369S probably damaging Het
Arhgap31 A G 16: 38,422,788 (GRCm39) S1093P probably damaging Het
Atp4b A G 8: 13,446,640 (GRCm39) probably null Het
Bmper G A 9: 23,136,059 (GRCm39) V47I probably benign Het
Caskin1 C A 17: 24,721,121 (GRCm39) T487K probably benign Het
Ccr7 C T 11: 99,036,204 (GRCm39) M239I probably damaging Het
Cdh23 C A 10: 60,246,601 (GRCm39) V944L possibly damaging Het
Cenpf A G 1: 189,416,065 (GRCm39) S87P probably damaging Het
Chd9 A T 8: 91,737,304 (GRCm39) D1461V probably benign Het
Col1a2 G A 6: 4,518,822 (GRCm39) probably benign Het
Cyb5r2 A T 7: 107,353,136 (GRCm39) M102K probably damaging Het
Cyp2j7 T C 4: 96,087,687 (GRCm39) T408A possibly damaging Het
Dnajb2 G T 1: 75,213,543 (GRCm39) E6* probably null Het
Dtx4 G A 19: 12,478,487 (GRCm39) A32V probably damaging Het
Eml5 T C 12: 98,807,807 (GRCm39) probably null Het
Eml6 A C 11: 29,755,136 (GRCm39) S880A probably damaging Het
Fsd2 C T 7: 81,194,715 (GRCm39) V483I probably benign Het
Inf2 T C 12: 112,574,015 (GRCm39) L773P unknown Het
Kif26b A G 1: 178,744,530 (GRCm39) Q1095R possibly damaging Het
Lrp1b A G 2: 40,555,099 (GRCm39) V340A unknown Het
Myh1 T C 11: 67,102,403 (GRCm39) V898A probably benign Het
Ncstn G T 1: 171,900,111 (GRCm39) N254K probably damaging Het
Nfatc1 T A 18: 80,741,583 (GRCm39) H139L possibly damaging Het
Nfe2l1 C T 11: 96,710,220 (GRCm39) probably null Het
Nfya G T 17: 48,699,912 (GRCm39) Y37* probably null Het
Obscn T C 11: 59,022,472 (GRCm39) R758G possibly damaging Het
Or2b6 A G 13: 21,822,952 (GRCm39) V247A probably damaging Het
Or7g26 T A 9: 19,230,608 (GRCm39) Y265* probably null Het
Otogl C T 10: 107,607,105 (GRCm39) V2093I probably benign Het
Phc2 A G 4: 128,601,776 (GRCm39) Y77C probably damaging Het
Pik3c2g C A 6: 139,676,096 (GRCm39) A80E probably benign Het
Plxnd1 G T 6: 115,936,276 (GRCm39) H1675N probably damaging Het
Pou4f3 A G 18: 42,528,987 (GRCm39) K310R probably damaging Het
Ppp1r12c T C 7: 4,489,565 (GRCm39) D199G probably damaging Het
Prss22 A G 17: 24,212,847 (GRCm39) Y297H probably benign Het
Psmb7 T A 2: 38,532,211 (GRCm39) H78L probably damaging Het
Rad51ap2 T C 12: 11,508,396 (GRCm39) C773R probably damaging Het
Rpl12 A T 2: 32,851,836 (GRCm39) N8Y probably damaging Het
Ryr3 C G 2: 112,506,218 (GRCm39) R3443P probably damaging Het
Sbf1 T C 15: 89,172,788 (GRCm39) probably benign Het
Scn3a A G 2: 65,325,379 (GRCm39) I1046T probably benign Het
Setd1a G A 7: 127,398,374 (GRCm39) probably benign Het
Slc15a2 G T 16: 36,602,755 (GRCm39) probably benign Het
Slc34a2 G A 5: 53,221,351 (GRCm39) V266I possibly damaging Het
Smtn G A 11: 3,476,449 (GRCm39) T144I probably benign Het
Spta1 A G 1: 174,002,122 (GRCm39) N84S probably benign Het
Sult6b1 G T 17: 79,214,291 (GRCm39) T6N probably damaging Het
Supt16 T C 14: 52,400,188 (GRCm39) E985G probably damaging Het
Tbcd T A 11: 121,384,637 (GRCm39) H39Q probably benign Het
Tpo G A 12: 30,142,585 (GRCm39) P713L probably damaging Het
Tsg101 T A 7: 46,542,242 (GRCm39) D99V probably damaging Het
Ttn G C 2: 76,581,215 (GRCm39) A23226G probably damaging Het
Ttn C T 2: 76,608,809 (GRCm39) V15990I probably benign Het
Ubald1 C A 16: 4,693,731 (GRCm39) M61I probably benign Het
Ush1c C T 7: 45,847,869 (GRCm39) D465N probably damaging Het
Vmn2r129 G T 4: 156,686,692 (GRCm39) noncoding transcript Het
Vps54 A G 11: 21,262,877 (GRCm39) I655V probably benign Het
Other mutations in Leprotl1
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0893:Leprotl1 UTSW 8 34,606,006 (GRCm39) critical splice donor site probably null
R0963:Leprotl1 UTSW 8 34,606,189 (GRCm39) missense probably damaging 1.00
R1679:Leprotl1 UTSW 8 34,607,986 (GRCm39) missense probably damaging 1.00
R1830:Leprotl1 UTSW 8 34,607,922 (GRCm39) missense probably benign
R7294:Leprotl1 UTSW 8 34,606,006 (GRCm39) critical splice donor site probably null
R9116:Leprotl1 UTSW 8 34,604,967 (GRCm39) missense probably benign 0.25
Predicted Primers PCR Primer
(F):5'- CCACCAGCTCATTGCAGAAG -3'
(R):5'- TCTCACTTGTGGGATTCCAGG -3'

Sequencing Primer
(F):5'- GGCACAAAAAGCTCTCTGCCTG -3'
(R):5'- ATTCCAGGTCCCGCTCAGAC -3'
Posted On 2015-06-12