Mutagenetix > Incidental Mutation

Incidental Mutation 'R4291:Vmn1r238'

323095

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r238

Ensembl Gene

ENSMUSG00000091539

Gene Name

vomeronasal 1 receptor, 238

Synonyms

MMRRC Submission

041081-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.056) question?

Stock #

R4291 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

3122492-3123412 bp(-) (GRCm38)

Type of Mutation

nonsense

DNA Base Change (assembly)

G to A at 3123214 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Glutamine to Stop codon at position 67 (Q67*)

Ref Sequence

ENSEMBL: ENSMUSP00000129804 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000165255]

AlphaFold

E9Q373

Predicted Effect

probably null
Transcript: ENSMUST00000165255
AA Change: Q67*

SMART Domains

Protein: ENSMUSP00000129804
Gene: ENSMUSG00000091539
AA Change: Q67*

Domain	Start	End	E-Value	Type
Pfam:TAS2R	7	302	5.3e-8	PFAM
Pfam:7tm_1	27	292	8.8e-7	PFAM
Pfam:V1R	34	298	1.9e-33	PFAM

Meta Mutation Damage Score

0.9755

Coding Region Coverage

1x: 99.3%
3x: 98.7%
10x: 97.6%
20x: 96.0%

Validation Efficiency

100% (62/62)

Allele List at MGI

Other mutations in this stock

Total: 53 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acad9	T	C	3: 36,066,188	F27S	probably benign	Het
AK157302	T	A	13: 21,495,545	D80E	probably damaging	Het
Amz2	T	C	11: 109,434,055		probably null	Het
Angel1	A	G	12: 86,720,283	Y440H	probably damaging	Het
Ankrd34c	T	A	9: 89,729,764	K175*	probably null	Het
Arid1b	C	A	17: 5,040,663	S546R	probably damaging	Het
Atf6b	T	A	17: 34,652,674	M428K	probably benign	Het
Brpf3	G	A	17: 28,823,975	V997M	probably benign	Het
Cckar	A	G	5: 53,706,497	S41P	probably benign	Het
Cd96	T	A	16: 46,071,749	Q292L	probably damaging	Het
Cdh18	C	A	15: 22,714,551		probably benign	Het
Cfb	T	G	17: 34,861,138	D122A	possibly damaging	Het
Copa	G	T	1: 172,092,397		probably benign	Het
Ctnna2	T	A	6: 76,882,745	K854N	probably damaging	Het
Cwh43	G	A	5: 73,411,932	V106M	probably benign	Het
Dact2	C	T	17: 14,196,571	E456K	probably benign	Het
Dnah8	T	C	17: 30,748,559	S2582P	probably benign	Het
Eef2	A	G	10: 81,179,580	T312A	probably benign	Het
Enpep	T	A	3: 129,270,317	R934*	probably null	Het
Fam240b	A	T	13: 64,481,813	M63K	possibly damaging	Het
Fhdc1	C	A	3: 84,444,826	V1031F	probably benign	Het
Gm6124	A	T	7: 39,222,771		noncoding transcript	Het
Gsn	G	A	2: 35,290,420	V147I	probably benign	Het
Gucy1a1	A	T	3: 82,094,759	F671Y	possibly damaging	Het
Hectd3	A	G	4: 116,995,692	E97G	probably damaging	Het
Kcnv1	G	A	15: 45,114,444	T66M	probably damaging	Het
Krba1	C	T	6: 48,415,665	P802S	possibly damaging	Het
Lca5l	C	T	16: 96,178,774	S52N	probably damaging	Het
Lmf1	T	C	17: 25,654,481	L320P	probably damaging	Het
Map3k4	G	T	17: 12,255,260	Q845K	probably benign	Het
Mapkapk3	T	C	9: 107,258,932		probably benign	Het
Mccc1	A	G	3: 35,990,068	V203A	probably damaging	Het
Mcm9	C	A	10: 53,547,572	M677I	probably benign	Het
Mkrn2	A	G	6: 115,617,434	T369A	possibly damaging	Het
Mthfr	C	A	4: 148,055,492	N623K	probably damaging	Het
Myh2	T	C	11: 67,181,159	V571A	probably benign	Het
Nom1	G	A	5: 29,446,372		probably null	Het
Nucb1	T	A	7: 45,495,280	D283V	probably damaging	Het
Olfr1120	G	A	2: 87,358,075	M210I	probably benign	Het
Olfr1396	T	A	11: 49,113,427	I100L	probably benign	Het
Olfr310	A	T	7: 86,269,760	F10I	probably damaging	Het
Pcdhb1	A	C	18: 37,265,417	L140F	probably damaging	Het
Ptgs2	G	A	1: 150,100,251	A10T	probably benign	Het
Rfx3	C	T	19: 27,800,232	R497Q	probably damaging	Het
Rps6kb1	A	T	11: 86,519,876		probably benign	Het
Slc22a21	T	C	11: 53,969,503	D34G	probably damaging	Het
Spata13	T	A	14: 60,709,555	M684K	probably damaging	Het
Tet3	T	C	6: 83,373,199	T961A	probably damaging	Het
Ttc27	T	C	17: 74,856,479	L694P	probably damaging	Het
Vmn2r101	A	T	17: 19,612,041	R766S	probably damaging	Het
Vwf	A	T	6: 125,642,322	Y1321F	probably damaging	Het
Wfdc1	C	A	8: 119,679,455	P103Q	probably damaging	Het
Zfp488	C	A	14: 33,970,894	C104F	possibly damaging	Het

Other mutations in Vmn1r238

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00427:Vmn1r238	APN	18	3123243	missense	probably benign	0.01
IGL01385:Vmn1r238	APN	18	3122770	missense	possibly damaging	0.83
IGL02716:Vmn1r238	APN	18	3123124	missense	probably damaging	1.00
R1219:Vmn1r238	UTSW	18	3123135	missense	possibly damaging	0.81
R1568:Vmn1r238	UTSW	18	3123358	missense	probably benign	0.00
R1864:Vmn1r238	UTSW	18	3123040	nonsense	probably null
R3024:Vmn1r238	UTSW	18	3123305	missense	probably benign	0.13
R4304:Vmn1r238	UTSW	18	3123040	nonsense	probably null
R4586:Vmn1r238	UTSW	18	3123294	missense	probably damaging	1.00
R4664:Vmn1r238	UTSW	18	3123300	missense	probably damaging	0.99
R5123:Vmn1r238	UTSW	18	3123243	missense	probably benign
R5430:Vmn1r238	UTSW	18	3122521	missense	possibly damaging	0.63
R5834:Vmn1r238	UTSW	18	3123168	missense	probably benign
R7186:Vmn1r238	UTSW	18	3122661	missense	probably damaging	0.99
R7206:Vmn1r238	UTSW	18	3122623	missense	possibly damaging	0.94
R7308:Vmn1r238	UTSW	18	3122875	missense	probably benign	0.09
R7346:Vmn1r238	UTSW	18	3123151	missense	probably damaging	1.00
R7467:Vmn1r238	UTSW	18	3123393	missense	probably benign	0.10
R7571:Vmn1r238	UTSW	18	3122721	missense	probably damaging	1.00
R7808:Vmn1r238	UTSW	18	3123033	missense	probably benign	0.03
R8085:Vmn1r238	UTSW	18	3123151	missense	probably damaging	1.00
R8086:Vmn1r238	UTSW	18	3123250	missense	probably damaging	1.00
R8325:Vmn1r238	UTSW	18	3122529	missense	probably benign	0.00
R8423:Vmn1r238	UTSW	18	3123365	nonsense	probably null
R8747:Vmn1r238	UTSW	18	3123232	missense	possibly damaging	0.87
R8930:Vmn1r238	UTSW	18	3123127	missense	probably benign	0.03
R8932:Vmn1r238	UTSW	18	3123127	missense	probably benign	0.03
R9279:Vmn1r238	UTSW	18	3122994	missense	probably damaging	0.99
R9382:Vmn1r238	UTSW	18	3122676	missense	probably damaging	0.99
R9644:Vmn1r238	UTSW	18	3122635	missense	probably benign	0.10
R9725:Vmn1r238	UTSW	18	3122577	missense	probably benign	0.00
Z1177:Vmn1r238	UTSW	18	3122505	missense	probably benign	0.00

Predicted Primers

PCR Primer
(F):5'- TGTTTAGAAGCAGGTGCACGAG -3'
(R):5'- GCAATAGAAACTTTTCTCTTCTGCCAG -3'

Sequencing Primer
(F):5'- TGCACGAGCCAACTGACTGAG -3'
(R):5'- CTTCTGCCAGATTACAGTGGGAATG -3'

Posted On

2015-06-20