|Institutional Source||Beutler Lab|
|Gene Name||protein phosphatase 2, regulatory subunit B', delta|
|Synonyms||TEG-271, B'delta, Tex271|
|Is this an essential gene?||Possibly non essential (E-score: 0.266)|
|Stock #||R4261 (G1)|
|Chromosomal Location||46682991-46705002 bp(-) (GRCm38)|
|Type of Mutation||nonsense|
|DNA Base Change (assembly)||G to A at 46687081 bp|
|Amino Acid Change||Glutamine to Stop codon at position 219 (Q219*)|
|Ref Sequence||ENSEMBL: ENSMUSP00000002839 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000002839] [ENSMUST00000002845]|
|Predicted Effect||probably null
AA Change: Q219*
AA Change: Q219*
|Predicted Effect||probably benign
|Predicted Effect||noncoding transcript
|Meta Mutation Damage Score||0.6|
|Coding Region Coverage||
|Validation Efficiency||96% (53/55)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a delta isoform of the regulatory subunit B56 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a gene-trap allele exhibit lethality, while heterozygous mice display decreased prepulse inhibition. Mice homozygous for a targeted knock-out allele exhibit decreased thermal nociception threshold, impaired coordination, and increasedlatency to removing an adhesive sticker. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Ppp2r5d||
(F):5'- ATCCAAGAGAGGCACTTGCTC -3'
(R):5'- CATCTCCAGGTACCAGGAAAG -3'
(F):5'- GCTCGCTCCACTTACACTAGGAG -3'
(R):5'- CTCCAGGTACCAGGAAAGGGATG -3'