Incidental Mutation 'R4293:Vmn2r101'
ID |
323188 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Vmn2r101
|
Ensembl Gene |
ENSMUSG00000094892 |
Gene Name |
vomeronasal 2, receptor 101 |
Synonyms |
EG627576 |
MMRRC Submission |
041082-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.124)
|
Stock # |
R4293 (G1)
|
Quality Score |
225 |
Status
|
Validated
|
Chromosome |
17 |
Chromosomal Location |
19797493-19832579 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
A to T
at 19832303 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Arginine to Serine
at position 766
(R766S)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000131583
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000171914]
|
AlphaFold |
E9PZS9 |
Predicted Effect |
probably damaging
Transcript: ENSMUST00000171914
AA Change: R766S
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
SMART Domains |
Protein: ENSMUSP00000131583 Gene: ENSMUSG00000094892 AA Change: R766S
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
Pfam:ANF_receptor
|
82 |
466 |
1.6e-36 |
PFAM |
Pfam:NCD3G
|
509 |
562 |
6.4e-22 |
PFAM |
Pfam:7tm_3
|
595 |
830 |
1.4e-51 |
PFAM |
|
Meta Mutation Damage Score |
0.6467 |
Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.8%
- 10x: 97.7%
- 20x: 96.2%
|
Validation Efficiency |
98% (60/61) |
Allele List at MGI |
|
Other mutations in this stock |
Total: 48 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Actn3 |
T |
C |
19: 4,915,468 (GRCm39) |
E428G |
probably benign |
Het |
Arfgef2 |
T |
C |
2: 166,732,211 (GRCm39) |
I1600T |
probably benign |
Het |
Arid3b |
A |
T |
9: 57,697,713 (GRCm39) |
|
probably benign |
Het |
Asgr2 |
C |
A |
11: 69,989,057 (GRCm39) |
T167K |
probably benign |
Het |
Atf6b |
T |
A |
17: 34,871,648 (GRCm39) |
M428K |
probably benign |
Het |
Atpaf1 |
A |
T |
4: 115,645,556 (GRCm39) |
M142L |
probably benign |
Het |
Bivm |
A |
T |
1: 44,177,793 (GRCm39) |
R364S |
probably damaging |
Het |
Bms1 |
T |
C |
6: 118,382,308 (GRCm39) |
|
probably null |
Het |
Brwd1 |
G |
A |
16: 95,818,804 (GRCm39) |
P1343S |
probably damaging |
Het |
Cdca2 |
T |
C |
14: 67,952,299 (GRCm39) |
D24G |
probably benign |
Het |
Celsr2 |
T |
C |
3: 108,300,993 (GRCm39) |
R2767G |
probably benign |
Het |
Cip2a |
T |
A |
16: 48,833,612 (GRCm39) |
F571Y |
probably benign |
Het |
Cyp2c55 |
A |
T |
19: 39,000,235 (GRCm39) |
I145F |
probably damaging |
Het |
Ddx18 |
T |
C |
1: 121,489,121 (GRCm39) |
T309A |
probably benign |
Het |
Dlg3 |
A |
T |
X: 99,840,288 (GRCm39) |
|
probably benign |
Het |
Fbf1 |
A |
G |
11: 116,039,720 (GRCm39) |
L713P |
probably damaging |
Het |
Fhdc1 |
C |
A |
3: 84,352,133 (GRCm39) |
V1031F |
probably benign |
Het |
Fnbp1 |
A |
G |
2: 30,995,362 (GRCm39) |
F24S |
probably damaging |
Het |
Gm16686 |
A |
T |
4: 88,673,710 (GRCm39) |
|
probably benign |
Het |
Gmps |
A |
G |
3: 63,898,040 (GRCm39) |
M275V |
probably damaging |
Het |
Igdcc4 |
A |
G |
9: 65,031,892 (GRCm39) |
|
probably null |
Het |
Kcnv1 |
G |
A |
15: 44,977,840 (GRCm39) |
T66M |
probably damaging |
Het |
Kif18a |
T |
C |
2: 109,123,398 (GRCm39) |
V224A |
probably benign |
Het |
Lbr |
C |
T |
1: 181,648,267 (GRCm39) |
C398Y |
probably damaging |
Het |
Lmf1 |
T |
C |
17: 25,873,455 (GRCm39) |
L320P |
probably damaging |
Het |
Mapkapk3 |
T |
C |
9: 107,136,131 (GRCm39) |
|
probably benign |
Het |
Mettl18 |
A |
G |
1: 163,824,171 (GRCm39) |
D164G |
probably damaging |
Het |
Myo5a |
A |
T |
9: 75,051,453 (GRCm39) |
T349S |
probably benign |
Het |
Or1ad6 |
T |
C |
11: 50,860,253 (GRCm39) |
M136T |
probably damaging |
Het |
Or8d2b |
A |
G |
9: 38,788,609 (GRCm39) |
I46V |
probably damaging |
Het |
Pcdhb5 |
T |
A |
18: 37,455,734 (GRCm39) |
S705T |
possibly damaging |
Het |
Phf14 |
C |
T |
6: 11,987,096 (GRCm39) |
P559S |
probably damaging |
Het |
Pik3c3 |
G |
A |
18: 30,477,043 (GRCm39) |
A855T |
probably damaging |
Het |
Plpp4 |
A |
G |
7: 128,909,356 (GRCm39) |
E22G |
probably damaging |
Het |
Rev1 |
A |
T |
1: 38,147,500 (GRCm39) |
D13E |
possibly damaging |
Het |
Sec16a |
A |
G |
2: 26,312,167 (GRCm39) |
Y1998H |
probably benign |
Het |
Slc4a5 |
C |
T |
6: 83,237,511 (GRCm39) |
R165C |
probably damaging |
Het |
Slfn10-ps |
T |
C |
11: 82,926,260 (GRCm39) |
|
noncoding transcript |
Het |
Slfn9 |
T |
C |
11: 82,873,334 (GRCm39) |
N523S |
probably benign |
Het |
Spata13 |
T |
A |
14: 60,947,004 (GRCm39) |
M684K |
probably damaging |
Het |
Srsf6 |
T |
C |
2: 162,776,636 (GRCm39) |
|
probably benign |
Het |
Stk32c |
T |
C |
7: 138,700,704 (GRCm39) |
|
probably null |
Het |
Tenm3 |
T |
C |
8: 48,848,693 (GRCm39) |
T49A |
probably damaging |
Het |
Tep1 |
T |
C |
14: 51,084,318 (GRCm39) |
I954V |
probably benign |
Het |
Tmem237 |
A |
G |
1: 59,158,995 (GRCm39) |
|
probably benign |
Het |
Vwce |
A |
G |
19: 10,636,996 (GRCm39) |
T693A |
probably benign |
Het |
Xpr1 |
A |
G |
1: 155,188,542 (GRCm39) |
F366S |
possibly damaging |
Het |
Zfp317 |
A |
G |
9: 19,557,990 (GRCm39) |
|
probably null |
Het |
|
Other mutations in Vmn2r101 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL01121:Vmn2r101
|
APN |
17 |
19,809,936 (GRCm39) |
missense |
probably damaging |
0.99 |
IGL02125:Vmn2r101
|
APN |
17 |
19,809,963 (GRCm39) |
missense |
possibly damaging |
0.95 |
IGL02300:Vmn2r101
|
APN |
17 |
19,832,199 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02682:Vmn2r101
|
APN |
17 |
19,832,507 (GRCm39) |
missense |
possibly damaging |
0.82 |
IGL02825:Vmn2r101
|
APN |
17 |
19,810,132 (GRCm39) |
missense |
probably benign |
0.00 |
IGL02862:Vmn2r101
|
APN |
17 |
19,831,867 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02943:Vmn2r101
|
APN |
17 |
19,831,666 (GRCm39) |
missense |
probably damaging |
0.99 |
R0371:Vmn2r101
|
UTSW |
17 |
19,810,394 (GRCm39) |
missense |
probably benign |
0.07 |
R0462:Vmn2r101
|
UTSW |
17 |
19,810,431 (GRCm39) |
missense |
probably benign |
0.04 |
R0492:Vmn2r101
|
UTSW |
17 |
19,809,245 (GRCm39) |
missense |
probably damaging |
1.00 |
R0654:Vmn2r101
|
UTSW |
17 |
19,810,373 (GRCm39) |
missense |
probably benign |
0.01 |
R1120:Vmn2r101
|
UTSW |
17 |
19,797,723 (GRCm39) |
splice site |
probably benign |
|
R1323:Vmn2r101
|
UTSW |
17 |
19,832,313 (GRCm39) |
missense |
probably damaging |
1.00 |
R1323:Vmn2r101
|
UTSW |
17 |
19,832,313 (GRCm39) |
missense |
probably damaging |
1.00 |
R1676:Vmn2r101
|
UTSW |
17 |
19,832,184 (GRCm39) |
missense |
probably benign |
0.00 |
R2023:Vmn2r101
|
UTSW |
17 |
19,810,368 (GRCm39) |
nonsense |
probably null |
|
R2149:Vmn2r101
|
UTSW |
17 |
19,809,225 (GRCm39) |
missense |
probably benign |
0.00 |
R2350:Vmn2r101
|
UTSW |
17 |
19,810,045 (GRCm39) |
missense |
probably benign |
0.01 |
R2760:Vmn2r101
|
UTSW |
17 |
19,809,901 (GRCm39) |
missense |
probably benign |
0.14 |
R3085:Vmn2r101
|
UTSW |
17 |
19,809,077 (GRCm39) |
splice site |
probably null |
|
R3086:Vmn2r101
|
UTSW |
17 |
19,809,077 (GRCm39) |
splice site |
probably null |
|
R3719:Vmn2r101
|
UTSW |
17 |
19,809,811 (GRCm39) |
missense |
possibly damaging |
0.50 |
R3771:Vmn2r101
|
UTSW |
17 |
19,809,919 (GRCm39) |
missense |
probably benign |
|
R3773:Vmn2r101
|
UTSW |
17 |
19,809,919 (GRCm39) |
missense |
probably benign |
|
R4225:Vmn2r101
|
UTSW |
17 |
19,831,951 (GRCm39) |
missense |
probably damaging |
1.00 |
R4248:Vmn2r101
|
UTSW |
17 |
19,809,376 (GRCm39) |
missense |
probably damaging |
1.00 |
R4290:Vmn2r101
|
UTSW |
17 |
19,832,303 (GRCm39) |
missense |
probably damaging |
1.00 |
R4291:Vmn2r101
|
UTSW |
17 |
19,832,303 (GRCm39) |
missense |
probably damaging |
1.00 |
R4307:Vmn2r101
|
UTSW |
17 |
19,810,423 (GRCm39) |
missense |
probably damaging |
1.00 |
R4721:Vmn2r101
|
UTSW |
17 |
19,832,287 (GRCm39) |
missense |
probably damaging |
0.99 |
R4829:Vmn2r101
|
UTSW |
17 |
19,832,229 (GRCm39) |
missense |
probably benign |
0.03 |
R5022:Vmn2r101
|
UTSW |
17 |
19,831,649 (GRCm39) |
critical splice acceptor site |
probably null |
|
R5110:Vmn2r101
|
UTSW |
17 |
19,831,897 (GRCm39) |
missense |
possibly damaging |
0.92 |
R5244:Vmn2r101
|
UTSW |
17 |
19,831,788 (GRCm39) |
missense |
probably damaging |
1.00 |
R5397:Vmn2r101
|
UTSW |
17 |
19,809,104 (GRCm39) |
missense |
probably damaging |
1.00 |
R5875:Vmn2r101
|
UTSW |
17 |
19,809,092 (GRCm39) |
missense |
probably damaging |
0.99 |
R5944:Vmn2r101
|
UTSW |
17 |
19,809,769 (GRCm39) |
missense |
probably benign |
0.00 |
R6216:Vmn2r101
|
UTSW |
17 |
19,811,267 (GRCm39) |
missense |
probably benign |
0.00 |
R6334:Vmn2r101
|
UTSW |
17 |
19,810,112 (GRCm39) |
missense |
possibly damaging |
0.83 |
R6512:Vmn2r101
|
UTSW |
17 |
19,809,146 (GRCm39) |
missense |
probably damaging |
1.00 |
R6607:Vmn2r101
|
UTSW |
17 |
19,832,296 (GRCm39) |
missense |
probably damaging |
1.00 |
R6965:Vmn2r101
|
UTSW |
17 |
19,811,284 (GRCm39) |
missense |
probably benign |
0.00 |
R7101:Vmn2r101
|
UTSW |
17 |
19,809,350 (GRCm39) |
missense |
probably null |
0.14 |
R7183:Vmn2r101
|
UTSW |
17 |
19,832,440 (GRCm39) |
missense |
probably damaging |
1.00 |
R7344:Vmn2r101
|
UTSW |
17 |
19,832,059 (GRCm39) |
missense |
probably benign |
0.38 |
R7375:Vmn2r101
|
UTSW |
17 |
19,831,652 (GRCm39) |
missense |
probably damaging |
1.00 |
R7574:Vmn2r101
|
UTSW |
17 |
19,831,899 (GRCm39) |
missense |
possibly damaging |
0.91 |
R7575:Vmn2r101
|
UTSW |
17 |
19,831,654 (GRCm39) |
missense |
probably benign |
0.01 |
R7592:Vmn2r101
|
UTSW |
17 |
19,811,443 (GRCm39) |
splice site |
probably null |
|
R7626:Vmn2r101
|
UTSW |
17 |
19,832,192 (GRCm39) |
nonsense |
probably null |
|
R7715:Vmn2r101
|
UTSW |
17 |
19,832,177 (GRCm39) |
missense |
probably damaging |
1.00 |
R7730:Vmn2r101
|
UTSW |
17 |
19,831,950 (GRCm39) |
missense |
possibly damaging |
0.81 |
R8078:Vmn2r101
|
UTSW |
17 |
19,810,507 (GRCm39) |
missense |
probably benign |
0.07 |
R8228:Vmn2r101
|
UTSW |
17 |
19,811,284 (GRCm39) |
missense |
probably benign |
0.00 |
R8283:Vmn2r101
|
UTSW |
17 |
19,832,253 (GRCm39) |
missense |
probably damaging |
1.00 |
R8712:Vmn2r101
|
UTSW |
17 |
19,811,397 (GRCm39) |
missense |
probably benign |
0.24 |
R8765:Vmn2r101
|
UTSW |
17 |
19,809,245 (GRCm39) |
missense |
probably damaging |
1.00 |
R9091:Vmn2r101
|
UTSW |
17 |
19,810,244 (GRCm39) |
missense |
probably benign |
|
R9092:Vmn2r101
|
UTSW |
17 |
19,809,807 (GRCm39) |
missense |
probably benign |
0.07 |
R9113:Vmn2r101
|
UTSW |
17 |
19,811,288 (GRCm39) |
missense |
possibly damaging |
0.56 |
R9158:Vmn2r101
|
UTSW |
17 |
19,809,161 (GRCm39) |
missense |
probably benign |
0.00 |
R9168:Vmn2r101
|
UTSW |
17 |
19,809,138 (GRCm39) |
missense |
probably damaging |
1.00 |
R9235:Vmn2r101
|
UTSW |
17 |
19,810,238 (GRCm39) |
missense |
probably damaging |
0.99 |
R9270:Vmn2r101
|
UTSW |
17 |
19,810,244 (GRCm39) |
missense |
probably benign |
|
R9290:Vmn2r101
|
UTSW |
17 |
19,811,395 (GRCm39) |
missense |
probably benign |
0.05 |
R9296:Vmn2r101
|
UTSW |
17 |
19,810,047 (GRCm39) |
missense |
probably damaging |
0.98 |
R9602:Vmn2r101
|
UTSW |
17 |
19,831,780 (GRCm39) |
nonsense |
probably null |
|
R9706:Vmn2r101
|
UTSW |
17 |
19,809,925 (GRCm39) |
missense |
probably damaging |
1.00 |
Z1088:Vmn2r101
|
UTSW |
17 |
19,809,237 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
Predicted Primers |
PCR Primer
(F):5'- TCAAGAGGTCCAAACTACATCATTC -3'
(R):5'- ACTTGGGTCCAAATATGAAGGC -3'
Sequencing Primer
(F):5'- CCAACTTCTTCTTTGTGGAATATGG -3'
(R):5'- TCCAAATATGAAGGCAAGGAGTG -3'
|
Posted On |
2015-06-20 |