Mutagenetix > Incidental Mutation

Incidental Mutation 'R4273:Vmn2r17'

322266

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r17

Ensembl Gene

ENSMUSG00000091879

Gene Name

vomeronasal 2, receptor 17

Synonyms

EG384221

MMRRC Submission

041645-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.092) question?

Stock #

R4273 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

109420013-109453387 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 109452966 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Cysteine to Tyrosine at position 710 (C710Y)

Ref Sequence

ENSEMBL: ENSMUSP00000131450 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000171841]

AlphaFold

E9PYF5

Predicted Effect

probably benign
Transcript: ENSMUST00000171841
AA Change: C710Y

PolyPhen 2 Score 0.445 (Sensitivity: 0.89; Specificity: 0.90)

SMART Domains

Protein: ENSMUSP00000131450
Gene: ENSMUSG00000091879
AA Change: C710Y

Domain	Start	End	E-Value	Type
signal peptide	1	24	N/A	INTRINSIC
Pfam:ANF_receptor	76	465	7e-26	PFAM
Pfam:NCD3G	508	562	3.5e-18	PFAM
Pfam:7tm_3	593	830	4.8e-55	PFAM

Coding Region Coverage

1x: 99.4%
3x: 98.8%
10x: 97.7%
20x: 96.1%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 65 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acer2	T	A	4: 86,874,598		probably null	Het
Adgrf2	T	A	17: 42,710,122	T604S	probably damaging	Het
Akap8l	T	A	17: 32,321,931	K533*	probably null	Het
Appbp2	T	C	11: 85,234,676	Y45C	probably damaging	Het
Arap2	T	C	5: 62,670,979	I950V	possibly damaging	Het
Arhgap31	T	C	16: 38,602,335	E1123G	possibly damaging	Het
Atp2c1	G	T	9: 105,435,140	N493K	probably benign	Het
Bcr	T	C	10: 75,125,111	I458T	probably damaging	Het
Brd4	G	A	17: 32,214,782	T468I	probably benign	Het
Cdh23	T	A	10: 60,311,161	D2774V	possibly damaging	Het
Cfdp1	T	C	8: 111,768,785	Y267C	probably damaging	Het
Chd6	C	A	2: 160,961,291	A2156S	probably benign	Het
Dazap2	C	A	15: 100,618,090	P100T	probably damaging	Het
Disp1	T	A	1: 183,087,644	I1071F	possibly damaging	Het
Dlgap1	T	A	17: 70,766,043	S686T	probably benign	Het
Dst	C	T	1: 34,192,340	R3183C	possibly damaging	Het
Enpp4	T	C	17: 44,101,807	N279D	probably benign	Het
Exoc3l	T	C	8: 105,289,961	*740W	probably null	Het
Exoc5	A	T	14: 49,015,480	C625*	probably null	Het
Fam98b	A	T	2: 117,260,231	N137Y	possibly damaging	Het
Fat4	T	A	3: 38,891,627	D1556E	probably damaging	Het
Fcer2a	C	A	8: 3,682,848	V319L	possibly damaging	Het
Fer1l6	T	C	15: 58,627,522	V1247A	probably benign	Het
Fmo4	A	G	1: 162,805,179	V201A	probably damaging	Het
Fras1	G	A	5: 96,614,904	G755D	probably benign	Het
Gm13078	A	T	4: 143,726,846	K175*	probably null	Het
Grid2	T	C	6: 63,909,045	Y142H	probably damaging	Het
Hspg2	C	T	4: 137,518,940	R1010C	probably damaging	Het
Ibtk	T	C	9: 85,726,731	Q376R	probably damaging	Het
Impdh2	T	C	9: 108,564,956	M414T	probably damaging	Het
Itm2c	A	G	1: 85,907,029	T160A	probably damaging	Het
Kcna2	T	A	3: 107,105,193	D363E	probably benign	Het
Lama2	C	T	10: 27,347,054	C412Y	probably damaging	Het
Lims2	C	G	18: 31,956,337	T151S	probably benign	Het
Mier1	T	C	4: 103,162,431	S423P	possibly damaging	Het
Mrgpra3	A	T	7: 47,589,432	W249R	probably benign	Het
Mtor	A	G	4: 148,550,152	H2410R	probably benign	Het
Mvp	C	T	7: 126,989,703	A631T	probably benign	Het
Nepro	T	C	16: 44,735,829	V450A	possibly damaging	Het
Ngrn	T	C	7: 80,264,521	V140A	probably damaging	Het
Nobox	T	C	6: 43,306,008	E231G	probably benign	Het
Olfr129	A	T	17: 38,055,272	I98N	probably damaging	Het
P3h2	T	A	16: 26,105,221	I155F	probably benign	Het
Pcdha3	C	T	18: 36,948,091	R629C	probably damaging	Het
Riok3	AGAAGCGG	AG	18: 12,135,941		probably benign	Het
Rttn	T	C	18: 89,091,896	I1675T	probably benign	Het
Sall2	C	A	14: 52,313,803	R643L	probably damaging	Het
Slc35f4	G	T	14: 49,304,301	T182N	possibly damaging	Het
Slc52a3	T	A	2: 152,005,740	I256N	possibly damaging	Het
Sox9	T	C	11: 112,785,154	S390P	possibly damaging	Het
Tango2	T	C	16: 18,302,790		probably benign	Het
Tas1r1	T	C	4: 152,032,157	E340G	possibly damaging	Het
Tek	G	A	4: 94,829,970	G524R	probably damaging	Het
Tmem260	A	T	14: 48,505,304	Y532F	probably benign	Het
Tsks	C	A	7: 44,957,929	L559I	probably damaging	Het
Unc79	C	A	12: 103,122,353	L1702I	probably damaging	Het
Vmn1r14	T	A	6: 57,234,148	I237N	probably damaging	Het
Zfp119b	G	T	17: 55,938,926	T420K	possibly damaging	Het
Zfp202	C	T	9: 40,207,494	R68*	probably null	Het
Zfp229	T	A	17: 21,746,821	S677R	probably benign	Het
Zfp462	C	T	4: 55,008,411	H126Y	probably benign	Het
Zfp52	C	A	17: 21,560,197	Y102*	probably null	Het
Zfp616	T	A	11: 74,083,700	M265K	probably benign	Het
Zfyve9	A	T	4: 108,680,976	I1031N	probably damaging	Het
Zmynd11	T	C	13: 9,697,690	Y203C	probably damaging	Het

Other mutations in Vmn2r17

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00325:Vmn2r17	APN	5	109427992	missense	probably benign	0.15
IGL01457:Vmn2r17	APN	5	109453032	missense	probably benign	0.00
IGL01527:Vmn2r17	APN	5	109453140	missense	probably damaging	1.00
IGL01693:Vmn2r17	APN	5	109452518	missense	probably damaging	1.00
IGL01738:Vmn2r17	APN	5	109429498	missense	probably damaging	1.00
IGL01767:Vmn2r17	APN	5	109420037	missense	probably benign	0.01
IGL01932:Vmn2r17	APN	5	109427050	missense	probably benign	0.00
IGL01970:Vmn2r17	APN	5	109427947	missense	probably damaging	0.97
IGL02009:Vmn2r17	APN	5	109452848	missense	possibly damaging	0.67
IGL02365:Vmn2r17	APN	5	109453309	missense	probably damaging	1.00
IGL02385:Vmn2r17	APN	5	109434381	missense	probably damaging	1.00
IGL02457:Vmn2r17	APN	5	109453146	missense	probably damaging	1.00
IGL02646:Vmn2r17	APN	5	109453080	missense	probably damaging	1.00
IGL02741:Vmn2r17	APN	5	109420211	missense	probably benign
IGL03213:Vmn2r17	APN	5	109434390	critical splice donor site	probably null
IGL03216:Vmn2r17	APN	5	109452890	missense	probably damaging	1.00
IGL03342:Vmn2r17	APN	5	109427916	missense	probably damaging	1.00
IGL03408:Vmn2r17	APN	5	109429372	splice site	probably benign
R0349:Vmn2r17	UTSW	5	109428336	missense	probably damaging	1.00
R0418:Vmn2r17	UTSW	5	109452881	missense	probably damaging	1.00
R0800:Vmn2r17	UTSW	5	109427326	splice site	probably benign
R0836:Vmn2r17	UTSW	5	109427956	missense	possibly damaging	0.89
R1715:Vmn2r17	UTSW	5	109428244	missense	probably benign	0.00
R1738:Vmn2r17	UTSW	5	109428511	missense	probably benign	0.10
R1801:Vmn2r17	UTSW	5	109428478	missense	probably damaging	1.00
R2054:Vmn2r17	UTSW	5	109452486	missense	probably damaging	0.98
R2060:Vmn2r17	UTSW	5	109427209	missense	probably benign	0.00
R2192:Vmn2r17	UTSW	5	109434278	missense	possibly damaging	0.81
R2315:Vmn2r17	UTSW	5	109428031	missense	probably damaging	1.00
R2374:Vmn2r17	UTSW	5	109427238	missense	probably benign
R3612:Vmn2r17	UTSW	5	109429597	missense	probably benign	0.00
R3832:Vmn2r17	UTSW	5	109428396	missense	probably damaging	1.00
R4494:Vmn2r17	UTSW	5	109428469	missense	probably damaging	1.00
R4597:Vmn2r17	UTSW	5	109429562	missense	probably benign	0.01
R4675:Vmn2r17	UTSW	5	109427183	missense	probably benign	0.00
R4701:Vmn2r17	UTSW	5	109427983	missense	probably damaging	0.99
R4754:Vmn2r17	UTSW	5	109452849	missense	probably damaging	0.99
R4841:Vmn2r17	UTSW	5	109434380	missense	probably damaging	1.00
R4842:Vmn2r17	UTSW	5	109434380	missense	probably damaging	1.00
R4865:Vmn2r17	UTSW	5	109427119	missense	probably damaging	1.00
R4902:Vmn2r17	UTSW	5	109453354	missense	probably benign	0.14
R4989:Vmn2r17	UTSW	5	109427873	missense	probably benign	0.07
R5101:Vmn2r17	UTSW	5	109428351	missense	probably damaging	0.99
R5109:Vmn2r17	UTSW	5	109429476	missense	probably benign	0.06
R5123:Vmn2r17	UTSW	5	109427908	missense	possibly damaging	0.90
R5474:Vmn2r17	UTSW	5	109434284	missense	probably damaging	1.00
R5485:Vmn2r17	UTSW	5	109420106	missense	probably benign	0.06
R5611:Vmn2r17	UTSW	5	109428164	missense	probably damaging	0.97
R5652:Vmn2r17	UTSW	5	109429564	missense	probably benign	0.10
R5717:Vmn2r17	UTSW	5	109427274	missense	possibly damaging	0.94
R5735:Vmn2r17	UTSW	5	109452850	missense	possibly damaging	0.67
R5766:Vmn2r17	UTSW	5	109427273	missense	possibly damaging	0.46
R6645:Vmn2r17	UTSW	5	109428381	missense	probably damaging	1.00
R6786:Vmn2r17	UTSW	5	109427829	missense	probably benign	0.30
R6821:Vmn2r17	UTSW	5	109429465	missense	probably damaging	1.00
R6979:Vmn2r17	UTSW	5	109428399	missense	possibly damaging	0.46
R6984:Vmn2r17	UTSW	5	109452667	missense	probably benign	0.10
R7269:Vmn2r17	UTSW	5	109428471	missense	possibly damaging	0.88
R7509:Vmn2r17	UTSW	5	109427829	missense	probably benign	0.30
R7736:Vmn2r17	UTSW	5	109452891	missense	probably benign	0.05
R7789:Vmn2r17	UTSW	5	109452965	missense	possibly damaging	0.77
R7814:Vmn2r17	UTSW	5	109427873	missense	probably benign	0.07
R7847:Vmn2r17	UTSW	5	109420197	missense	probably damaging	1.00
R7863:Vmn2r17	UTSW	5	109420169	missense	probably benign
R7893:Vmn2r17	UTSW	5	109428078	missense	probably benign	0.05
R8234:Vmn2r17	UTSW	5	109453369	missense	probably benign	0.01
R8382:Vmn2r17	UTSW	5	109428521	missense	probably benign	0.01
R8435:Vmn2r17	UTSW	5	109428306	missense	probably benign	0.01
R8465:Vmn2r17	UTSW	5	109452825	missense	probably damaging	0.99
R8555:Vmn2r17	UTSW	5	109452944	missense	probably damaging	0.99
R8900:Vmn2r17	UTSW	5	109427997	missense	probably benign	0.25
R9293:Vmn2r17	UTSW	5	109452846	missense	probably damaging	1.00
R9308:Vmn2r17	UTSW	5	109452639	missense	probably damaging	0.98
R9378:Vmn2r17	UTSW	5	109427866	missense	possibly damaging	0.94
R9597:Vmn2r17	UTSW	5	109427803	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- ATCCTACAGCAGACCACATTTG -3'
(R):5'- TGCTGAACGTTAGGAACTTGGC -3'

Sequencing Primer
(F):5'- CATTTGGAGTATTTTTCACAGTAGCC -3'
(R):5'- GCTTCATTGAATCTGTCAGGAAG -3'

Posted On

2015-06-20