Mutagenetix > Incidental Mutation

Incidental Mutation 'R4287:Vmn2r97'

322077

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r97

Ensembl Gene

ENSMUSG00000091491

Gene Name

vomeronasal 2, receptor 97

Synonyms

EG627367

MMRRC Submission

041652-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.071) question?

Stock #

R4287 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

19134584-19168333 bp(+) (GRCm39)

Type of Mutation

intron

DNA Base Change (assembly)

A to T at 19168337 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000156141 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000168710] [ENSMUST00000232219]

AlphaFold

K7N6Z2

Predicted Effect

probably benign
Transcript: ENSMUST00000168710

SMART Domains

Protein: ENSMUSP00000129313
Gene: ENSMUSG00000091491

Domain	Start	End	E-Value	Type
signal peptide	1	21	N/A	INTRINSIC
Pfam:ANF_receptor	82	442	2.9e-36	PFAM
Pfam:NCD3G	513	566	4.9e-21	PFAM
Pfam:7tm_3	599	834	1.7e-52	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000232219

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 99.4%
3x: 98.8%
10x: 97.6%
20x: 95.9%

Validation Efficiency

98% (40/41)

Allele List at MGI

Other mutations in this stock

Total: 37 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Anapc5	A	G	5: 122,938,664 (GRCm39)	V362A	probably benign	Het
Ash1l	T	A	3: 88,973,722 (GRCm39)	C2594S	probably damaging	Het
Ccdc82	C	A	9: 13,253,043 (GRCm39)	Q303K	probably benign	Het
Cog1	A	G	11: 113,544,853 (GRCm39)	Y345C	probably damaging	Het
Fpgt	T	C	3: 154,796,997 (GRCm39)		probably benign	Het
Glrb	A	T	3: 80,752,539 (GRCm39)	V408D	possibly damaging	Het
Gm7135	A	G	1: 97,328,123 (GRCm39)		noncoding transcript	Het
Il1rn	T	C	2: 24,239,557 (GRCm39)	L151P	probably damaging	Het
Itgav	G	T	2: 83,555,184 (GRCm39)	E36*	probably null	Het
Kidins220	G	A	12: 25,106,845 (GRCm39)	E1433K	possibly damaging	Het
Klk14	G	A	7: 43,341,501 (GRCm39)	C51Y	probably damaging	Het
Klra3	A	G	6: 130,311,265 (GRCm39)	C39R	probably benign	Het
Lce1i	A	G	3: 92,684,742 (GRCm39)	S145P	unknown	Het
Memo1	T	C	17: 74,562,293 (GRCm39)		probably null	Het
Mpp3	G	A	11: 101,914,289 (GRCm39)	A102V	probably damaging	Het
Mug2	T	A	6: 122,040,632 (GRCm39)	D727E	probably benign	Het
Ndufb8	T	C	19: 44,541,130 (GRCm39)	I107V	probably benign	Het
Or5h18	A	T	16: 58,847,976 (GRCm39)	M98K	probably benign	Het
Pnn	C	T	12: 59,118,956 (GRCm39)	T513I	possibly damaging	Het
Ric8a	A	G	7: 140,441,335 (GRCm39)	Y210C	probably damaging	Het
Ripor2	G	A	13: 24,908,992 (GRCm39)	V1037M	probably damaging	Het
Rreb1	A	T	13: 38,115,907 (GRCm39)	T1089S	probably benign	Het
Rrs1	C	T	1: 9,616,440 (GRCm39)	S231L	probably damaging	Het
Rrs1	C	T	1: 9,616,448 (GRCm39)	R234C	possibly damaging	Het
Sec23ip	A	G	7: 128,379,057 (GRCm39)	D838G	probably benign	Het
Setbp1	T	C	18: 78,902,276 (GRCm39)	I464V	probably benign	Het
Slc25a51	C	T	4: 45,399,768 (GRCm39)	V141M	probably benign	Het
Slc41a3	A	T	6: 90,617,904 (GRCm39)	H310L	probably benign	Het
Smurf1	A	G	5: 144,828,268 (GRCm39)	S363P	probably benign	Het
Tln1	C	T	4: 43,543,509 (GRCm39)	R1269Q	probably benign	Het
Tmed3	A	G	9: 89,586,951 (GRCm39)	S10P	probably benign	Het
Tomm70a	T	G	16: 56,960,985 (GRCm39)	Y313D	probably damaging	Het
Umodl1	A	G	17: 31,207,039 (GRCm39)	E810G	probably benign	Het
Unc5c	T	C	3: 141,420,435 (GRCm39)	I52T	probably damaging	Het
Unc5d	T	A	8: 29,209,824 (GRCm39)	Y432F	probably benign	Het
Zfp629	T	C	7: 127,211,110 (GRCm39)	Y233C	probably damaging	Het
Zfp986	T	C	4: 145,619,088 (GRCm39)		probably null	Het

Other mutations in Vmn2r97

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00897:Vmn2r97	APN	17	19,167,921 (GRCm39)	missense	probably benign	0.37
IGL00962:Vmn2r97	APN	17	19,149,490 (GRCm39)	missense	probably damaging	1.00
IGL01704:Vmn2r97	APN	17	19,168,073 (GRCm39)	missense	probably damaging	0.99
IGL01888:Vmn2r97	APN	17	19,149,286 (GRCm39)	nonsense	probably null
IGL02429:Vmn2r97	APN	17	19,150,596 (GRCm39)	missense	possibly damaging	0.94
IGL02742:Vmn2r97	APN	17	19,149,432 (GRCm39)	missense	probably damaging	0.97
IGL02934:Vmn2r97	APN	17	19,149,947 (GRCm39)	missense	probably benign	0.00
IGL02978:Vmn2r97	APN	17	19,168,298 (GRCm39)	missense	probably benign	0.01
IGL03230:Vmn2r97	APN	17	19,149,668 (GRCm39)	missense	probably benign	0.10
IGL03241:Vmn2r97	APN	17	19,148,438 (GRCm39)	missense	probably benign	0.11
IGL03050:Vmn2r97	UTSW	17	19,167,900 (GRCm39)	missense	possibly damaging	0.84
PIT4469001:Vmn2r97	UTSW	17	19,149,878 (GRCm39)	missense	probably benign	0.00
R0482:Vmn2r97	UTSW	17	19,167,930 (GRCm39)	missense	probably damaging	1.00
R0514:Vmn2r97	UTSW	17	19,134,734 (GRCm39)	missense	probably benign	0.25
R0944:Vmn2r97	UTSW	17	19,167,665 (GRCm39)	missense	probably benign	0.13
R1061:Vmn2r97	UTSW	17	19,148,440 (GRCm39)	nonsense	probably null
R1546:Vmn2r97	UTSW	17	19,168,110 (GRCm39)	missense	probably damaging	1.00
R1725:Vmn2r97	UTSW	17	19,149,397 (GRCm39)	missense	probably benign	0.43
R1860:Vmn2r97	UTSW	17	19,167,648 (GRCm39)	missense	probably benign	0.01
R1938:Vmn2r97	UTSW	17	19,149,593 (GRCm39)	missense	probably benign	0.01
R1944:Vmn2r97	UTSW	17	19,160,500 (GRCm39)	missense	probably benign	0.00
R2027:Vmn2r97	UTSW	17	19,149,944 (GRCm39)	missense	unknown
R2106:Vmn2r97	UTSW	17	19,168,100 (GRCm39)	missense	probably damaging	1.00
R2151:Vmn2r97	UTSW	17	19,167,584 (GRCm39)	nonsense	probably null
R2153:Vmn2r97	UTSW	17	19,167,584 (GRCm39)	nonsense	probably null
R2154:Vmn2r97	UTSW	17	19,167,584 (GRCm39)	nonsense	probably null
R2516:Vmn2r97	UTSW	17	19,167,814 (GRCm39)	missense	probably benign
R3739:Vmn2r97	UTSW	17	19,148,413 (GRCm39)	missense	probably damaging	1.00
R3744:Vmn2r97	UTSW	17	19,149,890 (GRCm39)	missense	probably benign
R3885:Vmn2r97	UTSW	17	19,148,596 (GRCm39)	missense	possibly damaging	0.90
R3899:Vmn2r97	UTSW	17	19,167,873 (GRCm39)	missense	probably damaging	0.96
R4115:Vmn2r97	UTSW	17	19,148,332 (GRCm39)	missense	probably benign	0.01
R4247:Vmn2r97	UTSW	17	19,167,542 (GRCm39)	missense	possibly damaging	0.83
R4439:Vmn2r97	UTSW	17	19,150,616 (GRCm39)	missense	probably benign	0.00
R4523:Vmn2r97	UTSW	17	19,149,333 (GRCm39)	missense	probably benign	0.03
R4783:Vmn2r97	UTSW	17	19,149,550 (GRCm39)	missense	probably benign
R4948:Vmn2r97	UTSW	17	19,167,561 (GRCm39)	missense	possibly damaging	0.95
R4981:Vmn2r97	UTSW	17	19,160,436 (GRCm39)	nonsense	probably null
R5029:Vmn2r97	UTSW	17	19,168,173 (GRCm39)	missense	probably damaging	1.00
R5200:Vmn2r97	UTSW	17	19,148,615 (GRCm39)	missense	probably damaging	1.00
R5541:Vmn2r97	UTSW	17	19,148,617 (GRCm39)	nonsense	probably null
R5637:Vmn2r97	UTSW	17	19,167,628 (GRCm39)	nonsense	probably null
R5765:Vmn2r97	UTSW	17	19,167,442 (GRCm39)	nonsense	probably null
R5885:Vmn2r97	UTSW	17	19,168,035 (GRCm39)	missense	possibly damaging	0.50
R6272:Vmn2r97	UTSW	17	19,167,861 (GRCm39)	missense	possibly damaging	0.70
R6553:Vmn2r97	UTSW	17	19,150,566 (GRCm39)	nonsense	probably null
R6818:Vmn2r97	UTSW	17	19,168,193 (GRCm39)	missense	possibly damaging	0.95
R6880:Vmn2r97	UTSW	17	19,134,770 (GRCm39)	missense	probably benign	0.00
R7012:Vmn2r97	UTSW	17	19,167,756 (GRCm39)	missense	probably damaging	0.99
R7023:Vmn2r97	UTSW	17	19,134,663 (GRCm39)	missense	probably damaging	1.00
R7044:Vmn2r97	UTSW	17	19,134,629 (GRCm39)	missense	probably benign	0.05
R7191:Vmn2r97	UTSW	17	19,150,548 (GRCm39)	missense	probably damaging	1.00
R7503:Vmn2r97	UTSW	17	19,148,470 (GRCm39)	missense	probably benign
R7862:Vmn2r97	UTSW	17	19,167,416 (GRCm39)	missense	probably damaging	1.00
R7876:Vmn2r97	UTSW	17	19,149,326 (GRCm39)	missense	probably damaging	0.97
R7890:Vmn2r97	UTSW	17	19,149,802 (GRCm39)	missense	probably benign	0.00
R7936:Vmn2r97	UTSW	17	19,150,662 (GRCm39)	missense	probably damaging	1.00
R7978:Vmn2r97	UTSW	17	19,167,854 (GRCm39)	missense	probably damaging	1.00
R8405:Vmn2r97	UTSW	17	19,134,802 (GRCm39)	critical splice donor site	probably null
R8755:Vmn2r97	UTSW	17	19,168,104 (GRCm39)	missense	probably damaging	1.00
R8790:Vmn2r97	UTSW	17	19,160,472 (GRCm39)	missense	probably damaging	1.00
R8850:Vmn2r97	UTSW	17	19,149,607 (GRCm39)	missense	probably benign	0.00
R9060:Vmn2r97	UTSW	17	19,134,585 (GRCm39)	start codon destroyed	probably null	0.94
R9079:Vmn2r97	UTSW	17	19,149,640 (GRCm39)	missense	probably benign
R9252:Vmn2r97	UTSW	17	19,167,849 (GRCm39)	missense	probably benign	0.00
R9278:Vmn2r97	UTSW	17	19,134,762 (GRCm39)	missense	probably benign	0.00
R9342:Vmn2r97	UTSW	17	19,149,368 (GRCm39)	missense	probably benign
R9422:Vmn2r97	UTSW	17	19,149,333 (GRCm39)	missense	probably benign	0.03
R9496:Vmn2r97	UTSW	17	19,149,227 (GRCm39)	missense	probably damaging	1.00
R9571:Vmn2r97	UTSW	17	19,149,919 (GRCm39)	missense	probably benign
R9601:Vmn2r97	UTSW	17	19,134,770 (GRCm39)	missense	probably benign
R9672:Vmn2r97	UTSW	17	19,149,442 (GRCm39)	missense	probably benign	0.00
R9773:Vmn2r97	UTSW	17	19,168,221 (GRCm39)	missense	probably benign	0.01
R9795:Vmn2r97	UTSW	17	19,167,561 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- CCACAGCACTAAAGGGAAGGTC -3'
(R):5'- CCTGAATGAAACTTCACACTGAG -3'

Sequencing Primer
(F):5'- CACTAAAGGGAAGGTCATGGTAGCC -3'
(R):5'- CATGTTGTTCATTTCCAAATATGGC -3'

Posted On

2015-06-20