Incidental Mutation 'R4272:Gcgr'
ID 322231
Institutional Source Beutler Lab
Gene Symbol Gcgr
Ensembl Gene ENSMUSG00000025127
Gene Name glucagon receptor
Synonyms GR
MMRRC Submission 041644-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R4272 (G1)
Quality Score 184
Status Validated
Chromosome 11
Chromosomal Location 120421525-120429812 bp(+) (GRCm39)
Type of Mutation unclassified
DNA Base Change (assembly) T to A at 120429250 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000034913 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000026119] [ENSMUST00000034913]
AlphaFold Q61606
Predicted Effect probably benign
Transcript: ENSMUST00000026119
SMART Domains Protein: ENSMUSP00000026119
Gene: ENSMUSG00000025127

DomainStartEndE-ValueType
signal peptide 1 27 N/A INTRINSIC
HormR 55 131 4.94e-27 SMART
Pfam:7tm_2 139 397 6.4e-79 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000034913
SMART Domains Protein: ENSMUSP00000034913
Gene: ENSMUSG00000061111

DomainStartEndE-ValueType
Pfam:FAM195 4 94 3.3e-26 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000128827
Predicted Effect noncoding transcript
Transcript: ENSMUST00000135515
Predicted Effect noncoding transcript
Transcript: ENSMUST00000143063
Predicted Effect noncoding transcript
Transcript: ENSMUST00000147877
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.4%
  • 20x: 95.5%
Validation Efficiency 98% (52/53)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a glucagon receptor that is important in controlling blood glucose levels. Defects in this gene are a cause of non-insulin-dependent diabetes mellitus (NIDDM).[provided by RefSeq, Jan 2010]
PHENOTYPE: Animals homozygous for a targeted mutation in this gene exhibit reduced blood glucose levels and increased plasma glucagon and amino acid levels associated with alpha-cell hyperplasia. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrf2 T A 17: 43,021,013 (GRCm39) T604S probably damaging Het
Ago3 T A 4: 126,248,884 (GRCm39) T556S possibly damaging Het
Arap2 T C 5: 62,828,322 (GRCm39) I950V possibly damaging Het
Arl5b A G 2: 15,077,990 (GRCm39) E105G probably damaging Het
Capza3 A G 6: 139,988,264 (GRCm39) I288V probably benign Het
Chka G A 19: 3,925,737 (GRCm39) probably benign Het
Cnpy4 G T 5: 138,190,853 (GRCm39) V159F probably damaging Het
Crb1 T C 1: 139,251,049 (GRCm39) I301V probably benign Het
Disp1 T A 1: 182,869,208 (GRCm39) I1071F possibly damaging Het
Dlec1 C T 9: 118,972,231 (GRCm39) A1417V probably damaging Het
Dlgap1 T A 17: 71,073,038 (GRCm39) S686T probably benign Het
Dync1li2 A G 8: 105,149,775 (GRCm39) S411P probably damaging Het
Efnb2 T A 8: 8,670,698 (GRCm39) S301C probably damaging Het
Enpp4 T C 17: 44,412,698 (GRCm39) N279D probably benign Het
Exoc3 A G 13: 74,340,763 (GRCm39) V347A probably damaging Het
Ezh1 A G 11: 101,085,734 (GRCm39) F641S probably damaging Het
Gm4887 G T 7: 104,470,535 (GRCm39) noncoding transcript Het
Hspg2 C T 4: 137,246,251 (GRCm39) R1010C probably damaging Het
Htt G A 5: 35,006,413 (GRCm39) V1441I possibly damaging Het
Ift70a1 A G 2: 75,810,818 (GRCm39) Y422H probably damaging Het
Lmtk2 A G 5: 144,120,044 (GRCm39) M1398V probably benign Het
Lrrc15 T C 16: 30,092,673 (GRCm39) N222S probably benign Het
Mctp2 A T 7: 71,909,079 (GRCm39) V78E possibly damaging Het
Medag A G 5: 149,345,628 (GRCm39) Y103C probably damaging Het
Mphosph9 G A 5: 124,442,266 (GRCm39) P361S probably damaging Het
Npffr2 G A 5: 89,715,882 (GRCm39) V70M probably damaging Het
Obox3-ps8 A C 17: 36,763,909 (GRCm39) noncoding transcript Het
Or4c117 A G 2: 88,955,706 (GRCm39) V123A probably damaging Het
Pdgfra G A 5: 75,343,731 (GRCm39) V751I probably benign Het
Phykpl T C 11: 51,476,355 (GRCm39) L25P probably damaging Het
Rgl1 A T 1: 152,412,040 (GRCm39) I443N probably benign Het
Riok3 AGAAGCGG AG 18: 12,268,998 (GRCm39) probably benign Het
Rragd T C 4: 32,996,099 (GRCm39) probably null Het
Rtcb A T 10: 85,793,483 (GRCm39) M30K probably damaging Het
Rusc2 T A 4: 43,415,533 (GRCm39) C280S probably damaging Het
Sall2 C A 14: 52,551,260 (GRCm39) R643L probably damaging Het
Skp2 C A 15: 9,116,947 (GRCm39) probably null Het
Slc52a3 T A 2: 151,847,660 (GRCm39) I256N possibly damaging Het
Sycp2 A T 2: 178,000,017 (GRCm39) D986E probably benign Het
Tas1r1 T C 4: 152,116,614 (GRCm39) E340G possibly damaging Het
Tnpo1 GCACCTCTGCTTCCTC GCACCTCTGCTTCCTCACCTCTGCTTCCTC 13: 99,003,637 (GRCm39) probably null Het
Trhr G A 15: 44,060,620 (GRCm39) V47I probably damaging Het
Trpm2 A T 10: 77,769,476 (GRCm39) N749K probably damaging Het
Ttc27 T A 17: 75,147,355 (GRCm39) W636R probably damaging Het
Ttn C A 2: 76,608,691 (GRCm39) R17775L probably damaging Het
Vmn2r55 A G 7: 12,402,106 (GRCm39) F394S probably benign Het
Zfp52 C A 17: 21,780,459 (GRCm39) Y102* probably null Het
Zyx A G 6: 42,327,880 (GRCm39) D70G probably damaging Het
Other mutations in Gcgr
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02286:Gcgr APN 11 120,428,757 (GRCm39) missense probably damaging 1.00
IGL02406:Gcgr APN 11 120,428,010 (GRCm39) missense probably damaging 0.99
IGL02756:Gcgr APN 11 120,427,811 (GRCm39) missense probably benign 0.03
IGL02942:Gcgr APN 11 120,427,643 (GRCm39) splice site probably null
PIT4651001:Gcgr UTSW 11 120,428,968 (GRCm39) missense probably damaging 1.00
R0519:Gcgr UTSW 11 120,426,982 (GRCm39) missense probably damaging 1.00
R0549:Gcgr UTSW 11 120,427,387 (GRCm39) missense probably benign 0.28
R1400:Gcgr UTSW 11 120,425,812 (GRCm39) missense probably benign 0.00
R5155:Gcgr UTSW 11 120,427,872 (GRCm39) missense probably benign 0.30
R6042:Gcgr UTSW 11 120,425,584 (GRCm39) start codon destroyed probably null 0.02
R6093:Gcgr UTSW 11 120,428,947 (GRCm39) missense probably damaging 1.00
R6867:Gcgr UTSW 11 120,427,295 (GRCm39) missense possibly damaging 0.63
R7224:Gcgr UTSW 11 120,425,538 (GRCm39) start gained probably benign
R8232:Gcgr UTSW 11 120,427,328 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CATGTGTTGGATGTCAGGTCCC -3'
(R):5'- TCTCCATAGAGGGCACACAG -3'

Sequencing Primer
(F):5'- CCCTAGGTCCTCAGGGAATTCAG -3'
(R):5'- CTCATAAGCTGAAGTTTCTCACAGGG -3'
Posted On 2015-06-20