Mutagenetix > Incidental Mutation

Incidental Mutation 'R4260:Gm11189'

322621

Institutional Source

Beutler Lab

Gene Symbol

Gm11189

Ensembl Gene

ENSMUSG00000058073

Gene Name

predicted gene 11189

Synonyms

MMRRC Submission

041073-MU

Accession Numbers

Essential gene?

Possibly essential (E-score: 0.603) question?

Stock #

R4260 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

53091511-53091885 bp(+) (GRCm39)

Type of Mutation

exon

DNA Base Change (assembly)

A to C at 53091703 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Gene Model

predicted gene model for transcript(s):

AlphaFold

no structure available at present

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000117979

Coding Region Coverage

1x: 99.3%
3x: 98.7%
10x: 97.5%
20x: 95.7%

Validation Efficiency

98% (50/51)

Allele List at MGI

Other mutations in this stock

Total: 42 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adnp2	G	A	18: 80,180,742 (GRCm39)	S52L	possibly damaging	Het
Best3	A	T	10: 116,860,131 (GRCm39)	M464L	probably benign	Het
Ccdc83	T	G	7: 89,877,599 (GRCm39)	D281A	possibly damaging	Het
Ccnf	G	A	17: 24,445,741 (GRCm39)	P502S	probably damaging	Het
Cd109	T	A	9: 78,543,745 (GRCm39)	S96R	possibly damaging	Het
Cep290	A	C	10: 100,350,354 (GRCm39)	E649D	probably damaging	Het
Cntnap5a	G	T	1: 116,374,325 (GRCm39)	A946S	probably benign	Het
Csnk2a2	A	T	8: 96,184,027 (GRCm39)	D177E	probably benign	Het
Cyld	T	C	8: 89,468,019 (GRCm39)	S551P	probably damaging	Het
Degs1	A	T	1: 182,106,806 (GRCm39)	I151N	probably benign	Het
Dnah12	A	G	14: 26,520,883 (GRCm39)	I1901V	probably benign	Het
Eif2ak3	G	A	6: 70,866,497 (GRCm39)	R597H	probably damaging	Het
Epg5	A	T	18: 78,002,336 (GRCm39)	H585L	possibly damaging	Het
Epg5	G	C	18: 78,058,914 (GRCm39)	W1889C	probably damaging	Het
Fam220a	G	C	5: 143,548,762 (GRCm39)	R58P	possibly damaging	Het
Gemin5	G	A	11: 58,059,185 (GRCm39)	A32V	probably damaging	Het
Grb2	A	G	11: 115,540,642 (GRCm39)	I85T	probably damaging	Het
Herc1	CTGAGGACTCTTTG	CTG	9: 66,355,630 (GRCm39)		probably null	Het
Ide	A	C	19: 37,306,585 (GRCm39)	S63A	unknown	Het
Kel	A	T	6: 41,663,357 (GRCm39)		probably benign	Het
Kifap3	C	A	1: 163,689,597 (GRCm39)	T527K	probably damaging	Het
Klra10	A	G	6: 130,249,644 (GRCm39)	W214R	probably damaging	Het
Luc7l3	A	T	11: 94,186,876 (GRCm39)		probably benign	Het
Mrpl4	A	G	9: 20,918,988 (GRCm39)	E211G	possibly damaging	Het
Or4k39	T	A	2: 111,238,850 (GRCm39)		noncoding transcript	Het
Or52n5	A	C	7: 104,587,803 (GRCm39)	E23D	probably damaging	Het
Pbld2	T	C	10: 62,860,186 (GRCm39)		probably benign	Het
Plcg1	T	C	2: 160,593,627 (GRCm39)		probably null	Het
Ppcs	A	G	4: 119,279,106 (GRCm39)	F149L	probably damaging	Het
Ptpdc1	A	G	13: 48,733,234 (GRCm39)	M802T	probably benign	Het
Ptprf	A	G	4: 118,083,280 (GRCm39)	F909S	possibly damaging	Het
Raph1	A	T	1: 60,542,124 (GRCm39)	M330K	possibly damaging	Het
Rprd1a	G	A	18: 24,621,352 (GRCm39)	R276C	possibly damaging	Het
Scg3	A	G	9: 75,558,979 (GRCm39)	Y406H	probably damaging	Het
Setdb1	G	A	3: 95,234,808 (GRCm39)	S965F	probably damaging	Het
Sgo2b	A	T	8: 64,381,330 (GRCm39)	F501I	probably benign	Het
Slc38a4	A	G	15: 96,896,374 (GRCm39)	Y498H	probably damaging	Het
Slc5a4b	A	G	10: 75,939,686 (GRCm39)	L150P	probably damaging	Het
Spata17	T	A	1: 186,780,677 (GRCm39)	T357S	possibly damaging	Het
Tmt1a	A	G	15: 100,210,951 (GRCm39)	D141G	probably benign	Het
Zap70	T	A	1: 36,818,189 (GRCm39)		probably benign	Het
Zfp985	G	A	4: 147,668,029 (GRCm39)	C299Y	probably damaging	Het

Predicted Primers

PCR Primer
(F):5'- CAGCTAGCATGGCAGATGAG -3'
(R):5'- TCTCAGGAAGTACGAACGGTGTC -3'

Sequencing Primer
(F):5'- AGGAGGAAGACCCCACCTTTG -3'
(R):5'- ACGGTGTCAAGATCCATAGTTGGC -3'

Posted On

2015-06-20