Incidental Mutation 'R4281:Or11h7'
ID 322910
Institutional Source Beutler Lab
Gene Symbol Or11h7
Ensembl Gene ENSMUSG00000058188
Gene Name olfactory receptor family 11 subfamily H member 7
Synonyms MOR106-12, Olfr746, GA_x6K02T2PMLR-6372116-6373060
MMRRC Submission 041649-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.125) question?
Stock # R4281 (G1)
Quality Score 120
Status Not validated
Chromosome 14
Chromosomal Location 50890696-50891640 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 50891029 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Arginine at position 112 (C112R)
Ref Sequence ENSEMBL: ENSMUSP00000151399 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000080616] [ENSMUST00000218546]
AlphaFold E9Q840
Predicted Effect probably benign
Transcript: ENSMUST00000080616
AA Change: C112R

PolyPhen 2 Score 0.183 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000079451
Gene: ENSMUSG00000058188
AA Change: C112R

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 3.9e-52 PFAM
Pfam:7tm_1 41 290 2.8e-23 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000218546
AA Change: C112R

PolyPhen 2 Score 0.183 (Sensitivity: 0.92; Specificity: 0.87)
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.8%
  • 10x: 97.5%
  • 20x: 95.7%
Validation Efficiency 92% (44/48)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arl6ip1 AAAATAAATAAATAAATAAATAAATA AAAATAAATAAATAAATAAATAAATAAATA 7: 117,721,122 (GRCm39) probably benign Het
B9d2 A G 7: 25,380,851 (GRCm39) T14A possibly damaging Het
Cavin3 A C 7: 105,130,981 (GRCm39) probably null Het
Defa27 A G 8: 21,805,632 (GRCm39) N24S probably benign Het
Defb40 A G 8: 19,028,093 (GRCm39) S14P probably damaging Het
Dnaaf11 A T 15: 66,252,378 (GRCm39) H429Q probably benign Het
Dnmt3a G A 12: 3,951,665 (GRCm39) G681R probably damaging Het
Evc2 T C 5: 37,495,938 (GRCm39) V16A probably benign Het
Fam210b T C 2: 172,193,468 (GRCm39) Y94H probably damaging Het
Gimap8 A C 6: 48,635,754 (GRCm39) R506S probably benign Het
Gmip T A 8: 70,266,251 (GRCm39) probably benign Het
Gpr39 G A 1: 125,605,728 (GRCm39) V219I probably benign Het
Gsn A G 2: 35,188,883 (GRCm39) Y434C probably damaging Het
Gtf2a1l A G 17: 89,019,065 (GRCm39) N383S possibly damaging Het
Hepacam2 G A 6: 3,475,938 (GRCm39) T329I probably damaging Het
Iqgap3 T C 3: 88,006,167 (GRCm39) V526A probably benign Het
Magea14 T C X: 51,057,867 (GRCm39) Y273C probably damaging Het
Mark4 T C 7: 19,167,371 (GRCm39) K456R probably benign Het
Nox4 A G 7: 86,946,732 (GRCm39) I143V possibly damaging Het
Or12j3 A G 7: 139,953,385 (GRCm39) I46T probably benign Het
Pcdh18 A G 3: 49,710,982 (GRCm39) L111P possibly damaging Het
Pnma5 T C X: 72,079,036 (GRCm39) M549V probably benign Het
Pnpla6 T C 8: 3,571,513 (GRCm39) L148P probably damaging Het
Ppp4r3c1 A T X: 88,976,105 (GRCm39) W31R probably damaging Het
Prkdc A G 16: 15,623,963 (GRCm39) probably null Het
Rars1 T C 11: 35,712,051 (GRCm39) E275G probably damaging Het
Rasa3 A G 8: 13,638,946 (GRCm39) V287A probably benign Het
Rimbp2 C T 5: 128,865,404 (GRCm39) R641Q possibly damaging Het
Slco6b1 A G 1: 96,925,115 (GRCm39) noncoding transcript Het
Sned1 A T 1: 93,213,577 (GRCm39) R426* probably null Het
Tmem132a C G 19: 10,839,090 (GRCm39) E451Q possibly damaging Het
Tmem229b-ps A G 10: 53,351,474 (GRCm39) noncoding transcript Het
Trim33 T A 3: 103,236,402 (GRCm39) V504D probably damaging Het
Usp47 A T 7: 111,709,200 (GRCm39) E1315D probably benign Het
Zbtb24 T C 10: 41,340,916 (GRCm39) S649P probably benign Het
Zfp28 A T 7: 6,396,700 (GRCm39) Q378H probably benign Het
Zfp612 A G 8: 110,816,691 (GRCm39) I594V probably damaging Het
Zfp692 T C 11: 58,205,091 (GRCm39) F447L probably damaging Het
Zranb3 A C 1: 127,891,614 (GRCm39) S787R possibly damaging Het
Other mutations in Or11h7
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03288:Or11h7 APN 14 50,890,832 (GRCm39) missense possibly damaging 0.78
IGL03333:Or11h7 APN 14 50,890,855 (GRCm39) nonsense probably null
R0217:Or11h7 UTSW 14 50,891,552 (GRCm39) missense probably damaging 1.00
R0621:Or11h7 UTSW 14 50,891,419 (GRCm39) missense possibly damaging 0.91
R1656:Or11h7 UTSW 14 50,891,465 (GRCm39) missense probably benign 0.16
R1975:Or11h7 UTSW 14 50,890,821 (GRCm39) missense probably damaging 1.00
R5763:Or11h7 UTSW 14 50,891,525 (GRCm39) missense possibly damaging 0.84
R6236:Or11h7 UTSW 14 50,891,257 (GRCm39) missense probably damaging 1.00
R6612:Or11h7 UTSW 14 50,891,090 (GRCm39) missense probably damaging 1.00
R7112:Or11h7 UTSW 14 50,891,583 (GRCm39) missense probably benign 0.03
R7125:Or11h7 UTSW 14 50,891,041 (GRCm39) missense possibly damaging 0.92
R7221:Or11h7 UTSW 14 50,891,528 (GRCm39) missense probably damaging 0.99
R7810:Or11h7 UTSW 14 50,891,450 (GRCm39) missense probably benign 0.43
R7881:Or11h7 UTSW 14 50,890,904 (GRCm39) missense probably damaging 1.00
R8002:Or11h7 UTSW 14 50,891,314 (GRCm39) missense probably damaging 0.99
R8681:Or11h7 UTSW 14 50,890,801 (GRCm39) missense probably benign 0.00
R9518:Or11h7 UTSW 14 50,891,101 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ATGGCCATCATTTGTGCAGTG -3'
(R):5'- TGATCAATGATATTGGGGCCACAG -3'

Sequencing Primer
(F):5'- CATCATTTGTGCAGTGAGATGGAACC -3'
(R):5'- TATTGGGGCCACAGAAAGACAATTG -3'
Posted On 2015-06-20