Incidental Mutation 'R4258:Mup6'
ID 321892
Institutional Source Beutler Lab
Gene Symbol Mup6
Ensembl Gene ENSMUSG00000078689
Gene Name major urinary protein 6
Synonyms Gm12544
MMRRC Submission 041071-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.065) question?
Stock # R4258 (G1)
Quality Score 225
Status Validated
Chromosome 4
Chromosomal Location 60003481-60007274 bp(+) (GRCm39)
Type of Mutation critical splice acceptor site
DNA Base Change (assembly) A to T at 60004812 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000103145 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000107517] [ENSMUST00000107520] [ENSMUST00000107521]
AlphaFold A2AV72
Predicted Effect probably null
Transcript: ENSMUST00000107517
SMART Domains Protein: ENSMUSP00000103141
Gene: ENSMUSG00000078689

DomainStartEndE-ValueType
signal peptide 1 17 N/A INTRINSIC
Pfam:Lipocalin 33 172 1.6e-35 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000107520
SMART Domains Protein: ENSMUSP00000103144
Gene: ENSMUSG00000078689

DomainStartEndE-ValueType
signal peptide 1 17 N/A INTRINSIC
Pfam:Lipocalin 33 172 1.6e-35 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000107521
SMART Domains Protein: ENSMUSP00000103145
Gene: ENSMUSG00000078689

DomainStartEndE-ValueType
Pfam:Lipocalin 25 164 1.4e-35 PFAM
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.8%
Validation Efficiency 95% (60/63)
Allele List at MGI
Other mutations in this stock
Total: 57 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4932415M13Rik T A 17: 54,031,441 (GRCm39) noncoding transcript Het
Ank3 T C 10: 69,840,592 (GRCm39) I984T probably benign Het
Arnt2 T C 7: 83,960,163 (GRCm39) T204A probably damaging Het
Arsi T C 18: 61,050,388 (GRCm39) W424R probably damaging Het
Aspg A T 12: 112,087,687 (GRCm39) N346I probably benign Het
Brdt A G 5: 107,507,775 (GRCm39) S668G probably damaging Het
Ccdc178 C T 18: 22,150,392 (GRCm39) probably null Het
Cfap58 A T 19: 47,937,923 (GRCm39) probably null Het
Chaf1a C A 17: 56,363,474 (GRCm39) H319Q unknown Het
Colec12 T C 18: 9,720,950 (GRCm39) S13P probably damaging Het
Cpne9 C T 6: 113,259,984 (GRCm39) probably benign Het
Cyp2c65 A C 19: 39,081,872 (GRCm39) D466A probably benign Het
Cyp3a25 T C 5: 145,928,248 (GRCm39) K266E probably damaging Het
Dennd1b G T 1: 138,990,678 (GRCm39) R214L probably damaging Het
Dock9 T C 14: 121,818,854 (GRCm39) I1533V probably benign Het
Dynlt1a C T 17: 6,361,184 (GRCm39) M102I probably benign Het
Edil3 G T 13: 89,325,272 (GRCm39) L220F probably damaging Het
Eml5 A G 12: 98,831,693 (GRCm39) Y383H probably benign Het
Epc1 T A 18: 6,450,130 (GRCm39) T393S probably benign Het
Fbxo8 A T 8: 57,041,076 (GRCm39) D164V probably benign Het
Gbp4 T A 5: 105,284,841 (GRCm39) N16I probably damaging Het
Gdf6 G A 4: 9,844,877 (GRCm39) V134I probably damaging Het
Gm5475 A G 15: 100,322,117 (GRCm39) probably benign Het
Gm6430 T G 1: 96,952,561 (GRCm39) noncoding transcript Het
Ighv9-4 A T 12: 114,263,765 (GRCm39) V56E probably damaging Het
Il3ra A T 14: 14,347,961 (GRCm38) N36Y probably damaging Het
Kif7 G T 7: 79,360,261 (GRCm39) C325* probably null Het
Lipo2 A T 19: 33,708,328 (GRCm39) F229I possibly damaging Het
Lrba A G 3: 86,352,656 (GRCm39) K1935E probably damaging Het
Mki67 A T 7: 135,297,017 (GRCm39) D2672E possibly damaging Het
Mtf1 A G 4: 124,732,576 (GRCm39) T545A probably benign Het
Myo9b T C 8: 71,808,409 (GRCm39) V1672A probably damaging Het
Nudt16l2 T C 9: 105,020,767 (GRCm39) I165V probably damaging Het
Or10al6 C A 17: 38,082,949 (GRCm39) P135Q probably damaging Het
Or10j5 C T 1: 172,785,205 (GRCm39) T281I possibly damaging Het
Or4k36 A T 2: 111,145,983 (GRCm39) H53L probably benign Het
Or5d37 T A 2: 87,923,362 (GRCm39) N306I probably damaging Het
Pcdhgb2 A T 18: 37,825,102 (GRCm39) I698F probably damaging Het
Pkn3 C T 2: 29,978,572 (GRCm39) H665Y probably damaging Het
Ppil6 T A 10: 41,383,531 (GRCm39) L99* probably null Het
Psg22 T A 7: 18,458,554 (GRCm39) V376E probably damaging Het
Pum1 G A 4: 130,457,591 (GRCm39) R201H probably damaging Het
Rasa2 A T 9: 96,439,433 (GRCm39) probably benign Het
Schip1 T A 3: 68,525,963 (GRCm39) M379K possibly damaging Het
Scn9a A T 2: 66,395,398 (GRCm39) probably benign Het
Sh3tc1 C T 5: 35,864,322 (GRCm39) A622T probably benign Het
Smarcd2 A T 11: 106,156,076 (GRCm39) I292N probably damaging Het
Ssxb17 C T X: 21,041,167 (GRCm39) S45N probably damaging Het
Stab1 G A 14: 30,876,629 (GRCm39) R862C possibly damaging Het
Tdrd5 T A 1: 156,087,312 (GRCm39) H870L probably benign Het
Tnfaip8 A G 18: 50,223,443 (GRCm39) R60G possibly damaging Het
Traf3ip3 C T 1: 192,880,254 (GRCm39) R25Q probably damaging Het
Unc5b T C 10: 60,601,150 (GRCm39) Y892C probably damaging Het
Vmn2r2 T G 3: 64,042,118 (GRCm39) D199A probably damaging Het
Washc2 C A 6: 116,185,202 (GRCm39) P12Q probably damaging Het
Zfp286 T C 11: 62,671,896 (GRCm39) I121V probably benign Het
Zfp606 T A 7: 12,228,267 (GRCm39) probably null Het
Other mutations in Mup6
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01109:Mup6 APN 4 60,006,001 (GRCm39) missense probably damaging 1.00
IGL01333:Mup6 APN 4 60,005,529 (GRCm39) missense probably damaging 1.00
IGL01608:Mup6 APN 4 60,006,021 (GRCm39) missense probably benign 0.34
IGL02471:Mup6 APN 4 60,003,971 (GRCm39) splice site probably benign
IGL02932:Mup6 APN 4 60,006,009 (GRCm39) missense probably damaging 1.00
IGL03070:Mup6 APN 4 60,003,999 (GRCm39) missense probably damaging 1.00
IGL03108:Mup6 APN 4 60,005,990 (GRCm39) missense possibly damaging 0.55
IGL03158:Mup6 APN 4 60,005,480 (GRCm39) missense possibly damaging 0.83
R0122:Mup6 UTSW 4 60,003,995 (GRCm39) nonsense probably null
R1271:Mup6 UTSW 4 60,003,579 (GRCm39) intron probably benign
R3434:Mup6 UTSW 4 60,004,116 (GRCm39) splice site probably null
R3435:Mup6 UTSW 4 60,004,116 (GRCm39) splice site probably null
R4465:Mup6 UTSW 4 60,004,000 (GRCm39) missense probably damaging 1.00
R4466:Mup6 UTSW 4 60,004,000 (GRCm39) missense probably damaging 1.00
R5021:Mup6 UTSW 4 59,964,352 (GRCm39) missense probably damaging 0.99
R5272:Mup6 UTSW 4 60,005,922 (GRCm39) missense probably damaging 0.99
R6396:Mup6 UTSW 4 60,004,837 (GRCm39) missense possibly damaging 0.84
R6861:Mup6 UTSW 4 60,004,093 (GRCm39) missense probably benign 0.02
R7818:Mup6 UTSW 4 60,004,884 (GRCm39) missense probably benign 0.05
R8238:Mup6 UTSW 4 60,003,634 (GRCm39) missense probably damaging 1.00
R9294:Mup6 UTSW 4 60,004,838 (GRCm39) missense probably benign 0.16
Predicted Primers PCR Primer
(F):5'- CACCAATGCCTGAAGTACGG -3'
(R):5'- TCCTGTGTTCAGACTCCAGC -3'

Sequencing Primer
(F):5'- CAATGCCTGAAGTACGGACTGC -3'
(R):5'- TGTGTTCAGACTCCAGCAACAC -3'
Posted On 2015-06-20