Incidental Mutation 'R4288:Gpr37l1'
ID 322084
Institutional Source Beutler Lab
Gene Symbol Gpr37l1
Ensembl Gene ENSMUSG00000026424
Gene Name G protein-coupled receptor 37-like 1
Synonyms D0Kist8, CAG-18
MMRRC Submission 041653-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.063) question?
Stock # R4288 (G1)
Quality Score 225
Status Validated
Chromosome 1
Chromosomal Location 135087988-135095419 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 135088922 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 381 (V381A)
Ref Sequence ENSEMBL: ENSMUSP00000027682 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000027682] [ENSMUST00000027684]
AlphaFold Q99JG2
Predicted Effect probably damaging
Transcript: ENSMUST00000027682
AA Change: V381A

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000027682
Gene: ENSMUSG00000026424
AA Change: V381A

DomainStartEndE-ValueType
signal peptide 1 24 N/A INTRINSIC
Pfam:7tm_1 147 416 4.4e-25 PFAM
low complexity region 430 439 N/A INTRINSIC
low complexity region 442 453 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000027684
SMART Domains Protein: ENSMUSP00000027684
Gene: ENSMUSG00000026426

DomainStartEndE-ValueType
ARF 1 185 2.25e-31 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000125774
SMART Domains Protein: ENSMUSP00000121545
Gene: ENSMUSG00000026426

DomainStartEndE-ValueType
Pfam:Roc 16 113 1e-12 PFAM
Pfam:Ras 18 162 4.2e-16 PFAM
Pfam:Arf 19 160 6.6e-41 PFAM
Pfam:Gtr1_RagA 26 155 3.7e-9 PFAM
Meta Mutation Damage Score 0.1539 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.8%
Validation Efficiency 97% (34/35)
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele may exhibit no abnormal phenotype, precocious cerebellum development and improved motor functions or abnormal blood pressure in female mice. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acmsd G A 1: 127,666,309 (GRCm39) V27M probably damaging Het
Acsl6 A G 11: 54,227,912 (GRCm39) T311A probably benign Het
Adss2 G A 1: 177,604,078 (GRCm39) R176W probably damaging Het
Akr7a5 T C 4: 139,041,415 (GRCm39) V108A probably benign Het
Atp13a1 A G 8: 70,246,728 (GRCm39) D209G possibly damaging Het
Bpnt2 A C 4: 4,778,231 (GRCm39) V169G probably damaging Het
Cdcp1 T A 9: 123,012,693 (GRCm39) I285F probably damaging Het
Ctnna2 C T 6: 77,582,204 (GRCm39) R339Q probably damaging Het
E130308A19Rik G A 4: 59,690,308 (GRCm39) M47I probably benign Het
Exosc9 C T 3: 36,617,365 (GRCm39) T373I probably benign Het
Fat4 T A 3: 38,945,912 (GRCm39) S1602T probably damaging Het
Fbn2 T C 18: 58,168,411 (GRCm39) I2309V probably damaging Het
Fbxo42 T C 4: 140,895,207 (GRCm39) Y57H probably damaging Het
Fcrl5 A G 3: 87,349,531 (GRCm39) D102G probably benign Het
Garin5b T A 7: 4,773,722 (GRCm39) N58Y possibly damaging Het
Hc G T 2: 34,920,414 (GRCm39) A644E probably damaging Het
Hspg2 C T 4: 137,246,251 (GRCm39) R1010C probably damaging Het
Lpar5 T C 6: 125,058,827 (GRCm39) Y183H probably benign Het
Ltn1 T A 16: 87,194,876 (GRCm39) N1341I possibly damaging Het
Mms19 A G 19: 41,933,992 (GRCm39) L938P probably damaging Het
Neb T G 2: 52,149,312 (GRCm39) E2516D probably damaging Het
Parp4 T C 14: 56,844,951 (GRCm39) V614A probably damaging Het
Pogk A G 1: 166,231,075 (GRCm39) L84P probably damaging Het
Stard13 G A 5: 150,968,642 (GRCm39) T994M probably damaging Het
Stk4 A G 2: 163,941,632 (GRCm39) S283G probably benign Het
Ttn T C 2: 76,640,742 (GRCm39) T13669A probably benign Het
Vil1 A G 1: 74,457,684 (GRCm39) T106A probably benign Het
Vmn1r18 A G 6: 57,367,392 (GRCm39) L54P probably damaging Het
Vmn1r227 G T 17: 20,956,092 (GRCm39) noncoding transcript Het
Zfp267 A G 3: 36,213,747 (GRCm39) N27S possibly damaging Het
Zfp748 T A 13: 67,689,202 (GRCm39) H686L probably damaging Het
Zyg11a C T 4: 108,041,666 (GRCm39) S658N probably damaging Het
Other mutations in Gpr37l1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00498:Gpr37l1 APN 1 135,089,440 (GRCm39) splice site probably benign
IGL01362:Gpr37l1 APN 1 135,089,216 (GRCm39) missense probably benign 0.00
IGL01678:Gpr37l1 APN 1 135,094,791 (GRCm39) missense probably damaging 1.00
IGL02394:Gpr37l1 APN 1 135,094,746 (GRCm39) missense probably damaging 1.00
ventura UTSW 1 135,088,922 (GRCm39) missense probably damaging 1.00
R0045:Gpr37l1 UTSW 1 135,088,883 (GRCm39) missense probably damaging 1.00
R1199:Gpr37l1 UTSW 1 135,094,710 (GRCm39) missense probably damaging 1.00
R1730:Gpr37l1 UTSW 1 135,089,268 (GRCm39) nonsense probably null
R1733:Gpr37l1 UTSW 1 135,089,273 (GRCm39) missense possibly damaging 0.62
R1755:Gpr37l1 UTSW 1 135,094,639 (GRCm39) missense probably damaging 1.00
R3930:Gpr37l1 UTSW 1 135,089,100 (GRCm39) missense probably benign 0.01
R4091:Gpr37l1 UTSW 1 135,089,301 (GRCm39) missense probably benign 0.25
R4111:Gpr37l1 UTSW 1 135,095,008 (GRCm39) missense possibly damaging 0.69
R4739:Gpr37l1 UTSW 1 135,094,783 (GRCm39) missense probably damaging 0.99
R5114:Gpr37l1 UTSW 1 135,094,676 (GRCm39) missense probably damaging 1.00
R6765:Gpr37l1 UTSW 1 135,094,860 (GRCm39) missense probably damaging 1.00
R8441:Gpr37l1 UTSW 1 135,094,875 (GRCm39) missense probably damaging 0.97
R8734:Gpr37l1 UTSW 1 135,095,167 (GRCm39) missense probably benign
R9122:Gpr37l1 UTSW 1 135,095,209 (GRCm39) missense probably benign 0.00
R9715:Gpr37l1 UTSW 1 135,089,391 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CATAGACTCAGCAAGGGGTG -3'
(R):5'- ATGACCTACCAGAATGCCCG -3'

Sequencing Primer
(F):5'- ACTCCCTGGGCTTGTGGAAG -3'
(R):5'- TACCAGAATGCCCGCATGTG -3'
Posted On 2015-06-20