Incidental Mutation 'R4295:Foxj3'
ID 323250
Institutional Source Beutler Lab
Gene Symbol Foxj3
Ensembl Gene ENSMUSG00000032998
Gene Name forkhead box J3
Synonyms C330039G02Rik, Fhd6
MMRRC Submission 041084-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.482) question?
Stock # R4295 (G1)
Quality Score 225
Status Not validated
Chromosome 4
Chromosomal Location 119396858-119486316 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) G to T at 119483494 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glycine to Stop codon at position 555 (G555*)
Ref Sequence ENSEMBL: ENSMUSP00000101917 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000044564] [ENSMUST00000106310]
AlphaFold Q8BUR3
Predicted Effect probably null
Transcript: ENSMUST00000044564
AA Change: G589*
SMART Domains Protein: ENSMUSP00000035746
Gene: ENSMUSG00000032998
AA Change: G589*

DomainStartEndE-ValueType
FH 76 164 6.03e-50 SMART
low complexity region 226 239 N/A INTRINSIC
low complexity region 263 274 N/A INTRINSIC
low complexity region 317 346 N/A INTRINSIC
low complexity region 372 434 N/A INTRINSIC
low complexity region 611 620 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000106310
AA Change: G555*
SMART Domains Protein: ENSMUSP00000101917
Gene: ENSMUSG00000032998
AA Change: G555*

DomainStartEndE-ValueType
FH 76 164 6.03e-50 SMART
low complexity region 192 205 N/A INTRINSIC
low complexity region 229 240 N/A INTRINSIC
low complexity region 283 312 N/A INTRINSIC
low complexity region 338 400 N/A INTRINSIC
low complexity region 577 586 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000133097
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.7%
  • 10x: 97.4%
  • 20x: 95.5%
Validation Efficiency
MGI Phenotype PHENOTYPE: Homozygous null mice have an abnormal skeletal muscle fiber type ratio in males as well as defects in muscle regeneration following injury. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4833420G17Rik T C 13: 119,606,249 (GRCm39) S164P probably benign Het
4933427D06Rik A G 6: 89,084,883 (GRCm39) noncoding transcript Het
Aldh1l2 C T 10: 83,331,784 (GRCm39) V674M possibly damaging Het
Angel1 A G 12: 86,767,057 (GRCm39) Y440H probably damaging Het
Atr A G 9: 95,756,479 (GRCm39) I870V probably benign Het
Cd200r4 T C 16: 44,653,239 (GRCm39) V3A probably damaging Het
Celf2 T C 2: 6,608,875 (GRCm39) N302S probably benign Het
Cip2a T A 16: 48,833,612 (GRCm39) F571Y probably benign Het
Dnah17 A T 11: 118,009,598 (GRCm39) I363N probably damaging Het
Fam98a A T 17: 75,848,342 (GRCm39) M124K probably damaging Het
Fhdc1 C A 3: 84,352,133 (GRCm39) V1031F probably benign Het
Gm4841 T C 18: 60,403,262 (GRCm39) N277S probably benign Het
Kcnv1 G A 15: 44,977,840 (GRCm39) T66M probably damaging Het
Kif18a T C 2: 109,123,398 (GRCm39) V224A probably benign Het
Lamb2 A G 9: 108,363,410 (GRCm39) D863G probably benign Het
Lbr C T 1: 181,648,267 (GRCm39) C398Y probably damaging Het
Lcn11 G A 2: 25,668,111 (GRCm39) A90T possibly damaging Het
Or14c46 A T 7: 85,918,968 (GRCm39) F10I probably damaging Het
Or2v2 T A 11: 49,004,254 (GRCm39) I100L probably benign Het
Or5m3 T C 2: 85,838,614 (GRCm39) Y165H probably benign Het
Or8d2b A G 9: 38,788,609 (GRCm39) I46V probably damaging Het
Or9a4 T A 6: 40,549,090 (GRCm39) F257I probably damaging Het
Pcdhb5 T A 18: 37,455,734 (GRCm39) S705T possibly damaging Het
Pcgf2 A T 11: 97,584,282 (GRCm39) Y24* probably null Het
Phf14 C T 6: 11,987,096 (GRCm39) P559S probably damaging Het
Pigf A G 17: 87,331,184 (GRCm39) I46T probably benign Het
Plpp4 A G 7: 128,909,356 (GRCm39) E22G probably damaging Het
Prdm10 A G 9: 31,227,590 (GRCm39) E65G possibly damaging Het
Sash1 A G 10: 8,606,006 (GRCm39) S795P possibly damaging Het
Slc22a21 T C 11: 53,860,329 (GRCm39) D34G probably damaging Het
Spata13 T A 14: 60,947,004 (GRCm39) M684K probably damaging Het
Srsf6 T C 2: 162,776,636 (GRCm39) probably benign Het
Stk32c T C 7: 138,700,704 (GRCm39) probably null Het
Tjp1 T C 7: 64,972,898 (GRCm39) D514G probably damaging Het
Ttll11 TCGCCGCCGCCGCCGCCGCCGC TCGCCGCCGCCGCCGCCGC 2: 35,869,564 (GRCm39) probably benign Het
Unc13c A G 9: 73,641,786 (GRCm39) S1236P probably damaging Het
Utp20 G T 10: 88,590,381 (GRCm39) D2364E possibly damaging Het
Vmn1r192 T A 13: 22,371,465 (GRCm39) I252F probably damaging Het
Vmn1r76 T C 7: 11,665,057 (GRCm39) I52M probably benign Het
Xndc1 T A 7: 101,730,694 (GRCm39) L288M possibly damaging Het
Zfp451 A T 1: 33,816,836 (GRCm39) F154L probably damaging Het
Other mutations in Foxj3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01072:Foxj3 APN 4 119,467,226 (GRCm39) missense probably benign 0.03
IGL01452:Foxj3 APN 4 119,478,825 (GRCm39) missense unknown
IGL02056:Foxj3 APN 4 119,442,954 (GRCm39) missense probably damaging 1.00
IGL02455:Foxj3 APN 4 119,477,434 (GRCm39) missense unknown
IGL02542:Foxj3 APN 4 119,477,540 (GRCm39) missense unknown
IGL02625:Foxj3 APN 4 119,482,114 (GRCm39) missense unknown
IGL03216:Foxj3 APN 4 119,467,180 (GRCm39) intron probably benign
R0087:Foxj3 UTSW 4 119,483,597 (GRCm39) missense unknown
R0488:Foxj3 UTSW 4 119,477,187 (GRCm39) nonsense probably null
R0512:Foxj3 UTSW 4 119,443,033 (GRCm39) splice site probably benign
R1531:Foxj3 UTSW 4 119,477,398 (GRCm39) missense unknown
R1799:Foxj3 UTSW 4 119,476,548 (GRCm39) missense probably benign 0.06
R1883:Foxj3 UTSW 4 119,467,226 (GRCm39) missense probably benign 0.20
R3690:Foxj3 UTSW 4 119,473,839 (GRCm39) splice site probably benign
R3691:Foxj3 UTSW 4 119,473,839 (GRCm39) splice site probably benign
R3838:Foxj3 UTSW 4 119,473,821 (GRCm39) missense possibly damaging 0.49
R4065:Foxj3 UTSW 4 119,467,206 (GRCm39) missense probably benign 0.09
R4576:Foxj3 UTSW 4 119,478,860 (GRCm39) missense unknown
R4750:Foxj3 UTSW 4 119,473,787 (GRCm39) missense probably damaging 0.99
R4782:Foxj3 UTSW 4 119,478,857 (GRCm39) missense unknown
R4799:Foxj3 UTSW 4 119,478,857 (GRCm39) missense unknown
R5305:Foxj3 UTSW 4 119,477,155 (GRCm39) missense possibly damaging 0.73
R5358:Foxj3 UTSW 4 119,476,596 (GRCm39) missense probably damaging 1.00
R5362:Foxj3 UTSW 4 119,477,340 (GRCm39) missense unknown
R5728:Foxj3 UTSW 4 119,430,959 (GRCm39) missense probably damaging 1.00
R5732:Foxj3 UTSW 4 119,443,008 (GRCm39) missense probably damaging 1.00
R6151:Foxj3 UTSW 4 119,480,468 (GRCm39) missense unknown
R6352:Foxj3 UTSW 4 119,442,975 (GRCm39) missense probably damaging 1.00
R6377:Foxj3 UTSW 4 119,430,945 (GRCm39) splice site probably null
R7034:Foxj3 UTSW 4 119,476,497 (GRCm39) missense probably damaging 0.97
R7672:Foxj3 UTSW 4 119,477,429 (GRCm39) missense unknown
R7912:Foxj3 UTSW 4 119,477,252 (GRCm39) missense possibly damaging 0.63
R8215:Foxj3 UTSW 4 119,478,808 (GRCm39) missense unknown
R9190:Foxj3 UTSW 4 119,477,538 (GRCm39) nonsense probably null
R9624:Foxj3 UTSW 4 119,483,589 (GRCm39) missense unknown
R9762:Foxj3 UTSW 4 119,483,540 (GRCm39) missense unknown
Predicted Primers PCR Primer
(F):5'- TCCCTACTATAAAATAAGGACCAGAGG -3'
(R):5'- ACCCAGCTAGAATCTCTGATTGTC -3'

Sequencing Primer
(F):5'- TATAAAATAAGGACCAGAGGAACCAC -3'
(R):5'- GAATCTCTGATTGTCTTCGAAAGG -3'
Posted On 2015-06-20