Mutagenetix > Incidental Mutation

Incidental Mutation 'R0003:Olfr1102'

32290

Institutional Source

Beutler Lab

Gene Symbol

Olfr1102

Ensembl Gene

ENSMUSG00000049843

Gene Name

olfactory receptor 1102

Synonyms

MOR179-4, GA_x6K02T2Q125-48487992-48488966

MMRRC Submission

038299-MU

Accession Numbers

Ncbi RefSeq: NM_207154.2; MGI: 3030936

Essential gene?

Probably non essential (E-score: 0.190) question?

Stock #

R0003 (G1)

Quality Score

220

Status

Validated

Chromosome

Chromosomal Location

86998398-87003618 bp(+) (GRCm38)

Type of Mutation

nonsense

DNA Base Change (assembly)

T to A at 87002366 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Stop codon at position 132 (Y132*)

Ref Sequence

ENSEMBL: ENSMUSP00000149634 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000055129] [ENSMUST00000214002]

AlphaFold

Q8VES2

Predicted Effect

probably null
Transcript: ENSMUST00000055129
AA Change: Y132*

SMART Domains

Protein: ENSMUSP00000052861
Gene: ENSMUSG00000049843
AA Change: Y132*

Domain	Start	End	E-Value	Type
low complexity region	8	19	N/A	INTRINSIC
Pfam:7tm_4	43	320	8.1e-52	PFAM
Pfam:7TM_GPCR_Srsx	47	322	8.7e-6	PFAM
Pfam:7tm_1	53	302	3.6e-19	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000214002
AA Change: Y132*

Meta Mutation Damage Score

0.9717

Coding Region Coverage

1x: 99.0%
3x: 98.1%
10x: 95.7%
20x: 90.7%

Validation Efficiency

94% (82/87)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 89 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2610507B11Rik	T	A	11: 78,286,578	V1903E	possibly damaging	Het
Adam19	T	A	11: 46,128,789	C439S	probably damaging	Het
Adnp2	T	C	18: 80,130,990	Y68C	probably damaging	Het
Ahctf1	A	T	1: 179,763,473	D1247E	probably benign	Het
Alms1	T	A	6: 85,629,210	M2614K	possibly damaging	Het
Alx3	A	G	3: 107,604,976	H310R	probably damaging	Het
Ambra1	C	T	2: 91,911,428	T1016M	probably damaging	Het
Ankrd35	A	G	3: 96,684,015	E539G	probably damaging	Het
Aptx	A	G	4: 40,695,145		probably benign	Het
Arsi	C	T	18: 60,916,986	R314C	probably benign	Het
Atp1a3	T	C	7: 24,989,564		probably benign	Het
Avl9	G	T	6: 56,736,483	R242L	probably benign	Het
BC067074	T	A	13: 113,368,776	S2146R	probably benign	Het
Bicra	G	T	7: 15,971,887	T1543K	probably benign	Het
Bzw2	A	C	12: 36,130,015	I71S	probably damaging	Het
Camk2a	C	T	18: 60,960,007	A302V	probably damaging	Het
Ccdc12	A	G	9: 110,656,597	E12G	possibly damaging	Het
Cd300lb	A	T	11: 114,928,338	F19Y	probably benign	Het
Clcn3	A	T	8: 60,927,296	C535*	probably null	Het
Cntnap5c	A	G	17: 58,199,017	T679A	probably benign	Het
Cpsf7	G	A	19: 10,539,629	S365N	possibly damaging	Het
Cyp20a1	T	C	1: 60,387,126		probably benign	Het
Decr2	A	T	17: 26,083,053	N234K	probably benign	Het
Def8	G	A	8: 123,456,495	A278T	probably damaging	Het
Dnah12	T	C	14: 26,772,644	F1300L	probably damaging	Het
Dock1	T	C	7: 134,730,064		probably benign	Het
Dpy19l4	A	T	4: 11,267,619	N440K	probably damaging	Het
Eprs	T	C	1: 185,414,391	V1206A	probably damaging	Het
Exoc6b	A	G	6: 84,854,699		probably null	Het
Fam184b	A	G	5: 45,555,194		probably benign	Het
Fcho1	A	T	8: 71,708,953	S858T	probably damaging	Het
Fgfr1	A	G	8: 25,568,198	D430G	possibly damaging	Het
Fmnl3	T	C	15: 99,321,132	T807A	probably damaging	Het
Gabra5	T	C	7: 57,413,728	Y316C	probably damaging	Het
Gh	A	G	11: 106,301,520	L16P	probably damaging	Het
Glipr2	A	T	4: 43,970,532	I87F	probably damaging	Het
Glrb	T	A	3: 80,855,914	I259F	probably damaging	Het
Gpr63	T	C	4: 25,007,651	L125P	probably damaging	Het
Grb2	A	G	11: 115,655,425	Y37H	probably damaging	Het
Haus2	G	A	2: 120,618,968		probably benign	Het
Hmgcr	T	C	13: 96,652,145	N749S	probably damaging	Het
Igf1r	T	C	7: 68,165,242	V297A	probably damaging	Het
Il12rb2	G	T	6: 67,316,286	P69H	probably damaging	Het
Ints3	C	A	3: 90,408,511	M315I	probably benign	Het
Izumo2	C	T	7: 44,715,409	T116I	probably benign	Het
Kctd19	A	C	8: 105,395,361	Y185D	probably damaging	Het
Lama4	A	G	10: 39,060,222	N631S	possibly damaging	Het
Lama5	T	G	2: 180,178,079		probably null	Het
Lamc1	A	C	1: 153,262,439	L223R	probably damaging	Het
Lgr4	G	A	2: 109,997,665		probably null	Het
Loxhd1	T	C	18: 77,339,500	L398P	probably damaging	Het
Mapk9	T	A	11: 49,867,039	D103E	possibly damaging	Het
March6	T	C	15: 31,469,532		probably benign	Het
Mlxipl	G	A	5: 135,133,189		probably benign	Het
Mrgbp	C	A	2: 180,583,438	D62E	probably benign	Het
Mtap	A	T	4: 89,151,998		probably benign	Het
Myt1	G	A	2: 181,801,871	G497S	probably damaging	Het
Naa25	T	G	5: 121,407,184		probably benign	Het
Nfat5	C	T	8: 107,339,075	R156W	probably damaging	Het
Nkpd1	T	C	7: 19,519,927	C73R	probably benign	Het
Nup210l	T	C	3: 90,119,911	I200T	probably damaging	Het
Nvl	C	A	1: 181,114,133	D581Y	probably damaging	Het
Olfr1500	T	C	19: 13,827,686	T237A	probably damaging	Het
Olfr568	T	C	7: 102,877,861	V247A	probably benign	Het
Olfr575	T	C	7: 102,954,978	M208V	probably benign	Het
Olfr905	A	G	9: 38,473,316	T190A	probably benign	Het
Pcdh7	G	T	5: 57,913,248	E1089D	probably benign	Het
Pik3cd	A	G	4: 149,656,379		probably null	Het
Plekhh2	A	T	17: 84,557,392	K69N	probably damaging	Het
Ptgdr2	G	A	19: 10,940,428	C103Y	probably damaging	Het
Rrad	A	C	8: 104,628,667	H236Q	probably benign	Het
Rslcan18	C	T	13: 67,098,469	A236T	probably benign	Het
Ryr2	C	A	13: 11,824,379	D503Y	probably damaging	Het
Siglec1	T	C	2: 131,075,060	T1092A	probably benign	Het
Siglecf	A	G	7: 43,355,926	T437A	probably benign	Het
Spta1	A	T	1: 174,205,273	Q965H	probably damaging	Het
Stk10	A	T	11: 32,589,460	E280V	probably benign	Het
Tfg	T	C	16: 56,690,988	Y326C	possibly damaging	Het
Tpp2	T	A	1: 43,960,139	S358T	possibly damaging	Het
Trim25	G	T	11: 89,015,772	V437L	probably benign	Het
Ttn	T	C	2: 76,743,683	D25622G	probably damaging	Het
Ube3b	T	A	5: 114,398,851	S303R	probably benign	Het
Ush2a	T	A	1: 188,578,491	V2088D	probably damaging	Het
Vmn2r103	A	G	17: 19,811,979	T672A	probably damaging	Het
Wdr11	G	T	7: 129,599,061	G79C	probably damaging	Het
Wdr89	T	A	12: 75,632,593	T296S	probably benign	Het
Zdhhc24	T	A	19: 4,880,374	L179M	possibly damaging	Het
Zfp981	T	C	4: 146,537,760	C381R	probably damaging	Het
Zim1	A	G	7: 6,676,948	I572T	probably benign	Het

Other mutations in Olfr1102

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01371:Olfr1102	APN	2	87002923	missense	probably benign	0.31
IGL01584:Olfr1102	APN	2	87002151	missense	probably benign	0.04
IGL01913:Olfr1102	APN	2	87002820	missense	possibly damaging	0.68
IGL02672:Olfr1102	APN	2	87002073	missense	probably benign	0.00
R0003:Olfr1102	UTSW	2	87002366	nonsense	probably null
R1674:Olfr1102	UTSW	2	87002233	missense	probably benign	0.07
R1688:Olfr1102	UTSW	2	87002386	missense	probably benign	0.01
R3826:Olfr1102	UTSW	2	87002044	missense	probably damaging	0.97
R3925:Olfr1102	UTSW	2	87002374	missense	possibly damaging	0.91
R4023:Olfr1102	UTSW	2	87002922	nonsense	probably null
R4730:Olfr1102	UTSW	2	87002166	missense	possibly damaging	0.48
R5154:Olfr1102	UTSW	2	87002038	missense	probably benign	0.00
R5525:Olfr1102	UTSW	2	87002339	missense	possibly damaging	0.95
R5685:Olfr1102	UTSW	2	87002277	missense	probably benign	0.02
R5788:Olfr1102	UTSW	2	87002301	missense	probably benign	0.01
R6280:Olfr1102	UTSW	2	87002020	missense	probably damaging	0.99
R7178:Olfr1102	UTSW	2	87002535	missense	probably benign	0.07
R9493:Olfr1102	UTSW	2	87002796	missense	probably benign	0.45
R9745:Olfr1102	UTSW	2	87002143	missense	probably benign	0.28
Z1176:Olfr1102	UTSW	2	87002610	missense	probably benign	0.04
Z1176:Olfr1102	UTSW	2	87002611	missense	probably benign	0.00

Predicted Primers

PCR Primer
(F):5'- ATCGAGGATTCACGGCTCCACAAC -3'
(R):5'- TGATGGGATTCAGCATGGGAATCAC -3'

Sequencing Primer
(F):5'- ACAACCCCATGTACTATTTTCTGAC -3'
(R):5'- TAGTTCAATGGAGCCTGCAC -3'

Posted On

2013-05-09