Incidental Mutation 'R4298:Prdm11'
ID 323412
Institutional Source Beutler Lab
Gene Symbol Prdm11
Ensembl Gene ENSMUSG00000075028
Gene Name PR domain containing 11
Synonyms 8030443D09Rik
MMRRC Submission 041086-MU
Accession Numbers
Essential gene? Possibly essential (E-score: 0.557) question?
Stock # R4298 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 92802363-92876512 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 92823728 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 179 (T179A)
Ref Sequence ENSEMBL: ENSMUSP00000136795 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000111272] [ENSMUST00000111274] [ENSMUST00000178666]
AlphaFold A2AGX3
Predicted Effect probably benign
Transcript: ENSMUST00000111272
AA Change: T131A

PolyPhen 2 Score 0.124 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000106903
Gene: ENSMUSG00000075028
AA Change: T131A

DomainStartEndE-ValueType
SANT 147 217 3.94e-3 SMART
low complexity region 291 312 N/A INTRINSIC
low complexity region 434 448 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000111274
AA Change: T179A

PolyPhen 2 Score 0.437 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000106905
Gene: ENSMUSG00000075028
AA Change: T179A

DomainStartEndE-ValueType
SET 115 232 5.16e-2 SMART
low complexity region 369 380 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000178666
AA Change: T179A

PolyPhen 2 Score 0.437 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000136795
Gene: ENSMUSG00000075028
AA Change: T179A

DomainStartEndE-ValueType
SET 115 232 5.16e-2 SMART
low complexity region 369 380 N/A INTRINSIC
Meta Mutation Damage Score 0.0856 question?
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.8%
  • 10x: 97.5%
  • 20x: 95.9%
Validation Efficiency 100% (54/54)
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc12 T C 8: 87,258,154 (GRCm39) probably null Het
Ccser2 T A 14: 36,612,337 (GRCm39) Q158L possibly damaging Het
Cct7 T A 6: 85,445,155 (GRCm39) C469S probably damaging Het
Chmp7 A T 14: 69,956,650 (GRCm39) probably null Het
Clcn4 C T 7: 7,299,737 (GRCm39) D31N possibly damaging Het
Col9a2 C G 4: 120,911,455 (GRCm39) R599G probably damaging Het
Ctdp1 A T 18: 80,493,172 (GRCm39) V441E probably benign Het
Cyp4a10 T C 4: 115,389,889 (GRCm39) L498P probably damaging Het
Dsc3 A T 18: 20,113,811 (GRCm39) N370K possibly damaging Het
Dusp12 G A 1: 170,708,198 (GRCm39) T173M probably benign Het
Ebf3 C T 7: 136,826,958 (GRCm39) R318Q possibly damaging Het
Epcam T C 17: 87,947,962 (GRCm39) probably null Het
Erich6 G T 3: 58,531,712 (GRCm39) A428D probably benign Het
Ext1 A T 15: 53,208,521 (GRCm39) I80N probably benign Het
Extl1 T C 4: 134,084,969 (GRCm39) E667G probably damaging Het
F2 T G 2: 91,459,665 (GRCm39) probably null Het
Fbxw16 T C 9: 109,275,625 (GRCm39) I135V probably benign Het
Glipr1l1 A T 10: 111,898,252 (GRCm39) D119V probably benign Het
Gprc5b G A 7: 118,583,437 (GRCm39) A144V possibly damaging Het
Lmbrd2 G A 15: 9,165,882 (GRCm39) R252H possibly damaging Het
Lyst A G 13: 13,809,472 (GRCm39) T381A probably damaging Het
Mcpt4 A T 14: 56,298,444 (GRCm39) V97D possibly damaging Het
Nefh A G 11: 4,890,066 (GRCm39) I851T probably benign Het
Nf1 A T 11: 79,275,070 (GRCm39) I44F probably damaging Het
Nyap2 A T 1: 81,218,811 (GRCm39) I278F probably damaging Het
Or4c52 A T 2: 89,845,993 (GRCm39) T240S probably benign Het
Or4f7d-ps1 G T 2: 111,674,789 (GRCm39) noncoding transcript Het
Pdcd4 C A 19: 53,908,092 (GRCm39) P201Q probably damaging Het
Pramel16 A T 4: 143,675,713 (GRCm39) L371* probably null Het
Qrfpr T A 3: 36,243,703 (GRCm39) I133F probably damaging Het
Rack1 T C 11: 48,692,453 (GRCm39) probably benign Het
Reln A C 5: 22,125,485 (GRCm39) C2733G probably damaging Het
Rrs1 C T 1: 9,616,448 (GRCm39) R234C possibly damaging Het
Sag G C 1: 87,772,737 (GRCm39) D402H probably benign Het
Sbk3 T A 7: 4,972,979 (GRCm39) T64S probably benign Het
Setx GTGGCT GT 2: 29,044,073 (GRCm39) 1814 probably null Het
Sh3gl1 C T 17: 56,326,173 (GRCm39) G111D probably damaging Het
Spata20 G A 11: 94,373,914 (GRCm39) R379W probably damaging Het
St3gal2 T C 8: 111,688,991 (GRCm39) M177T probably benign Het
Stk39 C T 2: 68,221,284 (GRCm39) G213D probably damaging Het
Szt2 A G 4: 118,222,603 (GRCm39) probably benign Het
Taf1d T C 9: 15,219,939 (GRCm39) S63P probably damaging Het
Tnfrsf13b C G 11: 61,031,643 (GRCm39) probably null Het
Ttn G T 2: 76,554,394 (GRCm39) A30807D probably damaging Het
Unc119 A G 11: 78,238,948 (GRCm39) N158S probably damaging Het
Vmn2r116 T A 17: 23,620,801 (GRCm39) I845N possibly damaging Het
Vmn2r12 C A 5: 109,239,830 (GRCm39) M244I probably benign Het
Zdhhc4 A G 5: 143,309,997 (GRCm39) V87A probably damaging Het
Zwilch A G 9: 64,062,444 (GRCm39) probably null Het
Other mutations in Prdm11
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01526:Prdm11 APN 2 92,843,102 (GRCm39) missense probably damaging 1.00
IGL02108:Prdm11 APN 2 92,806,048 (GRCm39) missense probably damaging 1.00
IGL02166:Prdm11 APN 2 92,843,208 (GRCm39) missense probably damaging 1.00
IGL02369:Prdm11 APN 2 92,805,864 (GRCm39) missense probably benign 0.00
IGL02388:Prdm11 APN 2 92,805,957 (GRCm39) missense possibly damaging 0.90
IGL02606:Prdm11 APN 2 92,805,948 (GRCm39) missense probably benign 0.02
IGL02967:Prdm11 APN 2 92,843,234 (GRCm39) missense probably damaging 1.00
IGL03085:Prdm11 APN 2 92,805,304 (GRCm39) missense possibly damaging 0.86
IGL03125:Prdm11 APN 2 92,810,967 (GRCm39) missense probably benign 0.22
E0370:Prdm11 UTSW 2 92,810,924 (GRCm39) missense probably damaging 1.00
R0607:Prdm11 UTSW 2 92,844,130 (GRCm39) missense possibly damaging 0.85
R0964:Prdm11 UTSW 2 92,819,567 (GRCm39) intron probably benign
R4011:Prdm11 UTSW 2 92,843,175 (GRCm39) missense probably damaging 1.00
R4951:Prdm11 UTSW 2 92,810,954 (GRCm39) missense probably damaging 1.00
R5150:Prdm11 UTSW 2 92,805,817 (GRCm39) missense probably damaging 1.00
R5320:Prdm11 UTSW 2 92,843,226 (GRCm39) missense probably benign 0.00
R5432:Prdm11 UTSW 2 92,806,158 (GRCm39) missense probably benign 0.00
R6442:Prdm11 UTSW 2 92,805,990 (GRCm39) missense probably benign 0.34
R6754:Prdm11 UTSW 2 92,844,137 (GRCm39) missense probably damaging 1.00
R7403:Prdm11 UTSW 2 92,817,036 (GRCm39) missense probably benign
R7480:Prdm11 UTSW 2 92,805,669 (GRCm39) missense probably benign 0.05
R7497:Prdm11 UTSW 2 92,843,052 (GRCm39) missense possibly damaging 0.93
R7633:Prdm11 UTSW 2 92,810,999 (GRCm39) missense probably damaging 1.00
R7873:Prdm11 UTSW 2 92,819,628 (GRCm39) missense probably benign 0.01
R7936:Prdm11 UTSW 2 92,806,106 (GRCm39) missense possibly damaging 0.67
R7939:Prdm11 UTSW 2 92,843,074 (GRCm39) missense probably damaging 1.00
R8548:Prdm11 UTSW 2 92,843,103 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TTTAGAGCCTCTGATGGAAGCC -3'
(R):5'- AACTTAGACAGCGGCTGAGG -3'

Sequencing Primer
(F):5'- CTCTGATGGAAGCCTGGGGAAC -3'
(R):5'- AGACAGCGGCTGAGGTTGTG -3'
Posted On 2015-06-20