Incidental Mutation 'R4304:Wfdc15b'
ID 322530
Institutional Source Beutler Lab
Gene Symbol Wfdc15b
Ensembl Gene ENSMUSG00000018211
Gene Name WAP four-disulfide core domain 15B
Synonyms Wfdc15, 9230106L14Rik, Swam1
MMRRC Submission 040865-MU
Accession Numbers
Essential gene? Not available question?
Stock # R4304 (G1)
Quality Score 225
Status Not validated
Chromosome 2
Chromosomal Location 164056374-164063580 bp(-) (GRCm39)
Type of Mutation start codon destroyed
DNA Base Change (assembly) A to C at 164057388 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Arginine at position 1 (M1R)
Ref Sequence ENSEMBL: ENSMUSP00000132507 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000018355] [ENSMUST00000109376] [ENSMUST00000164567]
AlphaFold Q9JHY4
Predicted Effect probably null
Transcript: ENSMUST00000018355
AA Change: M1R

PolyPhen 2 Score 0.861 (Sensitivity: 0.83; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000018355
Gene: ENSMUSG00000018211
AA Change: M1R

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
WAP 32 76 9.87e-4 SMART
Predicted Effect probably null
Transcript: ENSMUST00000109376
AA Change: M1R

PolyPhen 2 Score 0.861 (Sensitivity: 0.83; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000105001
Gene: ENSMUSG00000018211
AA Change: M1R

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
WAP 32 76 9.87e-4 SMART
Predicted Effect probably null
Transcript: ENSMUST00000164567
AA Change: M1R

PolyPhen 2 Score 0.861 (Sensitivity: 0.83; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000132507
Gene: ENSMUSG00000018211
AA Change: M1R

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
WAP 32 76 9.87e-4 SMART
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.4%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 30 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam32 A T 8: 25,391,545 (GRCm39) M323K probably damaging Het
Arhgap42 A G 9: 9,006,489 (GRCm39) S636P probably benign Het
Arhgef5 C T 6: 43,256,432 (GRCm39) A1180V probably damaging Het
Cep152 G A 2: 125,405,643 (GRCm39) Q1630* probably null Het
Cfap157 G A 2: 32,669,054 (GRCm39) R350W probably damaging Het
Cfap47 C G X: 78,541,635 (GRCm39) K469N probably damaging Het
Csgalnact1 A T 8: 68,825,294 (GRCm39) V400D possibly damaging Het
Fam3d G A 14: 8,349,324 (GRCm38) P209S probably damaging Het
Fig4 T A 10: 41,132,423 (GRCm39) D461V probably benign Het
Frmd4a C T 2: 4,337,889 (GRCm39) R32C probably benign Het
Gcfc2 G A 6: 81,919,988 (GRCm39) R397Q probably damaging Het
Gm20939 A C 17: 95,184,709 (GRCm39) Q452H probably benign Het
Gm5592 A T 7: 40,935,686 (GRCm39) M63L probably benign Het
H2-M3 T C 17: 37,583,295 (GRCm39) M252T probably benign Het
Lsm14a C A 7: 34,056,858 (GRCm39) probably null Het
Map4k4 T C 1: 40,013,132 (GRCm39) Y76H possibly damaging Het
Npc1 C T 18: 12,343,584 (GRCm39) A470T possibly damaging Het
Or4a68 A T 2: 89,270,542 (GRCm39) V27D probably damaging Het
Prr27 A G 5: 87,990,766 (GRCm39) H126R probably benign Het
Resf1 C T 6: 149,227,736 (GRCm39) Q261* probably null Het
Rptn C A 3: 93,304,238 (GRCm39) H524N probably benign Het
Slc4a11 A T 2: 130,530,058 (GRCm39) M240K probably benign Het
Smg1 T C 7: 117,738,741 (GRCm39) I3503V probably benign Het
Snx13 A G 12: 35,172,941 (GRCm39) K625E probably benign Het
Stk10 T C 11: 32,560,634 (GRCm39) V663A probably damaging Het
Tex11 C A X: 99,977,021 (GRCm39) A487S possibly damaging Het
Tpp1 T A 7: 105,399,516 (GRCm39) D84V possibly damaging Het
Vmn1r238 T A 18: 3,123,040 (GRCm39) R125* probably null Het
Vmn2r12 A G 5: 109,233,872 (GRCm39) L780P probably damaging Het
Wnk2 C T 13: 49,244,313 (GRCm39) D508N probably damaging Het
Other mutations in Wfdc15b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01892:Wfdc15b APN 2 164,057,388 (GRCm39) start codon destroyed probably null 0.86
R7200:Wfdc15b UTSW 2 164,057,037 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- CCCGATACTCTGGGCAATAG -3'
(R):5'- CAGGTCCTAGGACATCCAAC -3'

Sequencing Primer
(F):5'- CTGCGGAAGAATATCACAAGATG -3'
(R):5'- GGACATCCAACTGTTAATTCTGCTG -3'
Posted On 2015-06-20