Incidental Mutation 'R4255:Ankrd7'
ID 321779
Institutional Source Beutler Lab
Gene Symbol Ankrd7
Ensembl Gene ENSMUSG00000029517
Gene Name ankyrin repeat domain 7
Synonyms 4930532L20Rik
MMRRC Submission 041068-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R4255 (G1)
Quality Score 225
Status Validated
Chromosome 6
Chromosomal Location 18866317-18879585 bp(+) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) T to A at 18869880 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000111054 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000031489] [ENSMUST00000031489] [ENSMUST00000115396] [ENSMUST00000115396]
AlphaFold Q9D504
Predicted Effect probably null
Transcript: ENSMUST00000031489
SMART Domains Protein: ENSMUSP00000031489
Gene: ENSMUSG00000029517

DomainStartEndE-ValueType
low complexity region 46 55 N/A INTRINSIC
ANK 80 109 1.06e-4 SMART
ANK 113 142 5.45e-2 SMART
ANK 146 175 6.92e-4 SMART
ANK 179 208 1.94e-7 SMART
ANK 212 241 1.99e2 SMART
Predicted Effect probably null
Transcript: ENSMUST00000031489
SMART Domains Protein: ENSMUSP00000031489
Gene: ENSMUSG00000029517

DomainStartEndE-ValueType
low complexity region 46 55 N/A INTRINSIC
ANK 80 109 1.06e-4 SMART
ANK 113 142 5.45e-2 SMART
ANK 146 175 6.92e-4 SMART
ANK 179 208 1.94e-7 SMART
ANK 212 241 1.99e2 SMART
Predicted Effect probably null
Transcript: ENSMUST00000115396
SMART Domains Protein: ENSMUSP00000111054
Gene: ENSMUSG00000029517

DomainStartEndE-ValueType
low complexity region 46 55 N/A INTRINSIC
ANK 80 109 1.06e-4 SMART
ANK 113 143 3.07e2 SMART
ANK 147 176 6.92e-4 SMART
ANK 180 209 1.94e-7 SMART
ANK 213 242 1.99e2 SMART
Predicted Effect probably null
Transcript: ENSMUST00000115396
SMART Domains Protein: ENSMUSP00000111054
Gene: ENSMUSG00000029517

DomainStartEndE-ValueType
low complexity region 46 55 N/A INTRINSIC
ANK 80 109 1.06e-4 SMART
ANK 113 143 3.07e2 SMART
ANK 147 176 6.92e-4 SMART
ANK 180 209 1.94e-7 SMART
ANK 213 242 1.99e2 SMART
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.4%
  • 20x: 95.5%
Validation Efficiency 93% (50/54)
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb11 T C 2: 69,136,949 (GRCm39) I171V probably benign Het
Actc1 T C 2: 113,879,697 (GRCm39) N254S probably benign Het
Adgrg1 T G 8: 95,732,530 (GRCm39) probably null Het
Baz2b T C 2: 59,750,916 (GRCm39) probably benign Het
Brca2 A G 5: 150,464,634 (GRCm39) E1466G possibly damaging Het
Dagla G A 19: 10,234,316 (GRCm39) R332* probably null Het
Dnah5 T A 15: 28,438,248 (GRCm39) S3960T probably benign Het
Dnhd1 T A 7: 105,362,205 (GRCm39) L3689M probably damaging Het
Epn1 T A 7: 5,100,637 (GRCm39) L530Q probably damaging Het
Fgf17 C A 14: 70,879,162 (GRCm39) probably null Het
Fgfr4 G A 13: 55,314,064 (GRCm39) V593M probably damaging Het
Fmo4 A G 1: 162,621,895 (GRCm39) C439R probably benign Het
Fndc3b T C 3: 27,555,556 (GRCm39) K333E possibly damaging Het
Gpc6 A G 14: 118,188,553 (GRCm39) T396A probably benign Het
Igkv3-2 T A 6: 70,676,045 (GRCm39) V118D probably benign Het
Mtbp C A 15: 55,484,081 (GRCm39) S470R possibly damaging Het
Myh8 A G 11: 67,190,560 (GRCm39) D1295G probably benign Het
Myo1h T C 5: 114,468,198 (GRCm39) I331T possibly damaging Het
Myo7a T G 7: 97,721,171 (GRCm39) M1265L probably damaging Het
Or13a18 C A 7: 140,190,500 (GRCm39) Y132* probably null Het
Or2ak7 A T 11: 58,574,791 (GRCm39) I31F probably damaging Het
Or2o1 G A 11: 49,051,262 (GRCm39) W140* probably null Het
Pak1ip1 A G 13: 41,164,632 (GRCm39) probably benign Het
Pcdha11 A G 18: 37,145,843 (GRCm39) T645A probably benign Het
Peg12 A G 7: 62,113,479 (GRCm39) I206T possibly damaging Het
Pkhd1 A G 1: 20,664,158 (GRCm39) V140A probably damaging Het
Pramel29 T A 4: 143,934,054 (GRCm39) D351V possibly damaging Het
Prrc2c C A 1: 162,533,895 (GRCm39) probably benign Het
Ptprk A G 10: 28,082,241 (GRCm39) E70G probably benign Het
Rabl6 C T 2: 25,474,791 (GRCm39) E640K possibly damaging Het
Rasd2 G A 8: 75,948,538 (GRCm39) E155K probably damaging Het
Rufy4 T C 1: 74,186,822 (GRCm39) C537R probably damaging Het
Sdf4 A G 4: 156,085,214 (GRCm39) H183R probably benign Het
Slc12a9 C T 5: 137,319,694 (GRCm39) R607H probably damaging Het
Slc38a1 T C 15: 96,483,431 (GRCm39) D299G probably benign Het
Slc4a10 A G 2: 62,112,280 (GRCm39) N657S probably benign Het
Spata31d1c C G 13: 65,183,502 (GRCm39) S348* probably null Het
Spata31d1c T C 13: 65,183,531 (GRCm39) F358L probably benign Het
Srbd1 A T 17: 86,410,350 (GRCm39) S527R possibly damaging Het
Stag3 T C 5: 138,289,143 (GRCm39) V243A probably damaging Het
Tefm A T 11: 80,031,075 (GRCm39) S54T probably damaging Het
Terf1 T C 1: 15,875,903 (GRCm39) M1T probably null Het
Thsd7b G A 1: 129,688,024 (GRCm39) S645N possibly damaging Het
Trmt13 G T 3: 116,376,337 (GRCm39) S285* probably null Het
Ttn A T 2: 76,641,587 (GRCm39) L5176Q possibly damaging Het
Ush2a C T 1: 188,492,040 (GRCm39) R3110* probably null Het
Vnn3 T C 10: 23,741,720 (GRCm39) Y342H probably benign Het
Other mutations in Ankrd7
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01333:Ankrd7 APN 6 18,879,345 (GRCm39) missense probably damaging 0.99
IGL01336:Ankrd7 APN 6 18,868,277 (GRCm39) missense probably benign 0.05
IGL01916:Ankrd7 APN 6 18,868,250 (GRCm39) missense possibly damaging 0.65
IGL02398:Ankrd7 APN 6 18,866,696 (GRCm39) missense probably damaging 0.99
R0031:Ankrd7 UTSW 6 18,870,007 (GRCm39) nonsense probably null
R0157:Ankrd7 UTSW 6 18,866,539 (GRCm39) missense probably damaging 0.98
R0207:Ankrd7 UTSW 6 18,870,030 (GRCm39) missense probably benign 0.09
R2154:Ankrd7 UTSW 6 18,870,030 (GRCm39) missense probably benign 0.09
R4581:Ankrd7 UTSW 6 18,868,020 (GRCm39) missense probably damaging 0.99
R4582:Ankrd7 UTSW 6 18,868,020 (GRCm39) missense probably damaging 0.99
R4958:Ankrd7 UTSW 6 18,866,722 (GRCm39) missense probably benign 0.05
R5194:Ankrd7 UTSW 6 18,868,076 (GRCm39) missense possibly damaging 0.67
R6077:Ankrd7 UTSW 6 18,868,071 (GRCm39) missense probably benign 0.08
R6731:Ankrd7 UTSW 6 18,866,653 (GRCm39) missense probably damaging 1.00
R6898:Ankrd7 UTSW 6 18,868,100 (GRCm39) splice site probably null
R7170:Ankrd7 UTSW 6 18,868,389 (GRCm39) nonsense probably null
R7194:Ankrd7 UTSW 6 18,879,342 (GRCm39) missense probably benign 0.00
R7749:Ankrd7 UTSW 6 18,879,515 (GRCm39) splice site probably null
R8348:Ankrd7 UTSW 6 18,868,007 (GRCm39) missense probably damaging 0.96
R8383:Ankrd7 UTSW 6 18,868,410 (GRCm39) missense possibly damaging 0.86
R8448:Ankrd7 UTSW 6 18,868,007 (GRCm39) missense probably damaging 0.96
R8850:Ankrd7 UTSW 6 18,870,006 (GRCm39) missense probably damaging 1.00
R9530:Ankrd7 UTSW 6 18,868,258 (GRCm39) missense probably benign 0.00
R9751:Ankrd7 UTSW 6 18,868,024 (GRCm39) missense probably damaging 0.99
RF012:Ankrd7 UTSW 6 18,869,274 (GRCm39) missense possibly damaging 0.76
Z1177:Ankrd7 UTSW 6 18,866,563 (GRCm39) missense possibly damaging 0.73
Predicted Primers PCR Primer
(F):5'- TGAATCATCTGCTTCCAAGTGAC -3'
(R):5'- GTTTTGGAGAACTCACTCTGTGTATC -3'

Sequencing Primer
(F):5'- ATCTGCTTCCAAGTGACTTTGTG -3'
(R):5'- GAACTCACTCTGTGTATCTCAAAATC -3'
Posted On 2015-06-20