Incidental Mutation 'R4288:Zfp267'
ID 322091
Institutional Source Beutler Lab
Gene Symbol Zfp267
Ensembl Gene ENSMUSG00000033883
Gene Name zinc finger protein 267
Synonyms D3Ertd254e
MMRRC Submission 041653-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.128) question?
Stock # R4288 (G1)
Quality Score 225
Status Validated
Chromosome 3
Chromosomal Location 36205233-36224491 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 36213747 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Serine at position 27 (N27S)
Ref Sequence ENSEMBL: ENSMUSP00000142829 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000165956] [ENSMUST00000197653] [ENSMUST00000205077]
AlphaFold A0A0G2JEM5
Predicted Effect possibly damaging
Transcript: ENSMUST00000165956
AA Change: N26S

PolyPhen 2 Score 0.707 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000131779
Gene: ENSMUSG00000033883
AA Change: N26S

DomainStartEndE-ValueType
KRAB 3 63 2.91e-34 SMART
ZnF_C2H2 342 364 1.08e-1 SMART
ZnF_C2H2 395 417 1.56e-2 SMART
ZnF_C2H2 423 445 3.11e-2 SMART
ZnF_C2H2 451 473 5.9e-3 SMART
ZnF_C2H2 479 501 1.82e-3 SMART
ZnF_C2H2 507 529 5.21e-4 SMART
ZnF_C2H2 535 557 1.84e-4 SMART
ZnF_C2H2 563 585 1.95e-3 SMART
ZnF_C2H2 591 613 2.05e-2 SMART
ZnF_C2H2 619 641 1.6e-4 SMART
ZnF_C2H2 647 669 5.21e-4 SMART
ZnF_C2H2 675 697 1.69e-3 SMART
ZnF_C2H2 703 725 2.61e-4 SMART
ZnF_C2H2 731 753 1.12e-3 SMART
ZnF_C2H2 759 779 3.85e1 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000197653
AA Change: N27S

PolyPhen 2 Score 0.707 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000142829
Gene: ENSMUSG00000033883
AA Change: N27S

DomainStartEndE-ValueType
KRAB 4 64 1.2e-36 SMART
ZnF_C2H2 343 365 4.4e-4 SMART
ZnF_C2H2 396 418 6.7e-5 SMART
ZnF_C2H2 424 446 1.3e-4 SMART
ZnF_C2H2 452 474 2.5e-5 SMART
ZnF_C2H2 480 502 7.9e-6 SMART
ZnF_C2H2 508 530 2.2e-6 SMART
ZnF_C2H2 536 558 7.7e-7 SMART
ZnF_C2H2 564 586 8e-6 SMART
ZnF_C2H2 592 614 8.9e-5 SMART
ZnF_C2H2 620 642 6.6e-7 SMART
ZnF_C2H2 648 670 2.2e-6 SMART
ZnF_C2H2 676 698 7.1e-6 SMART
ZnF_C2H2 704 726 1.1e-6 SMART
ZnF_C2H2 732 754 4.8e-6 SMART
ZnF_C2H2 760 780 1.6e-1 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000205077
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.8%
Validation Efficiency 97% (34/35)
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acmsd G A 1: 127,666,309 (GRCm39) V27M probably damaging Het
Acsl6 A G 11: 54,227,912 (GRCm39) T311A probably benign Het
Adss2 G A 1: 177,604,078 (GRCm39) R176W probably damaging Het
Akr7a5 T C 4: 139,041,415 (GRCm39) V108A probably benign Het
Atp13a1 A G 8: 70,246,728 (GRCm39) D209G possibly damaging Het
Bpnt2 A C 4: 4,778,231 (GRCm39) V169G probably damaging Het
Cdcp1 T A 9: 123,012,693 (GRCm39) I285F probably damaging Het
Ctnna2 C T 6: 77,582,204 (GRCm39) R339Q probably damaging Het
E130308A19Rik G A 4: 59,690,308 (GRCm39) M47I probably benign Het
Exosc9 C T 3: 36,617,365 (GRCm39) T373I probably benign Het
Fat4 T A 3: 38,945,912 (GRCm39) S1602T probably damaging Het
Fbn2 T C 18: 58,168,411 (GRCm39) I2309V probably damaging Het
Fbxo42 T C 4: 140,895,207 (GRCm39) Y57H probably damaging Het
Fcrl5 A G 3: 87,349,531 (GRCm39) D102G probably benign Het
Garin5b T A 7: 4,773,722 (GRCm39) N58Y possibly damaging Het
Gpr37l1 A G 1: 135,088,922 (GRCm39) V381A probably damaging Het
Hc G T 2: 34,920,414 (GRCm39) A644E probably damaging Het
Hspg2 C T 4: 137,246,251 (GRCm39) R1010C probably damaging Het
Lpar5 T C 6: 125,058,827 (GRCm39) Y183H probably benign Het
Ltn1 T A 16: 87,194,876 (GRCm39) N1341I possibly damaging Het
Mms19 A G 19: 41,933,992 (GRCm39) L938P probably damaging Het
Neb T G 2: 52,149,312 (GRCm39) E2516D probably damaging Het
Parp4 T C 14: 56,844,951 (GRCm39) V614A probably damaging Het
Pogk A G 1: 166,231,075 (GRCm39) L84P probably damaging Het
Stard13 G A 5: 150,968,642 (GRCm39) T994M probably damaging Het
Stk4 A G 2: 163,941,632 (GRCm39) S283G probably benign Het
Ttn T C 2: 76,640,742 (GRCm39) T13669A probably benign Het
Vil1 A G 1: 74,457,684 (GRCm39) T106A probably benign Het
Vmn1r18 A G 6: 57,367,392 (GRCm39) L54P probably damaging Het
Vmn1r227 G T 17: 20,956,092 (GRCm39) noncoding transcript Het
Zfp748 T A 13: 67,689,202 (GRCm39) H686L probably damaging Het
Zyg11a C T 4: 108,041,666 (GRCm39) S658N probably damaging Het
Other mutations in Zfp267
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01524:Zfp267 APN 3 36,218,729 (GRCm39) missense possibly damaging 0.86
IGL02089:Zfp267 APN 3 36,218,877 (GRCm39) missense possibly damaging 0.53
IGL02162:Zfp267 APN 3 36,218,210 (GRCm39) missense probably benign 0.18
R0243:Zfp267 UTSW 3 36,219,303 (GRCm39) missense possibly damaging 0.47
R0512:Zfp267 UTSW 3 36,220,262 (GRCm39) missense probably damaging 0.96
R0722:Zfp267 UTSW 3 36,219,218 (GRCm39) missense probably benign 0.35
R0762:Zfp267 UTSW 3 36,220,016 (GRCm39) missense possibly damaging 0.92
R0792:Zfp267 UTSW 3 36,218,711 (GRCm39) missense probably benign 0.01
R0894:Zfp267 UTSW 3 36,218,935 (GRCm39) nonsense probably null
R1731:Zfp267 UTSW 3 36,218,620 (GRCm39) missense probably benign 0.18
R2098:Zfp267 UTSW 3 36,220,289 (GRCm39) missense probably benign
R2099:Zfp267 UTSW 3 36,218,361 (GRCm39) missense possibly damaging 0.86
R3709:Zfp267 UTSW 3 36,213,725 (GRCm39) missense possibly damaging 0.71
R3808:Zfp267 UTSW 3 36,219,792 (GRCm39) splice site probably null
R4035:Zfp267 UTSW 3 36,218,989 (GRCm39) missense possibly damaging 0.53
R4289:Zfp267 UTSW 3 36,213,747 (GRCm39) missense possibly damaging 0.71
R4959:Zfp267 UTSW 3 36,218,285 (GRCm39) missense possibly damaging 0.91
R4973:Zfp267 UTSW 3 36,218,285 (GRCm39) missense possibly damaging 0.91
R5102:Zfp267 UTSW 3 36,216,814 (GRCm39) missense possibly damaging 0.73
R5462:Zfp267 UTSW 3 36,219,969 (GRCm39) missense possibly damaging 0.95
R5548:Zfp267 UTSW 3 36,219,640 (GRCm39) missense possibly damaging 0.90
R5782:Zfp267 UTSW 3 36,219,128 (GRCm39) missense possibly damaging 0.73
R6153:Zfp267 UTSW 3 36,219,303 (GRCm39) missense possibly damaging 0.47
R6225:Zfp267 UTSW 3 36,220,352 (GRCm39) missense probably benign 0.18
R6602:Zfp267 UTSW 3 36,219,004 (GRCm39) missense possibly damaging 0.86
R6785:Zfp267 UTSW 3 36,219,601 (GRCm39) nonsense probably null
R7513:Zfp267 UTSW 3 36,218,792 (GRCm39) missense possibly damaging 0.53
R7846:Zfp267 UTSW 3 36,219,738 (GRCm39) missense probably benign 0.43
R8120:Zfp267 UTSW 3 36,218,640 (GRCm39) missense possibly damaging 0.96
R8265:Zfp267 UTSW 3 36,213,677 (GRCm39) start gained probably benign
R8415:Zfp267 UTSW 3 36,219,182 (GRCm39) missense probably damaging 0.98
R8826:Zfp267 UTSW 3 36,218,255 (GRCm39) missense possibly damaging 0.86
R9026:Zfp267 UTSW 3 36,219,066 (GRCm39) missense possibly damaging 0.96
R9159:Zfp267 UTSW 3 36,219,902 (GRCm39) missense possibly damaging 0.47
R9786:Zfp267 UTSW 3 36,219,853 (GRCm39) nonsense probably null
X0021:Zfp267 UTSW 3 36,218,340 (GRCm39) missense possibly damaging 0.72
Predicted Primers PCR Primer
(F):5'- CGGTGAATAGTTAGGATTGCTCAGC -3'
(R):5'- ATGAGGGTCTTATAGGCCACAGC -3'

Sequencing Primer
(F):5'- GAATAGTTAGGATTGCTCAGCTTATG -3'
(R):5'- GTGACACACCTACTCCAACAGGG -3'
Posted On 2015-06-20