Incidental Mutation 'R4272:Vmn2r55'
ID 322221
Institutional Source Beutler Lab
Gene Symbol Vmn2r55
Ensembl Gene ENSMUSG00000091045
Gene Name vomeronasal 2, receptor 55
Synonyms
MMRRC Submission 041644-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.098) question?
Stock # R4272 (G1)
Quality Score 106
Status Validated
Chromosome 7
Chromosomal Location 12385633-12422855 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 12402106 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Serine at position 394 (F394S)
Ref Sequence ENSEMBL: ENSMUSP00000132834 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000167771] [ENSMUST00000172743]
AlphaFold A0A3B2W3J6
Predicted Effect probably benign
Transcript: ENSMUST00000167771
AA Change: F394S

PolyPhen 2 Score 0.385 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000132834
Gene: ENSMUSG00000091045
AA Change: F394S

DomainStartEndE-ValueType
Pfam:ANF_receptor 5 398 6.1e-54 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000172743
AA Change: F394S

PolyPhen 2 Score 0.032 (Sensitivity: 0.95; Specificity: 0.82)
SMART Domains Protein: ENSMUSP00000133483
Gene: ENSMUSG00000091045
AA Change: F394S

DomainStartEndE-ValueType
Pfam:ANF_receptor 5 397 3.4e-57 PFAM
Pfam:7tm_3 525 762 3.7e-54 PFAM
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.4%
  • 20x: 95.5%
Validation Efficiency 98% (52/53)
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrf2 T A 17: 43,021,013 (GRCm39) T604S probably damaging Het
Ago3 T A 4: 126,248,884 (GRCm39) T556S possibly damaging Het
Arap2 T C 5: 62,828,322 (GRCm39) I950V possibly damaging Het
Arl5b A G 2: 15,077,990 (GRCm39) E105G probably damaging Het
Capza3 A G 6: 139,988,264 (GRCm39) I288V probably benign Het
Chka G A 19: 3,925,737 (GRCm39) probably benign Het
Cnpy4 G T 5: 138,190,853 (GRCm39) V159F probably damaging Het
Crb1 T C 1: 139,251,049 (GRCm39) I301V probably benign Het
Disp1 T A 1: 182,869,208 (GRCm39) I1071F possibly damaging Het
Dlec1 C T 9: 118,972,231 (GRCm39) A1417V probably damaging Het
Dlgap1 T A 17: 71,073,038 (GRCm39) S686T probably benign Het
Dync1li2 A G 8: 105,149,775 (GRCm39) S411P probably damaging Het
Efnb2 T A 8: 8,670,698 (GRCm39) S301C probably damaging Het
Enpp4 T C 17: 44,412,698 (GRCm39) N279D probably benign Het
Exoc3 A G 13: 74,340,763 (GRCm39) V347A probably damaging Het
Ezh1 A G 11: 101,085,734 (GRCm39) F641S probably damaging Het
Gcgr T A 11: 120,429,250 (GRCm39) probably benign Het
Gm4887 G T 7: 104,470,535 (GRCm39) noncoding transcript Het
Hspg2 C T 4: 137,246,251 (GRCm39) R1010C probably damaging Het
Htt G A 5: 35,006,413 (GRCm39) V1441I possibly damaging Het
Ift70a1 A G 2: 75,810,818 (GRCm39) Y422H probably damaging Het
Lmtk2 A G 5: 144,120,044 (GRCm39) M1398V probably benign Het
Lrrc15 T C 16: 30,092,673 (GRCm39) N222S probably benign Het
Mctp2 A T 7: 71,909,079 (GRCm39) V78E possibly damaging Het
Medag A G 5: 149,345,628 (GRCm39) Y103C probably damaging Het
Mphosph9 G A 5: 124,442,266 (GRCm39) P361S probably damaging Het
Npffr2 G A 5: 89,715,882 (GRCm39) V70M probably damaging Het
Obox3-ps8 A C 17: 36,763,909 (GRCm39) noncoding transcript Het
Or4c117 A G 2: 88,955,706 (GRCm39) V123A probably damaging Het
Pdgfra G A 5: 75,343,731 (GRCm39) V751I probably benign Het
Phykpl T C 11: 51,476,355 (GRCm39) L25P probably damaging Het
Rgl1 A T 1: 152,412,040 (GRCm39) I443N probably benign Het
Riok3 AGAAGCGG AG 18: 12,268,998 (GRCm39) probably benign Het
Rragd T C 4: 32,996,099 (GRCm39) probably null Het
Rtcb A T 10: 85,793,483 (GRCm39) M30K probably damaging Het
Rusc2 T A 4: 43,415,533 (GRCm39) C280S probably damaging Het
Sall2 C A 14: 52,551,260 (GRCm39) R643L probably damaging Het
Skp2 C A 15: 9,116,947 (GRCm39) probably null Het
Slc52a3 T A 2: 151,847,660 (GRCm39) I256N possibly damaging Het
Sycp2 A T 2: 178,000,017 (GRCm39) D986E probably benign Het
Tas1r1 T C 4: 152,116,614 (GRCm39) E340G possibly damaging Het
Tnpo1 GCACCTCTGCTTCCTC GCACCTCTGCTTCCTCACCTCTGCTTCCTC 13: 99,003,637 (GRCm39) probably null Het
Trhr G A 15: 44,060,620 (GRCm39) V47I probably damaging Het
Trpm2 A T 10: 77,769,476 (GRCm39) N749K probably damaging Het
Ttc27 T A 17: 75,147,355 (GRCm39) W636R probably damaging Het
Ttn C A 2: 76,608,691 (GRCm39) R17775L probably damaging Het
Zfp52 C A 17: 21,780,459 (GRCm39) Y102* probably null Het
Zyx A G 6: 42,327,880 (GRCm39) D70G probably damaging Het
Other mutations in Vmn2r55
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02684:Vmn2r55 APN 7 12,404,887 (GRCm39) missense probably damaging 1.00
IGL03035:Vmn2r55 APN 7 12,404,743 (GRCm39) missense probably benign 0.01
IGL03115:Vmn2r55 APN 7 12,404,558 (GRCm39) missense probably damaging 1.00
IGL03251:Vmn2r55 APN 7 12,405,120 (GRCm39) splice site probably benign
R0140:Vmn2r55 UTSW 7 12,402,104 (GRCm39) missense possibly damaging 0.58
R0511:Vmn2r55 UTSW 7 12,404,945 (GRCm39) missense possibly damaging 0.88
R1281:Vmn2r55 UTSW 7 12,404,825 (GRCm39) missense probably benign 0.02
R1564:Vmn2r55 UTSW 7 12,418,678 (GRCm39) missense probably damaging 1.00
R1602:Vmn2r55 UTSW 7 12,386,571 (GRCm39) missense probably damaging 1.00
R1785:Vmn2r55 UTSW 7 12,402,111 (GRCm39) missense probably damaging 0.98
R2939:Vmn2r55 UTSW 7 12,385,832 (GRCm39) missense probably damaging 1.00
R2993:Vmn2r55 UTSW 7 12,418,882 (GRCm39) missense probably damaging 1.00
R3151:Vmn2r55 UTSW 7 12,404,634 (GRCm39) missense probably benign 0.06
R4589:Vmn2r55 UTSW 7 12,404,822 (GRCm39) missense probably damaging 0.99
R4624:Vmn2r55 UTSW 7 12,404,627 (GRCm39) missense possibly damaging 0.83
R4965:Vmn2r55 UTSW 7 12,404,478 (GRCm39) missense possibly damaging 0.91
R5294:Vmn2r55 UTSW 7 12,385,791 (GRCm39) missense probably damaging 1.00
R5364:Vmn2r55 UTSW 7 12,404,830 (GRCm39) missense possibly damaging 0.51
R5395:Vmn2r55 UTSW 7 12,385,874 (GRCm39) missense probably damaging 1.00
R5401:Vmn2r55 UTSW 7 12,385,871 (GRCm39) missense probably benign
R5701:Vmn2r55 UTSW 7 12,404,492 (GRCm39) missense probably benign 0.00
R5771:Vmn2r55 UTSW 7 12,404,959 (GRCm39) missense probably damaging 1.00
R5846:Vmn2r55 UTSW 7 12,404,492 (GRCm39) missense probably benign 0.05
R6148:Vmn2r55 UTSW 7 12,402,069 (GRCm39) missense probably benign 0.01
R6159:Vmn2r55 UTSW 7 12,385,698 (GRCm39) missense probably damaging 1.00
R6541:Vmn2r55 UTSW 7 12,404,939 (GRCm39) missense probably damaging 1.00
R7286:Vmn2r55 UTSW 7 12,386,000 (GRCm39) missense probably damaging 0.99
R7483:Vmn2r55 UTSW 7 12,404,755 (GRCm39) missense probably benign 0.00
R8269:Vmn2r55 UTSW 7 12,404,585 (GRCm39) missense possibly damaging 0.86
R8749:Vmn2r55 UTSW 7 12,385,796 (GRCm39) missense probably damaging 1.00
R8914:Vmn2r55 UTSW 7 12,405,024 (GRCm39) missense probably benign 0.09
R9049:Vmn2r55 UTSW 7 12,418,908 (GRCm39) missense probably damaging 1.00
R9175:Vmn2r55 UTSW 7 12,385,793 (GRCm39) missense possibly damaging 0.67
R9344:Vmn2r55 UTSW 7 12,385,782 (GRCm39) nonsense probably null
R9498:Vmn2r55 UTSW 7 12,404,812 (GRCm39) missense probably damaging 1.00
R9715:Vmn2r55 UTSW 7 12,402,061 (GRCm39) missense probably damaging 1.00
Z1177:Vmn2r55 UTSW 7 12,405,106 (GRCm39) missense possibly damaging 0.91
Z1177:Vmn2r55 UTSW 7 12,385,764 (GRCm39) missense possibly damaging 0.83
Predicted Primers PCR Primer
(F):5'- TGAATGGCCTACATCCACTTCATG -3'
(R):5'- ATCCCTTCAGACACCATTTGG -3'

Sequencing Primer
(F):5'- GAGGAACCCTGGACTTGAAATTTCC -3'
(R):5'- TTTGGACAAGACACTGAACAGTC -3'
Posted On 2015-06-20