Mutagenetix > Incidental Mutation

Incidental Mutation 'R4256:Gm906'

321828

Institutional Source

Beutler Lab

Gene Symbol

Gm906

Ensembl Gene

ENSMUSG00000095300

Gene Name

predicted gene 906

Synonyms

LOC380882

MMRRC Submission

041069-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.057) question?

Stock #

R4256 (G1)

Quality Score

106

Status

Validated

Chromosome

Chromosomal Location

50245181-50250308 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to C at 50250105 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Serine to Alanine at position 54 (S54A)

Ref Sequence

ENSEMBL: ENSMUSP00000097121 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000099521]

AlphaFold

Q3V0M1

Predicted Effect

probably benign
Transcript: ENSMUST00000099521
AA Change: S54A

PolyPhen 2 Score 0.177 (Sensitivity: 0.92; Specificity: 0.87)

SMART Domains

Protein: ENSMUSP00000097121
Gene: ENSMUSG00000095300
AA Change: S54A

Domain	Start	End	E-Value	Type
low complexity region	69	82	N/A	INTRINSIC
Pfam:FAM75	96	414	5.3e-15	PFAM
SCOP:d1i5pa1	811	874	1e-2	SMART

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 99.3%
3x: 98.6%
10x: 97.2%
20x: 95.0%

Validation Efficiency

93% (41/44)

Allele List at MGI

Other mutations in this stock

Total: 38 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930578I06Rik	C	T	14: 63,973,209	R190H	probably benign	Het
5730559C18Rik	G	T	1: 136,214,350	N670K	probably benign	Het
Arsi	T	C	18: 60,917,316	W424R	probably damaging	Het
Atad2	A	G	15: 58,116,856	S411P	probably damaging	Het
Cdhr2	G	A	13: 54,714,005	V72I	probably damaging	Het
Celf4	T	C	18: 25,491,201	I414V	probably damaging	Het
Cfap43	G	A	19: 47,782,405	T689I	probably benign	Het
Cpne9	C	T	6: 113,283,023		probably benign	Het
Cyp3a11	A	T	5: 145,869,195	S121T	probably benign	Het
Dip2c	C	A	13: 9,609,056	Q864K	probably damaging	Het
Fbxo3	A	G	2: 104,051,165	T281A	probably damaging	Het
Gm5148	T	A	3: 37,714,609	H154L	unknown	Het
Gsdma2	T	A	11: 98,651,932		probably null	Het
Hfm1	T	C	5: 106,904,797	I273M	possibly damaging	Het
Hspa4l	A	G	3: 40,746,003	E14G	probably benign	Het
Lgals12	T	G	19: 7,606,716	E5D	possibly damaging	Het
Lsg1	T	G	16: 30,573,243	I237L	probably benign	Het
Mettl14	T	C	3: 123,383,605	E49G	probably damaging	Het
Nbeal1	A	G	1: 60,330,948	I2675V	probably benign	Het
Olfr1272	A	T	2: 90,282,062	V171E	probably damaging	Het
Olfr1391	A	T	11: 49,327,477	Q22L	probably benign	Het
Olfr178	T	G	16: 58,889,780	S147R	probably benign	Het
Padi1	A	T	4: 140,814,778	L611Q	probably damaging	Het
Pcdhac2	A	G	18: 37,144,711	D248G	probably damaging	Het
Plekhm1	C	A	11: 103,370,934	R940L	probably damaging	Het
Rasa3	A	G	8: 13,614,532		probably null	Het
Rspo2	C	A	15: 43,075,911	R161L	probably benign	Het
Sacs	A	G	14: 61,206,337	Y1944C	probably damaging	Het
Slc7a10	G	T	7: 35,198,715	M297I	probably damaging	Het
Ssh2	A	G	11: 77,408,183	T112A	possibly damaging	Het
Ttc7	A	T	17: 87,321,401		probably null	Het
Vmn1r64	T	A	7: 5,883,896	H216L	probably benign	Het
Vmn2r112	A	G	17: 22,618,412	K618R	probably damaging	Het
Vmp1	T	A	11: 86,661,188	I117L	probably benign	Het
Vsnl1	A	T	12: 11,332,055	Y108*	probably null	Het
Wdr31	A	G	4: 62,457,438		probably null	Het
Zfp329	A	G	7: 12,807,913	V284A	probably benign	Het
Zfp551	G	A	7: 12,416,391	H364Y	possibly damaging	Het

Other mutations in Gm906

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00575:Gm906	APN	13	50246716	missense	probably damaging	1.00
IGL02008:Gm906	APN	13	50246685	missense	probably benign	0.00
R0464:Gm906	UTSW	13	50248275	splice site	probably benign
R0481:Gm906	UTSW	13	50246964	missense	probably benign	0.33
R0781:Gm906	UTSW	13	50248260	missense	possibly damaging	0.70
R1110:Gm906	UTSW	13	50248260	missense	possibly damaging	0.70
R1945:Gm906	UTSW	13	50245491	missense	probably damaging	1.00
R3119:Gm906	UTSW	13	50246969	nonsense	probably null
R3824:Gm906	UTSW	13	50245512	missense	possibly damaging	0.73
R3861:Gm906	UTSW	13	50246851	missense	probably benign	0.00
R4607:Gm906	UTSW	13	50245506	missense	possibly damaging	0.86
R6126:Gm906	UTSW	13	50246290	missense	probably benign	0.18
R6550:Gm906	UTSW	13	50245446	missense	probably benign	0.00
R6913:Gm906	UTSW	13	50245257	missense	probably damaging	0.99
R6970:Gm906	UTSW	13	50246971	missense	possibly damaging	0.86
R7339:Gm906	UTSW	13	50247168	missense	possibly damaging	0.86
R7347:Gm906	UTSW	13	50245744	missense	probably benign	0.01
R7607:Gm906	UTSW	13	50250260	missense	possibly damaging	0.72
R7655:Gm906	UTSW	13	50247086	missense	probably benign	0.00
R7656:Gm906	UTSW	13	50247086	missense	probably benign	0.00
R7711:Gm906	UTSW	13	50247095	missense	probably benign	0.43
R7803:Gm906	UTSW	13	50246190	missense	probably benign	0.33
R8382:Gm906	UTSW	13	50247438	missense	possibly damaging	0.71
R8510:Gm906	UTSW	13	50250192	missense	probably benign	0.04
R9006:Gm906	UTSW	13	50247553	missense	possibly damaging	0.52
R9013:Gm906	UTSW	13	50247552	missense	possibly damaging	0.71
R9172:Gm906	UTSW	13	50247381	missense	probably benign	0.03
R9452:Gm906	UTSW	13	50246772	missense	possibly damaging	0.84
R9721:Gm906	UTSW	13	50246652	missense	possibly damaging	0.96

Predicted Primers

PCR Primer
(F):5'- AGCCCTTCAGAGTCTTTCTAGAGA -3'
(R):5'- GCTGCATTGCGATTCAGAAG -3'

Sequencing Primer
(F):5'- GAGGCAATTCATACTCAGCTGCTG -3'
(R):5'- GCGATTCAGAAGATGGAGAATTTTC -3'

Posted On

2015-06-20