Incidental Mutation 'R4284:Memo1'
ID 322008
Institutional Source Beutler Lab
Gene Symbol Memo1
Ensembl Gene ENSMUSG00000058704
Gene Name mediator of cell motility 1
Synonyms D930048L02Rik, 0610016J10Rik
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R4284 (G1)
Quality Score 225
Status Not validated
Chromosome 17
Chromosomal Location 74506031-74602516 bp(-) (GRCm39)
Type of Mutation critical splice acceptor site
DNA Base Change (assembly) T to C at 74562293 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000077553 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000078459] [ENSMUST00000078459]
AlphaFold Q91VH6
Predicted Effect probably null
Transcript: ENSMUST00000078459
SMART Domains Protein: ENSMUSP00000077553
Gene: ENSMUSG00000058704

DomainStartEndE-ValueType
Pfam:Memo 9 293 3.7e-84 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000078459
SMART Domains Protein: ENSMUSP00000077553
Gene: ENSMUSG00000058704

DomainStartEndE-ValueType
Pfam:Memo 9 293 3.7e-84 PFAM
Meta Mutation Damage Score 0.9483 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.8%
  • 10x: 97.5%
  • 20x: 95.7%
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a floxed allele activated postnatally exhibit a reduced life span, increased insulin sensitivity, small stature, graying hair, alopecia, kyphosis, loss of subcutaneous fat, loss of spermatozoa in the epididymis and increased active vitamin D. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Agl G A 3: 116,545,827 (GRCm39) S1323L possibly damaging Het
Capg T C 6: 72,538,082 (GRCm39) Y323H probably damaging Het
Cdh23 T C 10: 60,139,272 (GRCm39) T3314A possibly damaging Het
Cilp A T 9: 65,185,560 (GRCm39) T552S probably damaging Het
Cox16 T C 12: 81,521,293 (GRCm39) probably null Het
Ctu2 G A 8: 123,204,978 (GRCm39) V88I probably benign Het
Elfn1 A T 5: 139,958,069 (GRCm39) K358* probably null Het
Enpp6 T C 8: 47,522,050 (GRCm39) F328S probably damaging Het
Galnt12 T C 4: 47,104,231 (GRCm39) L163P probably damaging Het
Gcfc2 G A 6: 81,918,372 (GRCm39) R354H probably damaging Het
Hcn1 ACAGCAGCAGCAGCAGCAGCAGCAACAGCAACAACAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGC ACAGCAGCAGCAGCAGCAGCAACAGCAACAACAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGC 13: 118,112,269 (GRCm39) probably benign Het
Ikbke C T 1: 131,203,515 (GRCm39) probably null Het
Il1rn T C 2: 24,239,557 (GRCm39) L151P probably damaging Het
Jmjd6 T C 11: 116,733,534 (GRCm39) R48G probably damaging Het
Klk14 G A 7: 43,341,501 (GRCm39) C51Y probably damaging Het
Lilra6 T C 7: 3,911,803 (GRCm39) H285R possibly damaging Het
Lrp2 G A 2: 69,310,438 (GRCm39) R2712C possibly damaging Het
Magi3 C A 3: 103,923,184 (GRCm39) G1178* probably null Het
Mug2 T A 6: 122,040,632 (GRCm39) D727E probably benign Het
Relch A G 1: 105,649,012 (GRCm39) D717G probably damaging Het
Sema3c A G 5: 17,883,345 (GRCm39) T318A probably benign Het
Shroom3 G T 5: 93,090,945 (GRCm39) V1151F probably damaging Het
Slc20a2 G A 8: 23,051,365 (GRCm39) R466Q probably benign Het
Slc25a51 C T 4: 45,399,768 (GRCm39) V141M probably benign Het
Sox5 T C 6: 143,781,055 (GRCm39) K570E probably damaging Het
Ssbp1 T G 6: 40,454,851 (GRCm39) probably null Het
Sult5a1 A G 8: 123,875,969 (GRCm39) S116P probably damaging Het
Tktl2 T A 8: 66,965,808 (GRCm39) D455E probably damaging Het
Tm9sf1 T C 14: 55,878,780 (GRCm39) Y204C probably damaging Het
Tmem161a A G 8: 70,630,076 (GRCm39) probably benign Het
Ttn T A 2: 76,623,211 (GRCm39) K13663* probably null Het
Unc5c T C 3: 141,420,435 (GRCm39) I52T probably damaging Het
Other mutations in Memo1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01410:Memo1 APN 17 74,548,976 (GRCm39) nonsense probably null
IGL01570:Memo1 APN 17 74,524,103 (GRCm39) splice site probably benign
IGL02709:Memo1 APN 17 74,552,027 (GRCm39) missense probably damaging 1.00
IGL03172:Memo1 APN 17 74,551,996 (GRCm39) missense probably damaging 1.00
Tummy UTSW 17 74,508,273 (GRCm39) missense probably damaging 1.00
R0067:Memo1 UTSW 17 74,532,453 (GRCm39) missense probably damaging 1.00
R1068:Memo1 UTSW 17 74,532,550 (GRCm39) missense probably damaging 1.00
R1962:Memo1 UTSW 17 74,552,003 (GRCm39) missense possibly damaging 0.54
R1964:Memo1 UTSW 17 74,552,003 (GRCm39) missense possibly damaging 0.54
R2029:Memo1 UTSW 17 74,552,049 (GRCm39) missense probably null 0.99
R3236:Memo1 UTSW 17 74,509,347 (GRCm39) missense probably damaging 1.00
R4285:Memo1 UTSW 17 74,562,293 (GRCm39) critical splice acceptor site probably null
R4287:Memo1 UTSW 17 74,562,293 (GRCm39) critical splice acceptor site probably null
R4427:Memo1 UTSW 17 74,509,302 (GRCm39) missense probably benign 0.01
R4583:Memo1 UTSW 17 74,565,456 (GRCm39) nonsense probably null
R4607:Memo1 UTSW 17 74,565,456 (GRCm39) nonsense probably null
R4608:Memo1 UTSW 17 74,565,456 (GRCm39) nonsense probably null
R6118:Memo1 UTSW 17 74,509,302 (GRCm39) missense possibly damaging 0.52
R6769:Memo1 UTSW 17 74,508,273 (GRCm39) missense probably damaging 1.00
R6771:Memo1 UTSW 17 74,508,273 (GRCm39) missense probably damaging 1.00
R7226:Memo1 UTSW 17 74,509,338 (GRCm39) missense probably damaging 1.00
R7996:Memo1 UTSW 17 74,565,491 (GRCm39) missense probably damaging 1.00
R9696:Memo1 UTSW 17 74,524,041 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TTATGGTAGACTTTCAGACCAAGG -3'
(R):5'- AACAATTGCGTGTTCTCTACTACC -3'

Sequencing Primer
(F):5'- GTGTCAGAATGAAACATTTGACAAC -3'
(R):5'- GCGTGTTCTCTACTACCTTGTAAAG -3'
Posted On 2015-06-20