Incidental Mutation 'R4288:Zfp267'
ID |
322091 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Zfp267
|
Ensembl Gene |
ENSMUSG00000033883 |
Gene Name |
zinc finger protein 267 |
Synonyms |
D3Ertd254e |
MMRRC Submission |
041653-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.128)
|
Stock # |
R4288 (G1)
|
Quality Score |
225 |
Status
|
Validated
|
Chromosome |
3 |
Chromosomal Location |
36205233-36224491 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
A to G
at 36213747 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Asparagine to Serine
at position 27
(N27S)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000142829
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000165956]
[ENSMUST00000197653]
[ENSMUST00000205077]
|
AlphaFold |
A0A0G2JEM5 |
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000165956
AA Change: N26S
PolyPhen 2
Score 0.707 (Sensitivity: 0.86; Specificity: 0.92)
|
SMART Domains |
Protein: ENSMUSP00000131779 Gene: ENSMUSG00000033883 AA Change: N26S
Domain | Start | End | E-Value | Type |
KRAB
|
3 |
63 |
2.91e-34 |
SMART |
ZnF_C2H2
|
342 |
364 |
1.08e-1 |
SMART |
ZnF_C2H2
|
395 |
417 |
1.56e-2 |
SMART |
ZnF_C2H2
|
423 |
445 |
3.11e-2 |
SMART |
ZnF_C2H2
|
451 |
473 |
5.9e-3 |
SMART |
ZnF_C2H2
|
479 |
501 |
1.82e-3 |
SMART |
ZnF_C2H2
|
507 |
529 |
5.21e-4 |
SMART |
ZnF_C2H2
|
535 |
557 |
1.84e-4 |
SMART |
ZnF_C2H2
|
563 |
585 |
1.95e-3 |
SMART |
ZnF_C2H2
|
591 |
613 |
2.05e-2 |
SMART |
ZnF_C2H2
|
619 |
641 |
1.6e-4 |
SMART |
ZnF_C2H2
|
647 |
669 |
5.21e-4 |
SMART |
ZnF_C2H2
|
675 |
697 |
1.69e-3 |
SMART |
ZnF_C2H2
|
703 |
725 |
2.61e-4 |
SMART |
ZnF_C2H2
|
731 |
753 |
1.12e-3 |
SMART |
ZnF_C2H2
|
759 |
779 |
3.85e1 |
SMART |
|
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000197653
AA Change: N27S
PolyPhen 2
Score 0.707 (Sensitivity: 0.86; Specificity: 0.92)
|
SMART Domains |
Protein: ENSMUSP00000142829 Gene: ENSMUSG00000033883 AA Change: N27S
Domain | Start | End | E-Value | Type |
KRAB
|
4 |
64 |
1.2e-36 |
SMART |
ZnF_C2H2
|
343 |
365 |
4.4e-4 |
SMART |
ZnF_C2H2
|
396 |
418 |
6.7e-5 |
SMART |
ZnF_C2H2
|
424 |
446 |
1.3e-4 |
SMART |
ZnF_C2H2
|
452 |
474 |
2.5e-5 |
SMART |
ZnF_C2H2
|
480 |
502 |
7.9e-6 |
SMART |
ZnF_C2H2
|
508 |
530 |
2.2e-6 |
SMART |
ZnF_C2H2
|
536 |
558 |
7.7e-7 |
SMART |
ZnF_C2H2
|
564 |
586 |
8e-6 |
SMART |
ZnF_C2H2
|
592 |
614 |
8.9e-5 |
SMART |
ZnF_C2H2
|
620 |
642 |
6.6e-7 |
SMART |
ZnF_C2H2
|
648 |
670 |
2.2e-6 |
SMART |
ZnF_C2H2
|
676 |
698 |
7.1e-6 |
SMART |
ZnF_C2H2
|
704 |
726 |
1.1e-6 |
SMART |
ZnF_C2H2
|
732 |
754 |
4.8e-6 |
SMART |
ZnF_C2H2
|
760 |
780 |
1.6e-1 |
SMART |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000205077
|
Meta Mutation Damage Score |
0.1795 |
Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.7%
- 10x: 97.5%
- 20x: 95.8%
|
Validation Efficiency |
97% (34/35) |
Allele List at MGI |
|
Other mutations in this stock |
Total: 32 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Acmsd |
G |
A |
1: 127,666,309 (GRCm39) |
V27M |
probably damaging |
Het |
Acsl6 |
A |
G |
11: 54,227,912 (GRCm39) |
T311A |
probably benign |
Het |
Adss2 |
G |
A |
1: 177,604,078 (GRCm39) |
R176W |
probably damaging |
Het |
Akr7a5 |
T |
C |
4: 139,041,415 (GRCm39) |
V108A |
probably benign |
Het |
Atp13a1 |
A |
G |
8: 70,246,728 (GRCm39) |
D209G |
possibly damaging |
Het |
Bpnt2 |
A |
C |
4: 4,778,231 (GRCm39) |
V169G |
probably damaging |
Het |
Cdcp1 |
T |
A |
9: 123,012,693 (GRCm39) |
I285F |
probably damaging |
Het |
Ctnna2 |
C |
T |
6: 77,582,204 (GRCm39) |
R339Q |
probably damaging |
Het |
E130308A19Rik |
G |
A |
4: 59,690,308 (GRCm39) |
M47I |
probably benign |
Het |
Exosc9 |
C |
T |
3: 36,617,365 (GRCm39) |
T373I |
probably benign |
Het |
Fat4 |
T |
A |
3: 38,945,912 (GRCm39) |
S1602T |
probably damaging |
Het |
Fbn2 |
T |
C |
18: 58,168,411 (GRCm39) |
I2309V |
probably damaging |
Het |
Fbxo42 |
T |
C |
4: 140,895,207 (GRCm39) |
Y57H |
probably damaging |
Het |
Fcrl5 |
A |
G |
3: 87,349,531 (GRCm39) |
D102G |
probably benign |
Het |
Garin5b |
T |
A |
7: 4,773,722 (GRCm39) |
N58Y |
possibly damaging |
Het |
Gpr37l1 |
A |
G |
1: 135,088,922 (GRCm39) |
V381A |
probably damaging |
Het |
Hc |
G |
T |
2: 34,920,414 (GRCm39) |
A644E |
probably damaging |
Het |
Hspg2 |
C |
T |
4: 137,246,251 (GRCm39) |
R1010C |
probably damaging |
Het |
Lpar5 |
T |
C |
6: 125,058,827 (GRCm39) |
Y183H |
probably benign |
Het |
Ltn1 |
T |
A |
16: 87,194,876 (GRCm39) |
N1341I |
possibly damaging |
Het |
Mms19 |
A |
G |
19: 41,933,992 (GRCm39) |
L938P |
probably damaging |
Het |
Neb |
T |
G |
2: 52,149,312 (GRCm39) |
E2516D |
probably damaging |
Het |
Parp4 |
T |
C |
14: 56,844,951 (GRCm39) |
V614A |
probably damaging |
Het |
Pogk |
A |
G |
1: 166,231,075 (GRCm39) |
L84P |
probably damaging |
Het |
Stard13 |
G |
A |
5: 150,968,642 (GRCm39) |
T994M |
probably damaging |
Het |
Stk4 |
A |
G |
2: 163,941,632 (GRCm39) |
S283G |
probably benign |
Het |
Ttn |
T |
C |
2: 76,640,742 (GRCm39) |
T13669A |
probably benign |
Het |
Vil1 |
A |
G |
1: 74,457,684 (GRCm39) |
T106A |
probably benign |
Het |
Vmn1r18 |
A |
G |
6: 57,367,392 (GRCm39) |
L54P |
probably damaging |
Het |
Vmn1r227 |
G |
T |
17: 20,956,092 (GRCm39) |
|
noncoding transcript |
Het |
Zfp748 |
T |
A |
13: 67,689,202 (GRCm39) |
H686L |
probably damaging |
Het |
Zyg11a |
C |
T |
4: 108,041,666 (GRCm39) |
S658N |
probably damaging |
Het |
|
Other mutations in Zfp267 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL01524:Zfp267
|
APN |
3 |
36,218,729 (GRCm39) |
missense |
possibly damaging |
0.86 |
IGL02089:Zfp267
|
APN |
3 |
36,218,877 (GRCm39) |
missense |
possibly damaging |
0.53 |
IGL02162:Zfp267
|
APN |
3 |
36,218,210 (GRCm39) |
missense |
probably benign |
0.18 |
R0243:Zfp267
|
UTSW |
3 |
36,219,303 (GRCm39) |
missense |
possibly damaging |
0.47 |
R0512:Zfp267
|
UTSW |
3 |
36,220,262 (GRCm39) |
missense |
probably damaging |
0.96 |
R0722:Zfp267
|
UTSW |
3 |
36,219,218 (GRCm39) |
missense |
probably benign |
0.35 |
R0762:Zfp267
|
UTSW |
3 |
36,220,016 (GRCm39) |
missense |
possibly damaging |
0.92 |
R0792:Zfp267
|
UTSW |
3 |
36,218,711 (GRCm39) |
missense |
probably benign |
0.01 |
R0894:Zfp267
|
UTSW |
3 |
36,218,935 (GRCm39) |
nonsense |
probably null |
|
R1731:Zfp267
|
UTSW |
3 |
36,218,620 (GRCm39) |
missense |
probably benign |
0.18 |
R2098:Zfp267
|
UTSW |
3 |
36,220,289 (GRCm39) |
missense |
probably benign |
|
R2099:Zfp267
|
UTSW |
3 |
36,218,361 (GRCm39) |
missense |
possibly damaging |
0.86 |
R3709:Zfp267
|
UTSW |
3 |
36,213,725 (GRCm39) |
missense |
possibly damaging |
0.71 |
R3808:Zfp267
|
UTSW |
3 |
36,219,792 (GRCm39) |
splice site |
probably null |
|
R4035:Zfp267
|
UTSW |
3 |
36,218,989 (GRCm39) |
missense |
possibly damaging |
0.53 |
R4289:Zfp267
|
UTSW |
3 |
36,213,747 (GRCm39) |
missense |
possibly damaging |
0.71 |
R4959:Zfp267
|
UTSW |
3 |
36,218,285 (GRCm39) |
missense |
possibly damaging |
0.91 |
R4973:Zfp267
|
UTSW |
3 |
36,218,285 (GRCm39) |
missense |
possibly damaging |
0.91 |
R5102:Zfp267
|
UTSW |
3 |
36,216,814 (GRCm39) |
missense |
possibly damaging |
0.73 |
R5462:Zfp267
|
UTSW |
3 |
36,219,969 (GRCm39) |
missense |
possibly damaging |
0.95 |
R5548:Zfp267
|
UTSW |
3 |
36,219,640 (GRCm39) |
missense |
possibly damaging |
0.90 |
R5782:Zfp267
|
UTSW |
3 |
36,219,128 (GRCm39) |
missense |
possibly damaging |
0.73 |
R6153:Zfp267
|
UTSW |
3 |
36,219,303 (GRCm39) |
missense |
possibly damaging |
0.47 |
R6225:Zfp267
|
UTSW |
3 |
36,220,352 (GRCm39) |
missense |
probably benign |
0.18 |
R6602:Zfp267
|
UTSW |
3 |
36,219,004 (GRCm39) |
missense |
possibly damaging |
0.86 |
R6785:Zfp267
|
UTSW |
3 |
36,219,601 (GRCm39) |
nonsense |
probably null |
|
R7513:Zfp267
|
UTSW |
3 |
36,218,792 (GRCm39) |
missense |
possibly damaging |
0.53 |
R7846:Zfp267
|
UTSW |
3 |
36,219,738 (GRCm39) |
missense |
probably benign |
0.43 |
R8120:Zfp267
|
UTSW |
3 |
36,218,640 (GRCm39) |
missense |
possibly damaging |
0.96 |
R8265:Zfp267
|
UTSW |
3 |
36,213,677 (GRCm39) |
start gained |
probably benign |
|
R8415:Zfp267
|
UTSW |
3 |
36,219,182 (GRCm39) |
missense |
probably damaging |
0.98 |
R8826:Zfp267
|
UTSW |
3 |
36,218,255 (GRCm39) |
missense |
possibly damaging |
0.86 |
R9026:Zfp267
|
UTSW |
3 |
36,219,066 (GRCm39) |
missense |
possibly damaging |
0.96 |
R9159:Zfp267
|
UTSW |
3 |
36,219,902 (GRCm39) |
missense |
possibly damaging |
0.47 |
R9786:Zfp267
|
UTSW |
3 |
36,219,853 (GRCm39) |
nonsense |
probably null |
|
X0021:Zfp267
|
UTSW |
3 |
36,218,340 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
Predicted Primers |
PCR Primer
(F):5'- CGGTGAATAGTTAGGATTGCTCAGC -3'
(R):5'- ATGAGGGTCTTATAGGCCACAGC -3'
Sequencing Primer
(F):5'- GAATAGTTAGGATTGCTCAGCTTATG -3'
(R):5'- GTGACACACCTACTCCAACAGGG -3'
|
Posted On |
2015-06-20 |