Mutagenetix > Incidental Mutation

Incidental Mutation 'R4303:Vmn1r90'

322493

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r90

Ensembl Gene

ENSMUSG00000100586

Gene Name

vomeronasal 1 receptor 90

Synonyms

B430211C08Rik

MMRRC Submission

041090-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.052) question?

Stock #

R4303 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

14295167-14296096 bp(-) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

C to T at 14295495 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tryptophan to Stop codon at position 201 (W201*)

Ref Sequence

ENSEMBL: ENSMUSP00000153726 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000185220] [ENSMUST00000226264] [ENSMUST00000226510] [ENSMUST00000226802] [ENSMUST00000227566] [ENSMUST00000227788] [ENSMUST00000227692] [ENSMUST00000227855]

AlphaFold

A0A087WR36

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000044683

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000173220

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000173766

Predicted Effect

probably null
Transcript: ENSMUST00000185220
AA Change: W201*

SMART Domains

Protein: ENSMUSP00000140455
Gene: ENSMUSG00000100586
AA Change: W201*

Domain	Start	End	E-Value	Type
Pfam:TAS2R	8	296	3.9e-9	PFAM
Pfam:V1R	41	295	2.7e-13	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000226264
AA Change: W201*

Predicted Effect

probably null
Transcript: ENSMUST00000226510
AA Change: W119*

Predicted Effect

probably null
Transcript: ENSMUST00000226802
AA Change: W201*

Predicted Effect

probably null
Transcript: ENSMUST00000227566
AA Change: W194*

Predicted Effect

probably null
Transcript: ENSMUST00000227788
AA Change: W201*

Predicted Effect

probably null
Transcript: ENSMUST00000227692
AA Change: W201*

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000226981

Predicted Effect

probably null
Transcript: ENSMUST00000227855
AA Change: W201*

Meta Mutation Damage Score

0.9573

Coding Region Coverage

1x: 99.3%
3x: 98.8%
10x: 97.6%
20x: 96.1%

Validation Efficiency

98% (44/45)

Allele List at MGI

Other mutations in this stock

Total: 43 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcb8	T	C	5: 24,606,055 (GRCm39)	S247P	probably damaging	Het
Atg4b	A	G	1: 93,695,984 (GRCm39)	E41G	probably benign	Het
Bckdk	T	C	7: 127,504,502 (GRCm39)		probably benign	Het
Cacna2d1	A	G	5: 16,507,246 (GRCm39)		probably null	Het
Chaf1a	A	G	17: 56,351,068 (GRCm39)	D16G	unknown	Het
Defb12	A	G	8: 19,162,737 (GRCm39)	I65T	probably benign	Het
Dnah7c	T	C	1: 46,787,738 (GRCm39)	Y3264H	probably damaging	Het
Ehhadh	C	A	16: 21,581,602 (GRCm39)	K463N	probably damaging	Het
Ehmt2	G	A	17: 35,127,724 (GRCm39)	R901Q	possibly damaging	Het
Entrep1	G	A	19: 23,952,993 (GRCm39)	A439V	probably damaging	Het
Entrep1	C	T	19: 23,953,002 (GRCm39)	S436N	probably damaging	Het
Ern2	T	C	7: 121,777,069 (GRCm39)		probably null	Het
Esp6	A	G	17: 40,876,035 (GRCm39)	T28A	possibly damaging	Het
Gm17333	A	C	16: 77,649,767 (GRCm39)		noncoding transcript	Het
Heatr5a	T	C	12: 52,003,008 (GRCm39)	T165A	probably benign	Het
Hoxa5	T	C	6: 52,181,240 (GRCm39)	S31G	probably benign	Het
Ift80	A	G	3: 68,801,507 (GRCm39)	I744T	probably benign	Het
Kalrn	T	C	16: 34,055,761 (GRCm39)	K853E	probably damaging	Het
Krt36	A	T	11: 99,994,239 (GRCm39)	D279E	possibly damaging	Het
Map3k11	T	A	19: 5,740,852 (GRCm39)	V193E	probably damaging	Het
Mrgpra4	T	A	7: 47,630,684 (GRCm39)	M306L	probably benign	Het
Myo1a	A	G	10: 127,549,602 (GRCm39)	T428A	probably benign	Het
Nuggc	A	G	14: 65,848,621 (GRCm39)	H174R	possibly damaging	Het
Or14c40	G	A	7: 86,313,163 (GRCm39)	V98M	probably benign	Het
Or1e29	A	T	11: 73,667,664 (GRCm39)	M163K	possibly damaging	Het
Pigr	G	A	1: 130,769,554 (GRCm39)	D122N	probably benign	Het
Pik3ca	C	T	3: 32,494,084 (GRCm39)	R349*	probably null	Het
Rfxank	T	C	8: 70,588,862 (GRCm39)	D89G	probably damaging	Het
Rsf1	CGGCGGCGG	CGGCGGCGGTGGCGGCGG	7: 97,229,127 (GRCm39)		probably benign	Het
Serpina1a	A	G	12: 103,820,934 (GRCm39)	L348P	probably damaging	Het
Shank1	A	G	7: 43,991,898 (GRCm39)	Y701C	unknown	Het
Six4	G	T	12: 73,159,314 (GRCm39)	D207E	possibly damaging	Het
Slco3a1	G	T	7: 74,204,276 (GRCm39)	D21E	probably benign	Het
Sox6	C	T	7: 115,143,704 (GRCm39)		probably null	Het
Spta1	A	G	1: 174,007,418 (GRCm39)	N216S	probably damaging	Het
Stard13	T	C	5: 150,986,334 (GRCm39)	N392S	possibly damaging	Het
Tax1bp1	T	C	6: 52,704,263 (GRCm39)	V81A	possibly damaging	Het
Trim29	G	T	9: 43,222,419 (GRCm39)	V83L	probably damaging	Het
Wdr31	T	A	4: 62,378,626 (GRCm39)	N7I	probably damaging	Het
Ypel4	A	G	2: 84,567,151 (GRCm39)		probably benign	Het
Zfp39	T	C	11: 58,780,843 (GRCm39)	K640E	probably damaging	Het
Zfp579	A	G	7: 4,996,072 (GRCm39)		probably benign	Het
Zfp974	C	A	7: 27,609,657 (GRCm39)	K689N	possibly damaging	Het

Other mutations in Vmn1r90

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02395:Vmn1r90	APN	7	14,295,822 (GRCm39)	missense	probably damaging	1.00
IGL03282:Vmn1r90	APN	7	14,296,093 (GRCm39)	missense	possibly damaging	0.92
IGL03282:Vmn1r90	APN	7	14,295,426 (GRCm39)	missense	probably benign	0.36
IGL03365:Vmn1r90	APN	7	14,295,229 (GRCm39)	missense	probably damaging	0.99
R2519:Vmn1r90	UTSW	7	14,295,643 (GRCm39)	missense	probably damaging	1.00
R2996:Vmn1r90	UTSW	7	14,295,459 (GRCm39)	missense	probably damaging	1.00
R4086:Vmn1r90	UTSW	7	14,297,219 (GRCm39)	splice site	probably benign
R4508:Vmn1r90	UTSW	7	14,296,084 (GRCm39)	missense	probably benign	0.01
R4551:Vmn1r90	UTSW	7	14,295,894 (GRCm39)	missense	possibly damaging	0.88
R4672:Vmn1r90	UTSW	7	14,295,493 (GRCm39)	missense	probably benign	0.25
R4915:Vmn1r90	UTSW	7	14,295,950 (GRCm39)	missense	possibly damaging	0.82
R5227:Vmn1r90	UTSW	7	14,295,601 (GRCm39)	missense	possibly damaging	0.50
R5629:Vmn1r90	UTSW	7	14,296,011 (GRCm39)	missense	possibly damaging	0.48
R5888:Vmn1r90	UTSW	7	14,295,780 (GRCm39)	missense	probably damaging	1.00
R7532:Vmn1r90	UTSW	7	14,295,189 (GRCm39)	missense	possibly damaging	0.75
R7644:Vmn1r90	UTSW	7	14,295,616 (GRCm39)	nonsense	probably null
R9429:Vmn1r90	UTSW	7	14,295,647 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- TGCCTCAGCCACAGACGAG -3'
(R):5'- CCAAGGTCATAAGCTATTCCTGTTG -3'

Sequencing Primer
(F):5'- ACGAGAGTCTACAAAAACAATGTG -3'
(R):5'- GTCATAAGCTATTCCTGTTGTAGTTG -3'

Posted On

2015-06-20