Incidental Mutation 'R4260:Klra10'
| ID |
322606 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Klra10
|
| Ensembl Gene |
ENSMUSG00000072718 |
| Gene Name |
killer cell lectin-like receptor subfamily A, member 10 |
| Synonyms |
Ly49i2, Ly49J |
| MMRRC Submission |
041073-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.051)
|
| Stock # |
R4260 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
6 |
| Chromosomal Location |
130246157-130258891 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 130249644 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Tryptophan to Arginine
at position 214
(W214R)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000107651
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000112020]
|
| AlphaFold |
Q9R1G6 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000112020
AA Change: W214R
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000107651
Gene: ENSMUSG00000072718
AA Change: W214R
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
56 |
66 |
N/A |
INTRINSIC |
|
Blast:CLECT
|
73 |
117 |
2e-9 |
BLAST |
|
CLECT
|
143 |
258 |
6.43e-14 |
SMART |
|
| Meta Mutation Damage Score |
0.6467 |
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.7%
- 10x: 97.5%
- 20x: 95.7%
|
| Validation Efficiency |
98% (50/51) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 42 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adnp2 |
G |
A |
18: 80,180,742 (GRCm39) |
S52L |
possibly damaging |
Het |
| Best3 |
A |
T |
10: 116,860,131 (GRCm39) |
M464L |
probably benign |
Het |
| Ccdc83 |
T |
G |
7: 89,877,599 (GRCm39) |
D281A |
possibly damaging |
Het |
| Ccnf |
G |
A |
17: 24,445,741 (GRCm39) |
P502S |
probably damaging |
Het |
| Cd109 |
T |
A |
9: 78,543,745 (GRCm39) |
S96R |
possibly damaging |
Het |
| Cep290 |
A |
C |
10: 100,350,354 (GRCm39) |
E649D |
probably damaging |
Het |
| Cntnap5a |
G |
T |
1: 116,374,325 (GRCm39) |
A946S |
probably benign |
Het |
| Csnk2a2 |
A |
T |
8: 96,184,027 (GRCm39) |
D177E |
probably benign |
Het |
| Cyld |
T |
C |
8: 89,468,019 (GRCm39) |
S551P |
probably damaging |
Het |
| Degs1 |
A |
T |
1: 182,106,806 (GRCm39) |
I151N |
probably benign |
Het |
| Dnah12 |
A |
G |
14: 26,520,883 (GRCm39) |
I1901V |
probably benign |
Het |
| Eif2ak3 |
G |
A |
6: 70,866,497 (GRCm39) |
R597H |
probably damaging |
Het |
| Epg5 |
A |
T |
18: 78,002,336 (GRCm39) |
H585L |
possibly damaging |
Het |
| Epg5 |
G |
C |
18: 78,058,914 (GRCm39) |
W1889C |
probably damaging |
Het |
| Fam220a |
G |
C |
5: 143,548,762 (GRCm39) |
R58P |
possibly damaging |
Het |
| Gemin5 |
G |
A |
11: 58,059,185 (GRCm39) |
A32V |
probably damaging |
Het |
| Gm11189 |
A |
C |
11: 53,091,703 (GRCm39) |
|
noncoding transcript |
Het |
| Grb2 |
A |
G |
11: 115,540,642 (GRCm39) |
I85T |
probably damaging |
Het |
| Herc1 |
CTGAGGACTCTTTG |
CTG |
9: 66,355,630 (GRCm39) |
|
probably null |
Het |
| Ide |
A |
C |
19: 37,306,585 (GRCm39) |
S63A |
unknown |
Het |
| Kel |
A |
T |
6: 41,663,357 (GRCm39) |
|
probably benign |
Het |
| Kifap3 |
C |
A |
1: 163,689,597 (GRCm39) |
T527K |
probably damaging |
Het |
| Luc7l3 |
A |
T |
11: 94,186,876 (GRCm39) |
|
probably benign |
Het |
| Mrpl4 |
A |
G |
9: 20,918,988 (GRCm39) |
E211G |
possibly damaging |
Het |
| Or4k39 |
T |
A |
2: 111,238,850 (GRCm39) |
|
noncoding transcript |
Het |
| Or52n5 |
A |
C |
7: 104,587,803 (GRCm39) |
E23D |
probably damaging |
Het |
| Pbld2 |
T |
C |
10: 62,860,186 (GRCm39) |
|
probably benign |
Het |
| Plcg1 |
T |
C |
2: 160,593,627 (GRCm39) |
|
probably null |
Het |
| Ppcs |
A |
G |
4: 119,279,106 (GRCm39) |
F149L |
probably damaging |
Het |
| Ptpdc1 |
A |
G |
13: 48,733,234 (GRCm39) |
M802T |
probably benign |
Het |
| Ptprf |
A |
G |
4: 118,083,280 (GRCm39) |
F909S |
possibly damaging |
Het |
| Raph1 |
A |
T |
1: 60,542,124 (GRCm39) |
M330K |
possibly damaging |
Het |
| Rprd1a |
G |
A |
18: 24,621,352 (GRCm39) |
R276C |
possibly damaging |
Het |
| Scg3 |
A |
G |
9: 75,558,979 (GRCm39) |
Y406H |
probably damaging |
Het |
| Setdb1 |
G |
A |
3: 95,234,808 (GRCm39) |
S965F |
probably damaging |
Het |
| Sgo2b |
A |
T |
8: 64,381,330 (GRCm39) |
F501I |
probably benign |
Het |
| Slc38a4 |
A |
G |
15: 96,896,374 (GRCm39) |
Y498H |
probably damaging |
Het |
| Slc5a4b |
A |
G |
10: 75,939,686 (GRCm39) |
L150P |
probably damaging |
Het |
| Spata17 |
T |
A |
1: 186,780,677 (GRCm39) |
T357S |
possibly damaging |
Het |
| Tmt1a |
A |
G |
15: 100,210,951 (GRCm39) |
D141G |
probably benign |
Het |
| Zap70 |
T |
A |
1: 36,818,189 (GRCm39) |
|
probably benign |
Het |
| Zfp985 |
G |
A |
4: 147,668,029 (GRCm39) |
C299Y |
probably damaging |
Het |
|
| Other mutations in Klra10 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01505:Klra10
|
APN |
6 |
130,249,680 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02060:Klra10
|
APN |
6 |
130,249,688 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02249:Klra10
|
APN |
6 |
130,256,367 (GRCm39) |
missense |
probably benign |
0.07 |
|
IGL02681:Klra10
|
APN |
6 |
130,256,382 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02684:Klra10
|
APN |
6 |
130,258,845 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
FR4342:Klra10
|
UTSW |
6 |
130,249,710 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0324:Klra10
|
UTSW |
6 |
130,249,613 (GRCm39) |
splice site |
probably null |
|
|
R1072:Klra10
|
UTSW |
6 |
130,258,811 (GRCm39) |
missense |
probably benign |
0.11 |
|
R1466:Klra10
|
UTSW |
6 |
130,256,394 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1466:Klra10
|
UTSW |
6 |
130,256,394 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1466:Klra10
|
UTSW |
6 |
130,256,278 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1466:Klra10
|
UTSW |
6 |
130,256,278 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2125:Klra10
|
UTSW |
6 |
130,256,241 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2266:Klra10
|
UTSW |
6 |
130,246,264 (GRCm39) |
missense |
probably benign |
0.13 |
|
R2427:Klra10
|
UTSW |
6 |
130,256,298 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4495:Klra10
|
UTSW |
6 |
130,256,311 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5897:Klra10
|
UTSW |
6 |
130,258,792 (GRCm39) |
nonsense |
probably null |
|
|
R6123:Klra10
|
UTSW |
6 |
130,256,339 (GRCm39) |
missense |
probably benign |
0.04 |
|
R6221:Klra10
|
UTSW |
6 |
130,246,235 (GRCm39) |
missense |
probably benign |
|
|
R6478:Klra10
|
UTSW |
6 |
130,249,507 (GRCm39) |
splice site |
probably null |
|
|
R6520:Klra10
|
UTSW |
6 |
130,252,755 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6551:Klra10
|
UTSW |
6 |
130,252,718 (GRCm39) |
missense |
probably benign |
0.36 |
|
R7445:Klra10
|
UTSW |
6 |
130,252,819 (GRCm39) |
missense |
probably benign |
0.38 |
|
R7453:Klra10
|
UTSW |
6 |
130,257,327 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7744:Klra10
|
UTSW |
6 |
130,249,724 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R8079:Klra10
|
UTSW |
6 |
130,252,738 (GRCm39) |
missense |
probably benign |
|
|
R8320:Klra10
|
UTSW |
6 |
130,246,211 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8963:Klra10
|
UTSW |
6 |
130,249,617 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9419:Klra10
|
UTSW |
6 |
130,256,435 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9725:Klra10
|
UTSW |
6 |
130,252,849 (GRCm39) |
missense |
probably benign |
|
|
RF060:Klra10
|
UTSW |
6 |
130,252,784 (GRCm39) |
small deletion |
probably benign |
|
|
| Predicted Primers |
PCR Primer
(F):5'- AGGCACTTTTGGTCAACTCC -3'
(R):5'- CATGAACCGAGGACACTTGAAG -3'
Sequencing Primer
(F):5'- CCTTTTGTAACACTTGATCAGGAAC -3'
(R):5'- TGAATATGATGAGACTGAGTGGTG -3'
|
| Posted On |
2015-06-20 |
Incidental Mutation