Mutagenetix > Incidental Mutation

Incidental Mutation 'R0001:Nlrp1b'

32256

Institutional Source

Beutler Lab

Gene Symbol

Nlrp1b

Ensembl Gene

ENSMUSG00000070390

Gene Name

NLR family, pyrin domain containing 1B

Synonyms

Nalp1b

MMRRC Submission

038297-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.063) question?

Stock #

R0001 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

71043928-71121559 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 71052585 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Serine to Proline at position 948 (S948P)

Ref Sequence

ENSEMBL: ENSMUSP00000104155 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000094046] [ENSMUST00000108514] [ENSMUST00000108515] [ENSMUST00000108516] [ENSMUST00000136493]

AlphaFold

A1Z198

Predicted Effect

probably damaging
Transcript: ENSMUST00000094046
AA Change: S945P

PolyPhen 2 Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000091588
Gene: ENSMUSG00000070390
AA Change: S945P

Domain	Start	End	E-Value	Type
Pfam:NACHT	131	300	6.7e-43	PFAM
LRR	627	654	2.24e0	SMART
LRR	656	683	8.82e0	SMART
LRR	684	711	3.49e-5	SMART
Pfam:FIIND	812	1064	8.2e-104	PFAM
Pfam:CARD	1083	1166	3.1e-22	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000108514
AA Change: S948P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000104154
Gene: ENSMUSG00000070390
AA Change: S948P

Domain	Start	End	E-Value	Type
Pfam:NACHT	131	300	2.1e-40	PFAM
LRR	630	657	2.24e0	SMART
LRR	659	686	8.82e0	SMART
LRR	687	714	3.49e-5	SMART
Pfam:FIIND	814	1068	2.4e-136	PFAM
Pfam:CARD	1086	1169	3.7e-22	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000108515
AA Change: S948P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000104155
Gene: ENSMUSG00000070390
AA Change: S948P

Domain	Start	End	E-Value	Type
Pfam:NACHT	131	300	6.9e-41	PFAM
LRR	630	657	2.24e0	SMART
LRR	659	686	8.82e0	SMART
LRR	687	714	3.49e-5	SMART
Pfam:FIIND	815	1067	5e-104	PFAM
Pfam:CARD	1086	1169	1e-22	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000108516
AA Change: S945P

PolyPhen 2 Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000104156
Gene: ENSMUSG00000070390
AA Change: S945P

Domain	Start	End	E-Value	Type
Pfam:NACHT	131	300	2.2e-42	PFAM
LRR	627	654	2.24e0	SMART
LRR	656	683	8.82e0	SMART
LRR	684	711	3.49e-5	SMART
Pfam:FIIND	811	1065	3.9e-136	PFAM
Pfam:CARD	1083	1166	1.1e-21	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000136493

SMART Domains

Protein: ENSMUSP00000121155
Gene: ENSMUSG00000070390

Domain	Start	End	E-Value	Type
Pfam:NACHT	131	300	8.9e-43	PFAM
PDB:4IM6\|A	610	662	6e-10	PDB
Blast:LRR	627	654	3e-11	BLAST

Meta Mutation Damage Score

0.3091

Coding Region Coverage

1x: 99.2%
3x: 98.5%
10x: 96.9%
20x: 94.6%

Validation Efficiency

99% (76/77)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the Ced-4 family of apoptosis proteins. Ced-family members contain a caspase recruitment domain (CARD) and are known to be key mediators of programmed cell death. The encoded protein contains a distinct N-terminal pyrin-like motif, which is possibly involved in protein-protein interactions. This protein interacts strongly with caspase 2 and weakly with caspase 9. Overexpression of this gene was demonstrated to induce apoptosis in cells. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit protection from anthrax lethal toxin-induced lung injury and pyroptosis of macrophages. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 77 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2900092C05Rik	T	A	7: 12,288,534 (GRCm39)		probably benign	Het
A4galt	A	G	15: 83,112,490 (GRCm39)	F98L	probably benign	Het
Abca4	T	G	3: 121,874,660 (GRCm39)		probably benign	Het
Acacb	C	T	5: 114,342,894 (GRCm39)		probably benign	Het
Agbl1	A	T	7: 76,069,611 (GRCm39)	H367L	probably damaging	Het
Apoa4	C	A	9: 46,154,190 (GRCm39)	Q264K	probably benign	Het
Camsap2	A	T	1: 136,210,626 (GRCm39)		probably benign	Het
Cdan1	C	A	2: 120,554,232 (GRCm39)	R939L	probably benign	Het
Ceacam18	G	A	7: 43,286,300 (GRCm39)	V58I	possibly damaging	Het
Ciita	A	T	16: 10,332,297 (GRCm39)		probably benign	Het
Clk4	T	A	11: 51,159,592 (GRCm39)		probably benign	Het
Cntnap2	T	C	6: 46,507,105 (GRCm39)	D215G	probably benign	Het
Col11a2	T	C	17: 34,280,586 (GRCm39)	S1218P	probably benign	Het
Col20a1	T	C	2: 180,626,205 (GRCm39)		probably benign	Het
Ctsb	A	G	14: 63,373,071 (GRCm39)	E76G	probably benign	Het
Ctu2	T	C	8: 123,205,659 (GRCm39)	C161R	probably benign	Het
Dhx29	T	C	13: 113,101,090 (GRCm39)	L1211P	probably damaging	Het
Dhx9	G	T	1: 153,338,382 (GRCm39)	T759K	probably damaging	Het
Dmxl1	T	C	18: 50,021,964 (GRCm39)		probably benign	Het
Dpysl3	C	T	18: 43,491,440 (GRCm39)	E226K	possibly damaging	Het
Eif2d	A	T	1: 131,095,864 (GRCm39)	K453*	probably null	Het
Epha7	T	C	4: 28,961,279 (GRCm39)		probably benign	Het
Fat3	T	C	9: 16,289,169 (GRCm39)	D118G	probably damaging	Het
Fhip2a	T	A	19: 57,370,188 (GRCm39)	H477Q	probably benign	Het
Foxn4	T	A	5: 114,398,931 (GRCm39)	Q159L	probably damaging	Het
Frs2	G	T	10: 116,910,781 (GRCm39)	H194N	possibly damaging	Het
Fut8	A	T	12: 77,522,089 (GRCm39)	*576L	probably null	Het
Galns	T	C	8: 123,322,622 (GRCm39)		probably benign	Het
Gamt	G	A	10: 80,094,895 (GRCm39)		probably benign	Het
Gpn1	T	A	5: 31,652,961 (GRCm39)		probably benign	Het
Ipcef1	G	T	10: 6,850,600 (GRCm39)	H330Q	probably damaging	Het
Itga4	A	C	2: 79,156,931 (GRCm39)	Y1024S	probably damaging	Het
Jak2	A	G	19: 29,259,787 (GRCm39)	I229V	probably benign	Het
Katnal1	A	G	5: 148,858,085 (GRCm39)	S42P	probably damaging	Het
Kcnu1	A	T	8: 26,349,298 (GRCm39)	D142V	probably damaging	Het
Lig3	C	T	11: 82,681,417 (GRCm39)	R470W	probably damaging	Het
Mgat4c	A	G	10: 102,224,817 (GRCm39)	S344G	probably benign	Het
Miox	C	T	15: 89,220,477 (GRCm39)	L189F	possibly damaging	Het
Mipol1	C	T	12: 57,507,625 (GRCm39)		probably benign	Het
Mki67	C	T	7: 135,300,901 (GRCm39)	V1378M	probably damaging	Het
Mki67	T	A	7: 135,302,748 (GRCm39)	D762V	probably damaging	Het
Mmp9	A	G	2: 164,790,303 (GRCm39)	T43A	probably benign	Het
Muc6	T	C	7: 141,227,841 (GRCm39)	T1316A	possibly damaging	Het
Naip5	A	G	13: 100,351,158 (GRCm39)		probably null	Het
Naip5	C	A	13: 100,359,622 (GRCm39)	S538I	probably benign	Het
Nek3	A	T	8: 22,648,628 (GRCm39)		probably benign	Het
Nyap2	A	T	1: 81,169,822 (GRCm39)	H193L	probably benign	Het
Or52h1	T	A	7: 103,828,680 (GRCm39)	K312*	probably null	Het
Or9s23	A	G	1: 92,501,183 (GRCm39)	K97E	possibly damaging	Het
Patl2	G	A	2: 121,956,191 (GRCm39)		probably benign	Het
Pcdhb11	A	T	18: 37,557,042 (GRCm39)	R791W	probably benign	Het
Pkd1l3	C	A	8: 110,355,265 (GRCm39)		probably benign	Het
Pkn2	A	T	3: 142,534,749 (GRCm39)	V73D	probably benign	Het
Pknox1	A	T	17: 31,818,610 (GRCm39)	H281L	probably damaging	Het
Polr3a	A	G	14: 24,502,257 (GRCm39)		probably benign	Het
Prss38	A	G	11: 59,264,006 (GRCm39)		probably benign	Het
Rad54l2	A	G	9: 106,585,416 (GRCm39)	F783S	probably damaging	Het
Rbm5	T	C	9: 107,619,623 (GRCm39)	R125G	probably damaging	Het
Rnpep	A	G	1: 135,200,223 (GRCm39)		probably benign	Het
Slc1a5	T	A	7: 16,527,562 (GRCm39)		probably null	Het
Slc22a4	G	A	11: 53,918,829 (GRCm39)		probably benign	Het
Spink12	T	C	18: 44,240,763 (GRCm39)	C50R	probably damaging	Het
Spmip5	G	A	19: 58,777,603 (GRCm39)	A61V	probably damaging	Het
Svep1	G	A	4: 58,066,460 (GRCm39)	T3208I	possibly damaging	Het
Tgm5	G	T	2: 120,908,127 (GRCm39)	D16E	probably damaging	Het
Tpp2	A	G	1: 44,010,886 (GRCm39)	N558D	probably benign	Het
Trappc9	A	T	15: 72,835,511 (GRCm39)	L507Q	probably damaging	Het
Trpm3	A	T	19: 22,692,695 (GRCm39)	Q262L	possibly damaging	Het
Ttn	A	G	2: 76,607,316 (GRCm39)		probably benign	Het
Ttn	G	A	2: 76,662,433 (GRCm39)		probably benign	Het
Ubr4	T	A	4: 139,179,099 (GRCm39)	L3316Q	probably damaging	Het
Uckl1	T	A	2: 181,216,448 (GRCm39)	Y136F	probably damaging	Het
Vmn1r28	G	A	6: 58,242,702 (GRCm39)	A182T	probably benign	Het
Vps39	A	G	2: 120,148,534 (GRCm39)	V870A	probably benign	Het
Zdhhc25	A	G	15: 88,485,112 (GRCm39)	D149G	probably benign	Het
Zfp648	C	T	1: 154,081,032 (GRCm39)	T397M	probably damaging	Het
Zic2	C	A	14: 122,716,369 (GRCm39)	T435K	probably damaging	Het

Other mutations in Nlrp1b

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00161:Nlrp1b	APN	11	71,072,007 (GRCm39)	intron	probably benign
IGL00571:Nlrp1b	APN	11	71,054,799 (GRCm39)	missense	probably null	0.48
IGL01358:Nlrp1b	APN	11	71,072,682 (GRCm39)	missense	possibly damaging	0.91
IGL01937:Nlrp1b	APN	11	71,072,233 (GRCm39)	missense	probably damaging	0.98
IGL01945:Nlrp1b	APN	11	71,072,233 (GRCm39)	missense	probably damaging	0.98
IGL02375:Nlrp1b	APN	11	71,052,506 (GRCm39)	missense	probably damaging	1.00
IGL02552:Nlrp1b	APN	11	71,063,057 (GRCm39)	missense	possibly damaging	0.96
IGL02552:Nlrp1b	APN	11	71,072,878 (GRCm39)	missense	possibly damaging	0.57
IGL02588:Nlrp1b	APN	11	71,073,105 (GRCm39)	nonsense	probably null
IGL02833:Nlrp1b	APN	11	71,051,998 (GRCm39)	missense	probably benign
IGL02955:Nlrp1b	APN	11	71,060,637 (GRCm39)	missense	possibly damaging	0.73
IGL03002:Nlrp1b	APN	11	71,059,685 (GRCm39)	missense	probably benign	0.00
IGL03033:Nlrp1b	APN	11	71,052,665 (GRCm39)	missense	probably benign	0.22
IGL03122:Nlrp1b	APN	11	71,072,659 (GRCm39)	missense	probably benign	0.00
IGL03131:Nlrp1b	APN	11	71,052,741 (GRCm39)	missense	possibly damaging	0.82
androcles	UTSW	11	71,062,901 (GRCm39)	nonsense	probably null
Fangled	UTSW	11	71,062,997 (GRCm39)	missense	possibly damaging	0.94
glitz	UTSW	11	71,072,376 (GRCm39)	missense	possibly damaging	0.89
honeydew	UTSW	11	71,108,710 (GRCm39)	missense	possibly damaging	0.93
Mush	UTSW	11	71,046,905 (GRCm39)	missense	probably damaging	1.00
Thorn	UTSW	11	71,047,126 (GRCm39)	splice site	probably benign
R0022:Nlrp1b	UTSW	11	71,052,755 (GRCm39)	missense	possibly damaging	0.61
R0022:Nlrp1b	UTSW	11	71,052,755 (GRCm39)	missense	possibly damaging	0.61
R0038:Nlrp1b	UTSW	11	71,062,997 (GRCm39)	missense	possibly damaging	0.94
R0038:Nlrp1b	UTSW	11	71,062,997 (GRCm39)	missense	possibly damaging	0.94
R0164:Nlrp1b	UTSW	11	71,054,925 (GRCm39)	missense	probably damaging	1.00
R0164:Nlrp1b	UTSW	11	71,054,925 (GRCm39)	missense	probably damaging	1.00
R0271:Nlrp1b	UTSW	11	71,052,591 (GRCm39)	missense	possibly damaging	0.51
R0464:Nlrp1b	UTSW	11	71,109,070 (GRCm39)	missense	probably damaging	1.00
R0504:Nlrp1b	UTSW	11	71,073,241 (GRCm39)	missense	probably damaging	0.99
R0605:Nlrp1b	UTSW	11	71,047,005 (GRCm39)	missense	possibly damaging	0.88
R0863:Nlrp1b	UTSW	11	71,072,173 (GRCm39)	missense	probably benign	0.00
R1075:Nlrp1b	UTSW	11	71,072,512 (GRCm39)	missense	probably benign	0.35
R1221:Nlrp1b	UTSW	11	71,072,290 (GRCm39)	missense	probably benign	0.07
R1501:Nlrp1b	UTSW	11	71,046,885 (GRCm39)	missense	probably damaging	1.00
R1654:Nlrp1b	UTSW	11	71,072,124 (GRCm39)	missense	probably damaging	0.99
R1671:Nlrp1b	UTSW	11	71,092,085 (GRCm39)	missense	probably benign	0.45
R1676:Nlrp1b	UTSW	11	71,073,637 (GRCm39)	missense	probably benign	0.13
R1694:Nlrp1b	UTSW	11	71,107,681 (GRCm39)	critical splice donor site	probably null
R1709:Nlrp1b	UTSW	11	71,092,099 (GRCm39)	missense	probably benign	0.11
R1770:Nlrp1b	UTSW	11	71,050,979 (GRCm39)	missense	probably benign	0.22
R1775:Nlrp1b	UTSW	11	71,052,647 (GRCm39)	missense	probably damaging	1.00
R1851:Nlrp1b	UTSW	11	71,073,442 (GRCm39)	missense	possibly damaging	0.96
R1932:Nlrp1b	UTSW	11	71,072,964 (GRCm39)	missense	probably damaging	0.96
R2063:Nlrp1b	UTSW	11	71,051,912 (GRCm39)	missense	probably benign	0.09
R2189:Nlrp1b	UTSW	11	71,060,621 (GRCm39)	missense	probably damaging	1.00
R2223:Nlrp1b	UTSW	11	71,046,815 (GRCm39)	splice site	probably benign
R2284:Nlrp1b	UTSW	11	71,047,110 (GRCm39)	missense	probably benign	0.00
R2434:Nlrp1b	UTSW	11	71,047,552 (GRCm39)	splice site	probably null
R3079:Nlrp1b	UTSW	11	71,108,794 (GRCm39)	missense	probably benign	0.27
R3775:Nlrp1b	UTSW	11	71,047,126 (GRCm39)	splice site	probably benign
R3980:Nlrp1b	UTSW	11	71,072,437 (GRCm39)	missense	possibly damaging	0.56
R4016:Nlrp1b	UTSW	11	71,063,911 (GRCm39)	missense	probably damaging	1.00
R4085:Nlrp1b	UTSW	11	71,052,588 (GRCm39)	missense	probably damaging	0.98
R4542:Nlrp1b	UTSW	11	71,119,151 (GRCm39)	missense	probably damaging	1.00
R4623:Nlrp1b	UTSW	11	71,052,669 (GRCm39)	missense	probably benign	0.00
R4726:Nlrp1b	UTSW	11	71,072,232 (GRCm39)	missense	probably benign	0.10
R4764:Nlrp1b	UTSW	11	71,073,489 (GRCm39)	missense	probably damaging	1.00
R4885:Nlrp1b	UTSW	11	71,108,710 (GRCm39)	missense	possibly damaging	0.93
R4910:Nlrp1b	UTSW	11	71,108,103 (GRCm39)	missense	probably benign	0.09
R4997:Nlrp1b	UTSW	11	71,109,160 (GRCm39)	missense	probably damaging	1.00
R5046:Nlrp1b	UTSW	11	71,050,898 (GRCm39)	missense	possibly damaging	0.95
R5126:Nlrp1b	UTSW	11	71,072,359 (GRCm39)	missense	possibly damaging	0.67
R5369:Nlrp1b	UTSW	11	71,072,625 (GRCm39)	missense	probably benign
R5388:Nlrp1b	UTSW	11	71,062,967 (GRCm39)	missense	probably damaging	1.00
R5445:Nlrp1b	UTSW	11	71,108,701 (GRCm39)	missense	probably benign	0.21
R5546:Nlrp1b	UTSW	11	71,108,102 (GRCm39)	missense	probably benign	0.04
R5567:Nlrp1b	UTSW	11	71,072,229 (GRCm39)	missense	probably benign
R5826:Nlrp1b	UTSW	11	71,072,022 (GRCm39)	missense	probably benign	0.17
R5955:Nlrp1b	UTSW	11	71,108,691 (GRCm39)	missense	probably damaging	1.00
R5995:Nlrp1b	UTSW	11	71,072,572 (GRCm39)	missense	probably damaging	1.00
R6059:Nlrp1b	UTSW	11	71,107,836 (GRCm39)	missense	possibly damaging	0.53
R6170:Nlrp1b	UTSW	11	71,046,905 (GRCm39)	missense	probably damaging	1.00
R6191:Nlrp1b	UTSW	11	71,109,283 (GRCm39)	nonsense	probably null
R6250:Nlrp1b	UTSW	11	71,072,625 (GRCm39)	missense	probably benign	0.11
R6312:Nlrp1b	UTSW	11	71,119,223 (GRCm39)	missense	probably benign	0.38
R6352:Nlrp1b	UTSW	11	71,072,527 (GRCm39)	missense	probably damaging	0.99
R6807:Nlrp1b	UTSW	11	71,108,530 (GRCm39)	missense	probably damaging	1.00
R6854:Nlrp1b	UTSW	11	71,119,259 (GRCm39)	missense	possibly damaging	0.93
R6908:Nlrp1b	UTSW	11	71,108,122 (GRCm39)	missense	probably benign
R6938:Nlrp1b	UTSW	11	71,109,042 (GRCm39)	missense	probably damaging	1.00
R7098:Nlrp1b	UTSW	11	71,109,100 (GRCm39)	missense	possibly damaging	0.89
R7142:Nlrp1b	UTSW	11	71,062,901 (GRCm39)	nonsense	probably null
R7149:Nlrp1b	UTSW	11	71,072,482 (GRCm39)	nonsense	probably null
R7349:Nlrp1b	UTSW	11	71,072,943 (GRCm39)	missense	probably benign	0.36
R7354:Nlrp1b	UTSW	11	71,072,376 (GRCm39)	missense	possibly damaging	0.89
R7750:Nlrp1b	UTSW	11	71,059,665 (GRCm39)	missense	probably benign	0.11
R7913:Nlrp1b	UTSW	11	71,108,537 (GRCm39)	missense	possibly damaging	0.93
R8031:Nlrp1b	UTSW	11	71,107,747 (GRCm39)	missense	probably benign	0.15
R8087:Nlrp1b	UTSW	11	71,062,897 (GRCm39)	missense	probably benign	0.04
R8164:Nlrp1b	UTSW	11	71,119,243 (GRCm39)	missense	possibly damaging	0.78
R8378:Nlrp1b	UTSW	11	71,052,545 (GRCm39)	missense	possibly damaging	0.95
R8405:Nlrp1b	UTSW	11	71,073,356 (GRCm39)	missense	possibly damaging	0.66
R8441:Nlrp1b	UTSW	11	71,073,204 (GRCm39)	missense	probably damaging	1.00
R8792:Nlrp1b	UTSW	11	71,050,919 (GRCm39)	missense	probably benign	0.02
R8898:Nlrp1b	UTSW	11	71,073,288 (GRCm39)	missense	probably damaging	1.00
R8953:Nlrp1b	UTSW	11	71,052,632 (GRCm39)	missense	probably damaging	0.96
R8963:Nlrp1b	UTSW	11	71,108,658 (GRCm39)	missense	probably damaging	1.00
R9145:Nlrp1b	UTSW	11	71,109,193 (GRCm39)	missense	probably benign
R9184:Nlrp1b	UTSW	11	71,072,067 (GRCm39)	missense	probably damaging	1.00
R9286:Nlrp1b	UTSW	11	71,060,573 (GRCm39)	missense	probably benign
R9322:Nlrp1b	UTSW	11	71,108,118 (GRCm39)	missense	probably benign	0.12
R9453:Nlrp1b	UTSW	11	71,072,913 (GRCm39)	missense	probably damaging	0.98
R9533:Nlrp1b	UTSW	11	71,109,095 (GRCm39)	missense	probably benign	0.12
R9659:Nlrp1b	UTSW	11	71,073,132 (GRCm39)	missense	possibly damaging	0.77
Z1176:Nlrp1b	UTSW	11	71,073,096 (GRCm39)	missense	probably damaging	1.00
Z1177:Nlrp1b	UTSW	11	71,108,050 (GRCm39)	missense	probably benign	0.03
Z1177:Nlrp1b	UTSW	11	71,072,125 (GRCm39)	nonsense	probably null
Z1186:Nlrp1b	UTSW	11	71,073,370 (GRCm39)	missense	probably benign	0.00
Z1186:Nlrp1b	UTSW	11	71,073,280 (GRCm39)	missense	probably benign	0.00
Z1186:Nlrp1b	UTSW	11	71,073,266 (GRCm39)	missense	probably benign
Z1186:Nlrp1b	UTSW	11	71,073,148 (GRCm39)	missense	probably benign
Z1186:Nlrp1b	UTSW	11	71,073,135 (GRCm39)	missense	probably benign
Z1186:Nlrp1b	UTSW	11	71,072,625 (GRCm39)	missense	probably benign
Z1186:Nlrp1b	UTSW	11	71,072,539 (GRCm39)	missense	probably benign
Z1186:Nlrp1b	UTSW	11	71,072,534 (GRCm39)	missense	probably benign	0.02
Z1186:Nlrp1b	UTSW	11	71,073,503 (GRCm39)	missense	probably benign
Z1186:Nlrp1b	UTSW	11	71,073,396 (GRCm39)	missense	probably benign	0.02
Z1186:Nlrp1b	UTSW	11	71,073,378 (GRCm39)	missense	probably benign
Z1187:Nlrp1b	UTSW	11	71,073,370 (GRCm39)	missense	probably benign	0.00
Z1187:Nlrp1b	UTSW	11	71,073,280 (GRCm39)	missense	probably benign	0.00
Z1187:Nlrp1b	UTSW	11	71,073,266 (GRCm39)	missense	probably benign
Z1187:Nlrp1b	UTSW	11	71,073,148 (GRCm39)	missense	probably benign
Z1187:Nlrp1b	UTSW	11	71,072,625 (GRCm39)	missense	probably benign
Z1187:Nlrp1b	UTSW	11	71,072,539 (GRCm39)	missense	probably benign
Z1187:Nlrp1b	UTSW	11	71,072,534 (GRCm39)	missense	probably benign	0.02
Z1187:Nlrp1b	UTSW	11	71,073,503 (GRCm39)	missense	probably benign
Z1187:Nlrp1b	UTSW	11	71,073,396 (GRCm39)	missense	probably benign	0.02
Z1187:Nlrp1b	UTSW	11	71,073,378 (GRCm39)	missense	probably benign
Z1188:Nlrp1b	UTSW	11	71,073,378 (GRCm39)	missense	probably benign
Z1188:Nlrp1b	UTSW	11	71,073,396 (GRCm39)	missense	probably benign	0.02
Z1188:Nlrp1b	UTSW	11	71,073,503 (GRCm39)	missense	probably benign
Z1188:Nlrp1b	UTSW	11	71,072,534 (GRCm39)	missense	probably benign	0.02
Z1188:Nlrp1b	UTSW	11	71,072,539 (GRCm39)	missense	probably benign
Z1188:Nlrp1b	UTSW	11	71,072,625 (GRCm39)	missense	probably benign
Z1188:Nlrp1b	UTSW	11	71,073,135 (GRCm39)	missense	probably benign
Z1188:Nlrp1b	UTSW	11	71,073,148 (GRCm39)	missense	probably benign
Z1188:Nlrp1b	UTSW	11	71,073,266 (GRCm39)	missense	probably benign
Z1188:Nlrp1b	UTSW	11	71,073,280 (GRCm39)	missense	probably benign	0.00
Z1188:Nlrp1b	UTSW	11	71,073,370 (GRCm39)	missense	probably benign	0.00
Z1189:Nlrp1b	UTSW	11	71,073,370 (GRCm39)	missense	probably benign	0.00
Z1189:Nlrp1b	UTSW	11	71,073,280 (GRCm39)	missense	probably benign	0.00
Z1189:Nlrp1b	UTSW	11	71,073,266 (GRCm39)	missense	probably benign
Z1189:Nlrp1b	UTSW	11	71,073,148 (GRCm39)	missense	probably benign
Z1189:Nlrp1b	UTSW	11	71,073,135 (GRCm39)	missense	probably benign
Z1189:Nlrp1b	UTSW	11	71,072,625 (GRCm39)	missense	probably benign
Z1189:Nlrp1b	UTSW	11	71,072,539 (GRCm39)	missense	probably benign
Z1189:Nlrp1b	UTSW	11	71,072,534 (GRCm39)	missense	probably benign	0.02
Z1189:Nlrp1b	UTSW	11	71,073,503 (GRCm39)	missense	probably benign
Z1189:Nlrp1b	UTSW	11	71,073,396 (GRCm39)	missense	probably benign	0.02
Z1189:Nlrp1b	UTSW	11	71,073,378 (GRCm39)	missense	probably benign
Z1190:Nlrp1b	UTSW	11	71,073,370 (GRCm39)	missense	probably benign	0.00
Z1190:Nlrp1b	UTSW	11	71,073,378 (GRCm39)	missense	probably benign
Z1190:Nlrp1b	UTSW	11	71,073,396 (GRCm39)	missense	probably benign	0.02
Z1190:Nlrp1b	UTSW	11	71,073,503 (GRCm39)	missense	probably benign
Z1190:Nlrp1b	UTSW	11	71,072,534 (GRCm39)	missense	probably benign	0.02
Z1190:Nlrp1b	UTSW	11	71,072,539 (GRCm39)	missense	probably benign
Z1190:Nlrp1b	UTSW	11	71,072,625 (GRCm39)	missense	probably benign
Z1190:Nlrp1b	UTSW	11	71,073,135 (GRCm39)	missense	probably benign
Z1190:Nlrp1b	UTSW	11	71,073,148 (GRCm39)	missense	probably benign
Z1190:Nlrp1b	UTSW	11	71,073,266 (GRCm39)	missense	probably benign
Z1190:Nlrp1b	UTSW	11	71,073,280 (GRCm39)	missense	probably benign	0.00
Z1191:Nlrp1b	UTSW	11	71,073,280 (GRCm39)	missense	probably benign	0.00
Z1191:Nlrp1b	UTSW	11	71,073,266 (GRCm39)	missense	probably benign
Z1191:Nlrp1b	UTSW	11	71,073,148 (GRCm39)	missense	probably benign
Z1191:Nlrp1b	UTSW	11	71,073,135 (GRCm39)	missense	probably benign
Z1191:Nlrp1b	UTSW	11	71,072,625 (GRCm39)	missense	probably benign
Z1191:Nlrp1b	UTSW	11	71,072,539 (GRCm39)	missense	probably benign
Z1191:Nlrp1b	UTSW	11	71,072,534 (GRCm39)	missense	probably benign	0.02
Z1191:Nlrp1b	UTSW	11	71,073,503 (GRCm39)	missense	probably benign
Z1191:Nlrp1b	UTSW	11	71,073,396 (GRCm39)	missense	probably benign	0.02
Z1191:Nlrp1b	UTSW	11	71,073,378 (GRCm39)	missense	probably benign
Z1191:Nlrp1b	UTSW	11	71,073,370 (GRCm39)	missense	probably benign	0.00
Z1192:Nlrp1b	UTSW	11	71,073,396 (GRCm39)	missense	probably benign	0.02
Z1192:Nlrp1b	UTSW	11	71,073,378 (GRCm39)	missense	probably benign
Z1192:Nlrp1b	UTSW	11	71,073,370 (GRCm39)	missense	probably benign	0.00
Z1192:Nlrp1b	UTSW	11	71,073,280 (GRCm39)	missense	probably benign	0.00
Z1192:Nlrp1b	UTSW	11	71,073,266 (GRCm39)	missense	probably benign
Z1192:Nlrp1b	UTSW	11	71,073,148 (GRCm39)	missense	probably benign
Z1192:Nlrp1b	UTSW	11	71,072,625 (GRCm39)	missense	probably benign
Z1192:Nlrp1b	UTSW	11	71,072,534 (GRCm39)	missense	probably benign	0.02
Z1192:Nlrp1b	UTSW	11	71,073,503 (GRCm39)	missense	probably benign

Predicted Primers

PCR Primer
(F):5'- GAAGGCTGAATCATACACACCAGGG -3'
(R):5'- GCAAGCACATTTGACTTCAAGGTGG -3'

Sequencing Primer
(F):5'- AGGGTTTCCCTCACAGAACTG -3'
(R):5'- GGTGGCCCACTTTCAAGAAC -3'

Posted On

2013-05-09