Incidental Mutation 'R4302:Or7g30'
ID 322461
Institutional Source Beutler Lab
Gene Symbol Or7g30
Ensembl Gene ENSMUSG00000052182
Gene Name olfactory receptor family 7 subfamily G member 30
Synonyms Olfr849, GA_x6K02T2PVTD-13176842-13177780, MOR151-1
MMRRC Submission 041089-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.146) question?
Stock # R4302 (G1)
Quality Score 225
Status Validated
Chromosome 9
Chromosomal Location 19352211-19353149 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 19352295 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 29 (T29A)
Ref Sequence ENSEMBL: ENSMUSP00000149769 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000063923] [ENSMUST00000217273]
AlphaFold Q8VFF6
Predicted Effect probably benign
Transcript: ENSMUST00000063923
AA Change: T29A

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000064123
Gene: ENSMUSG00000052182
AA Change: T29A

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 1.9e-51 PFAM
Pfam:7TM_GPCR_Srsx 35 305 7.6e-6 PFAM
Pfam:7tm_1 41 290 2.6e-23 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000157237
Predicted Effect probably benign
Transcript: ENSMUST00000217273
AA Change: T29A

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.6%
  • 10x: 97.4%
  • 20x: 95.5%
Validation Efficiency 100% (42/42)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Agl T C 3: 116,540,279 (GRCm39) Y1445C probably damaging Het
Arhgef12 G A 9: 42,929,645 (GRCm39) Q217* probably null Het
Bcas1 A G 2: 170,260,547 (GRCm39) V44A probably benign Het
Cfap251 T C 5: 123,431,873 (GRCm39) I549T probably benign Het
Clic4 A G 4: 134,953,350 (GRCm39) V98A probably benign Het
Col6a3 A T 1: 90,735,336 (GRCm39) I771N probably damaging Het
Creb3l1 T C 2: 91,823,664 (GRCm39) I183V probably damaging Het
Dnhd1 T A 7: 105,343,161 (GRCm39) W1502R probably damaging Het
Dync2h1 A T 9: 7,077,880 (GRCm39) S2941T probably benign Het
Gm973 A G 1: 59,590,399 (GRCm39) Y302C possibly damaging Het
Hcfc1 A G X: 72,992,972 (GRCm39) S1398P probably benign Het
Igsf10 T C 3: 59,226,171 (GRCm39) I2501V probably damaging Het
Kcnh8 GAGACCAACGAGCAGCTGATGCTTCAGA GAGA 17: 53,032,934 (GRCm39) 74 probably benign Het
Loxl4 T A 19: 42,596,030 (GRCm39) Y141F probably benign Het
Man2a2 T A 7: 80,001,487 (GRCm39) E1140V possibly damaging Het
Mgam A G 6: 40,740,019 (GRCm39) D1664G probably benign Het
Mill2 A T 7: 18,590,456 (GRCm39) T179S probably damaging Het
Ncf4 T C 15: 78,144,962 (GRCm39) probably benign Het
Nol12 T C 15: 78,824,341 (GRCm39) S154P probably damaging Het
Nup58 A G 14: 60,484,875 (GRCm39) S50P probably benign Het
Or11j4 T C 14: 50,630,903 (GRCm39) I230T probably benign Het
Or12d16-ps1 T A 17: 37,706,377 (GRCm39) N315K probably benign Het
Pdss1 T C 2: 22,805,517 (GRCm39) I265T probably damaging Het
Piezo2 T C 18: 63,257,801 (GRCm39) probably null Het
Rad50 T A 11: 53,592,832 (GRCm39) N106I probably benign Het
Rhpn2 A G 7: 35,090,270 (GRCm39) T631A probably benign Het
Rps11 T C 7: 44,772,368 (GRCm39) M80V probably benign Het
Rrm1 T C 7: 102,097,031 (GRCm39) Y104H probably benign Het
Sgsm3 T A 15: 80,894,502 (GRCm39) probably benign Het
Slc9c1 A T 16: 45,365,154 (GRCm39) L162F probably benign Het
Son A G 16: 91,455,299 (GRCm39) T1349A possibly damaging Het
Stk24 A G 14: 121,529,494 (GRCm39) L386S probably benign Het
Tfcp2 G T 15: 100,412,730 (GRCm39) N307K possibly damaging Het
Trbv21 T A 6: 41,179,702 (GRCm39) V6D probably benign Het
Trip11 A T 12: 101,860,027 (GRCm39) D282E probably damaging Het
Ttn G T 2: 76,706,811 (GRCm39) probably benign Het
Vmn2r129 G T 4: 156,686,692 (GRCm39) noncoding transcript Het
Vmn2r38 A G 7: 9,100,562 (GRCm39) probably null Het
Vps8 T A 16: 21,314,664 (GRCm39) L158Q probably damaging Het
Other mutations in Or7g30
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01285:Or7g30 APN 9 19,352,266 (GRCm39) missense probably benign 0.01
IGL01599:Or7g30 APN 9 19,353,111 (GRCm39) missense probably benign 0.00
IGL01885:Or7g30 APN 9 19,352,760 (GRCm39) missense probably benign 0.01
IGL02258:Or7g30 APN 9 19,352,295 (GRCm39) missense probably benign 0.00
IGL02258:Or7g30 APN 9 19,352,293 (GRCm39) missense possibly damaging 0.66
IGL02282:Or7g30 APN 9 19,352,914 (GRCm39) missense probably benign 0.42
R1293:Or7g30 UTSW 9 19,352,728 (GRCm39) missense probably benign 0.27
R1931:Or7g30 UTSW 9 19,352,647 (GRCm39) missense possibly damaging 0.93
R2444:Or7g30 UTSW 9 19,352,311 (GRCm39) missense possibly damaging 0.78
R4181:Or7g30 UTSW 9 19,353,031 (GRCm39) missense possibly damaging 0.86
R4231:Or7g30 UTSW 9 19,352,886 (GRCm39) missense probably damaging 1.00
R4233:Or7g30 UTSW 9 19,352,886 (GRCm39) missense probably damaging 1.00
R4236:Or7g30 UTSW 9 19,352,886 (GRCm39) missense probably damaging 1.00
R4651:Or7g30 UTSW 9 19,352,591 (GRCm39) nonsense probably null
R5006:Or7g30 UTSW 9 19,352,545 (GRCm39) missense probably benign 0.30
R5088:Or7g30 UTSW 9 19,353,067 (GRCm39) missense probably damaging 1.00
R5501:Or7g30 UTSW 9 19,352,290 (GRCm39) missense possibly damaging 0.93
R6775:Or7g30 UTSW 9 19,352,718 (GRCm39) missense possibly damaging 0.56
R7038:Or7g30 UTSW 9 19,352,888 (GRCm39) missense possibly damaging 0.88
R8010:Or7g30 UTSW 9 19,352,988 (GRCm39) missense probably benign 0.02
R8850:Or7g30 UTSW 9 19,352,817 (GRCm39) missense probably damaging 0.96
R9154:Or7g30 UTSW 9 19,352,531 (GRCm39) missense probably benign 0.39
R9523:Or7g30 UTSW 9 19,352,580 (GRCm39) missense possibly damaging 0.73
Predicted Primers PCR Primer
(F):5'- CCCTGTCAAACAAAACAGTGTTTC -3'
(R):5'- TGATGGTGTGATCCTCCCTCTG -3'

Sequencing Primer
(F):5'- CCATGATGTTTACTATGAAACCTTGC -3'
(R):5'- GGTGTGATCCTCCCTCTGAATGTTC -3'
Posted On 2015-06-20