|Institutional Source||Beutler Lab|
|Gene Name||tripartite motif-containing 29|
|Is this an essential gene?||Non essential (E-score: 0.000)|
|Stock #||R4303 (G1)|
|Chromosomal Location||43310848-43336115 bp(+) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||G to T at 43311122 bp|
|Amino Acid Change||Valine to Leucine at position 83 (V83L)|
|Ref Sequence||ENSEMBL: ENSMUSP00000034511 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000034511]|
|Predicted Effect||probably damaging
AA Change: V83L
PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
AA Change: V83L
|Meta Mutation Damage Score||0.6467|
|Coding Region Coverage||
|Validation Efficiency||98% (44/45)|
|MGI Phenotype||FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the TRIM protein family. It has multiple zinc finger motifs and a leucine zipper motif. It has been proposed to form homo- or heterodimers which are involved in nucleic acid binding. Thus, it may act as a transcriptional regulatory factor involved in carcinogenesis and/or differentiation. It may also function in the suppression of radiosensitivity since it is associated with ataxia telangiectasia phenotype. [provided by RefSeq, Jul 2008]|
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Trim29||
(F):5'- TACCATGGAAGGTGCCGATG -3'
(R):5'- GTAGCTATTCCTGCGGACTTCC -3'
(F):5'- AAGGTGCCGATGCCTGC -3'
(R):5'- ACGATGGTCACCGTGGG -3'